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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Mr. William C. Mills,IIIN/A396,3501.81%2016-04-15
Bevil J. HoggN/A304,4371.39%2010-03-11
Douglas M. BruceN/A243,5731.11%2012-02-14
Mr. Martin C. StammerN/A121,0500.55%2016-08-23
Mr. Michael P. KaminskiN/A107,3690.49%2013-04-01
Melissa WalkerN/A81,4410.37%2010-02-17
James M. StolzeN/A81,3040.37%2009-06-10
Frank ChengN/A74,8850.34%2016-08-23
David W. BenferN/A68,7140.31%2016-05-24
David GiffinN/A68,6570.31%2016-08-23

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Mills William C. IIICEO
(Click for the stocks that their CEOs have bought)
2014-12-12Buy10,000239,711$1.4514.5-53.1239,711 (Direct)
Mills William C. IIICEO2014-12-05Buy10,000229,711$1.4314.3-52.45229,711 (Direct)
Mills William C. IIICEO2014-08-11Buy10,000219,711$2.7527.5-75.27219,711 (Direct)
MIDDLETON FRED ADirector2013-08-23Sell14,6001,592,107$3.6753.58-81.4775,472 (Direct)
0 (Middleton McNeil Retirement Trust)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Alafi Christopher D10% Owner2013-08-20Sell261,2411,307,043$3.74977.04-81.8224,593 (Direct)
1,266,628 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
222 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2013-08-07Sell78,9741,296,592$10.13800.01-93.2988,072 (Direct)
960,764 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
28,117 (Sanderling Ventures Management VI)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
MIDDLETON FRED ADirector2012-11-30Buy24,3601,101,114$1.5337.27-55.5676,072 (Direct)
782,272 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
28,117 (Sanderling Ventures Management VI)
3,060 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
Benfer DavidDirector2012-05-31Buy3,0006,935$2.57.5-72.84,910 (Direct)
2,025 (Spouse)
Duggan Samuel W IICFO2012-05-11Buy5,00015,000$3.517.5-80.5710,000 (Direct)
5,000 (Samuel W. Duggan II Trust U/A DTD 4/21/2000)
Kelley William MDirector2011-12-09Buy2,0004,260$9.418.8-92.773,860 (Direct)
400 (Med Tech Partners)
MIDDLETON FRED ADirector2011-09-15Buy485484,541$13.86.69-95.0731,976 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-09-12Buy6,447437,788$13.486.39-94.9322,829 (Direct)
399,137 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
Alafi Christopher DDirector2011-09-09Buy3,553431,342$13.347.26-94.8922,829 (Direct)
392,691 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2011-09-01Buy1,712484,056$13.723.45-95.0431,491 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Kaminski Michael PPresident and CEO2011-09-01Buy1,04012,927$14.314.87-95.2412,557 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Cheng FrankSenior VP, Marketing and BD2011-08-19Buy1,5003,930$9.914.85-93.133,930 (Direct)
Giffin DavidVP, Human Resources2011-08-18Buy9524,477$10.510-93.524,477 (Direct)
Duros Karen WitteSr. VP, Gen. Counsel & Sec.2011-08-16Buy1,0002,620$11.611.6-94.142,620 (Direct)
Kaminski Michael PPresident and CEO2011-08-11Buy1,27111,887$11.815-94.2411,517 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Kaminski Michael PPresident and CEO2011-06-15Buy50010,616$30.115.05-97.7410,246 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
MIDDLETON FRED ADirector2011-06-14Buy1,000482,344$3030-97.7329,779 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-06-03Buy5,000427,788$33.5167.5-97.9722,829 (Direct)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
389,137 (Alafi Capital Company LLC)
3,000 (by Mother)
Kaminski Michael PPresident and CEO2011-03-07Buy6800$37.125.23-98.17Link
