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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDN/A786,9170.55%2013-07-24
Mr. Robert E. ConwayN/A633,3860.44%2011-10-04
Dr. Anthony D. Piscopio,PhDN/A553,5270.39%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDN/A177,7630.12%2011-06-30
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerN/A107,463less than 0.1%2016-04-01
Dr. Victor Sandor, M.D.N/A104,843less than 0.1%2016-04-01
Mr. John R. MooreN/A39,754less than 0.1%2016-04-01
Andrews R. RobbinsN/A36,008less than 0.1%2016-04-01
Dr. Nicholas A. SaccomanoN/A35,186less than 0.1%2016-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.1995712.85
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.62700
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.8-1.91
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.3-21.4
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.6-21.4
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.5-34.31
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2-33.09
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.1-38.78
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.2-37.93
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.5-51.22Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$8560-553,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.25178-56.36Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.25330-56.3612,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.5-37.8220 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.2-37.8211,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.4-40
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.9-40.79
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.5-37.82
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.2-48.7211,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.5-44.6216,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.4-36.7311,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.135.8594,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.174.7696,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.153.1996,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.970.62
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.145.7598,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.173.0899,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.178.2276,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.968.22177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.159.2979,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.162.1610,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.14480,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.365.9576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.151.2682,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.225.87551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.130.9184,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.118.42Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.29.09Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.115.76Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.123.71Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.112.5Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.89.09Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.110.77Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.111.11Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.710.09Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.18.11Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.18.43Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.29669.42Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.125Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.79029.03Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.510.77Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.115.76Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.16.82Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.115.38Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.14.65Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.8-2.96Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.1-4.76Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.146.34Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.150Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.347.54Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.144.58Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.333.83Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.135.34Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.179.1Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.179.1Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.629.96Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.7-13.67Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.7-8.86Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.617.65
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.715.02
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.89.76
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.2-33.21
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.4-41.56
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.1-43.49
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-72.31
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.6-68.61
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-74.38
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-74.29
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.5-72.39
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-71.2
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.1-69.95
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-69.23
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-66.82
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-64.04
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.8-63.82
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.5-62.07Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.2-60.09Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-61.62Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-61.62Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-58.81Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.7-55.88Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.8-41.46Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.6-47.98Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.8-51.81Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.4-68.61Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.8-67.12Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.7-46.27Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-60.4Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.8-60.66Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-60Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.2-58.33Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.9-58.04Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-58.53Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.7-56.83Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.8-58.86Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.3-57.45Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-60Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-60.44Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.8-61.5Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-59.37Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-59.82Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.1-52.06Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9-28Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.2-28Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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