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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
FISHERMAN JASON SDirector2016-12-22Buy10,00050,000$3.9639.67.8350,000 (Direct)
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2016-12-05Buy2,5002,500$4.1110.283.892,500 (Direct)
Truitt JosephChief Commercial Officer2016-12-02Buy3,5003,500$4.0614.215.173,500 (Direct)
MANNING MARTHA EEVP, General Counsel2016-12-02Buy2,5002,500$4.0910.234.42,500 (Direct)
Deshpande MilindCEO
(Click for the stocks that their CEOs have bought)
2016-12-02Buy2,5002,500$4.0610.155.172,500 (Direct)
Barrish Joel CChief Scientific Officer2016-12-02Buy2,5002,500$4.0610.155.172,500 (Direct)
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-59.33Link
Fenton Mary KayCFO2015-12-28Sell43,5000$10.08438.48-57.64Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-58.0131,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.53-48.0531,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.2-43.1431,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO2015-01-23Sell13,1250$16210-73.31Link
Deshpande MilindPresident and CEO2015-01-21Sell100,0000$151500-71.53Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.54-58.14
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.46-61.77
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.35-62.18
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.18-99.98
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.31-65.7
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.46-63.28
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.62-62.31
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-60.54Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.55-55.19
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.24-57.3Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.63-54.57Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$840-46.635,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.47392-49.17
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$8440-46.635,000 (Direct)
FRASHIER GARY EDirector2014-06-16Sell55,0000$8440-46.63Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.5-45.4Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.54-44.55
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.45-44.26
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.02301-29.07Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.51-44.9Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.627.84
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.9524.13
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.8231.79
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.8738.19
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.6237.3
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.843.29100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.567.45
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.4562.3640,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.672.18
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7274.29
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1553.05
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.766.8
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.523.05
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.98834443.29
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.72-42.064,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.58-40.614,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.15-37.4825,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.35-3490,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.63-33.39
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.57-33.9
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.68-32.54
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.284034.96-32.01
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.68-33.59
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.85-47.745,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.3-44.0420,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.85-48.985,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.2-46.0285,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.7-45.7410,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.58-47.283,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.05-57.33,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$890-46.633,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.3-33.59Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.8-31.0265,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.59-31.025,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.499864-42.99
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.41-60.173,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.84-60.09Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-66.19Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.88-58.3Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.16-63.253,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.43-57.552,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-64.42Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.15-44.473,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.55-393,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.8-28.3645,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.916.04-27.633,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$675-28.83Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.9-20.7840,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.961-46.36
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.37-42.91
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.53-44.76
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.76-45.88
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$8157-46.633,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.47-47.28Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.13-43.67Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.43-43.14Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.34-43.14Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.55-393,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.51-33.73,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.08-39.0915,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.6-35.3Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.88-43.07Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.530-43.07Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.55-39Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.36-28.83Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.92-28.71Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.42-27.63Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.48-15.94Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.56-12.14Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.75-14.6Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.491214071.49Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.1413.26Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.522Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.5933.02Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.7735.13Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.7120.96Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.691047.9615.72Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.3320.96Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.4522.35Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.3828.23Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.13349.47
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5327
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200327
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7327
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.4789.78
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8476.45
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.09-26.25

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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