Kaminski Michael PPresident and CEO2010-11-18Buy28011,846$35.69.97-98.09Link
Kaminski Michael PPresident and CEO2010-11-18Buy2807,686$35.69.97-98.09Link
Alafi Christopher DDirector, 10% Owner2010-08-18Buy2,600422,473$32.584.5-97.91Link
MIDDLETON FRED ADirector, 10% Owner2010-08-18Buy2,600458,173$32.584.5-97.91Link
JOHNSTON DANIEL JCFO2010-05-10Buy1,0004,179$40.340.3-98.31Link
Kaminski Michael PPresident and CEO2010-05-10Buy25011,566$41.610.4-98.37Link
Hogg Bevil JDirector2010-03-12Sell3,20030,444$55.3176.96-98.77Link
Alafi Christopher DDirector, 10% Owner2010-03-03Buy5,00022,514$48.3241.5-98.59Link
Walker MelissaSr. VP, Reg., Quality & Compl.2009-12-15Sell2507,924$42.210.55-98.39Link
Hogg Bevil JDirector2009-12-09Sell6,50028,088$36.2235.3-98.12Link
Kaminski Michael PPresident & CEO2009-09-01Buy14170$34.94.92-98.05Link
MIDDLETON FRED ADirector, 10% Owner2009-08-31Buy50025,459$35.417.7-98.08Link
Alafi Christopher DDirector, 10% Owner2009-08-26Buy3,0003,000$34.9104.7-98.05Link
Kaminski Michael PPresident & CEO2009-06-04Buy2309,915$44.410.21-98.47
Alafi Christopher DDirector, 10% Owner2009-05-29Buy1,500389,137$34.551.75-98.03
MIDDLETON FRED ADirector, 10% Owner2009-05-26Buy2,77924,959$34.595.88-98.03
Alafi Christopher DDirector, 10% Owner2009-05-14Buy5,0005,000$34.8174-98.05
Benfer DavidDirector2009-03-13Buy350525$37.913.27-98.21
Walker MelissaSr. VP, Reg., Quality & Compl.2009-03-11Sell2007,649$367.2-98.11
MIDDLETON FRED ADirector, 10% Owner2008-12-29Buy101,2131,627$46.44696.28-98.53
Alafi Christopher DDirector2008-12-29Buy101,213388,037$46.44696.28-98.53
Alafi Christopher DDirector2008-11-20Buy1,000286,824$35.335.3-98.07
MIDDLETON FRED ADirector, 10% Owner2008-11-18Buy2922,179$300.88-97.73
Alafi Christopher DDirector2008-11-18Buy4,408285,824$35.6156.91-98.09
Lele Abhijeet JDirector2008-11-17Buy2,1405,140$25.354.14-97.31
SHIFRIN KEVIN TSr. VP, Marketing & Bus. Dev.2008-11-17Buy7504,270$27.520.63-97.53
MIDDLETON FRED ADirector, 10% Owner2008-06-13Buy1,18020,959$51.160.3-98.67
Alafi Christopher DDirector2008-03-14Buy110279,183$36.13.97-98.12
Alafi Christopher DDirector2008-03-14Buy9,060279,073$36.9334.31-98.16
Kelley William MDirector2008-03-14Buy6001,500$37.122.26-98.17
MIDDLETON FRED ADirector, 10% Owner2008-03-14Buy2,32019,779$36.885.38-98.15
Alafi Christopher DDirector2008-03-13Buy34,500270,013$36.61262.7-98.14
MIDDLETON FRED ADirector, 10% Owner2008-03-12Buy12017,459$37.84.54-98.2
Lele Abhijeet JDirector2008-03-11Buy3,0003,000$35.4106.2-98.08
MIDDLETON FRED ADirector, 10% Owner2008-03-11Buy2,38017,339$34.983.06-98.05
MESSEY ROBERT JDirector2008-03-11Buy1,0001,390$34.634.6-98.03
Benfer DavidDirector2008-03-07Buy600350$38.923.34-98.25
MIDDLETON FRED ADirector, 10% Owner2008-03-07Buy50,000615$391950-98.26
PRYSTOWSKY ERIC NDirector2008-03-05Buy1,0001,000$39.339.3-98.27
ACHARYA ABHIDirector2008-03-05Buy1,0002,111$39.839.8-98.29
Mills William C. IIIDirector2008-03-05Buy5002,500$4020-98.3
Benfer DavidDirector2007-09-10Buy300150$126.537.95-99.46
Kaminski Michael PPresident & COO2007-08-24Sell2,7104,185$130352.3-99.48
MIDDLETON FRED ADirector2007-06-21Sell120$120.41.47-99.44
Walker MelissaSVP, Reg, Quality & Compliance2007-06-15Sell2015,849$121.224.3-99.44
Kaminski Michael PCOO2007-06-06Sell1,7906,895$120.1214.98-99.43
Mills William C. IIIDirector2007-05-15Buy1,0002,000$113.5113.5-99.4
Alafi Christopher DDirector2007-03-15Buy1,000232,925$108.9108.9-99.38
Mills William C. IIIDirector2006-10-19Sell330$1203.95-99.43
