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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDN/A786,9170.54%2013-07-24
Mr. Robert E. ConwayN/A633,3860.44%2011-10-04
Dr. Anthony D. Piscopio,PhDN/A553,5270.38%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDN/A177,7630.12%2011-06-30
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerN/A107,463less than 0.1%2016-04-01
Dr. Victor Sandor, M.D.N/A104,843less than 0.1%2016-04-01
Mr. John R. MooreN/A39,754less than 0.1%2016-04-01
Andrews R. RobbinsN/A36,008less than 0.1%2016-04-01
Dr. Nicholas A. SaccomanoN/A35,186less than 0.1%2016-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-09-15Sell400,00019,150,650$3.514005.43
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-09-15Buy400,00019,150,650$3.5114045.13
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.1995715.67
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.62702.5
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.750.54
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.27-19.43
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.64-19.43
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.45-32.66
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2-31.41
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.1-37.24
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.16-36.38
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.5-50Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$8560-53.883,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.25178-55.27Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.25330-55.2712,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.55-36.2720 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.16-36.2711,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.37-38.5
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.89-39.31
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.49-36.27
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.2-47.4411,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.5-43.2316,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.43-35.1511,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.0939.2594,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.1179.1396,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.157.0296,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.9374.88
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.0949.3998,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.1177.499,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.1182.6776,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.9272.43177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.0963.2779,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.166.2210,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.147.680,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.2570.05576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.0955.0482,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.229.02551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.0834.1884,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.0721.38Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.1711.82Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.0718.65Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.0826.8Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.0715.31Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.7611.82Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.1313.54Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.0713.89Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.712.84Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.0610.81Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.0711.14Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.0212.16Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.0828.13Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.0532.26Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.5413.54Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.0718.65Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.079.5Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.1518.27Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.077.27Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84-0.54Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06-2.38Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.0950Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.153.75Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.3451.23Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.0948.19Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.2837.17Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.0838.72Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.1183.58Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.1283.58Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.6433.21Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68-11.51Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65-6.58Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.5820.59
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.6617.89
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.8412.5
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.17-31.54
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.4-40.1
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.1-42.07
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-71.62
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-67.83
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-73.74
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-73.64
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-71.7
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-70.48
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-69.2
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-68.46
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-65.99
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-63.14
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.75-62.91
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.45-61.12Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.22-59.09Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-60.66Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-60.66Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-57.78Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.7-54.78Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.75-40Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.6-46.68Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.82-50.6Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-67.83Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.75-66.3Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.65-44.93Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-59.41Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.75-59.67Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-59Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.2-57.29Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.9-56.99Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-57.49Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.7-55.76Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.75-57.83Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.3-56.38Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-59Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-59.45Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.75-60.53Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-58.35Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-58.82Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.14-50.87Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9-26.2Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.18-26.2Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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