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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
MIDDLETON FRED ADirector2015-06-15Sell26,0641,414,232$1.5740.92-63.6946,810 (Direct)
1,107,189 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-12Sell16,2731,440,296$1.6126.2-64.646,810 (Direct)
1,133,253 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-09Sell106,8761,456,569$1.65176.35-65.4546,810 (Direct)
1,149,526 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Benfer DavidDirector2015-03-13Buy3,00044,990$1.955.85-70.7742,290 (Direct)
2,700 (Spouse)
MESSEY ROBERT JDirector2015-03-04Sell1,41035,818$2.333.29-75.5435,818 (Direct)
0 (By Trust)
Mills William C. IIICEO
(Click for the stocks that their CEOs have bought)
2014-12-12Buy10,000239,711$1.4514.5-60.69239,711 (Direct)
Mills William C. IIICEO2014-12-05Buy10,000229,711$1.4314.3-60.14229,711 (Direct)
Mills William C. IIICEO2014-08-11Buy10,000219,711$2.7527.5-79.27219,711 (Direct)
MIDDLETON FRED ADirector2013-08-23Sell14,6001,592,107$3.6753.58-84.4775,472 (Direct)
0 (Middleton McNeil Retirement Trust)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Alafi Christopher D10% Owner2013-08-20Sell261,2411,307,043$3.74977.04-84.7624,593 (Direct)
1,266,628 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
222 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2013-08-07Sell78,9741,296,592$10.13800.01-94.3788,072 (Direct)
960,764 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
28,117 (Sanderling Ventures Management VI)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
MIDDLETON FRED ADirector2012-11-30Buy24,3601,101,114$1.5337.27-62.7576,072 (Direct)
782,272 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
28,117 (Sanderling Ventures Management VI)
3,060 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
Benfer DavidDirector2012-05-31Buy3,0006,935$2.57.5-77.24,910 (Direct)
2,025 (Spouse)
Duggan Samuel W IICFO2012-05-11Buy5,00015,000$3.517.5-83.7110,000 (Direct)
5,000 (Samuel W. Duggan II Trust U/A DTD 4/21/2000)
Kelley William MDirector2011-12-09Buy2,0004,260$9.418.8-93.943,860 (Direct)
400 (Med Tech Partners)
MIDDLETON FRED ADirector2011-09-15Buy485484,541$13.86.69-95.8731,976 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-09-12Buy6,447437,788$13.486.39-95.7522,829 (Direct)
399,137 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
Alafi Christopher DDirector2011-09-09Buy3,553431,342$13.347.26-95.7122,829 (Direct)
392,691 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2011-09-01Buy1,712484,056$13.723.45-95.8431,491 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Kaminski Michael PPresident and CEO2011-09-01Buy1,04012,927$14.314.87-96.0112,557 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Cheng FrankSenior VP, Marketing and BD2011-08-19Buy1,5003,930$9.914.85-94.243,930 (Direct)
Giffin DavidVP, Human Resources2011-08-18Buy9524,477$10.510-94.574,477 (Direct)
Duros Karen WitteSr. VP, Gen. Counsel & Sec.2011-08-16Buy1,0002,620$11.611.6-95.092,620 (Direct)
Kaminski Michael PPresident and CEO2011-08-11Buy1,27111,887$11.815-95.1711,517 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Kaminski Michael PPresident and CEO2011-06-15Buy50010,616$30.115.05-98.1110,246 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
MIDDLETON FRED ADirector2011-06-14Buy1,000482,344$3030-98.129,779 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-06-03Buy5,000427,788$33.5167.5-98.322,829 (Direct)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
389,137 (Alafi Capital Company LLC)
