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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Mr. David P. PerryN/A361,3060.8%2014-03-04
Mr. Paul L. BernsPresident and CEO230,3110.51%2016-03-22
Mr. Geoffrey M. ParkerN/A94,8400.21%2015-03-23
Vincent IppolitoEVP & Chief Commercial Officer67,9850.15%2016-03-02
Paul H. KlingensteinN/A58,0010.13%2010-11-30
Dr. Lee T. Zane, M.D.,M.A.S.SVP and Chief Medical Officer44,0440.1%2016-02-03
Dr. Anders D. Hove,M.D.Director33,886less than 0.1%2016-05-16
Ryan T. SullivanEVP and General Counsel30,132less than 0.1%2016-04-29
Sanjay ChandaN/A29,087less than 0.1%2015-03-04
Mr. Graeme BellN/A11,006less than 0.1%2016-02-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Leonard Keith RDirector2016-05-23Sell9,000794$99.7897.3-0.27794 (Direct)
Hove Anders DDirector2016-05-16Sell353,88133,886$99.5935243-0.1633,886 (Direct)
0 (By Funds and LLC's)
Sullivan Ryan TEVP and General Counsel2016-04-29Sell3,12530,132$66.33207.349.930,132 (Direct)
Hove Anders DDirector2016-04-08Sell229,301130,120$71.116303.339.8533,886 (Direct)
96,234 (By Funds and LLC's)
BERNS PAUL LPresident and CEO
(Click for the stocks that their CEOs have bought)
2016-03-22Sell37,500230,311$60.312261.664.86230,311 (Direct)
IPPOLITO VINCENT PEVP & Chief Commercial Officer2016-03-02Sell9,00067,985$63.86574.755.767,985 (Direct)
IPPOLITO VINCENT PEVP & Chief Commercial Officer2016-01-19Sell20,00070,985$95.411908.24.2170,985 (Direct)
Zane LeeSVP and Chief Medical Officer2016-01-15Sell1,46627,281$89.57131.311.0127,281 (Direct)
IPPOLITO VINCENT PEVP & Chief Commercial Officer2016-01-04Sell85570,985$112.2896-11.4470,985 (Direct)
Sullivan Ryan TSr. VP and General Counsel2016-01-04Sell73327,007$111.7881.9-11.0527,007 (Direct)
BERNS PAUL LPresident and CEO2016-01-04Sell2,533252,227$112.35284.6-11.5252,227 (Direct)
Zane LeeSVP and Chief Medical Officer2015-12-15Sell14,00028,747$113.171584.4-12.1428,747 (Direct)
BERNS PAUL LPresident and CEO2015-12-11Sell20,000254,760$117.262345.2-15.21254,760 (Direct)
Sullivan Ryan TSr. VP and General Counsel2015-12-10Sell10,00027,740$110.411104.1-9.9427,740 (Direct)
IPPOLITO VINCENT PEVP & Chief Commercial Officer2015-12-09Sell20,00071,840$107.92158-7.8571,840 (Direct)
BERNS PAUL LPresident and CEO2015-09-15Sell20,000254,760$139.832796.6-28.89254,760 (Direct)
Zane LeeSVP and Chief Medical Officer2015-09-15Sell14,00028,744$139.841957.8-28.928,744 (Direct)
BERNS PAUL LPresident and CEO2015-08-13Sell20,000254,760$138.692773.8-28.31254,760 (Direct)
Zane LeeSVP and Chief Medical Officer2015-06-15Sell12,00028,156$69.05828.64428,156 (Direct)
Maples Kirk RSVP, Program Management2015-06-01Sell6007,220$70.3142.241.427,220 (Direct)
Plattner Jacob jSenior VP, Research2015-05-15Sell8,92022,860$63.73568.556.025,020 (Direct)
17,840 (See Footnote)
Rodriguez Carmen RSnr VP Reg Afrs & Qual. Assur.2015-05-14Sell61,9427,020$62.733885.658.57,020 (Direct)
Maples Kirk RSVP, Program Management2015-05-12Sell6,0607,820$61.07370.162.817,820 (Direct)
Maples Kirk RSVP, Program Management2015-05-01Sell6007,820$53.9532.484.37,820 (Direct)
Sullivan Ryan TSr. VP and General Counsel2015-04-29Sell3,12527,740$53.61167.585.4727,740 (Direct)
BERNS PAUL LPresident and CEO2015-04-27Sell50,000253,760$63.64318256.24253,760 (Direct)
Plattner Jacob jSenior VP, Research2015-04-15Sell8,92031,780$62.81560.358.35,020 (Direct)
26,760 (See Footnote)
