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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Bevil J. HoggDirector304,4371.45%2010-03-11
Mr. William C. Mills,IIICEO269,1121.28%2015-04-14
Douglas M. BruceSr. V.P., R & D243,5731.16%2012-02-14
Michael P. KaminskiPresident and CEO107,3690.51%2013-04-01
Melissa WalkerSr. VP, Reg., Quality & Compl.81,4410.39%2010-02-17
James M. StolzeN/A81,3040.39%2009-06-10
Mr. Martin C. StammerN/A70,9130.34%2015-03-30
Frank ChengSenior VP, Marketing and BD57,8160.28%2015-03-30
David GiffinVP, Human Resources56,0200.27%2015-03-30
Karen Witte DurosSr. VP, Gen. Counsel & Sec.54,9710.26%2015-03-30

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
MIDDLETON FRED ADirector2015-06-15Sell26,0641,414,232$1.5740.9-8.2846,810 (Direct)
1,107,189 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-12Sell16,2731,440,296$1.6126.2-10.5646,810 (Direct)
1,133,253 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-09Sell106,8761,456,569$1.65176.3-12.7346,810 (Direct)
1,149,526 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Benfer DavidDirector2015-03-13Buy3,00044,990$1.955.9-26.1542,290 (Direct)
2,700 (Spouse)
MESSEY ROBERT JDirector2015-03-04Sell1,41035,818$2.333.3-38.235,818 (Direct)
0 (By Trust)
Mills William C. IIICEO
(Click for the stocks that their CEOs have bought)
2014-12-12Buy10,000239,711$1.4514.5-0.69239,711 (Direct)
MIDDLETON FRED ADirector2014-12-09Sell8,5511,553,445$1.5112.9-4.6436,810 (Direct)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Mills William C. IIICEO2014-12-05Buy10,000229,711$1.4314.30.7229,711 (Direct)
MIDDLETON FRED ADirector2014-12-03Sell15,8091,561,996$1.5925.1-9.4345,361 (Direct)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Mills William C. IIICEO2014-08-11Buy10,000219,711$2.7527.5-47.64219,711 (Direct)
MIDDLETON FRED ADirector2014-03-13Sell24,3021,567,805$4.21102.3-65.851,170 (Direct)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2013-08-23Sell14,6001,592,107$3.6753.6-60.7675,472 (Direct)
0 (Middleton McNeil Retirement Trust)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Alafi Christopher D10% Owner2013-08-20Sell261,2411,307,043$3.74977-61.524,593 (Direct)
1,266,628 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
222 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2013-08-07Sell78,9741,296,592$10.13800-85.7888,072 (Direct)
960,764 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
28,117 (Sanderling Ventures Management VI)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
MIDDLETON FRED ADirector2012-11-30Buy24,3601,101,114$1.5337.3-5.8876,072 (Direct)
782,272 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
28,117 (Sanderling Ventures Management VI)
3,060 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
Benfer DavidDirector2012-05-31Buy3,0006,935$0.250.8-42.449,097 (Direct)
20,250 (Spouse)
Duggan Samuel W IICFO2012-05-11Buy5,00015,000$0.351.8-58.86100,000 (Direct)
50,000 (Samuel W. Duggan II Trust U/A DTD 4/21/2000)
Kelley William MDirector2011-12-09Buy2,0004,260$0.941.9-84.6838,600 (Direct)
4,000 (Med Tech Partners)
MIDDLETON FRED ADirector2011-09-15Buy485484,541$1.380.7-89.57319,755 (Direct)
1,581,607 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
30,609 (Sanderling VI Beteiligungs GmbH & Co. KG)
36,470 (Sanderling VI Limited Partnership)
16,116 (Sanderling Ventures Management VI)
781,351 (Sanderling Venture Partners II, L.P.)
15,000 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
532,758 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
110,971 (Sanderling V Beteiligungs GmbH & Co. KG)
397,164 (Sanderling V Biomedical Co-Investment Fund, L.P.)
119,566 (Sanderling V Limited Partnership)
677,906 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
224,515 (Sanderling Venture Partners iV Co-Investment Fund)
828 (Sanderling Ventures Management V)
797 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-09-12Buy6,447437,788$1.348.6-89.25228,286 (Direct)
3,991,373 (Alafi Capital Company LLC)
126,000 (Christopher Alafi Trust)
2,225 (Alafi Family Foundation)
30,000 (by Mother)

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

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