Mills William C. IIIDirector2006-06-30Sell301,024$104.53.14-99.35Link
Walker MelissaVP, Regulatory & Quality2006-06-15Sell8604,862$9178.26-99.25Link
Sehra RuchirChief Medical Officer2006-06-14Buy1103,635$90.59.96-99.25Link
Hogg Bevil JPresident & CEO2006-06-08Buy1,00036,090$89.689.6-99.24Link
Benfer DavidDirector2006-06-06Buy260560$96.725.14-99.3Link
Kelley William MDirector2006-06-01Buy5001,300$98.949.45-99.31Link
Kaminski Michael PCOO2006-05-24Sell1,0004,185$100.9100.9-99.33Link
Sehra RuchirChief Medical Officer2006-05-16Buy1003,341$105.210.52-99.35Link
MESSEY ROBERT JDirector2006-05-15Buy340410$106.636.24-99.36Link
Hogg Bevil JPresident & CEO2006-04-11Sell1,00030,090$118.1118.1-99.42Link
Hogg Bevil JPresident & CEO2006-04-07Sell7,50031,090$120.9906.75-99.44Link
Mills William C. IIIDirector2006-01-23Sell61,054$152.50.92-99.55Link
Mills William C. IIIDirector2006-01-13Sell301,060$106.43.19-99.36Link
Mills William C. IIIDirector2006-01-10Sell181,090$911.67-99.25Link
Mills William C. IIIDirector2005-12-28Sell561,108$90.75.11-99.25Link
Mills William C. IIIDirector2005-12-20Sell601,164$83.35-99.18Link
ALAFI MOSHE10% Owner2005-12-06Buy3,210224,245$72.1231.46-99.06Link
Alafi Christopher DDirector, 10% Owner2005-12-06Buy2,339239,838$72.6169.83-99.06Link
ALAFI CAPITAL CO LLC10% Owner2005-12-06Buy2,339224,245$72.6169.83-99.06Link
ALAFI CAPITAL CO LLC10% Owner2005-12-05Buy871221,906$70.761.57-99.04Link
Sehra RuchirVP of Clinical Affairs2005-12-05Buy502,550$70.93.55-99.04Link
Alafi Christopher DDirector, 10% Owner2005-12-02Buy131237,499$719.29-99.04Link
Benfer DavidDirector2005-11-28Buy200300$7014-99.03Link
MIDDLETON FRED ADirector2005-11-18Buy380250,513$63.224.02-98.92Link
Mills William C. IIIDirector2005-09-12Sell121,224$90.11.08-99.25Link
Kelley William MDirector2005-08-23Buy400800$85.334.12-99.2Link
Kelley William MDirector2005-08-15Buy400400$93.537.4-99.27Link
Kaminski Michael PCOO2005-08-15Buy252,275$90.42.26-99.25Link
Mills William C. IIIDirector2005-08-12Sell301,236$81.32.44-99.16Link
Mills William C. IIIDirector2005-07-29Sell261,266$101.12.65-99.33Link
Mills William C. IIIDirector2005-07-26Sell821,293$887.18-99.23Link
Mills William C. IIIDirector2005-07-21Sell221,374$84.31.83-99.19Link
Mills William C. IIIDirector2005-07-19Sell41,396$850.36-99.2Link
Mills William C. IIIDirector2005-07-18Sell41,400$840.34-99.19Link
Mills William C. IIIDirector2005-07-13Sell521,404$83.14.32-99.18Link
Mills William C. IIIDirector2005-07-11Sell131,456$83.81.08-99.19Link
Mills William C. IIIDirector2005-07-06Sell671,469$81.85.44-99.17Link
Mills William C. IIIDirector2005-07-01Sell121,536$80.10.95-99.15Link
Mills William C. IIIDirector2005-06-28Sell41,547$800.3-99.15Link
Mills William C. IIIDirector2005-06-24Sell81,551$800.61-99.15Link
Johnson Gregory RDirector2005-06-15Buy50062,607$79.539.75-99.14Link
MIDDLETON FRED ADirector2005-06-08Buy583250,133$71.941.9-99.05Link
Mills William C. IIIDirector2005-05-19Sell151,552$801.18-99.15Link
MIDDLETON FRED ADirector2005-05-17Buy100319,850$77.97.79-99.13Link
Mills William C. IIIDirector2005-05-12Sell71,566$800.58-99.15Link
Mills William C. IIIDirector2005-05-09Sell111,574$80.10.87-99.15Link
MIDDLETON FRED ADirector2004-08-27Buy817323,522$77.163.01-99.12Link
Bruce Douglas MichaelSr. V.P., R & D2004-08-17Buy1010$800.8-99.15Link
Parker David JDirector2004-08-17Buy150150$8012-99.15Link
Mills William C. IIIDirector2004-08-17Buy1,0001,582$8080-99.15Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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