Maples Kirk RSVP, Program Management2015-04-01Sell6008,420$57.0234.274.388,420 (Direct)
Parker Geoffrey M.Executive Vice President & CFO2015-03-23Buy3,000104,840$52.43157.389.6494,840 (Direct)
10,000 (See Footnote)
BERNS PAUL LPresident and CEO2015-03-19Sell37,500308,760$56.072102.677.33308,760 (Direct)
Plattner Jacob jSenior VP, Research2015-03-16Sell8,92040,700$55.649678.835,020 (Direct)
35,680 (See Footnote)
Zane LeeSVP and Chief Medical Officer2015-03-16Sell12,00028,156$56.44677.376.1728,156 (Direct)
Chanda SanjaySVP, Drug Development2015-03-04Sell5,00029,087$45225120.9629,087 (Direct)
IPPOLITO VINCENT PEVP & Chief Commercial Officer2015-03-03Sell9,00070,603$43.88394.9126.670,603 (Direct)
Plattner Jacob jSenior VP, Research2015-03-02Sell6,87549,620$44.02302.6125.875,020 (Direct)
44,600 (See Footnote)
Maples Kirk RSVP, Program Management2015-03-02Sell6009,020$43.9526.4126.239,020 (Direct)
Plattner Jacob jSenior VP, Research2015-02-02Sell6,87551,475$37.35256.8166.21
51,475 (See Footnote)
Maples Kirk RSVP, Program Management2015-02-02Sell6004,600$37.4122.4165.784,600 (Direct)
Plattner Jacob jSenior VP, Research2015-01-02Sell6,87558,350$32.09220.6209.85
58,350 (See Footnote)
Maples Kirk RSVP, Program Management2015-01-02Sell6004,200$31.9619.2211.114,200 (Direct)
BERNS PAUL LPresident and CEO2014-12-26Sell25,000325,000$30.82770.5222.62325,000 (Direct)
Shapiro LucyDirector2014-12-12Sell289,68528,000$35.1110170.8183.2
28,000 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Zane LeeSVP and Chief Medical Officer2014-12-11Sell4,9007,000$36.09176.8175.517,000 (Direct)
Maples Kirk RSVP, Program Management2014-12-09Sell60,0004,800$36.522191.2172.264,800 (Direct)
Maples Kirk RSVP, Program Management2014-12-01Sell6004,800$33.3820197.874,800 (Direct)
Plattner Jacob jSenior VP, Research2014-12-01Sell6,87565,225$33.34229.2198.23
65,225 (See Footnote)
Chanda SanjaySVP, Drug Development2014-11-26Sell5,0003,995$35175184.093,995 (Direct)
Plattner Jacob jSenior VP, Research2014-11-03Sell6,87572,100$29.32201.6239.12
72,100 (See Footnote)
Maples Kirk RSVP, Program Management2014-11-03Sell6005,400$29.117.5241.685,400 (Direct)
Maples Kirk RSVP, Program Management2014-10-01Sell6006,000$23.8514.3316.96,000 (Direct)
Plattner Jacob jSenior VP, Research2014-10-01Sell6,87578,975$24.47168.2306.33
78,975 (See Footnote)
Hove Anders DDirector2014-09-26Sell20,0002,725,535$25500297.72
2,725,535 (By Funds)
Hove Anders DDirector2014-09-19Sell740,0002,745,535$24.8718403.8299.8
2,745,535 (By Funds)
Hove Anders DDirector2014-09-16Sell90,0003,485,535$24.992249.1297.88
3,485,535 (By Funds)
Chanda SanjaySVP, Drug Development2014-09-10Sell10,0003,995$24.25242.5310.023,995 (Direct)
Parker Geoffrey M.Executive Vice President & CFO2014-09-08Buy6,59097,000$21.82143.8355.6887,000 (Direct)
10,000 (See Footnote)
Plattner Jacob jSenior VP, Research2014-09-02Sell6,87585,850$23.34160.5326.01
85,850 (See Footnote)
Maples Kirk RSVP, Program Management2014-09-02Sell33,8796,600$23.3789.4326.746,600 (Direct)
LESCHLY MARKDirector2014-08-27Sell13,0670$22.5294341.91Link
Plattner Jacob jSenior VP, Research2014-08-13Sell6,87592,725$20137.5397.15
92,725 (See Footnote)
Maples Kirk RSVP, Program Management2014-08-13Sell3,9598,294$19.9679398.158,294 (Direct)
Maples Kirk RSVP, Program Management2014-06-04Sell1,6200$14.723.8576.39Link
Maples Kirk RSVP, Program Management2014-05-20Sell1,5001,620$14.1521.2602.691,620 (Direct)
