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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Solomon S. Steiner,PhDN/A1,555,0262.42%2011-09-22
David KroinN/A1,009,1881.57%2010-01-13
Scott A. WeismanN/A298,1360.46%2010-03-01
Desouza Errol BN/A159,4160.25%2015-09-30
Erik SteinerN/A79,5450.12%2013-03-12
Robert FeldsteinN/A70,5640.11%2007-05-16
Mr. Gerard J. MichelN/A43,810less than 0.1%2014-03-12
Dr. Alan Krasner,M.D.N/A35,687less than 0.1%2014-03-12
Dr. Charles A. Sanders,M.D.N/A19,096less than 0.1%2011-09-30
Mr. Paul BavierN/A18,977less than 0.1%2014-03-12

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Pereira Brian JGDirector2013-12-20Sell4,7340$2.2610.7-82.3Link
LIEBERMAN IRADirector2013-12-20Buy10,80011,292$2.2924.73-82.5311,292 (Direct)
Bavier Paul SGeneral Counsel/Corp. Sec.2012-12-07Sell12,25612,340$2.834.32-85.7112,340 (Direct)
Bavier Paul SGeneral Counsel/Corp. Sec.2012-11-02Sell3,50027,334$2.819.84-85.7727,334 (Direct)
Krasner Alan SethChief Medical Officer2012-11-02Sell3,50027,334$2.819.84-85.7727,334 (Direct)
DESOUZA ERROL BCEO
(Click for the stocks that their CEOs have bought)
2012-09-20Buy10,00067,892$3.3433.4-88.0267,892 (Direct)
Bavier Paul SGeneral Counsel/Corp. Sec.2012-03-13Sell2,09612,338$2.364.95-83.0512,338 (Direct)
Pereira Brian JGDirector2011-12-16Sell3,7504,734$2.69.75-84.624,734 (Direct)
Steiner SolomonDirector2011-09-26Sell32,695388,757$4.36142.55-90.83388,757 (Direct)
Steiner SolomonDirector2011-09-21Sell79,129421,451$4.72373.49-91.53421,451 (Direct)
Krasner Alan SethChief Medical Officer2011-09-20Sell9643,024$4.684.51-91.453,024 (Direct)
URCIUOLI J ARTHURDirector2011-09-20Buy2,5007,500$4.7211.8-91.53
7,500 (See Footnote (3))
Steiner SolomonDirector2011-09-16Sell56,644500,581$4.88276.42-91.8500,581 (Direct)
Steiner Solomon10% Owner2011-09-06Sell25,675557,225$4.56117.08-91.23557,225 (Direct)
Steiner Solomon10% Owner2011-09-02Sell23,199597,400$4.8111.36-91.67597,400 (Direct)
Steiner SolomonDirector2011-08-30Sell39,938620,599$4.88194.9-91.8
620,599 (See Footnote)
SANDERS CHARLES ADirector2011-08-10Buy2,5003,790$4.6411.6-91.383,790 (Direct)
Steiner SolomonDirector2011-05-25Sell35,400696,725$8.12287.44-95.07
696,725 (See Footnote (2))
Steiner SolomonDirector, 10% Owner2011-03-10Sell42,5520$8.92379.56-95.52Link
Steiner SolomonDirector, 10% Owner2011-03-04Sell17,2810$8.24142.4-95.15Link
Steiner SolomonDirector, 10% Owner2011-02-28Sell74,7930$8.4628.26-95.24Link
Steiner SolomonDirector, 10% Owner2011-02-22Sell22,4930$7.92178.15-94.95Link
Steiner SolomonDirector, 10% Owner2011-02-16Sell107,4820$8859.85-95Link
STEINER ERIKVice-President, Operations2011-02-10Sell2,5000$8.3220.8-95.19Link
Bavier Paul SGeneral Counsel/Corp. Sec.2011-02-09Sell9150$8.167.46-95.1Link
MICHEL GERARD JCFO, VP of Corp and Dev/Treas2011-02-08Sell1,0000$8.28.2-95.12Link
