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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Mr. William H. LewisN/A108,9660.37%2010-10-27
Mr. Marc D. BeerN/A78,6310.27%2014-08-28
Mr. Paul G. ThomasN/A36,9780.13%2012-01-03
Dr. Sol J. Barer,PhDN/A29,8900.1%2011-05-05
Dr. Antonio M. Gotto,Jr,M.D.,D.Phil.N/A13,916less than 0.1%2010-10-21
Mr. David I. ScheerN/A10,000less than 0.1%2015-12-01
Mr. Mark J. FitzpatrickN/A9,500less than 0.1%2014-08-19
Dr. William Andrews, M.D.N/A4,660less than 0.1%2015-03-29
Ms. Anne M. VanlentN/A4,000less than 0.1%2014-05-08
Ms. Mary WegerN/A3,038less than 0.1%2015-03-29

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Broadfin Healthcare Master Fun10% Owner2016-09-13Buy75,0004,361,291$1.75131.2574.864,361,291 (Direct)
Broadfin Healthcare Master Fun10% Owner2016-09-12Buy276,0004,286,291$1.66458.1684.344,286,291 (Direct)
Broadfin Healthcare Master Fun10% Owner2015-11-11Buy40,1004,010,291$10.96439.5-72.084,010,291 (Direct)
Fitzpatrick Mark J.CFO
(Click for the stocks that their CFOs have bought)
2014-08-19Buy1,1509,500$30.6435.24-90.019,500 (Direct)
Beer Marc DCEO
(Click for the stocks that their CEOs have bought)
2014-07-31Buy10,000325,862$33.65336.5-90.9179,400 (Direct)
183,245 (By revocable trust)
55,861 (By grantor retained annuity trust)
7,156 (By Roth IRA)
200 (By son)
Beer Marc DCEO2014-06-03Buy10,000315,862$30.12301.2-89.8469,400 (Direct)
183,245 (By revocable trust)
55,861 (By grantor retained annuity trust)
7,156 (By Roth IRA)
200 (By son)
Beer Marc DCEO2014-05-27Buy10,000305,862$31.59315.9-90.3159,400 (Direct)
183,245 (By revocable trust)
55,861 (By grantor retained annuity trust)
7,156 (By Roth IRA)
200 (By son)
Beer Marc DCEO2014-05-20Buy10,000289,462$30.53305.3-89.9843,000 (Direct)
183,245 (By revocable trust)
55,861 (By grantor retained annuity trust)
7,156 (By Roth IRA)
200 (By son)
Beer Marc DCEO2014-05-08Buy30,000279,462$35.311059.3-91.3333,000 (Direct)
183,245 (By revocable trust)
55,861 (By grantor retained annuity trust)
7,156 (By Roth IRA)
200 (By son)
VANLENT ANNEDirector2014-05-08Buy4,0004,000$33.78135.12-90.944,000 (Direct)
Fraser CraigPres., US/Int. Comm. & Manuf.2014-04-30Sell2,2500$43.5597.99-92.97Link
Fraser CraigPres., US/Int. Comm. & Manuf.2014-03-31Sell2,2500$46.2103.95-93.38Link
Sumeray MarkChief Medical Officer2014-03-14Sell2,0000$51.34102.68-94.04Link
Sumeray MarkChief Medical Officer2014-02-14Sell2,0000$63.49126.98-95.18Link
Fraser CraigPres., US/Int. Comm. & Manuf.2014-02-11Sell2,2500$67150.75-95.43Link
Fitzpatrick Mark J.CFO2014-02-10Sell7,5005,850$62.61469.58-95.115,850 (Direct)
Sumeray MarkChief Medical Officer2014-01-16Sell2,0000$58.63117.26-94.78Link
Fraser CraigPres., US/Int. Comm. & Manuf.2014-01-02Sell2,2500$71.11160-95.7Link
Sumeray MarkChief Medical Officer2014-01-02Sell1,0000$70.9370.93-95.69Link
Sumeray MarkChief Medical Officer2013-12-16Sell2,0000$66.34132.68-95.39Link
