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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
MIDDLETON FRED ADirector2015-06-15Sell26,0641,414,232$1.5740.92-61.7846,810 (Direct)
1,107,189 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-12Sell16,2731,440,296$1.6126.2-62.7346,810 (Direct)
1,133,253 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-09Sell106,8761,456,569$1.65176.35-63.6446,810 (Direct)
1,149,526 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Benfer DavidDirector2015-03-13Buy3,00044,990$1.955.85-69.2342,290 (Direct)
2,700 (Spouse)
MESSEY ROBERT JDirector2015-03-04Sell1,41035,818$2.333.29-74.2535,818 (Direct)
0 (By Trust)
Mills William C. IIICEO
(Click for the stocks that their CEOs have bought)
2014-12-12Buy10,000239,711$1.4514.5-58.62239,711 (Direct)
Mills William C. IIICEO2014-12-05Buy10,000229,711$1.4314.3-58.04229,711 (Direct)
Mills William C. IIICEO2014-08-11Buy10,000219,711$2.7527.5-78.18219,711 (Direct)
MIDDLETON FRED ADirector2013-08-23Sell14,6001,592,107$3.6753.58-83.6575,472 (Direct)
0 (Middleton McNeil Retirement Trust)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Alafi Christopher D10% Owner2013-08-20Sell261,2411,307,043$3.74977.04-83.9624,593 (Direct)
1,266,628 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
222 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2013-08-07Sell78,9741,296,592$10.13800.01-94.0888,072 (Direct)
960,764 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
28,117 (Sanderling Ventures Management VI)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
MIDDLETON FRED ADirector2012-11-30Buy24,3601,101,114$1.5337.27-60.7876,072 (Direct)
782,272 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
28,117 (Sanderling Ventures Management VI)
3,060 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
Benfer DavidDirector2012-05-31Buy3,0006,935$2.57.5-764,910 (Direct)
2,025 (Spouse)
Duggan Samuel W IICFO2012-05-11Buy5,00015,000$3.517.5-82.8610,000 (Direct)
5,000 (Samuel W. Duggan II Trust U/A DTD 4/21/2000)
Kelley William MDirector2011-12-09Buy2,0004,260$9.418.8-93.623,860 (Direct)
400 (Med Tech Partners)
MIDDLETON FRED ADirector2011-09-15Buy485484,541$13.86.69-95.6531,976 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-09-12Buy6,447437,788$13.486.39-95.5222,829 (Direct)
399,137 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
Alafi Christopher DDirector2011-09-09Buy3,553431,342$13.347.26-95.4922,829 (Direct)
392,691 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2011-09-01Buy1,712484,056$13.723.45-95.6231,491 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Kaminski Michael PPresident and CEO2011-09-01Buy1,04012,927$14.314.87-95.812,557 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Cheng FrankSenior VP, Marketing and BD2011-08-19Buy1,5003,930$9.914.85-93.943,930 (Direct)
Giffin DavidVP, Human Resources2011-08-18Buy9524,477$10.510-94.294,477 (Direct)
Duros Karen WitteSr. VP, Gen. Counsel & Sec.2011-08-16Buy1,0002,620$11.611.6-94.832,620 (Direct)
Kaminski Michael PPresident and CEO2011-08-11Buy1,27111,887$11.815-94.9211,517 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Kaminski Michael PPresident and CEO2011-06-15Buy50010,616$30.115.05-98.0110,246 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
MIDDLETON FRED ADirector2011-06-14Buy1,000482,344$3030-9829,779 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-06-03Buy5,000427,788$33.5167.5-98.2122,829 (Direct)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
389,137 (Alafi Capital Company LLC)
