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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Mr. David R. HollandN/A106,4180.24%2015-10-30
Dr. Kenneth Green,PhDSVP & Chief Scientific Officer92,3530.2%2015-12-16
Mr. C. Daniel MyersN/A89,9840.2%2015-10-30
Ms. Susan CaballaN/A79,4200.18%2014-04-30
Mr. Richard S. Eiswirth, JrCOO and CFO34,974less than 0.1%2015-12-15
Glen BradleyN/A10,047less than 0.1%2012-12-13
Peter J. Pizzo,IIIN/A7,500less than 0.1%2012-12-13
Dr. Calvin W. Roberts,M.D.Director6,389less than 0.1%2015-09-03
Dr. Brian K. Halak,PhDN/A1,692less than 0.1%2015-07-16

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
BAVP, L.P.10% Owner2016-04-21Sell478,6733,998,718$2.591239.76-52.513,998,718 (Direct)
EISWIRTH RICHARD S JRCOO and CFO
(Click for the stocks that their CFOs have bought)
2015-12-16Sell46,66934,974$2.31107.81-46.7534,974 (Direct)
Flynn James E2015-12-08Buy272,2495,878,015$3.01819.47-59.14
4,760,408 (Through Deerfield Special Situations Fund, L.P.)
728,718 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Flynn James E2015-12-03Buy243,2525,605,766$3729.76-59
4,624,284 (Through Deerfield Special Situations Fund, L.P.)
592,593 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Flynn James E2015-11-06Buy73,2505,362,514$2.98218.29-58.72
4,502,658 (Through Deerfield Special Situations Fund, L.P.)
470,967 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Flynn James E2015-10-30Buy16,5425,289,264$349.63-59
4,466,033 (Through Deerfield Special Situations Fund, L.P.)
434,342 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Flynn James E2015-10-28Buy59,3425,272,722$3178.03-59
4,457,762 (Through Deerfield Special Situations Fund, L.P.)
426,071 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Flynn James E2015-10-26Buy60,3645,213,380$3181.09-59
4,428,091 (Through Deerfield Special Situations Fund, L.P.)
396,400 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Flynn James E2015-10-21Buy390,0405,153,016$2.971158.42-58.59
4,397,909 (Through Deerfield Special Situations Fund, L.P.)
366,218 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
EISWIRTH RICHARD S JRCOO and CFO
(Click for the stocks that their CFOs have bought)
2015-10-15Sell13,62534,974$2.6936.65-54.2834,974 (Direct)
Flynn James E2015-10-09Buy321,7854,762,976$2.42778.72-49.17
4,202,889 (Through Deerfield Special Situations Fund, L.P.)
171,198 (Through Deerfield Private Design Fund III, L.P.)
181,222 (Through Deerfield Private Design Fund II, L.P.)
207,667 (Through Deerfield Private Design International II, L.P.)
Roberts Calvin W.Director2015-09-03Buy6,424302,024$319.27-596,389 (Direct)
101,845 (See Footnote (1))
2,350 (See Footnote (2))
95,620 (See Footnote (3))
95,820 (See Footnote (4))
Roberts Calvin W.Director2015-08-24Buy8,539295,600$325.62-596,389 (Direct)
2,150 (See Footnote (2))
95,620 (See Footnote (3))
95,820 (See Footnote (4))
95,621 (See Footnote (5))
Green KennethSVP & Chief Scientific Officer2015-08-21Sell20,00048,235$3.2965.8-62.6148,235 (Direct)
Green KennethSVP & Chief Scientific Officer2015-08-17Sell20,00068,235$3.978-68.4668,235 (Direct)
BAVP, L.P.10% Owner2015-07-22Sell9324,477,391$54.66-75.44,477,391 (Direct)
BAVP, L.P.10% Owner2015-06-26Sell1,0244,478,323$55.12-75.44,478,323 (Direct)
BAVP, L.P.10% Owner2015-06-19Sell5,5684,479,347$527.84-75.44,479,347 (Direct)
Myers C. DanielPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-05-01Sell2,00088,980$4.378.74-71.8588,980 (Direct)
Myers C. DanielPresident and CEO2015-05-01Sell2,00088,995$4.378.74-71.8588,995 (Direct)
