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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Kevin Koch, PhDN/A786,9170.55%2013-07-24
Mr. Robert E. ConwayN/A633,3860.44%2011-10-04
Dr. Anthony D. Piscopio,PhDN/A553,5270.39%2004-04-29
Dr.Professor Marvin H. Caruthers,PhDN/A177,7630.12%2011-06-30
Mr. R. Michael CarruthersN/A112,265less than 0.1%2013-07-24
Ron SquarerN/A107,463less than 0.1%2016-04-01
Dr. Victor Sandor, M.D.N/A104,843less than 0.1%2016-04-01
Mr. John R. MooreN/A39,754less than 0.1%2016-04-01
Andrews R. RobbinsN/A36,008less than 0.1%2016-04-01
Dr. Nicholas A. SaccomanoN/A35,186less than 0.1%2016-04-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Redmile Group, LLC10% Owner2016-01-20Buy300,00019,150,650$3.199578.15
19,150,650 (See footnote)
Redmile Group, LLC10% Owner2016-01-12Buy75,00018,850,650$3.6270-4.17
18,850,650 (See Footnote)
Redmile Group, LLC10% Owner2016-01-11Buy925,00018,775,650$3.673394.75-5.99
18,775,650 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy782,59218,033,102$4.583584.27-24.67
18,033,102 (See footnote)
Redmile Group, LLC10% Owner2015-10-01Buy600,14017,850,650$4.582748.64-24.67
17,850,650 (See footnote)
Redmile Group, LLC10% Owner2015-08-26Buy49,90017,250,510$5.48273.45-37.04
17,250,510 (See footnote)
Redmile Group, LLC10% Owner2015-08-25Buy790,00017,200,610$5.384250.2-35.87
17,200,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-12Buy532,50032,616,220$5.883131.1-41.33
16,205,610 (See footnote)
16,410,610 (See Footnote)
Redmile Group, LLC10% Owner2015-08-10Buy1,048,99315,878,110$5.86084.16-40.52
15,878,110 (See footnote)
BAUM CHARLES MDirector2015-05-08Sell25,0000$7.38184.5-53.25Link
LEFKOFF KYLEDirector2015-03-03Sell70,00048,585$8560-56.883,585 (Direct)
45,000 (See footnote)
Robbins Andrews RSVP, Commercial Operations2015-03-02Sell21,5760$8.25178-58.18Link
Squarer RonCEO
(Click for the stocks that their CEOs have bought)
2015-03-02Sell40,00012,927$8.25330-58.1812,927 (Direct)
MOORE JOHN RVP, General Counsel2013-11-29Sell11,66620$5.7967.55-40.4120 (Direct)
MOORE JOHN RVP, General Counsel2013-11-13Sell20011,686$5.791.16-40.4111,686 (Direct)
Ratcliffe LiamDirector2013-09-27Sell1,125,7280$66754.37-42.5
0 (See footnote)
Ratcliffe LiamDirector2013-09-16Sell1,673,1721,125,728$6.0810172.89-43.26
1,125,728 (See footnote)
Ratcliffe LiamDirector2013-09-06Sell577,2862,798,900$5.793342.49-40.41
2,798,900 (See footnote)
MOORE JOHN RVP, General Counsel2013-08-02Sell75,38411,886$7.02529.2-50.8511,886 (Direct)
MOORE JOHN RVP, General Counsel2013-07-23Sell5,00016,645$6.532.5-46.9216,645 (Direct)
MOORE JOHN RVP, General Counsel2012-10-08Sell28,54711,886$5.69162.43-39.3711,886 (Direct)
0 (Held by spouse)
CARRUTHERS MICHAELCFO2012-02-10Sell1,54594,570$2.654.0930.1994,570 (Direct)
CARRUTHERS MICHAELCFO2012-01-12Sell1,99496,115$2.064.1167.4896,115 (Direct)
CARRUTHERS MICHAELCFO2011-12-12Sell1,74396,295$2.354.146.8196,295 (Direct)
BVF PARTNERS L P/IL10% Owner2011-12-05Buy183,8535,938,900$2.11387.9363.51
4,893,000 (See Explanation of Responses)
1,045,900 (See Explanation of Respones)
CARRUTHERS MICHAELCFO2011-11-11Sell1,65698,038$2.474.0939.6898,038 (Direct)
CARRUTHERS MICHAELCFO2011-10-12Sell1,97799,694$2.084.1165.8799,694 (Direct)
