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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Dennis LiottaN/A100,000less than 0.1%2013-11-22
Nicholas J. Simon,IIIN/A51,515less than 0.1%2012-06-04
Dr. Jason S. Fisherman,M.D.N/A40,000less than 0.1%2013-11-18
Nicole VitulloDirector31,431less than 0.1%2015-11-09
Kurt C. GravesN/A22,709less than 0.1%2012-06-11
Dr. John C. Pottage,Jr,M.D.N/A12,500less than 0.1%2006-10-25
Mr. Gary E. FrashierN/A5,000less than 0.1%2014-06-16
Gautam Shah,PhDN/A3,125less than 0.1%2012-12-31
Mr. Christopher A. WhiteN/A2,242less than 0.1%2006-10-31
Dr. Elizabeth A. Olek, D.O.N/A2,000less than 0.1%2012-01-10

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-16.19Link
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2015-12-28Sell43,5000$10.08438.5-12.7Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-13.4731,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.57.0631,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.217.1831,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO
(Click for the stocks that their CFOs have bought)
2015-01-23Sell13,1250$16210-45Link
Deshpande MilindPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-01-21Sell100,0000$151500-41.33Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.5-13.73
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.5-21.22
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.4-22.05
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.2-99.96
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.3-29.32
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.5-24.33
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.6-22.33
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-18.67Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.6-7.66
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.2-12Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.6-6.38Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$840105,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.473924.76
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0000$844010Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.512.53Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.514.29
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$8440105,000 (Direct)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.514.88
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.0230146.18Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.513.55Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.6163.47
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.9155.81
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.8171.6
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.9184.79
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.6182.96
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.8195.3100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.5245.1
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.5234.640,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.6254.84
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7259.18
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1215.41
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.7243.75
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.5153.6
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.988344195.3
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.719.44,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.622.394,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.228.8425,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.436.0190,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.637.29
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.636.22
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.739.02
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.28403540.13
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.736.86
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.97.715,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.315.3320,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.95.145,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.211.2585,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.711.8210,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.68.643,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.1-123,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$890103,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.336.86Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.842.1665,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.642.165,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.49986417.49
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.4-17.913,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.8-17.76Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-30.32Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.9-14.06Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.2-24.273,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.4-12.522,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-26.67Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.214.433,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.525.713,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.847.6545,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.91649.153,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$67546.67Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.963.2740,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.96110.55
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.417.65
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.513.84
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.811.53
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$8157103,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.58.64Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.116.09Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.417.18Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.317.18Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.525.713,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.536.653,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.125.5315,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.633.33Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.917.33Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.53017.33Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.525.71Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.446.67Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.946.91Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.449.15Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.573.23Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.681.07Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.876Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.4912140253.41Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.1133.42Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.5151.43Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.6174.14Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.8178.48Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.7149.29Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.691048138.48Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.3149.29Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.4152.15Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.4164.26Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.1826.32
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5780
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200780
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7780
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.5291.11
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8263.64
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.151.99

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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