Switch to:

Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Dennis LiottaN/A100,000less than 0.1%2013-11-22
Nicholas J. Simon,IIIN/A51,515less than 0.1%2012-06-04
Dr. Jason S. Fisherman,M.D.N/A40,000less than 0.1%2013-11-18
Nicole VitulloDirector31,431less than 0.1%2015-11-09
Kurt C. GravesN/A22,709less than 0.1%2012-06-11
Dr. John C. Pottage,Jr,M.D.N/A12,500less than 0.1%2006-10-25
Mr. Gary E. FrashierN/A5,000less than 0.1%2014-06-16
Gautam Shah,PhDN/A3,125less than 0.1%2012-12-31
Mr. Christopher A. WhiteN/A2,242less than 0.1%2006-10-31
Dr. Elizabeth A. Olek, D.O.N/A2,000less than 0.1%2012-01-10

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-13.81Link
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2015-12-28Sell43,5000$10.08438.5-10.22Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-11.0131,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.510.131,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.220.5131,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO
(Click for the stocks that their CFOs have bought)
2015-01-23Sell13,1250$16210-43.44Link
Deshpande MilindPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-01-21Sell100,0000$151500-39.67Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.5-11.27
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.5-18.98
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.4-19.84
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.2-99.96
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.3-27.31
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.5-22.18
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.6-20.12
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-16.36Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.6-5.04
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.2-9.5Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.6-3.72Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$84013.135,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.473927.74
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0000$844013.13Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.515.73Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.517.53
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$844013.135,000 (Direct)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.518.15
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.0230150.33Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.516.77Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.6170.96
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.9163.08
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.8179.32
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.9192.88
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.6191
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.8203.69100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.5254.9
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.5244.1140,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.6264.92
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7269.39
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1224.37
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.7253.52
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.5160.81
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.988344203.69
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.722.84,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.625.874,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.232.525,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.439.8890,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.641.19
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.640.09
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.742.97
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.28403544.11
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.740.75
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.910.775,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.318.6120,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.98.125,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.214.4185,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.714.9910,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.611.733,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.1-9.53,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$89013.133,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.340.75Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.846.265,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.646.25,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.49986420.83
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.4-15.583,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.8-15.42Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-28.35Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.9-11.62Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.2-22.123,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.4-10.042,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-24.58Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.217.693,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.529.293,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.851.8545,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.91653.393,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$67550.83Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.967.940,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.96113.69
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.420.99
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.517.08
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.814.7
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$815713.133,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.511.73Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.119.39Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.420.51Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.320.51Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.529.293,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.540.533,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.129.115,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.637.12Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.920.67Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.53020.67Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.529.29Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.450.83Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.951.09Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.453.39Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.578.15Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.686.21Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.881Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.4912140263.45Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.1140.05Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.5158.57Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.6181.93Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.8186.39Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.7156.37Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.691048145.26Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.3156.37Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.4159.31Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.4171.77Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.1852.63
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5805
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200805
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7805
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.5302.22
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8273.97
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.156.3

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

To find out why GuruFocus thinks data on insider trade are interesting, please read:
Also See GuruFocus Insider Trade Screener:

Get WordPress Plugins for easy affiliate links on Stock Tickers and Guru Names | Earn affiliate commissions by embedding GuruFocus Charts
GuruFocus Affiliate Program: Earn up to $400 per referral. ( Learn More)
FEEDBACK