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Top Direct Holders

HolderPositionShares% of Shares
Report Date
Dr. Dennis LiottaDirector100,0000.1%2013-11-22
Nicholas J. Simon,IIIN/A51,515less than 0.1%2012-06-04
Dr. Jason S. Fisherman,M.D.Director40,000less than 0.1%2013-11-18
Kurt C. GravesDirector22,709less than 0.1%2012-06-11
Dr. John C. Pottage,Jr,M.D.SVP and Chief Medical Officer12,500less than 0.1%2006-10-25
Mr. Gary E. FrashierDirector5,000less than 0.1%2014-06-16
Gautam Shah,PhDEVP and Chief Compliance Ofc.3,125less than 0.1%2012-12-31
Mr. Christopher A. WhiteN/A2,242less than 0.1%2006-10-31
Dr. Elizabeth A. Olek, D.O.SVP and CMO2,000less than 0.1%2012-01-10

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Fenton Mary KayEVP and CFO
(Click for the stocks that their CFOs have bought)
Deshpande MilindPresident and CEO
(Click for the stocks that their CEOs have bought)
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0147,811,000$10.213586.57.75Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,91510,229,209$11.1726505.5-1.61Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07112,672,287$11.2929298.4-2.66Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36214,695,762$12.4521219.3-11.73Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36214,695,762$20356.334694504.2-99.95Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29315,366,014$11.639714.5-5.5Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35218,024,807$11.3330719.6-3Link
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,00025,000$10.82270.51.57Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00021,805,285$9.5340359.615.32Link
Deshpande MilindPresident and CEO2014-08-18Sell216,624124,424$102166.29.9Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,812158,000$9.44660.616.91Link
FRASHIER GARY EDirector2014-08-13Sell5,00010,000$84037.38Link
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.4739230.83Link
FRASHIER GARY EDirector2014-06-16Sell55,0000$844037.38Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.540.54Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.542.73Link
FRASHIER GARY EDirector2014-06-16Sell55,00040,000$844037.38Link
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.543.47Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

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