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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDN/A786,9170.55%2013-07-24
Mr. Robert E. ConwayN/A633,3860.44%2011-10-04
Dr. Anthony D. Piscopio,PhDN/A553,5270.39%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDN/A177,7630.12%2011-06-30
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerN/A107,463less than 0.1%2016-04-01
Dr. Victor Sandor, M.D.N/A104,843less than 0.1%2016-04-01
Mr. John R. MooreN/A39,754less than 0.1%2016-04-01
Andrews R. RobbinsN/A36,008less than 0.1%2016-04-01
Dr. Nicholas A. SaccomanoN/A35,186less than 0.1%2016-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.1995713.48
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.62700.56
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.75-1.36
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.27-20.96
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.64-20.96
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.45-33.94
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2-32.71
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.1-38.44
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.16-37.59
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.5-50.95Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$8560-54.753,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.25178-56.12Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.25330-56.1212,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.55-37.4820 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.16-37.4811,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.37-39.67
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.89-40.46
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.49-37.48
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.2-48.4311,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.5-44.3116,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.43-36.3811,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.0936.694,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.1175.7396,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.154.0496,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.9371.56
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.0946.5698,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.1174.0499,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.1179.2176,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.9269.16177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.0960.1879,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.163.0610,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.144.880,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.2566.82576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.0952.182,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.226.57551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.0831.6484,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.0719.08Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.179.7Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.0716.4Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.0824.4Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.0713.13Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.769.7Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.1311.38Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.0711.73Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.710.7Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.068.71Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.079.04Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.0210.03Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.0825.69Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.0529.75Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.5411.38Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.0716.4Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.077.42Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.1516.03Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.075.23Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84-2.43Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06-4.23Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.0947.15Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.150.83Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.3448.36Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.0945.38Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.2834.57Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.0836.09Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.1180.1Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.1280.1Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.6430.69Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68-13.19Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65-8.35Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.5818.3
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.6615.65
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.8410.37
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.17-32.84
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.4-41.23
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.1-43.17
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-72.15
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-68.44
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-74.23
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-74.14
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-72.24
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-71.04
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-69.78
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-69.06
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-66.64
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-63.84
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.75-63.62
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.45-61.85Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.22-59.87Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-61.41Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-61.41Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-58.58Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.7-55.64Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.75-41.14Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.6-47.69Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.82-51.54Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-68.44Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.75-66.94Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.65-45.97Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-60.18Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.75-60.44Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-59.78Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.2-58.1Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.9-57.81Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-58.29Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.7-56.59Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.75-58.63Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.3-57.21Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-59.78Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-60.22Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.75-61.28Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-59.14Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-59.6Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.14-51.8Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9-27.6Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.18-27.6Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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