Steiner SolomonDirector, 10% Owner2010-12-21Sell31,250996,725$7218.75-94.29Link
SANDERS CHARLES ADirector2010-05-11Buy1,2501,290$22.3627.95-98.21Link
WEISMAN SCOTTDirector2010-03-01Sell10,00074,534$18180-97.78Link
KROIN DAVIDDirector2010-01-14Sell20,811252,297$20.28422.05-98.03Link
KROIN DAVIDDirector2010-01-12Sell17,303273,108$20.12348.13-98.01Link
KROIN DAVIDDirector2009-12-31Sell19,723290,411$20.24399.18-98.02Link
WEISMAN SCOTTDirector2009-12-31Sell5,62584,534$19.68110.7-97.97Link
KROIN DAVIDDirector2009-10-21Sell325310,133$206.5-98Link
KROIN DAVIDDirector2009-10-19Sell817310,458$20.0816.4-98.01Link
WEISMAN SCOTTDirector2009-10-19Sell1,87590,159$2037.5-98Link
KROIN DAVIDDirector2009-10-16Sell3,650311,275$20.2473.88-98.02Link
KROIN DAVIDDirector2009-10-14Sell4,225314,925$20.8888.22-98.08Link
KROIN DAVIDDirector2009-10-12Sell3,366319,150$20.7669.87-98.07Link
KROIN DAVIDDirector2009-10-08Sell6,503322,516$20.72134.75-98.07Link
KROIN DAVIDDirector2009-10-06Sell3,980329,019$20.9283.26-98.09Link
KROIN DAVIDDirector2009-09-23Sell2,449332,999$20.850.93-98.08Link
KROIN DAVIDDirector2009-09-21Sell3,534335,448$20.8873.78-98.08Link
WEISMAN SCOTTDirector2009-09-21Sell96392,034$2120.22-98.1Link
WEISMAN SCOTTDirector2009-09-18Sell1,53792,997$2132.28-98.1Link
KROIN DAVIDDirector2009-09-17Sell2,667338,981$20.855.47-98.08Link
KROIN DAVIDDirector2009-09-15Sell6,725341,648$21.04141.49-98.1Link
KROIN DAVIDDirector2009-09-11Sell2,150348,373$20.7644.63-98.07Link
KROIN DAVIDDirector2009-09-09Sell1,126350,523$20.5223.1-98.05Link
KROIN DAVIDDirector2009-09-04Sell1,575351,649$20.1231.69-98.01Link
KROIN DAVIDDirector2009-09-01Sell506353,224$20.210.22-98.02Link
KROIN DAVIDDirector2009-08-31Sell975353,730$20.1619.66-98.02Link
KROIN DAVIDDirector2009-08-25Sell3,650356,180$20.8876.21-98.08Link
KROIN DAVIDDirector2009-08-21Sell2,025359,830$20.1240.74-98.01Link
KROIN DAVIDDirector2009-08-19Sell1,625361,855$2032.5-98Link
GREAT POINT PARTNERS I LP10% Owner2009-08-17Sell1,355363,480$20.0827.2-98.01Link
GREAT POINT PARTNERS I LP10% Owner2009-08-12Sell275364,834$205.5-98Link
GREAT POINT PARTNERS I LP10% Owner2009-08-11Sell1,100365,109$20.1222.13-98.01Link
KROIN DAVIDDirector2009-08-11Sell1,100365,109$20.1222.13-98.01Link
GREAT POINT PARTNERS I LP10% Owner2009-08-07Sell1,920366,209$20.2438.86-98.02Link
KROIN DAVIDDirector2009-08-05Sell1,925368,129$20.0438.58-98Link
GREAT POINT PARTNERS I LP10% Owner2009-08-05Sell1,925368,129$20.0438.58-98Link
GREAT POINT PARTNERS I LP10% Owner2009-08-03Sell425370,054$20.128.55-98.01Link
KROIN DAVIDDirector2009-08-03Sell425370,054$20.128.55-98.01Link
KROIN DAVIDDirector2009-07-30Sell3,425370,479$20.2469.32-98.02Link
GREAT POINT PARTNERS I LP10% Owner2009-07-30Sell3,425370,479$20.2469.32-98.02Link
GREAT POINT PARTNERS I LP10% Owner2009-07-28Sell3,100373,904$20.864.48-98.08Link