CARRUTHERS MICHAELCFO2011-09-12Sell2,03476,978$2.024.1170.7976,978 (Direct)
CARUTHERS MARVIN HDirector2011-08-16Sell2,300446,934$2.144.9261.21177,763 (Direct)
269,040 (Held by GRAT)
131 (Held in Family LLC; disclaimed by Reporting Person)
CARRUTHERS MICHAELCFO2011-08-12Sell1,81079,012$2.264.0952.6579,012 (Direct)
LEFKOFF KYLEDirector2011-08-11Buy5,00049,585$2.2211.155.4110,000 (Direct)
15,000 (In 401k Profit Sharing Plan)
24,585 (Held as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-07-12Sell1,63880,822$2.54.13880,822 (Direct)
CONWAY ROBERTCEO2011-06-17Buy25,000656,196$2.1754.2558.99576,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-06-10Sell1,72082,460$2.384.0944.9682,460 (Direct)
CONWAY ROBERTCEO2011-05-13Buy20,000631,196$2.8657.220.63551,196 (Direct)
80,000 (Held by spouse as custodian for UTMA for benefit of minor children)
CARRUTHERS MICHAELCFO2011-05-12Sell1,48484,180$2.754.0825.4584,180 (Direct)
CARRUTHERS MICHAELCFO2011-04-12Sell1,3400$3.044.0713.49Link
MOORE JOHN RVP, General Counsel2011-04-05Sell3560$3.31.174.55Link
CARRUTHERS MICHAELCFO2011-03-11Sell1,3100$3.114.0710.93Link
CARRUTHERS MICHAELCFO2011-02-11Sell1,4030$2.914.0818.56Link
CARRUTHERS MICHAELCFO2011-01-12Sell1,27289,717$3.24.077.81Link
MOORE JOHN RVP, General Counsel2011-01-11Sell2,959356$3.39.764.55Link
MOORE JOHN RVP, General Counsel2011-01-06Sell24,0393,315$3.2578.136.15Link
CARRUTHERS MICHAELCFO2010-12-10Sell1,25689,650$3.244.076.48Link
LEFKOFF KYLEDirector2010-11-18Sell10,00044,585$3.2732.75.5Link
CARRUTHERS MICHAELCFO2010-11-12Sell1,22090,906$3.334.063.6Link
CARRUTHERS MICHAELCFO2010-10-12Sell1,22592,126$3.324.073.92Link
MOORE JOHN RVP, General Counsel2010-10-05Sell20,06727,354$3.2966.024.86Link
CARRUTHERS MICHAELCFO2010-09-14Sell1,41570,353$2.884.0819.79Link
CARRUTHERS MICHAELCFO2010-08-23Sell1771,768$2.790.0523.66Link
MOORE JOHN RVP, General Counsel2010-08-03Sell6,31921,317$3.2520.546.15Link
CARRUTHERS MICHAELCFO2010-07-23Sell1,30971,785$3.114.0710.93Link
CARRUTHERS MICHAELCFO2010-06-23Sell1,20873,094$3.374.072.37Link
CARUTHERS MARVIN HDirector2010-06-08Sell1,650449,234$3.125.1510.58Link
CARRUTHERS MICHAELCFO2010-05-21Sell1,18374,302$3.444.070.29Link
LEFKOFF KYLEDirector2010-05-07Buy4,00054,585$3.7114.84-7.01Link
CARRUTHERS MICHAELCFO2010-04-23Sell1,07475,485$3.784.06-8.73Link
CARRUTHERS MICHAELCFO2010-03-23Sell1,66176,559$2.464.0940.24Link
CARRUTHERS MICHAELCFO2010-02-23Sell1,70778,220$2.44.143.75Link
CARRUTHERS MICHAELCFO2010-02-05Sell6,28679,927$2.4415.3441.39Link
CARRUTHERS MICHAELCFO2010-01-22Sell1,64486,213$2.494.0938.55Link
CARRUTHERS MICHAELCFO2010-01-06Sell5,68186,706$2.6915.2828.25Link
CARRUTHERS MICHAELCFO2009-12-23Sell1,53394,432$2.664.0829.7Link
CARRUTHERS MICHAELCFO2009-11-23Sell2,04593,920$2.014.1171.64Link
CARRUTHERS MICHAELCFO2009-10-23Sell2,04995,965$2.014.1271.64Link
CARRUTHERS MICHAELCFO2009-09-25Sell1,31579,308$2.773.6424.55Link
CARRUTHERS MICHAELCFO2009-08-24Sell88280,623$4.173.68-17.27Link
CARRUTHERS MICHAELCFO2009-07-30Sell92580,738$3.953.65-12.66Link
CARRUTHERS MICHAELCFO2009-06-22Sell1,17081,663$3.063.5812.75
CARRUTHERS MICHAELCFO2009-05-26Sell1,17082,833$3.133.6610.22
LEFKOFF KYLEDirector2008-11-13Buy3,0006,000$3.289.845.18
LEFKOFF KYLEDirector2008-03-10Buy3,0003,000$5.3916.17-35.99
