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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDN/A786,9170.55%2013-07-24
Mr. Robert E. ConwayN/A633,3860.44%2011-10-04
Dr. Anthony D. Piscopio,PhDN/A553,5270.39%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDN/A177,7630.12%2011-06-30
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerN/A107,463less than 0.1%2016-04-01
Dr. Victor Sandor, M.D.N/A104,843less than 0.1%2016-04-01
Mr. John R. MooreN/A39,754less than 0.1%2016-04-01
Andrews R. RobbinsN/A36,008less than 0.1%2016-04-01
Dr. Nicholas A. SaccomanoN/A35,186less than 0.1%2016-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.19957-3.45
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270-14.44
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.8-16.08
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.3-32.75
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.6-32.75
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.5-43.8
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2-42.75
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.1-47.62
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.2-46.9
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.5-58.27Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$8560-61.53,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.25178-62.67Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.25330-62.6712,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5-46.820 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.2-46.811,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.4-48.67
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.9-49.34
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.5-46.8
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.2-56.1311,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.5-52.6216,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4-45.8711,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.116.2394,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.149.5196,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.131.0696,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.945.97
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.124.798,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.148.0899,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.152.4876,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.943.93177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.136.2879,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.138.7410,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.123.280,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.341.94576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.129.4182,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.27.69551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.11284,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.11.32Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.2-6.67Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.1-0.96Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.15.84Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.1-3.75Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.8-6.67Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.1-5.23Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.1-4.94Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.7-5.81Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.1-7.51Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.1-7.23Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966-6.38Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.16.94Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.79010.39Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.5-5.23Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.1-0.96Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.1-8.61Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.1-1.28Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.1-10.47Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.8-16.98Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.1-18.52Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.125.2Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.128.33Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.326.23Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.123.69Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.314.5Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.115.79Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.153.23Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.153.23Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.611.19Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.7-26.14Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.7-22.03Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.60.65
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.7-1.6
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.8-6.1
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.2-42.86
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.4-50
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.1-51.65
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-76.31
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.6-73.15
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-78.08
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-78
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.5-76.38
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-75.36
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.1-74.29
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-73.68
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-71.61
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-69.23
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.8-69.05
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.5-67.54Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.2-65.85Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-67.16Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-67.16Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-64.76Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.7-62.25Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.8-49.92Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.6-55.49Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8-58.77Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.4-73.15Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.8-71.87Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.7-54.03Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-66.12Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.8-66.34Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-65.78Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.2-64.35Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.9-64.1Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-64.52Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.7-63.07Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.8-64.8Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.3-63.59Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-65.78Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-66.15Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.8-67.06Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-65.24Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-65.63Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1-58.99Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9-38.4Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.2-38.4Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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