BAVP, L.P.10% Owner2015-04-27Sell3,1144,484,915$5.0215.63-75.54,484,915 (Direct)
BAVP, L.P.10% Owner2015-04-23Sell4,3624,488,029$521.81-75.44,488,029 (Direct)
BAVP, L.P.10% Owner2015-04-20Sell30,3004,492,391$5.03152.41-75.554,492,391 (Direct)
BAVP, L.P.10% Owner2015-04-15Sell35,8004,522,691$5.03180.07-75.554,522,691 (Direct)
Myers C. DanielPresident and CEO2015-04-01Sell2,00090,317$4.929.84-7590,317 (Direct)
EISWIRTH RICHARD S JRCOO and CFO2015-03-06Buy10,00032,474$4.8448.4-74.5932,474 (Direct)
Myers C. DanielPresident and CEO2015-03-02Sell2,00092,317$5.2110.42-76.3992,317 (Direct)
Myers C. DanielPresident and CEO2015-02-02Sell2,00096,317$5.4310.86-77.3596,317 (Direct)
Holland DavidSVP of Sales and Marketing2015-01-02Sell5,000102,084$5.5627.8-77.88102,084 (Direct)
Myers C. DanielPresident and CEO2015-01-02Sell2,000102,817$5.5111.02-77.68102,817 (Direct)
Myers C. DanielPresident and CEO2014-12-01Sell2,000104,817$5.9911.98-79.47104,817 (Direct)
Holland DavidSVP of Sales and Marketing2014-12-01Sell5,000102,084$5.7128.55-78.46102,084 (Direct)
Myers C. DanielPresident and CEO2014-11-03Sell2,000106,817$5.3510.7-77.01106,817 (Direct)
Holland DavidSVP of Sales and Marketing2014-11-03Sell5,000102,084$5.3426.7-76.97102,084 (Direct)
BAVP, L.P.10% Owner2014-10-27Sell57,9184,558,491$6.34367.2-80.64,558,491 (Direct)
Lee Patrick10% Owner2014-10-01Sell621,1913,013,793$5.423366.86-77.31
3,013,793 (See Footnotes(F1,F2,F3,F4,F5,F6,F7,F8,F9,F10))
Holland DavidSVP of Sales and Marketing2014-10-01Sell5,000100,862$5.2626.3-76.62100,862 (Direct)
Myers C. DanielPresident and CEO2014-10-01Sell2,000108,357$5.4210.84-77.31108,357 (Direct)
BAVP, L.P.10% Owner2014-09-11Sell2,8164,616,409$6.2517.6-80.324,616,409 (Direct)
BAVP, L.P.10% Owner2014-09-04Sell39,5004,619,225$6.33250.04-80.574,619,225 (Direct)
Holland DavidSVP of Sales and Marketing2014-09-02Sell5,000100,862$6.1930.95-80.13100,862 (Direct)
Myers C. DanielPresident and CEO2014-09-02Sell2,000110,357$6.1912.38-80.13110,357 (Direct)
BAVP, L.P.10% Owner2014-08-29Sell7,4004,658,725$6.2746.4-80.384,658,725 (Direct)
Holland DavidSVP of Sales and Marketing2014-08-01Sell5,000100,862$5.6428.2-78.19100,862 (Direct)
Holland DavidSVP of Sales & Marketing2014-07-01Sell5,00098,362$6.0230.1-79.5798,362 (Direct)
BAVP, L.P.10% Owner2014-06-30Sell6004,666,125$6.253.75-80.324,666,125 (Direct)
Myers C. DanielPresident and CEO2014-06-06Sell5,000111,130$5.5627.8-77.88111,130 (Direct)
Holland DavidSenior Vice President of Sales2014-06-02Sell5,00098,362$5.7328.65-78.5398,362 (Direct)
Holland DavidSVP of Sales and Marketing2014-05-01Sell5,00098,362$5.9329.65-79.2698,362 (Direct)
BAVP, L.P.10% Owner2014-04-24Sell196,3694,666,725$6.561288.18-81.254,666,725 (Direct)
Holland DavidSVP of Sales and Marketing2014-04-01Sell10,00098,362$8.0180.1-84.6498,362 (Direct)
Holland DavidSVP of Sales and Marketing2014-03-04Sell10,00098,362$6.8468.4-82.0298,362 (Direct)
Myers C. DanielPresident and CEO2014-03-04Sell22,775116,130$7.1161.7-82.68116,130 (Direct)
Caballa SusanSee Remarks2014-03-04Sell8,93177,432$7.0162.61-82.4577,432 (Direct)
EISWIRTH RICHARD S JRCOO and CFO2014-01-17Sell50,00017,474$8.1405-84.8117,474 (Direct)
Domain Partners VI, L.P.10% Owner2014-01-16Sell296,7603,590,931$6.391896.3-80.753,590,931 (Direct)
DP VI Associates, L.P.10% Owner2014-01-16Sell3,24034,907$6.3920.7-80.7534,907 (Direct)
Polaris Venture Management Co 2013-07-17Sell122,9373,090,769$4.8590.1-74.38
3,090,769 (See Footnote)
DP VI Associates, L.P.10% Owner2013-06-20Sell11438,147$5.010.57-75.4538,147 (Direct)
