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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Dennis LiottaN/A100,000less than 0.1%2013-11-22
Nicholas J. Simon,IIIN/A51,515less than 0.1%2012-06-04
Dr. Jason S. Fisherman,M.D.N/A40,000less than 0.1%2013-11-18
Nicole VitulloN/A31,431less than 0.1%2015-11-09
Kurt C. GravesN/A22,709less than 0.1%2012-06-11
Dr. John C. Pottage,Jr,M.D.N/A12,500less than 0.1%2006-10-25
Mr. Gary E. FrashierN/A5,000less than 0.1%2014-06-16
Gautam Shah,PhDN/A3,125less than 0.1%2012-12-31
Mr. Christopher A. WhiteN/A2,242less than 0.1%2006-10-31
Dr. Elizabeth A. Olek, D.O.N/A2,000less than 0.1%2012-01-10

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2016-12-05Buy2,5002,500$4.1110.282.192,500 (Direct)
Barrish Joel CChief Scientific Officer2016-12-02Buy2,5002,500$4.0610.153.452,500 (Direct)
Deshpande MilindCEO
(Click for the stocks that their CEOs have bought)
2016-12-02Buy2,5002,500$4.0610.153.452,500 (Direct)
MANNING MARTHA EEVP, General Counsel2016-12-02Buy2,5002,500$4.0910.232.692,500 (Direct)
Truitt JosephChief Commercial Officer2016-12-02Buy3,5003,500$4.0614.213.453,500 (Direct)
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-60Link
Fenton Mary KayCFO2015-12-28Sell43,5000$10.08438.48-58.33Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-58.731,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.53-48.9131,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.2-44.0731,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO2015-01-23Sell13,1250$16210-73.75Link
Deshpande MilindPresident and CEO2015-01-21Sell100,0000$151500-72Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.54-58.82
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.46-62.4
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.35-62.8
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.18-99.98
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.31-66.27
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.46-63.89
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.62-62.93
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-61.18Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.55-55.93
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.24-58Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.63-55.32Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$840-47.55,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.47392-50
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$8440-47.55,000 (Direct)
FRASHIER GARY EDirector2014-06-16Sell55,0000$8440-47.5Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.5-46.29Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.54-45.45
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.45-45.17
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.02301-30.23Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.51-45.81Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.625.75
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.9522.09
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.8229.63
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.8735.92
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.6235.05
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.840.94100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.564.71
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.4559.740,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.669.35
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7271.43
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1550.54
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.764.06
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.521.04
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.98834440.94
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.72-43.014,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.58-41.594,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.15-38.5125,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.35-35.0990,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.63-34.48
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.57-34.98
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.68-33.65
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.284034.96-33.12
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.68-34.68
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.85-48.595,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.3-44.9520,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.85-49.825,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.2-46.985,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.7-46.6310,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.58-48.153,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.05-583,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$890-47.53,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.3-34.68Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.8-32.1565,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.59-32.155,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.499864-43.93
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.41-60.823,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.84-60.75Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-66.75Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.88-58.98Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.16-63.863,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.43-58.252,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-65Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.15-45.383,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.55-403,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.8-29.5345,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.916.04-28.813,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$675-30Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.9-22.0840,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.961-47.24
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.37-43.85
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.53-45.67
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.76-46.77
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$8157-47.53,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.47-48.15Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.13-44.59Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.43-44.07Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.34-44.07Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.55-403,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.51-34.783,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.08-40.0915,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.6-36.36Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.88-44Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.530-44Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.55-40Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.36-30Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.92-29.88Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.42-28.81Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.48-17.32Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.56-13.58Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.75-16Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.491214068.67Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.1411.41Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.520Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.5930.84Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.7732.91Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.7118.98Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.691047.9613.82Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.3318.98Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.4520.34Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.3826.13Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.13342.11
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5320
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200320
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7320
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.4786.67
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8473.55
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.09-27.46

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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