3,000 (by Mother)
Kaminski Michael PPresident and CEO2011-03-07Buy6800$37.125.23-98.46Link
Kaminski Michael PPresident and CEO2010-11-18Buy2807,686$35.69.97-98.4Link
Kaminski Michael PPresident and CEO2010-11-18Buy28011,846$35.69.97-98.4Link
Alafi Christopher DDirector, 10% Owner2010-08-18Buy2,600422,473$32.584.5-98.25Link
MIDDLETON FRED ADirector, 10% Owner2010-08-18Buy2,600458,173$32.584.5-98.25Link
JOHNSTON DANIEL JCFO2010-05-10Buy1,0004,179$40.340.3-98.59Link
Kaminski Michael PPresident and CEO2010-05-10Buy25011,566$41.610.4-98.63Link
Hogg Bevil JDirector2010-03-12Sell3,20030,444$55.3176.96-98.97Link
Alafi Christopher DDirector, 10% Owner2010-03-03Buy5,00022,514$48.3241.5-98.82Link
Walker MelissaSr. VP, Reg., Quality & Compl.2009-12-15Sell2507,924$42.210.55-98.65Link
Hogg Bevil JDirector2009-12-09Sell6,50028,088$36.2235.3-98.43Link
Kaminski Michael PPresident & CEO2009-09-01Buy14170$34.94.92-98.37Link
MIDDLETON FRED ADirector, 10% Owner2009-08-31Buy50025,459$35.417.7-98.39Link
Alafi Christopher DDirector, 10% Owner2009-08-26Buy3,0003,000$34.9104.7-98.37Link
Kaminski Michael PPresident & CEO2009-06-04Buy2309,915$44.410.21-98.72
Alafi Christopher DDirector, 10% Owner2009-05-29Buy1,500389,137$34.551.75-98.35
MIDDLETON FRED ADirector, 10% Owner2009-05-26Buy2,77924,959$34.595.88-98.35
Alafi Christopher DDirector, 10% Owner2009-05-14Buy5,0005,000$34.8174-98.36
Benfer DavidDirector2009-03-13Buy350525$37.913.27-98.5
Walker MelissaSr. VP, Reg., Quality & Compl.2009-03-11Sell2007,649$367.2-98.42
MIDDLETON FRED ADirector, 10% Owner2008-12-29Buy101,2131,627$46.44696.28-98.77
Alafi Christopher DDirector2008-12-29Buy101,213388,037$46.44696.28-98.77
Alafi Christopher DDirector2008-11-20Buy1,000286,824$35.335.3-98.39
MIDDLETON FRED ADirector, 10% Owner2008-11-18Buy2922,179$300.88-98.1
Alafi Christopher DDirector2008-11-18Buy4,408285,824$35.6156.91-98.4
Lele Abhijeet JDirector2008-11-17Buy2,1405,140$25.354.14-97.75
SHIFRIN KEVIN TSr. VP, Marketing & Bus. Dev.2008-11-17Buy7504,270$27.520.63-97.93
MIDDLETON FRED ADirector, 10% Owner2008-06-13Buy1,18020,959$51.160.3-98.88
Alafi Christopher DDirector2008-03-14Buy110279,183$36.13.97-98.42
Alafi Christopher DDirector2008-03-14Buy9,060279,073$36.9334.31-98.46
Kelley William MDirector2008-03-14Buy6001,500$37.122.26-98.46
MIDDLETON FRED ADirector, 10% Owner2008-03-14Buy2,32019,779$36.885.38-98.45
Alafi Christopher DDirector2008-03-13Buy34,500270,013$36.61262.7-98.44
MIDDLETON FRED ADirector, 10% Owner2008-03-12Buy12017,459$37.84.54-98.49
Lele Abhijeet JDirector2008-03-11Buy3,0003,000$35.4106.2-98.39
MIDDLETON FRED ADirector, 10% Owner2008-03-11Buy2,38017,339$34.983.06-98.37
MESSEY ROBERT JDirector2008-03-11Buy1,0001,390$34.634.6-98.35
Benfer DavidDirector2008-03-07Buy600350$38.923.34-98.53
MIDDLETON FRED ADirector, 10% Owner2008-03-07Buy50,000615$391950-98.54
PRYSTOWSKY ERIC NDirector2008-03-05Buy1,0001,000$39.339.3-98.55
ACHARYA ABHIDirector2008-03-05Buy1,0002,111$39.839.8-98.57
Mills William C. IIIDirector2008-03-05Buy5002,500$4020-98.58
Benfer DavidDirector2007-09-10Buy300150$126.537.95-99.55
Kaminski Michael PPresident & COO2007-08-24Sell2,7104,185$130352.3-99.56
MIDDLETON FRED ADirector2007-06-21Sell120$120.41.47-99.53
Walker MelissaSVP, Reg, Quality & Compliance2007-06-15Sell2015,849$121.224.3-99.53
Kaminski Michael PCOO2007-06-06Sell1,7906,895$120.1214.98-99.53
Mills William C. IIIDirector2007-05-15Buy1,0002,000$113.5113.5-99.5
Alafi Christopher DDirector2007-03-15Buy1,000232,925$108.9108.9-99.48
Mills William C. IIIDirector2006-10-19Sell330$1203.95-99.53
