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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDN/A786,9170.47%2013-07-24
Mr. Robert E. ConwayN/A633,3860.38%2011-10-04
Dr. Anthony D. Piscopio,PhDN/A553,5270.33%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDN/A177,7630.11%2011-06-30
Dr. Victor Sandor, M.D.N/A169,6160.1%2016-09-22
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerN/A107,463less than 0.1%2016-04-01
Mr. John R. MooreN/A39,754less than 0.1%2016-04-01
Andrews R. RobbinsN/A36,008less than 0.1%2016-04-01
Dr. Nicholas A. SaccomanoN/A35,186less than 0.1%2016-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-09-28Sell2,492,57816,658,072$6.3615852.836.16
16,658,072 (See Footnote(F2,))
Redmile Group, LLC10% Owner2016-09-15Sell400,00019,150,650$3.51400147.43
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-09-15Buy400,00019,150,650$3.511404146.72
19,150,650 (See footnote(F5,))
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.19957171.47
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270140.56
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.75135.97
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.6489.08
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.2789.08
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.4558.03
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.260.97
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.147.28
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.1649.31
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.517.34Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$85608.253,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.251784.97Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.253304.9712,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5549.5720 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.1649.5711,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.3744.33
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.8942.43
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.4949.57
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.223.3611,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.533.2316,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4352.211,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.09226.7994,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.11320.3996,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.1268.5196,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.93310.43
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.09250.6198,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.11316.3599,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.11328.7176,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.92304.67177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.09283.1979,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.1290.0910,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.1246.480,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.25299.08576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.09263.8782,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.2202.8551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.08214.9184,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.07184.87Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.17162.42Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.07178.46Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.08197.59Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.07170.63Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.76162.42Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.13166.46Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.07167.28Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.7164.83Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.06160.06Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.07160.84Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.02163.22Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.08200.69Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.05210.39Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.54166.46Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.07178.46Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.07156.97Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.15177.56Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.07151.74Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84133.42Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06129.1Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.09252.03Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.1260.83Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.34254.92Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.09247.79Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.28221.93Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.08225.56Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.11330.85Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.12330.85Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.64212.64Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68107.67Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65119.24Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.58183.01
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.66176.68
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.84164.02
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.1760.67
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.440.58
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.135.95
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-33.38
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-24.5
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-38.36
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-38.14
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-33.59
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-30.72
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-27.71
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-25.98
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-20.18
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-13.49
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.75-12.96
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.45-8.75Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.22-3.99Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-7.68Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-7.68Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-0.92Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.76.13Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.7540.81Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.625.14Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8215.93Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-24.5Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.75-20.91Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.6529.25Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-4.73Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.75-5.36Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-3.78Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.20.23Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.90.93Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-0.23Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.73.84Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.75-1.03Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.32.36Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-3.78Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-4.84Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.75-7.38Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-2.26Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-3.35Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1415.31Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.973.2Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.1873.2Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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