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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Richard Hamilton, PhDN/A222,0990.8%2015-01-21
Mr. Paul KucN/A115,3670.41%2015-01-22
Dr. Richard Flavell, PhDN/A112,1830.4%2012-07-06
Dr. Roger Pennell, PhDN/A85,2330.31%2014-09-12
Mr. Pascal BrandysN/A58,5660.21%2012-02-21
Dr. J. Jefferson Gwyn, PhDN/A49,0330.18%2014-03-25
Ms. Wilfriede Margareta Maria Van AsscheN/A45,3330.16%2015-01-21
Thomas D. KileyN/A16,666less than 0.1%2012-11-05
Mr. Raymond DebbaneN/A16,666less than 0.1%2012-02-21
Mr. Michael StephensonN/A1,000less than 0.1%2013-05-06

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Ambergate Trust10% Owner2013-01-16Buy5,36044,875$36.88197.68-98.9244,875 (Direct)
Ambergate Trust10% Owner2013-01-15Buy16,40844,875$37.52615.63-98.9344,875 (Direct)
Ambergate Trust10% Owner2013-01-07Buy3344,875$32.881.09-98.7844,875 (Direct)
Ambergate Trust10% Owner2012-12-28Buy3,43844,875$33.28114.4-98.844,875 (Direct)
Ambergate Trust10% Owner2012-12-20Buy12,26144,875$31.12381.57-98.7144,875 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-07-09Sell16914,023$68.9611.62-99.4214,023 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-07-06Sell101,875$68.080.68-99.411,875 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-07-05Sell9614,191$70.886.78-99.4414,191 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-07-05Sell211,885$70.881.48-99.441,885 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-07-02Sell23614,287$70.3216.59-99.4314,287 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-07-02Sell521,906$70.323.68-99.431,906 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-26Sell37514,523$79.5229.82-99.514,523 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-26Sell1251,958$79.529.94-99.51,958 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-20Sell152,083$75.041.1-99.472,083 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-20Sell4414,898$75.043.28-99.4714,898 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-19Sell67714,942$73.0449.42-99.4514,942 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-19Sell2262,098$73.0416.47-99.452,098 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-11Sell3015,618$80.642.39-99.515,618 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-11Sell102,323$80.640.8-99.52,323 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-07Sell972,333$80.887.83-99.512,333 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-07Sell29115,648$80.8823.51-99.5115,648 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-05Sell15415,939$80.1612.3-99.515,939 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-05Sell512,430$80.164.09-99.52,430 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-06-01Sell2616,092$802.05-99.516,092 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-06-01Sell92,481$800.69-99.52,481 (Direct)
Carlson Robert W Jr.See Remarks2012-06-01Buy1,18846,063$79.5294.43-99.51,188 (Direct)
44,875 (See Footnote)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-05-31Sell112,490$80.080.84-99.52,490 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-05-31Sell3116,118$80.082.5-99.516,118 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-05-29Sell1142,500$869.81-99.532,500 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-05-29Sell34216,149$8629.42-99.5316,149 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-05-24Sell912,614$81.687.42-99.512,614 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-05-24Sell27316,491$81.6822.26-99.5116,491 (Direct)
Flavell Richard BaileyChief Scientific Officer2012-05-22Sell916,764$88.240.83-99.5516,764 (Direct)
van Assche Wilfriede MargaretaSVP & Gen. Counsel & Secretary2012-05-22Sell32,705$88.240.28-99.552,705 (Direct)
ARTAL LUXEMBOURG S A10% Owner2012-02-27Buy105,769507,117$10411000-99.62507,117 (Direct)
Ambergate Trust10% Owner2012-02-27Buy19,231269,046$1042000-99.62269,046 (Direct)

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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