Sumeray MarkChief Medical Officer2013-12-02Sell3,0000$70.42211.26-95.65Link
Fraser CraigPres., US/Int. Comm. & Manuf.2013-12-02Sell2,2500$70.41158.42-95.65Link
Sumeray MarkChief Medical Officer2013-11-15Sell2,0000$76.09152.18-95.98Link
Fitzpatrick Mark J.CFO2013-11-11Sell7,5005,850$79.04592.8-96.135,850 (Direct)
Carter Martha J.Chief Regulatory Officer & SVP2013-11-01Sell5,0001,500$82.81414.05-96.31,500 (Direct)
Sumeray MarkChief Medical Officer2013-11-01Sell3,5000$83.28291.48-96.33Link
Fraser CraigPres., US/Int. Comm. & Manuf.2013-11-01Sell2,2500$83.23187.27-96.32Link
Beer Marc DCEO2013-10-30Sell40,000203,082$87.793511.6-96.51195,726 (Direct)
7,156 (By Roth IRA)
200 (By son)
SMITH SANDFORD DDirector2013-10-29Sell2,5020$95237.69-96.78Link
Sumeray MarkChief Medical Officer2013-10-15Sell2,0000$80.33160.66-96.19Link
Fraser CraigPres., US/Int. Comm. & Manuf.2013-10-07Sell20,0000$93.161863.2-96.72Link
Sumeray MarkChief Medical Officer2013-10-07Sell3,5000$93.17326.1-96.72Link
Sumeray MarkChief Medical Officer2013-09-16Sell2,0000$89.77179.54-96.59Link
PERCEPTIVE ADVISORS LLC10% Owner2013-09-05Sell750,00012,743,704$89.266900-96.57
3,473,426 (See Footnotes(F1,F2,F6))
3,573,426 (See Footnotes(F1,F3,F6))
2,873,426 (See Footnotes(F1,F4,F6))
2,823,426 (See Footnotes(F1,F5,F6))
Scheer DavidDirector2013-08-21Sell20,000650,154$84.581691.6-96.3810,000 (Direct)
640,154 (See Footnote)
Sumeray MarkChief Medical Officer2013-08-16Sell2,0000$88.71177.42-96.55Link
Beer Marc DCEO2013-08-15Sell60,000206,417$88.545312.4-96.54199,061 (Direct)
7,156 (By Roth IRA)
200 (By son)
Fitzpatrick Mark J.CFO2013-08-14Sell7,500500$93.44700.8-96.73500 (Direct)
SMITH SANDFORD DDirector2013-08-12Sell10,0000$92.32923.2-96.69Link
Sumeray MarkChief Medical Officer2013-07-15Sell2,0000$78.77157.54-96.12Link
Sumeray MarkChief Medical Officer2013-06-17Sell6,0000$65.27391.62-95.31Link
Sumeray MarkChief Medical Officer2013-05-15Sell6,0000$47.32283.92-93.53Link
Sumeray MarkChief Medical Officer2013-04-22Sell6,0000$40.74244.44-92.49Link
PERCEPTIVE ADVISORS LLC10% Owner2013-02-01Buy50,0003,373,426$27.791389.5-88.99
3,373,426 (See Footnotes(F1,F2,F3))
Carter Martha J.Chief Regulatory Officer & SVP2013-01-23Buy5001,500$27.8113.91-891,500 (Direct)
PERCEPTIVE ADVISORS LLC10% Owner2013-01-18Buy50,0003,323,426$27.621381-88.92
3,323,426 (See Footnotes(F1,F2,F3))
PERCEPTIVE ADVISORS LLC10% Owner2013-01-17Buy50,0006,521,852$26.731336.5-88.55
3,248,426 (See Footnotes(F1,F2,F4))
3,273,426 (See Footnotes(F1,F3,F4))
PERCEPTIVE ADVISORS LLC10% Owner2013-01-11Buy475,0006,296,852$27.0712858.25-88.7
3,073,426 (See Footnotes(F1,F2,F3))
3,223,426 (See Footnotes(F1,F3))
PERCEPTIVE ADVISORS LLC10% Owner2012-12-04Buy20,0002,615,293$21.27425.4-85.61
2,615,293 (See Footnotes(F1,F2))
PERCEPTIVE ADVISORS LLC10% Owner2012-11-29Buy30,0002,595,293$22.71681.3-86.53
2,595,293 (SEE FOOTNOTES(F1,F2))
PERCEPTIVE ADVISORS LLC10% Owner2012-11-28Buy150,0002,565,293$21.253187.5-85.6
2,565,293 (SEE FOOTNOTES(F1,F2))