WILLIAMS DOUGLAS EDirector2008-03-06Buy2,5002,500$6.1615.4-43.99
ZABRISKIE JOHN LDirector2008-03-05Buy30,00030,000$6.37191.1-45.84
CARRUTHERS MICHAELCFO2007-09-19Sell10,00040,812$13130-73.46
VAN LUNSEN GIL JDirector2007-08-09Sell12,0005,260$11.47137.64-69.92
KOCH KEVINPresident & CSO2007-02-05Sell20,000555,354$14.05281-75.44
KOCH KEVINPresident & CSO2007-01-19Sell26,900575,354$14376.6-75.36
MOORE JOHN RVP, General Counsel2006-11-20Sell27,2630$13.04355.51-73.54
CONWAY ROBERTCEO2006-11-15Sell50,000243,241$12.5625-72.4
CARRUTHERS MICHAELCFO2006-11-13Sell14,87030,449$11.98178.14-71.2
LEFKOFF KYLEDirector2006-11-09Sell51,0001,000$11.7596.7-70.51
CARRUTHERS MICHAELCFO2006-11-08Sell10,00045,319$10.85108.5-68.2
CONWAY ROBERTCEO2006-11-03Sell100,000193,241$10.011001-65.53
CARRUTHERS MICHAELCFO2006-10-27Sell5,00055,319$9.9549.75-65.33
CARRUTHERS MICHAELCFO2006-03-07Sell5,00060,449$9.4947.45-63.65Link
LEFKOFF KYLEDirector2006-02-21Sell11,00089,135$9.0299.22-61.75Link
KOCH KEVINPresident & CSO2006-02-17Sell20,000744,540$9.38187.6-63.22Link
MOORE JOHN RVP, General Counsel2006-02-17Sell4,4562,252$9.3841.8-63.22Link
CARRUTHERS MICHAELCFO2006-02-17Sell10,00065,449$8.7487.4-60.53Link
CARRUTHERS MICHAELCFO2006-02-13Sell8,90975,449$8.1672.7-57.72Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-06-17Sell5,00084,243$6.1530.75-43.9Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2005-03-31Sell5,00084,072$6.9234.6-50.14Link
VAN LUNSEN GIL JDirector2005-03-24Buy1,3153,260$7.479.82-53.82Link
PISCOPIO TONYVice President, Chemistry2004-04-29Sell5,000553,527$11.4757.35-69.92Link
PISCOPIO TONYVice President, Chemistry2004-04-28Sell5,000558,527$10.9554.75-68.49Link
PISCOPIO TONYVP/Dir of Chemistry2004-04-27Sell29,500563,527$6.7197.65-48.51Link
PISCOPIO TONYVP Chem,Dir Proc. Chem2004-04-23Sell10,000593,027$9.0990.9-62.05Link
PISCOPIO TONYVice President, Chemistry2004-04-21Sell5,000603,027$9.1545.75-62.3Link
PISCOPIO TONYVice President, Chemistry2004-04-20Sell5,000608,027$945-61.67Link
PISCOPIO TONYVice President, Chemistry2004-04-19Sell5,000613,027$8.6443.2-60.07Link
PISCOPIO TONYVice President, Chemistry2004-04-16Sell5,000618,027$8.5842.9-59.79Link
PISCOPIO TONYVice President, Chemistry2004-04-15Sell5,000623,027$8.6843.4-60.25Link
PISCOPIO TONYVice President, Chemistry2004-04-14Sell5,000628,027$8.3441.7-58.63Link
PISCOPIO TONYVice President, Chemistry2004-04-13Sell5,000633,027$8.7543.75-60.57Link
PISCOPIO TONYVice President, Chemistry2004-04-12Sell5,000638,027$8.4642.3-59.22Link
PISCOPIO TONYVice President, Chemistry2004-04-08Sell5,000643,027$945-61.67Link
PISCOPIO TONYVice President, Chemistry2004-04-07Sell5,000648,027$9.145.5-62.09Link
PISCOPIO TONYVice President, Chemistry2004-04-06Sell5,000653,027$9.3546.75-63.1Link
PISCOPIO TONYVice President, Chemistry2004-04-05Sell5,000658,027$8.8644.3-61.06Link
PISCOPIO TONYVP of Chemistry2004-04-02Sell10,000663,027$8.9689.6-61.5Link
CARRUTHERS MICHAELCHIEF FINANCIAL OFFICER2004-02-26Sell14,00088,973$7.51105.14-54.06Link
VAN LUNSEN GIL JDirector2003-11-10Buy5801,945$52.9-31Link
BVF PARTNERS L P/IL2003-11-05Sell3,865,0350$519325.18-31Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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