KROIN DAVIDDirector2009-07-28Sell3,100373,904$20.864.48-98.08Link
GREAT POINT PARTNERS I LP10% Owner2009-07-24Sell19,739377,004$20.88412.15-98.08Link
KROIN DAVIDDirector2009-07-24Sell19,739377,004$20.88412.15-98.08Link
GREAT POINT PARTNERS I LP10% Owner2009-07-22Sell12,708396,743$20.92265.84-98.09
KROIN DAVIDDirector2009-07-22Sell12,708396,743$20.92265.84-98.09
KROIN DAVIDDirector2009-07-20Sell1,821409,450$20.236.78-98.02
GREAT POINT PARTNERS I LP10% Owner2009-07-20Sell1,821409,450$20.236.78-98.02
KROIN DAVIDDirector2009-07-16Sell2,309411,271$2046.19-98
GREAT POINT PARTNERS I LP10% Owner2009-07-16Sell2,309411,271$2046.19-98
KROIN DAVIDDirector2009-07-13Sell175413,580$203.5-98
GREAT POINT PARTNERS I LP10% Owner2009-07-13Sell175413,580$203.5-98
KROIN DAVIDDirector2009-07-08Sell100413,755$20.082.01-98.01
GREAT POINT PARTNERS I LP10% Owner2009-07-08Sell100413,755$20.082.01-98.01
KROIN DAVIDDirector2009-07-07Sell1,925413,855$20.1238.73-98.01
GREAT POINT PARTNERS I LP10% Owner2009-07-07Sell1,925413,855$20.1238.73-98.01
GREAT POINT PARTNERS I LP10% Owner2009-07-01Sell7,965415,780$20.64164.4-98.06
KROIN DAVIDDirector2009-07-01Sell7,965415,780$20.64164.4-98.06
GREAT POINT PARTNERS I LP10% Owner2009-07-01Sell7,965415,780$20.64164.4-98.06
KROIN DAVIDDirector2009-07-01Sell7,965415,780$20.64164.4-98.06
GREAT POINT PARTNERS I LP10% Owner2009-06-29Sell11,050423,745$21232.05-98.1
KROIN DAVIDDirector2009-06-29Sell11,050423,745$21232.05-98.1
GREAT POINT PARTNERS I LP10% Owner2009-06-25Sell3,398434,795$20.1668.51-98.02
KROIN DAVIDDirector2009-06-25Sell3,398434,795$20.1668.51-98.02
KROIN DAVIDDirector2009-06-18Sell1,050438,194$21.0422.09-98.1
GREAT POINT PARTNERS I LP10% Owner2009-06-18Sell1,050438,194$21.0422.09-98.1
KROIN DAVIDDirector2009-06-16Sell13,900439,244$22.12307.47-98.19
GREAT POINT PARTNERS I LP10% Owner2009-06-15Sell13,900439,244$22.12307.47-98.19
Wertheimer Samuel PDirector2009-06-10Sell6,747371,476$20.96141.42-98.09
ORBIMED ADVISORS LLCDirector2009-06-10Sell6,747371,476$20.96141.42-98.09
PFUTZNER ANDREASChief Medical Officer in Europ2008-11-06Buy500500$10.25.1-96.08
Ginsberg Barry HDirector2008-09-25Buy1,2501,425$1923.75-97.89
POHL RODERIKEVice President Research2008-09-17Buy2525$21.760.54-98.16
WEISMAN SCOTTDirector2008-08-15Sell1,25094,534$73.692-99.46
WEISMAN SCOTTDirector2008-07-28Sell7,50095,784$68510-99.41
WEISMAN SCOTTDirector2008-06-20Sell450103,284$60.1627.09-99.34
WEISMAN SCOTTDirector2008-06-20Sell2,050103,734$59.28121.51-99.33
WEISMAN SCOTTDirector2008-05-21Sell2,500105,784$64.2160.5-99.38
Pereira Brian JGDirector2008-02-12Buy7,5007,500$62465-99.35
Steiner SolomonPresident & CEO, Director, 10% Owner2008-02-12Sell27,5001,011,067$621705-99.35
ORBIMED ADVISORS LLCDirector, 10% Owner2008-02-12Sell38,500453,223$57.922229.92-99.31
