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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDPresident & CSO786,9170.55%2013-07-24
Mr. Robert E. ConwayCEO633,3860.44%2011-10-04
Dr. Anthony D. Piscopio,PhDVP/Dir of Chemistry553,5270.39%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDDirector177,7630.12%2011-06-30
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerCEO108,166less than 0.1%2015-04-01
Dr. Victor Sandor, M.D.N/A107,494less than 0.1%2015-09-22
Mr. John R. MooreVP, General Counsel42,259less than 0.1%2015-04-01
Andrews R. RobbinsSVP, Commercial Operations39,375less than 0.1%2015-03-02
Dr. Nicholas A. SaccomanoN/A35,800less than 0.1%2015-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.19957-8.15
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270-18.61
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.8-20.16
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.3-36.03
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.6-36.03
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.5-46.53
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2-45.54
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.1-50.17
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.2-49.48
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.5-60.3Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$8560-63.383,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.25178-64.48Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.25330-64.4812,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5-49.420 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.2-49.411,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.4-51.17
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.9-51.81
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.5-49.4
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.2-58.2611,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.5-54.9216,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4-48.5111,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.110.5794,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.142.2396,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.124.6896,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.938.86
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.118.6298,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.140.8799,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.145.0576,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.936.92177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.129.6579,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.131.9810,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.117.280,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.335.02576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.123.1182,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.22.45551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.16.5584,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.1-3.62Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.2-11.21Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.1-5.79Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.10.69Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.1-8.44Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.8-11.21Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.1-9.85Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.1-9.57Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.7-10.4Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.1-12.01Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.1-11.75Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966-10.94Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.11.74Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.7905.02Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.5-9.85Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.1-5.79Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.1-13.06Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.1-6.09Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.1-14.83Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.8-21.02Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.1-22.49Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.119.11Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.122.08Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.320.08Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.117.67Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.38.92Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.110.15Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.145.77Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.145.77Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.65.78Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.7-29.74Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.7-25.82Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.6-4.25
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.7-6.39
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.8-10.67
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.2-45.64
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.4-52.44
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.1-54
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-77.46
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.6-74.46
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-79.15
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-79.07
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.5-77.53
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-76.56
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.1-75.54
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-74.96
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-73
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-70.73
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.8-70.55
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.5-69.13Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.2-67.52Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-68.76Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-68.76Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-66.48Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.7-64.09Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.8-52.36Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.6-57.66Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8-60.78Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.4-74.46Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.8-73.24Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.7-56.27Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-67.77Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.8-67.98Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-67.44Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.2-66.09Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.9-65.85Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-66.24Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.7-64.87Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.8-66.51Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.3-65.37Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-67.44Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-67.8Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.8-68.66Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-66.93Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-67.3Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1-60.99Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9-41.4Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.2-41.4Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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