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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-09-28Sell2,492,57816,658,072$6.3615852.878.77
16,658,072 (See Footnote(F2,))
Redmile Group, LLC10% Owner2016-09-15Sell400,00019,150,650$3.51400224.86
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-09-15Buy400,00019,150,650$3.511404223.93
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.19957256.43
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270215.83
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.75209.81
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.64148.25
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.27148.25
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.45107.48
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2111.34
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.193.37
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.1696.03
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.554.07Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$856042.133,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.2517837.82Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.2533037.8212,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5596.3720 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.1696.3711,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.3789.5
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.8987.01
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.4996.37
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.261.9711,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.574.9216,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4399.8211,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.09329.0694,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.11451.9496,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.1383.8396,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.93438.86
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.09360.3298,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.11446.6399,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.11462.8776,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.92431.31177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.09403.179,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.1412.1610,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.1354.880,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.25423.96576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.09377.7382,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.2297.55551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.08313.4584,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.07274.01Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.17244.55Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.07265.59Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.08290.72Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.07255.31Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.76244.55Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.13249.85Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.07250.93Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.7247.71Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.06241.44Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.07242.47Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.02245.59Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.08294.79Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.05307.53Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.54249.85Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.07265.59Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.07237.39Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.15264.42Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.07230.52Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84206.47Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06200.79Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.09362.2Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.1373.75Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.34365.98Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.09356.63Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.28322.68Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.08327.44Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.11465.67Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.12465.67Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.64310.47Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68172.66Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65187.85Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.58271.57
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.66263.26
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.84246.65
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.17110.95
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.484.58
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.178.49
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-12.54
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-0.87
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-19.07
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-18.79
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-12.81
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-9.04
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-5.09
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-2.82
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.54.79
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.01100113.59
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.7514.27
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.4519.81Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.2226.05Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.621.22Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.821.22Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.430.09Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.739.34Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.7584.88Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.664.31Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8252.21Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-0.87Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.753.84Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.6569.7Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.925.08Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.7524.26Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$94526.33Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.231.6Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.932.52Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.430.99Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.736.33Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.7529.94Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.334.4Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$94526.33Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.524.95Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.7521.6Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.328.33Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.626.9Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1451.4Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9127.4Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.18127.4Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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