3,000 (by Mother)
Kaminski Michael PPresident and CEO2011-03-07Buy6800$37.125.23-98.38Link
Kaminski Michael PPresident and CEO2010-11-18Buy2807,686$35.69.97-98.31Link
Kaminski Michael PPresident and CEO2010-11-18Buy28011,846$35.69.97-98.31Link
Alafi Christopher DDirector, 10% Owner2010-08-18Buy2,600422,473$32.584.5-98.15Link
MIDDLETON FRED ADirector, 10% Owner2010-08-18Buy2,600458,173$32.584.5-98.15Link
JOHNSTON DANIEL JCFO2010-05-10Buy1,0004,179$40.340.3-98.51Link
Kaminski Michael PPresident and CEO2010-05-10Buy25011,566$41.610.4-98.56Link
Hogg Bevil JDirector2010-03-12Sell3,20030,444$55.3176.96-98.92Link
Alafi Christopher DDirector, 10% Owner2010-03-03Buy5,00022,514$48.3241.5-98.76Link
Walker MelissaSr. VP, Reg., Quality & Compl.2009-12-15Sell2507,924$42.210.55-98.58Link
Hogg Bevil JDirector2009-12-09Sell6,50028,088$36.2235.3-98.34Link
Kaminski Michael PPresident & CEO2009-09-01Buy14170$34.94.92-98.28Link
MIDDLETON FRED ADirector, 10% Owner2009-08-31Buy50025,459$35.417.7-98.31Link
Alafi Christopher DDirector, 10% Owner2009-08-26Buy3,0003,000$34.9104.7-98.28Link
Kaminski Michael PPresident & CEO2009-06-04Buy2309,915$44.410.21-98.65
Alafi Christopher DDirector, 10% Owner2009-05-29Buy1,500389,137$34.551.75-98.26
MIDDLETON FRED ADirector, 10% Owner2009-05-26Buy2,77924,959$34.595.88-98.26
Alafi Christopher DDirector, 10% Owner2009-05-14Buy5,0005,000$34.8174-98.28
Benfer DavidDirector2009-03-13Buy350525$37.913.27-98.42
Walker MelissaSr. VP, Reg., Quality & Compl.2009-03-11Sell2007,649$367.2-98.33
MIDDLETON FRED ADirector, 10% Owner2008-12-29Buy101,2131,627$46.44696.28-98.71
Alafi Christopher DDirector2008-12-29Buy101,213388,037$46.44696.28-98.71
Alafi Christopher DDirector2008-11-20Buy1,000286,824$35.335.3-98.3
MIDDLETON FRED ADirector, 10% Owner2008-11-18Buy2922,179$300.88-98
Alafi Christopher DDirector2008-11-18Buy4,408285,824$35.6156.91-98.31
Lele Abhijeet JDirector2008-11-17Buy2,1405,140$25.354.14-97.63
SHIFRIN KEVIN TSr. VP, Marketing & Bus. Dev.2008-11-17Buy7504,270$27.520.63-97.82
MIDDLETON FRED ADirector, 10% Owner2008-06-13Buy1,18020,959$51.160.3-98.83
Alafi Christopher DDirector2008-03-14Buy110279,183$36.13.97-98.34
Alafi Christopher DDirector2008-03-14Buy9,060279,073$36.9334.31-98.37
Kelley William MDirector2008-03-14Buy6001,500$37.122.26-98.38
MIDDLETON FRED ADirector, 10% Owner2008-03-14Buy2,32019,779$36.885.38-98.37
Alafi Christopher DDirector2008-03-13Buy34,500270,013$36.61262.7-98.36
MIDDLETON FRED ADirector, 10% Owner2008-03-12Buy12017,459$37.84.54-98.41
Lele Abhijeet JDirector2008-03-11Buy3,0003,000$35.4106.2-98.31
MIDDLETON FRED ADirector, 10% Owner2008-03-11Buy2,38017,339$34.983.06-98.28
MESSEY ROBERT JDirector2008-03-11Buy1,0001,390$34.634.6-98.27
Benfer DavidDirector2008-03-07Buy600350$38.923.34-98.46
MIDDLETON FRED ADirector, 10% Owner2008-03-07Buy50,000615$391950-98.46
PRYSTOWSKY ERIC NDirector2008-03-05Buy1,0001,000$39.339.3-98.47
ACHARYA ABHIDirector2008-03-05Buy1,0002,111$39.839.8-98.49
Mills William C. IIIDirector2008-03-05Buy5002,500$4020-98.5
Benfer DavidDirector2007-09-10Buy300150$126.537.95-99.53
Kaminski Michael PPresident & COO2007-08-24Sell2,7104,185$130352.3-99.54
MIDDLETON FRED ADirector2007-06-21Sell120$120.41.47-99.5
Walker MelissaSVP, Reg, Quality & Compliance2007-06-15Sell2015,849$121.224.3-99.5
Kaminski Michael PCOO2007-06-06Sell1,7906,895$120.1214.98-99.5
Mills William C. IIIDirector2007-05-15Buy1,0002,000$113.5113.5-99.47
Alafi Christopher DDirector2007-03-15Buy1,000232,925$108.9108.9-99.45
Mills William C. IIIDirector2006-10-19Sell330$1203.95-99.5
