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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
FISHERMAN JASON SDirector2016-12-22Buy10,00050,000$3.9639.63.2850,000 (Direct)
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2016-12-05Buy2,5002,500$4.1110.28-0.492,500 (Direct)
Truitt JosephChief Commercial Officer2016-12-02Buy3,5003,500$4.0614.210.743,500 (Direct)
MANNING MARTHA EEVP, General Counsel2016-12-02Buy2,5002,500$4.0910.2302,500 (Direct)
Deshpande MilindCEO
(Click for the stocks that their CEOs have bought)
2016-12-02Buy2,5002,500$4.0610.150.742,500 (Direct)
Barrish Joel CChief Scientific Officer2016-12-02Buy2,5002,500$4.0610.150.742,500 (Direct)
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-61.05Link
Fenton Mary KayCFO2015-12-28Sell43,5000$10.08438.48-59.42Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-59.7831,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.53-50.2431,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.2-45.5431,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO2015-01-23Sell13,1250$16210-74.44Link
Deshpande MilindPresident and CEO2015-01-21Sell100,0000$151500-72.73Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.54-59.9
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.46-63.38
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.35-63.77
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.18-99.98
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.31-67.15
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.46-64.83
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.62-63.9
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-62.2Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.55-57.08
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.24-59.1Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.63-56.49Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$840-48.885,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.47392-51.31
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$8440-48.885,000 (Direct)
FRASHIER GARY EDirector2014-06-16Sell55,0000$8440-48.88Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.5-47.7Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.54-46.88
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.45-46.61
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.02301-32.06Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.51-47.23Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.622.46
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.9518.9
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.8226.23
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.8732.36
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.6231.51
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.837.25100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.560.39
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.4555.5140,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.664.92
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7266.94
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1546.59
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.759.77
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.517.87
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.98834437.25
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.72-44.54,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.58-43.124,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.15-40.1225,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.35-36.7990,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.63-36.19
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.57-36.69
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.68-35.39
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.284034.96-34.87
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.68-36.39
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.85-49.945,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.3-46.420,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.85-51.145,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.2-48.2985,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.7-48.0310,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.58-49.513,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.05-59.13,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$890-48.883,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.3-36.39Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.8-33.9365,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.59-33.935,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.499864-45.39
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.41-61.853,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.84-61.78Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-67.62Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.88-60.06Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.16-64.83,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.43-59.342,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-65.92Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.15-46.813,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.55-41.573,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.8-31.3845,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.916.04-30.683,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$675-31.83Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.9-24.1240,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.961-48.62
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.37-45.32
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.53-47.09
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.76-48.16
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$8157-48.883,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.47-49.51Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.13-46.04Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.43-45.54Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.34-45.54Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.55-41.573,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.51-36.493,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.08-41.6515,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.6-38.03Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.88-45.47Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.530-45.47Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.55-41.57Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.36-31.83Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.92-31.72Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.42-30.68Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.48-19.49Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.56-15.84Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.75-18.2Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.491214064.26Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.148.49Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.516.86Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.5927.41Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.7729.43Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.7115.86Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.691047.9610.84Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.3315.86Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.4517.19Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.3822.82Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.13330.53
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5309
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200309
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7309
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.4781.78
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8469.01
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.09-29.36

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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