Domain Partners VI, L.P.10% Owner2013-06-20Sell10,5163,887,691$5.0152.69-75.453,887,691 (Direct)
DP VI Associates, L.P.10% Owner2013-06-19Sell60338,261$5.393.25-77.1838,261 (Direct)
Domain Partners VI, L.P.10% Owner2013-06-19Sell55,2783,898,207$5.39297.95-77.183,898,207 (Direct)
Polaris Venture Management Co 2013-06-18Sell37,0633,211,433$5.44201.62-77.39
3,211,433 (See footnote)
DP VI Associates, L.P.10% Owner2013-06-17Sell1,38438,864$5.297.32-76.7538,864 (Direct)
Domain Partners VI, L.P.10% Owner2013-06-17Sell126,7093,953,485$5.29670.29-76.753,953,485 (Direct)
DP VI Associates, L.P.10% Owner2013-06-11Sell5940,248$50.3-75.440,248 (Direct)
Domain Partners VI, L.P.10% Owner2013-06-11Sell5,3374,080,194$526.69-75.44,080,194 (Direct)
Holland DavidSVP of Sales & Marketing2013-05-17Sell30,00098,362$4.13123.9-70.2298,362 (Direct)
DP VI Associates, L.P.10% Owner2013-05-16Sell48340,307$4.62.22-73.2640,307 (Direct)
Domain Partners VI, L.P.10% Owner2013-05-16Sell44,2424,085,531$4.6203.51-73.264,085,531 (Direct)
Pizzo Peter J. IIIDirector2012-12-13Buy5,0007,500$1.447.2-14.587,500 (Direct)
BRADLEY GLENDirector2012-12-13Buy10,04710,047$1.4214.27-13.3810,047 (Direct)
EISWIRTH RICHARD S JRCOO and CFO2012-12-13Buy5,00015,299$1.447.2-14.5815,299 (Direct)
Myers C. DanielPresident and CEO2012-12-03Sell7,700117,900$1.9515.02-36.92117,900 (Direct)
Myers C. DanielPresident and CEO2012-11-01Sell5,950124,616$2.5214.99-51.19124,616 (Direct)
Myers C. DanielPresident and CEO2012-10-01Sell5,900139,066$2.5214.87-51.19139,066 (Direct)
Myers C. DanielPresident and CEO2012-09-04Sell6,350144,966$2.3614.99-47.88144,966 (Direct)
Myers C. DanielPresident and CEO2012-08-13Sell6,745151,316$2.2214.97-44.59151,316 (Direct)
Caballa SusanSEE REMARKS2011-08-19Buy3,00057,277$7.1521.45-82.857,277 (Direct)
Caballa SusanSEE REMARKS2011-08-19Buy3,00057,277$7.1521.45-82.857,277 (Direct)
Green KennethSVP & Chief Scientific Officer2011-06-07Sell21,9690$8175.75-84.63Link
DOVEY BRIAN H10% Owner2011-06-02Sell6,9144,189,427$8.0455.59-84.7
4,129,773 (By Domain Partners VI, L.P.)
18,864 (By One Palmer Square Associates VI, L.L.C.)
40,790 (By DP VI Associates, L.P.)
BLAIR JAMES C10% Owner2011-06-02Sell6,9144,189,427$8.0455.59-84.7
4,129,773 (By Domain Partners VI, L.P.)
18,864 (By One Palmer Square Associates VI, L.L.C.)
40,790 (By DP VI Associates, L.P.)
DP VI Associates, L.P.10% Owner2011-06-02Sell6,91440,790$8.0455.59-84.740,790 (Direct)
VITULLO NICOLE10% Owner2011-06-02Sell6,9144,189,427$8.0455.59-84.7
4,129,773 (By Domain Partners VI, L.P.)
18,864 (By One Palmer Square Associates VI, L.L.C.)
40,790 (By DP VI Associates, L.P.)
SCHOEMAKER KATHLEEN K10% Owner2011-06-02Sell6,9144,189,427$8.0455.59-84.7
4,129,773 (By Domain Partners VI, L.P.)
18,864 (By One Palmer Square Associates VI, L.L.C.)
40,790 (By DP VI Associates, L.P.)
TREU JESSE I10% Owner2011-06-02Sell6,9144,189,427$8.0455.59-84.7
4,129,773 (By Domain Partners VI, L.P.)
18,864 (By One Palmer Square Associates VI, L.L.C.)
40,790 (By DP VI Associates, L.P.)
Myers C. DanielPresident and CEO2011-03-15Sell45,5230$7.06321.39-82.58Link
Roberts Calvin W.Director2011-03-10Buy30,0000$7.75232.5-84.13Link
Myers C. DanielPresident and CEO2011-03-10Sell9,6240$7.6673.72-83.94Link
Roberts Calvin W.Director2011-02-25Buy17,6000$7.92139.39-84.47Link
Pizzo Peter J. IIIDirector2010-11-09Buy2,5002,500$9.9524.88-87.64Link
Roberts Calvin W.Director2010-11-05Buy12,6002,600$10.47131.92-88.25Link
Polaris Venture Management Co 2010-04-27Buy378,0280$114158.31-88.82Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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