Mills William C. IIIDirector2006-06-30Sell301,024$104.53.14-99.43Link
Walker MelissaVP, Regulatory & Quality2006-06-15Sell8604,862$9178.26-99.34Link
Sehra RuchirChief Medical Officer2006-06-14Buy1103,635$90.59.96-99.34Link
Hogg Bevil JPresident & CEO2006-06-08Buy1,00036,090$89.689.6-99.33Link
Benfer DavidDirector2006-06-06Buy260560$96.725.14-99.38Link
Kelley William MDirector2006-06-01Buy5001,300$98.949.45-99.39Link
Kaminski Michael PCOO2006-05-24Sell1,0004,185$100.9100.9-99.41Link
Sehra RuchirChief Medical Officer2006-05-16Buy1003,341$105.210.52-99.43Link
MESSEY ROBERT JDirector2006-05-15Buy340410$106.636.24-99.44Link
Hogg Bevil JPresident & CEO2006-04-11Sell1,00030,090$118.1118.1-99.49Link
Hogg Bevil JPresident & CEO2006-04-07Sell7,50031,090$120.9906.75-99.5Link
Mills William C. IIIDirector2006-01-23Sell61,054$152.50.92-99.61Link
Mills William C. IIIDirector2006-01-13Sell301,060$106.43.19-99.44Link
Mills William C. IIIDirector2006-01-10Sell181,090$911.67-99.34Link
Mills William C. IIIDirector2005-12-28Sell561,108$90.75.11-99.34Link
Mills William C. IIIDirector2005-12-20Sell601,164$83.35-99.28Link
ALAFI MOSHE10% Owner2005-12-06Buy3,210224,245$72.1231.46-99.17Link
Alafi Christopher DDirector, 10% Owner2005-12-06Buy2,339239,838$72.6169.83-99.17Link
ALAFI CAPITAL CO LLC10% Owner2005-12-06Buy2,339224,245$72.6169.83-99.17Link
ALAFI CAPITAL CO LLC10% Owner2005-12-05Buy871221,906$70.761.57-99.15Link
Sehra RuchirVP of Clinical Affairs2005-12-05Buy502,550$70.93.55-99.15Link
Alafi Christopher DDirector, 10% Owner2005-12-02Buy131237,499$719.29-99.15Link
Benfer DavidDirector2005-11-28Buy200300$7014-99.14Link
MIDDLETON FRED ADirector2005-11-18Buy380250,513$63.224.02-99.05Link
Mills William C. IIIDirector2005-09-12Sell121,224$90.11.08-99.33Link
Kelley William MDirector2005-08-23Buy400800$85.334.12-99.3Link
Kelley William MDirector2005-08-15Buy400400$93.537.4-99.36Link
Kaminski Michael PCOO2005-08-15Buy252,275$90.42.26-99.34Link
Mills William C. IIIDirector2005-08-12Sell301,236$81.32.44-99.26Link
Mills William C. IIIDirector2005-07-29Sell261,266$101.12.65-99.41Link
Mills William C. IIIDirector2005-07-26Sell821,293$887.18-99.32Link
Mills William C. IIIDirector2005-07-21Sell221,374$84.31.83-99.29Link
Mills William C. IIIDirector2005-07-19Sell41,396$850.36-99.29Link
Mills William C. IIIDirector2005-07-18Sell41,400$840.34-99.29Link
Mills William C. IIIDirector2005-07-13Sell521,404$83.14.32-99.28Link
Mills William C. IIIDirector2005-07-11Sell131,456$83.81.08-99.28Link
Mills William C. IIIDirector2005-07-06Sell671,469$81.85.44-99.27Link
Mills William C. IIIDirector2005-07-01Sell121,536$80.10.95-99.25Link
Mills William C. IIIDirector2005-06-28Sell41,547$800.3-99.25Link
Mills William C. IIIDirector2005-06-24Sell81,551$800.61-99.25Link
Johnson Gregory RDirector2005-06-15Buy50062,607$79.539.75-99.25Link
MIDDLETON FRED ADirector2005-06-08Buy583250,133$71.941.9-99.17Link
Mills William C. IIIDirector2005-05-19Sell151,552$801.18-99.25Link
MIDDLETON FRED ADirector2005-05-17Buy100319,850$77.97.79-99.23Link
Mills William C. IIIDirector2005-05-12Sell71,566$800.58-99.25Link
Mills William C. IIIDirector2005-05-09Sell111,574$80.10.87-99.25Link
MIDDLETON FRED ADirector2004-08-27Buy817323,522$77.163.01-99.22Link
Bruce Douglas MichaelSr. V.P., R & D2004-08-17Buy1010$800.8-99.25Link
Parker David JDirector2004-08-17Buy150150$8012-99.25Link
Mills William C. IIIDirector2004-08-17Buy1,0001,582$8080-99.25Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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