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|Current Price||Change from Average||Comment||Current Shares|
|ISIS||George Soros||2011-06-30||Sold Out||$8.54 - $9.38|
|$ 38.75||334%||Sold Out||0|
|ISIS||George Soros||2011-03-31||Buy||$8.57 - $10.35|
|$ 38.75||321%||New holding, 22300 sh.||22,300|
|ISIS||Jean-Marie Eveillard||2010-12-31||Sold Out||-0.01%||$8.05 - $10.51|
|$ 38.75||309%||Sold Out||0|
|ISIS||Jean-Marie Eveillard||2010-09-30||Buy||0.01%||$7.775 - $10.07|
|$ 38.75||342%||New holding, 100000 sh.||100,000|
|ISIS||George Soros||2010-09-30||Sold Out||$7.775 - $10.07|
|$ 38.75||342%||Sold Out||0|
|ISIS||George Soros||2010-06-30||Buy||$8.84 - $11.13|
|$ 38.75||290%||New holding, 16100 sh.||16,100|
|ISIS||Jean-Marie Eveillard||2010-03-31||Sold Out||-0.01%||$8.66 - $11.76|
|$ 38.75||276%||Sold Out||0|
|ISIS||Jean-Marie Eveillard||2009-12-31||Buy||0.01%||$9.94 - $14.16|
|$ 38.75||224%||New holding, 50000 sh.||50,000|
|ISIS||Jean-Marie Eveillard||2007-12-31||Sold Out||$15.4 - $17.69|
|$ 38.75||132%||Sold Out||0|
|ISIS||Jean-Marie Eveillard||2007-09-30||Buy||$9.74 - $14.97|
|$ 38.75||220%||New holding, 25000 sh.||25,000|
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