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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Dennis LiottaDirector100,000less than 0.1%2013-11-22
Nicholas J. Simon,IIIN/A51,515less than 0.1%2012-06-04
Dr. Jason S. Fisherman,M.D.Director40,000less than 0.1%2013-11-18
Kurt C. GravesDirector22,709less than 0.1%2012-06-11
Dr. John C. Pottage,Jr,M.D.SVP and Chief Medical Officer12,500less than 0.1%2006-10-25
Mr. Gary E. FrashierDirector5,000less than 0.1%2014-06-16
Gautam Shah,PhDEVP and Chief Compliance Ofc.3,125less than 0.1%2012-12-31
Mr. Christopher A. WhiteN/A2,242less than 0.1%2006-10-31
Dr. Elizabeth A. Olek, D.O.SVP and CMO2,000less than 0.1%2012-01-10

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Fenton Mary KayEVP and CFO
(Click for the stocks that their CFOs have bought)
2015-01-23Sell13,1250$16210-49.31Link
Deshpande MilindPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-01-21Sell100,0000$151500-45.93Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.5-20.49
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.5-27.39
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.4-28.17
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.2-99.96
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.3-34.86
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.5-30.27
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.6-28.42
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-25.05Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.6-14.9
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.2-18.9Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.6-13.72Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$8401.385,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.47392-3.45
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0000$84401.38Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.53.71Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.55.32
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$84401.385,000 (Direct)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.55.87
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

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