Mills William C. IIIDirector2006-06-30Sell301,024$104.53.14-99.45Link
Walker MelissaVP, Regulatory & Quality2006-06-15Sell8604,862$9178.26-99.37Link
Sehra RuchirChief Medical Officer2006-06-14Buy1103,635$90.59.96-99.37Link
Hogg Bevil JPresident & CEO2006-06-08Buy1,00036,090$89.689.6-99.36Link
Benfer DavidDirector2006-06-06Buy260560$96.725.14-99.41Link
Kelley William MDirector2006-06-01Buy5001,300$98.949.45-99.42Link
Kaminski Michael PCOO2006-05-24Sell1,0004,185$100.9100.9-99.44Link
Sehra RuchirChief Medical Officer2006-05-16Buy1003,341$105.210.52-99.46Link
MESSEY ROBERT JDirector2006-05-15Buy340410$106.636.24-99.47Link
Hogg Bevil JPresident & CEO2006-04-11Sell1,00030,090$118.1118.1-99.52Link
Hogg Bevil JPresident & CEO2006-04-07Sell7,50031,090$120.9906.75-99.53Link
Mills William C. IIIDirector2006-01-23Sell61,054$152.50.92-99.63Link
Mills William C. IIIDirector2006-01-13Sell301,060$106.43.19-99.46Link
Mills William C. IIIDirector2006-01-10Sell181,090$911.67-99.37Link
Mills William C. IIIDirector2005-12-28Sell561,108$90.75.11-99.37Link
Mills William C. IIIDirector2005-12-20Sell601,164$83.35-99.32Link
ALAFI MOSHE10% Owner2005-12-06Buy3,210224,245$72.1231.46-99.21Link
Alafi Christopher DDirector, 10% Owner2005-12-06Buy2,339239,838$72.6169.83-99.21Link
ALAFI CAPITAL CO LLC10% Owner2005-12-06Buy2,339224,245$72.6169.83-99.21Link
ALAFI CAPITAL CO LLC10% Owner2005-12-05Buy871221,906$70.761.57-99.19Link
Sehra RuchirVP of Clinical Affairs2005-12-05Buy502,550$70.93.55-99.2Link
Alafi Christopher DDirector, 10% Owner2005-12-02Buy131237,499$719.29-99.2Link
Benfer DavidDirector2005-11-28Buy200300$7014-99.19Link
MIDDLETON FRED ADirector2005-11-18Buy380250,513$63.224.02-99.1Link
Mills William C. IIIDirector2005-09-12Sell121,224$90.11.08-99.37Link
Kelley William MDirector2005-08-23Buy400800$85.334.12-99.33Link
Kelley William MDirector2005-08-15Buy400400$93.537.4-99.39Link
Kaminski Michael PCOO2005-08-15Buy252,275$90.42.26-99.37Link
Mills William C. IIIDirector2005-08-12Sell301,236$81.32.44-99.3Link
Mills William C. IIIDirector2005-07-29Sell261,266$101.12.65-99.44Link
Mills William C. IIIDirector2005-07-26Sell821,293$887.18-99.35Link
Mills William C. IIIDirector2005-07-21Sell221,374$84.31.83-99.32Link
Mills William C. IIIDirector2005-07-19Sell41,396$850.36-99.33Link
Mills William C. IIIDirector2005-07-18Sell41,400$840.34-99.32Link
Mills William C. IIIDirector2005-07-13Sell521,404$83.14.32-99.31Link
Mills William C. IIIDirector2005-07-11Sell131,456$83.81.08-99.32Link
Mills William C. IIIDirector2005-07-06Sell671,469$81.85.44-99.3Link
Mills William C. IIIDirector2005-07-01Sell121,536$80.10.95-99.29Link
Mills William C. IIIDirector2005-06-28Sell41,547$800.3-99.29Link
Mills William C. IIIDirector2005-06-24Sell81,551$800.61-99.29Link
Johnson Gregory RDirector2005-06-15Buy50062,607$79.539.75-99.28Link
MIDDLETON FRED ADirector2005-06-08Buy583250,133$71.941.9-99.21Link
Mills William C. IIIDirector2005-05-19Sell151,552$801.18-99.29Link
MIDDLETON FRED ADirector2005-05-17Buy100319,850$77.97.79-99.27Link
Mills William C. IIIDirector2005-05-12Sell71,566$800.58-99.29Link
Mills William C. IIIDirector2005-05-09Sell111,574$80.10.87-99.29Link
MIDDLETON FRED ADirector2004-08-27Buy817323,522$77.163.01-99.26Link
Bruce Douglas MichaelSr. V.P., R & D2004-08-17Buy1010$800.8-99.29Link
Parker David JDirector2004-08-17Buy150150$8012-99.29Link
Mills William C. IIIDirector2004-08-17Buy1,0001,582$8080-99.29Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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