Steiner SolomonPresident & CEO, Director, 10% Owner2008-02-01Sell35221,298$69.6824.51-99.43
POHL RODERIKEVP Research2008-01-31Sell56638,677$70.5639.9-99.43
POHL RODERIKEVP Research2008-01-30Sell58539,243$71.3241.7-99.44
POHL RODERIKEVP Research2008-01-29Sell50039,828$7236-99.44
POHL RODERIKEVP Research2008-01-28Sell28740,328$70.420.22-99.43
POHL RODERIKEVP Research2008-01-28Sell28740,428$70.420.22-99.43
POHL RODERIKEVP Research2008-01-28Sell28740,328$70.420.22-99.43
POHL RODERIKEVP Research2008-01-25Sell74840,615$72.4454.19-99.45
POHL RODERIKEVP Research2008-01-23Sell81540,548$74.5660.73-99.46
POHL RODERIKEVP Research2008-01-18Sell30041,363$72.7621.83-99.45
POHL RODERIKEVP Research2008-01-18Sell1,20041,663$74.5289.42-99.46
POHL RODERIKEVP Research2008-01-17Sell40042,863$85.434.16-99.53
POHL RODERIKEVP Research2008-01-16Sell78843,263$88.869.93-99.55
POHL RODERIKEVP Research2008-01-15Sell71344,175$94.0467-99.57
POHL RODERIKEVP Research2008-01-14Sell2,41344,888$92.96224.27-99.57
POHL RODERIKEVP Research2008-01-09Sell1,35447,301$93.8127.01-99.57
POHL RODERIKEVP Research2008-01-09Sell1,35447,301$93.8127.01-99.57
WARE R TIMMISCorp. Secy and General Counsel2008-01-07Sell2,82518,808$94.44266.79-99.58
WARE R TIMMISCorp. Secy and General Counsel2008-01-07Sell2,60021,633$96.92251.99-99.59
WARE R TIMMISCorp. Secy and General Counsel2008-01-04Sell2,40816,401$100.48241.91-99.6
WARE R TIMMISCorp. Secy and General Counsel2008-01-04Sell2,45024,233$91.96225.3-99.57
WARE R TIMMISCorp. Secy and General Counsel2008-01-03Sell92526,683$90.9684.14-99.56
Steiner SolomonPresident & CEO, Director, 10% Owner2008-01-02Sell4,67523,926$92.88434.19-99.57
Steiner SolomonPresident & CEO, Director, 10% Owner2008-01-02Sell1,97821,650$91.76181.5-99.56
POHL RODERIKEVP Research2007-12-27Sell71348,655$92.9666.23-99.57
POHL RODERIKEVP RESEARCH2007-12-26Sell1,76649,367$91.52161.6-99.56
POHL RODERIKEVP RESEARCH2007-12-24Sell1,27251,133$88.04111.96-99.55
POHL RODERIKEVP Research2007-12-18Sell2,50052,405$80.52201.3-99.5
Steiner SolomonPresident & CEO, Director, 10% Owner2007-12-18Sell3,03928,726$79.88242.74-99.5
Steiner SolomonPresident & CEO, Director, 10% Owner2007-12-18Sell5028,676$78.683.93-99.49
WEISMAN SCOTTDirector2007-12-17Sell1,250109,534$78.5298.15-99.49
Steiner SolomonPresident & CEO, Director, 10% Owner2007-12-17Sell15031,765$78.211.73-99.49
Steiner SolomonPresident & CEO, Director, 10% Owner2007-12-17Sell4,97531,915$78.72391.63-99.49
POHL RODERIKEVP Research2007-12-17Sell2,50054,905$78.68196.7-99.49
POHL RODERIKEVP Research2007-12-03Sell1,12057,292$72.4481.13-99.45
POHL RODERIKEVP Research2007-11-28Sell13058,412$729.36-99.44
POHL RODERIKEVP Research2007-11-23Sell2,50058,542$68170-99.41
REDING F SCOTTCFO2007-05-16Buy1,183823$6070.95-99.33

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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