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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-09-28Sell2,492,57816,658,072$6.3615852.875.79
16,658,072 (See Footnote(F2,))
Redmile Group, LLC10% Owner2016-09-15Sell400,00019,150,650$3.51400219.43
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-09-15Buy400,00019,150,650$3.511404218.52
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.19957250.47
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270210.56
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.75204.63
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.64144.1
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.27144.1
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.45104.01
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2107.81
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.190.14
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.1692.76
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.551.49Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$856039.753,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.2517835.52Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.2533035.5212,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5593.0920 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.1693.0911,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.3786.33
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.8983.88
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.4993.09
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.259.2611,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.57216,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4396.4911,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.09321.8994,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.11442.7296,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.1375.7496,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.93429.86
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.09352.6398,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.11437.599,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.11453.4776,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.92422.43177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.09394.6979,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.1403.610,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.1347.280,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.25415.21576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.09369.7582,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.2290.91551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.08306.5584,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.07267.76Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.17238.79Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.07259.49Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.08284.19Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.07249.38Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.76238.79Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.13244Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.07245.06Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.7241.9Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.06235.74Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.07236.75Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.02239.82Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.08288.19Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.05300.72Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.54244Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.07259.49Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.07231.75Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.15258.33Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.07225Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84201.35Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06195.77Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.09354.47Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.1365.83Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.34358.2Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.09349Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.28315.61Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.08320.3Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.11456.22Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.12456.22Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.64303.61Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68168.11Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65183.04Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.58265.36
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.66257.19
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.84240.85
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.17107.42
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.481.49
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.175.51
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-14
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-2.53
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-20.43
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-20.14
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-14.26
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-10.56
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-6.68
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-4.44
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.53.04
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.01100111.69
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.7512.36
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.4517.81Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.2223.95Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.619.19Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.819.19Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.427.92Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.737.01Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.7581.79Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.661.56Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8249.67Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-2.53Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.752.1Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.6566.87Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.922.99Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.7522.19Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$94524.22Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.229.4Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.930.3Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.428.8Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.734.05Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.7527.77Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.332.15Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$94524.22Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.522.86Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.7519.57Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.326.19Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.624.78Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1448.87Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9123.6Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.18123.6Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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