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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-09-28Sell2,492,57816,658,072$6.3615852.848.74
16,658,072 (See Footnote(F2,))
Redmile Group, LLC10% Owner2016-09-15Sell400,00019,150,650$3.51400170.29
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-09-15Buy400,00019,150,650$3.511404169.52
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.19957196.55
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270162.78
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.75157.77
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.64106.55
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.27106.55
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.4572.63
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.275.84
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.160.88
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.1663.1
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.528.18Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$856018.253,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.2517814.67Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.2533014.6712,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5563.3920 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.1663.3911,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.3757.67
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.8955.59
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.4963.39
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.234.7611,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.545.5416,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4366.2611,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.09256.9894,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.11359.2296,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.1302.5596,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.93348.34
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.0928398,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.11354.8199,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.11368.3276,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.92342.06177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.09318.5879,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.1326.1310,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.1278.480,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.25335.94576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.09297.4882,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.2230.77551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.0824484,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.07211.18Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.17186.67Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.07204.18Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.08225.09Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.07195.63Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.76186.67Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.13191.08Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.07191.98Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.7189.3Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.06184.08Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.07184.94Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.02187.54Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.08228.47Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.05239.07Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.54191.08Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.07204.18Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.07180.71Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.15203.21Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.07175Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84154.99Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06150.26Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.09284.55Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.1294.17Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.34287.7Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.09279.92Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.28251.67Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.08255.64Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.11370.65Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.12370.65Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.64241.52Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68126.86Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65139.49Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.58209.15
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.66202.24
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.84188.41
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.1775.51
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.453.57
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.148.51
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-27.23
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-17.52
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-32.67
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-32.43
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-27.45
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-24.32
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-21.04
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-19.15
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-12.81
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-5.49
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.75-4.92
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.45-0.32Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.224.88Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.60.85Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.80.85Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.48.24Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.715.93Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.7553.82Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.636.71Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8226.64Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-17.52Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.75-13.61Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.6541.19Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.94.07Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.753.39Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$9455.11Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.29.49Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.910.26Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.48.99Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.713.43Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.758.11Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.311.82Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$9455.11Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.53.96Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.751.18Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.36.77Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.65.58Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1425.97Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.989.2Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.1889.2Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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