ALTA BIOPHARMA PARTNERS III LP10% Owner2012-10-16Sell200,7332,336,387$18.333679.44-83.312,280,197 (Direct)
56,190 (See footnote)
Carter Martha J.Chief Regulatory Officer2012-03-30Buy1,0001,000$14.0314.03-78.191,000 (Direct)
Beer Marc DCEO2012-03-29Buy1,000205,417$13.7413.74-77.73198,061 (Direct)
7,156 (by Roth IRA)
200 (by son)
Fitzpatrick Mark J.CFO2012-03-23Buy5000$14.157.08-78.37Link
Beer Marc DCEO2012-03-22Buy1,000204,417$13.9613.96-78.08197,061 (Direct)
7,156 (by Roth IRA)
200 (By son)
ADVENT INTERNATIONAL CORP/MAMember of Group > 10%2012-03-09Sell100,0002,457,879$15.871587-80.72
2,457,879 (See Footnote)
ADVENT INTERNATIONAL LLCMember of Group > 10%2012-03-09Sell98,8972,430,765$15.871569.5-80.72
2,430,765 (See Footnote)
ADVENT HEALTHCARE & LIFE SCIENMember of Group > 10%2012-03-09Sell40,077985,052$15.87636.02-80.72985,052 (Direct)
Advent Healthcare & Life ScienMember of Group > 10%2012-03-09Sell58,8201,445,713$15.87933.47-80.721,445,713 (Direct)
AHLS III GP LIMITED PARTNERSHIMember of Group > 10%2012-03-09Sell98,8972,430,765$15.871569.5-80.72
2,430,765 (See Footnote)
Advent Partners HLS III LimiteMember of Group > 10%2012-03-09Sell1,10327,114$15.8717.5-80.7227,114 (Direct)
ADVENT INTERNATIONAL CORP/MAMember of Group > 10%2012-01-31Sell75,0002,557,879$17.141285.5-82.15
2,557,879 (See Footnote)
Advent Healthcare & Life ScienMember of Group > 10%2012-01-31Sell44,1141,504,533$17.14756.11-82.151,504,533 (Direct)
ADVENT HEALTHCARE & LIFE SCIENMember of Group > 10%2012-01-31Sell30,0581,025,129$17.14515.19-82.151,025,129 (Direct)
AHLS III GP LIMITED PARTNERSHIMember of Group > 10%2012-01-31Sell74,1722,529,662$17.141271.31-82.15
2,529,662 (See Footnote)
Advent Partners HLS III LimiteMember of Group > 10%2012-01-31Sell82828,217$17.1414.19-82.1528,217 (Direct)
ADVENT INTERNATIONAL LLCMember of Group > 10%2012-01-31Sell74,1722,529,662$17.141271.31-82.15
2,529,662 (See Footnote)
Index Venture Associates III L10% Owner2012-01-30Sell50,0002,081,827$17.08854-82.08
2,081,827 (See footnote)
Advent Partners HLS III LimiteMember of Group > 10%2011-12-09Sell22429,045$16.893.78-81.8829,045 (Direct)
Advent Healthcare & Life ScienMember of Group > 10%2011-12-09Sell11,9181,548,647$16.89201.3-81.881,548,647 (Direct)
ADVENT HEALTHCARE & LIFE SCIENMember of Group > 10%2011-12-09Sell8,1211,055,187$16.89137.16-81.881,055,187 (Direct)
AHLS III GP LIMITED PARTNERSHIMember of Group > 10%2011-12-09Sell20,0392,603,834$16.89338.46-81.88
2,603,834 (See Footnote)
ADVENT INTERNATIONAL LLCMember of Group > 10%2011-12-09Sell20,0392,603,834$16.89338.46-81.88
2,603,834 (See Footnote)
ADVENT INTERNATIONAL CORP/MAMember of Group > 10%2011-12-09Sell20,2632,632,879$16.89342.24-81.88
2,632,879 (See Footnote)
Advent Partners HLS III LimiteMember of Group > 10%2011-12-06Sell6129,269$16.961.03-81.9629,269 (Direct)
Advent Healthcare & Life ScienMember of Group > 10%2011-12-06Sell3,2741,560,565$16.9655.53-81.961,560,565 (Direct)