Maples Kirk RSVP, Program Management2014-04-21Sell1,5003,120$15.623.4537.373,120 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2014-03-24Buy5,00096,000$20.11100.6394.4386,000 (Direct)
10,000 (See Footnote)
Shapiro LucyDirector2014-03-21Sell80,000228,664$21.141691.2370.3436,248 (Direct)
192,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Maples Kirk RSVP, Program Management2014-03-20Sell3,0004,620$22.3967.2344.084,620 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2014-03-18Buy2,41096,000$22.654.5339.9686,000 (Direct)
10,000 (See Footnote)
PERRY DAVID PPresident and CEO2014-03-05Sell65,000361,306$20.221314.3391.74361,306 (Direct)
Maples Kirk RSVP, Program Management2014-02-20Sell3,0007,620$19.3358414.387,620 (Direct)
PERRY DAVID PPresident and CEO2014-02-05Sell15,000426,306$17255484.88426,306 (Direct)
Maples Kirk RSVP, Program Management2014-01-21Sell3,0009,620$20.2760.8390.539,620 (Direct)
PERRY DAVID PPresident and CEO2014-01-09Sell65,000441,306$16.321060.8509.25441,306 (Direct)
Maples Kirk RSVP, Program Management2013-12-20Sell3,00012,620$16.7350.2494.3212,620 (Direct)
PERRY DAVID PPresident and CEO2013-12-09Sell4,03350,631$16.2365.5-38.74506,306 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2013-11-26Buy1,00025,100$13.413.4-25.885,000 (Direct)
156,000 (See footnote)
10,000 (Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
Parker Geoffrey M.Senior Vice President and CFO2013-11-25Buy1,00024,100$12.8512.9-22.6285,000 (Direct)
146,000 (See footnote)
10,000 (Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
VENROCK ASSOCIATES IV L P10% Owner2013-11-15Sell15,0000$14.06210.9-29.28Link
Hove Anders DDirector, 10% Owner2013-11-15Sell15,0000$14.06210.9-29.28Link
Maples Kirk RSVP, Program Management2013-08-14Sell1050$9.7112.4Link
Parker Geoffrey M.Senior Vice President and CFO2013-08-13Buy5,00015,100$8.3441.719.225,000 (Direct)
136,000 (See footnote)
10,000 (Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
Parker Geoffrey M.Senior Vice President and CFO2013-06-19Buy2,30510,000$5.21291.214,000 (Direct)
86,000 (See footnote)
10,000 (Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
Parker Geoffrey M.Senior Vice President and CFO2013-06-18Buy2,0007,695$5.2210.490.484,000 (Direct)
10,000 (Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
62,954 (See footnote)
Maples Kirk RSVP, Program Management2013-06-14Sell5605$5.39384.4752 (Direct)
Shapiro LucyDirector2013-04-19Sell2,50030,866$8.0220.123.9836,248 (Direct)
272,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Shapiro LucyDirector2013-03-22Sell2,00033,366$6.9113.843.8936,248 (Direct)
297,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Maples Kirk RSVP, Program Management2012-11-26Sell300465$5.221.690.484,652 (Direct)
Maples Kirk RSVP, Program Management2012-11-01Sell300765$5.811.771.147,652 (Direct)
Shapiro LucyDirector2012-10-05Sell3,00035,366$6.672049.0736,248 (Direct)
317,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Shapiro LucyDirector2012-10-01Sell2,00038,366$6.5713.151.3436,248 (Direct)
347,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Shapiro LucyDirector2012-09-26Sell1,00040,366$6.586.651.1136,248 (Direct)
367,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Shapiro LucyDirector2012-09-24Sell2,00041,366$6.3312.757.0836,248 (Direct)
377,416 (MCADAMS-SHAPIRO FAMILY TRUST DTD MAY 24, 1999)
Maples Kirk RSVP, Program Management2012-09-24Sell3001,065$6.55251.810,652 (Direct)
