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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Dennis LiottaDirector100,000less than 0.1%2013-11-22
Nicholas J. Simon,IIIN/A51,515less than 0.1%2012-06-04
Dr. Jason S. Fisherman,M.D.Director40,000less than 0.1%2013-11-18
Nicole VitulloDirector31,431less than 0.1%2015-11-09
Kurt C. GravesDirector22,709less than 0.1%2012-06-11
Dr. John C. Pottage,Jr,M.D.SVP and Chief Medical Officer12,500less than 0.1%2006-10-25
Mr. Gary E. FrashierDirector5,000less than 0.1%2014-06-16
Gautam Shah,PhDEVP and Chief Compliance Ofc.3,125less than 0.1%2012-12-31
Mr. Christopher A. WhiteN/A2,242less than 0.1%2006-10-31
Dr. Elizabeth A. Olek, D.O.SVP and CMO2,000less than 0.1%2012-01-10

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-43.62Link
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2015-12-28Sell43,5000$10.08438.5-41.27Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-41.7931,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.5-27.9831,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.2-21.1731,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO
(Click for the stocks that their CFOs have bought)
2015-01-23Sell13,1250$16210-63Link
Deshpande MilindPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-01-21Sell100,0000$151500-60.53Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.5-41.96
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.5-47
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.4-47.56
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.2-99.97
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.3-52.45
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.5-49.1
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.6-47.75
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-45.29Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.6-37.88
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.2-40.8Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.6-37.02Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$840-265,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.47392-29.52
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0000$8440-26Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.5-24.3Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.5-23.12
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$8440-265,000 (Direct)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.5-22.72
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.02301-1.66Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.5-23.61Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.677.25
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.972.09
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.882.72
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.991.59
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.690.35
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.898.66100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.5132.16
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.5125.140,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.6138.71
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7141.63
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1112.19
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.7131.25
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.570.61
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.98834498.66
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.7-19.674,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.6-17.664,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.2-13.3225,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.4-8.590,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.6-7.64
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.6-8.36
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.7-6.48
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.284035-5.73
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.7-7.93
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.9-27.545,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.3-22.4120,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.9-29.275,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.2-25.1685,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.7-24.7810,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.6-26.913,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.1-40.83,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$890-263,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.3-7.93Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.8-4.3665,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.6-4.365,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.499864-20.96
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.4-44.783,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.8-44.67Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-53.13Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.9-42.19Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.2-49.053,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.4-41.152,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-50.67Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.2-23.023,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.5-15.433,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.8-0.6745,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.9160.343,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$675-1.33Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.99.8340,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.961-25.63
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.4-20.86
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.5-23.42
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.8-24.97
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$8157-263,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.5-26.91Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.1-21.9Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.4-21.17Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.3-21.17Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.5-15.433,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.5-8.073,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.1-15.5515,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.6-10.3Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.9-21.07Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.530-21.07Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.5-15.43Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.4-1.33Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.9-1.17Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.40.34Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.516.54Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.621.81Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.818.4Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.4912140137.75Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.157.03Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.569.14Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.684.42Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.887.34Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.767.71Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.69104860.43Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.367.71Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.469.63Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.477.78Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.1523.16
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5492
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200492
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7492
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.5163.11
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8144.63
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.12.25

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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