ADVENT HEALTHCARE & LIFE SCIENMember of Group > 10%2011-12-06Sell2,2301,063,308$16.9637.82-81.961,063,308 (Direct)
AHLS III GP LIMITED PARTNERSHIMember of Group > 10%2011-12-06Sell5,5042,623,873$16.9693.35-81.96
2,623,873 (See Footnote)
ADVENT INTERNATIONAL LLCMember of Group > 10%2011-12-06Sell5,5042,623,873$16.9693.35-81.96
2,623,873 (See Footnote)
ADVENT INTERNATIONAL CORP/MAMember of Group > 10%2011-12-06Sell5,5652,653,142$16.9694.38-81.96
2,653,142 (See Footnote)
Beer Marc DCEO2011-09-01Buy6,754197,663$14.7599.62-79.25191,791 (Direct)
5,672 (Roth IRA)
200 (By son)
Beer Marc DCEO2011-08-01Buy6,330239,834$15.7499.63-80.56116,752 (Direct)
123,082 (Roth IRA)
Advent Partners HLS III LimiteMember of Group > 10%2011-07-29Sell5729,330$14.610.83-79.0629,330 (Direct)
Advent Healthcare & Life ScienMember of Group > 10%2011-07-29Sell3,0151,563,839$14.6144.05-79.061,563,839 (Direct)
ADVENT HEALTHCARE & LIFE SCIENMember of Group > 10%2011-07-29Sell2,0541,065,538$14.6130.01-79.061,065,538 (Direct)
AHLS III GP LIMITED PARTNERSHIMember of Group > 10%2011-07-29Sell5,0692,629,377$14.6174.06-79.06
2,629,377 (see footnote)
ADVENT INTERNATIONAL LLCMember of Group > 10%2011-07-29Sell5,0692,629,377$14.6174.06-79.06
2,629,377 (see footnote)
ADVENT INTERNATIONAL CORP/MAMember of Group > 10%2011-07-29Sell5,1262,658,707$14.6174.89-79.06
2,658,707 (see footnote)
Index Venture Associates III L10% Owner2011-07-29Sell36,7882,131,827$14.61537.47-79.06
2,131,827 (See footnote)
Ollier MicheleDirector, 10% Owner2011-07-29Sell36,7882,131,827$14.61537.47-79.06
2,131,827 (See footnote)
Advent Partners HLS III LimiteMember of Group > 10%2011-06-29Sell1,34929,387$14.6119.71-79.0629,387 (Direct)
Advent Healthcare & Life ScienMember of Group > 10%2011-06-29Sell71,9231,566,854$14.611050.8-79.061,566,854 (Direct)
ADVENT HEALTHCARE & LIFE SCIENMember of Group > 10%2011-06-29Sell49,0051,067,592$14.61715.96-79.061,067,592 (Direct)
AHLS III GP LIMITED PARTNERSHIMember of Group > 10%2011-06-29Sell120,9282,634,446$14.611766.76-79.06
2,634,446 (see footnote)
ADVENT INTERNATIONAL LLCMember of Group > 10%2011-06-29Sell120,9282,634,446$14.611766.76-79.06
2,634,446 (see footnote)
ADVENT INTERNATIONAL CORP/MAMember of Group > 10%2011-06-29Sell122,2772,663,833$14.611786.47-79.06
2,663,833 (see footnote)
Index Venture Associates III L10% Owner2011-06-29Sell877,7232,168,435$14.6112823.53-79.06
2,168,435 (See footnote)
Ollier MicheleDirector, 10% Owner2011-06-29Sell877,7232,168,435$14.6112823.53-79.06
2,168,435 (See footnote)
Beer Marc DCEO2011-06-01Buy5,332228,172$18.799.71-83.64111,420 (Direct)
116,752 (Roth IRA)
Beer Marc DCEO2011-04-04Buy5,9570$16.7399.66-81.71Link
Scheer DavidDirector2011-03-11Buy10,0000$15.26152.6-79.95Link
Beer Marc DCEO2010-12-15Buy200210,726$12.332.47-75.18Link
Kiley AlisonDirector, 10% Owner2010-10-27Buy315,7892,680,551$9.53000-67.79Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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