VENROCK ASSOCIATES V LP10% Owner2012-09-20Sell1,9270$6.312.157.83Link
VENROCK ASSOCIATES IV L P10% Owner2012-09-20Sell1,9270$6.312.157.83Link
Hove Anders DDirector, 10% Owner2012-09-20Sell1,9270$6.312.157.83Link
VENROCK ASSOCIATES V LP10% Owner2012-09-14Sell3,5000$6.5122.852.73Link
VENROCK ASSOCIATES IV L P10% Owner2012-09-14Sell3,5000$6.5122.852.73Link
Hove Anders DDirector, 10% Owner2012-09-14Sell3,5000$6.5122.852.73Link
VENROCK ASSOCIATES V LP10% Owner2012-09-13Sell2,5180$6.5916.650.88Link
VENROCK ASSOCIATES IV L P10% Owner2012-09-13Sell2,5180$6.5916.650.88Link
Hove Anders DDirector, 10% Owner2012-09-13Sell2,5180$6.5916.650.88Link
Maples Kirk RSVP, Program Management2012-08-27Sell3001,365$6.171.961.1513,652 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2012-08-22Buy5005,595$6.193.160.6355,954 (Direct)
Maples Kirk RSVP, Program Management2012-07-30Sell631$6.030-96.715,652 (Direct)
Maples Kirk RSVP, Program Management2012-07-30Sell631$6.030-96.715,652 (Direct)
Maples Kirk RSVP, Program Management2012-06-25Sell637$5.440-96.3418,652 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2012-06-05Buy16100$4.810.1-95.8749,954 (Direct)
Maples Kirk RSVP, Program Management2012-05-29Sell643$5.340-96.2821,652 (Direct)
Maples Kirk RSVP, Program Management2012-04-23Sell649$5.460-96.3624,652 (Direct)
Maples Kirk RSVP, Program Management2012-03-26Sell655$6.450-96.9227,652 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2012-03-20Buy2084$6.080.1-96.7342,000 (Direct)
Maples Kirk RSVP, Program Management2012-02-27Sell667$5.90-96.6333,652 (Direct)
Maples Kirk RSVP, Program Management2012-01-30Sell663$7.110-97.231,652 (Direct)
Maples Kirk RSVP, Program Management2012-01-10Sell669$5.480-96.3734,652 (Direct)
Maples Kirk RS.V.P., Program Management2011-12-30Sell2075$6.150.1-96.7737,652 (Direct)
Maples Kirk RSVP Program Management2011-12-29Sell1295$6.140.1-96.7647,652 (Direct)
Maples Kirk RS.V.P., Program Management2011-11-28Sell8107$4.910-95.9553,652 (Direct)
Maples Kirk RSVP Program Management2011-10-31Sell8115$6.650.1-97.0157,652 (Direct)
Maples Kirk RS.V.P., Program Management2011-09-26Sell8123$5.220-96.1961,652 (Direct)
Maples Kirk RS.V.P., Program Management2011-08-29Sell8131$4.820-95.8765,652 (Direct)
Maples Kirk RSVP, Program Management2011-07-25Sell8139$6.160-96.7769,652 (Direct)
Maples Kirk RSVP, Program Management2011-06-27Sell8147$6.40.1-96.8973,652 (Direct)
Maples Kirk RSVP, Program Management2011-06-06Sell10155$6.050.1-96.7177,652 (Direct)
Maples Kirk RSVP, Program Management2011-06-01Sell10165$60.1-96.6982,652 (Direct)
Maples Kirk RSVP, Program Management2011-05-25Sell17175$6.20.1-96.7987,652 (Direct)
Parker Geoffrey M.Sr. V.P. & CFO2011-05-24Buy2060$5.950.1-96.6630,000 (Direct)
Parker Geoffrey M.Senior Vice President and CFO2011-05-10Buy4040$6.170.2-96.7820,000 (Direct)
Aberdare Ventures II, L.P.10% Owner2010-11-30Buy6003,504$53-96.02Link
LESCHLY MARKDirector, 10% Owner2010-11-30Buy4,80011,243$524-96.02Link
KLINGENSTEIN PAUL HDirector2010-11-30Buy6003,620$53-96.02Link
RHO VENTURES IV QP LP10% Owner2010-11-30Buy4,80011,243$524-96.02Link
VENROCK ASSOCIATES IV L P10% Owner2010-11-30Buy1,2005,251$56-96.02Link
Hove Anders DDirector, 10% Owner2010-11-30Buy1,2009,251$56-96.02Link
GLAXOSMITHKLINE PLC10% Owner2010-11-24Buy2,0005,543$510-96.02Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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