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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Christopher M. Starr,PhDSVP, Chief Scientific Officer295,1760.18%2005-12-01
Jean-Jacques BienaimeCEO228,7540.14%2015-11-30
Dr. Robert A. Baffi,PhDEVP, Technical Operations99,500less than 0.1%2015-06-04
Mr. Fredric D. PriceCEO79,285less than 0.1%2004-05-06
Dr. Henry J. Fuchs,M.D.EVP, Chief Medical Officer72,846less than 0.1%2015-06-04
G. Eric DavisSVP, General Counsel66,156less than 0.1%2015-12-16
Mr. Stephen AselageEVP, Chief Business Officer59,030less than 0.1%2012-07-02
Jeffrey H. CooperSVP, CFO41,089less than 0.1%2012-04-30
Dr. Emil D. Kakkis,M.D.Chief Medical Officer39,621less than 0.1%2009-03-02
Dr. Elaine J. Heron,PhDDirector35,625less than 0.1%2015-09-08

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Davis George EricSVP, General Counsel2015-12-16Sell1,36266,156$100136.2-31.5966,156 (Direct)
BIENAIME JEAN JACQUESCEO
(Click for the stocks that their CEOs have bought)
2015-11-30Sell1,000254,512$94.7494.7-27.79228,754 (Direct)
25,758 (Shares held by Bienaime Family Trust)
LAWLIS V BRYANDirector2015-11-16Sell8,55011,850$106.9914-36.0111,850 (Direct)
GREY MICHAEL GDirector2015-11-16Sell7,50026,250$104.27782-34.3926,250 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-11-16Sell20,00028,229$104.32086-34.4128,229 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-11-02Sell2635,605$117.563.1-41.8135,605 (Direct)
BIENAIME JEAN JACQUESCEO2015-10-15Sell1,000255,512$108.24108.2-36.8228,754 (Direct)
26,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-09-14Sell1,000256,512$131.43131.4-47.95228,754 (Direct)
27,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-08-12Sell1,500257,512$134.72202.1-49.22228,754 (Direct)
28,758 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-07-20Sell3,00035,605$150450-54.3935,605 (Direct)
BIENAIME JEAN JACQUESCEO2015-07-07Sell1,500259,012$139.07208.6-50.81228,754 (Direct)
30,258 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2015-06-05Sell1,64928,229$122.3201.7-44.0628,229 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-06-05Sell1,86472,846$122.32228-44.0772,846 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-06-04Sell1,36235,605$122.35166.6-44.0935,605 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-06-01Sell5,52331,679$124.73688.9-45.1531,679 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-06-01Sell37738,455$123.7646.7-44.7238,455 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-05-26Sell1,62539,245$126.55205.6-45.9439,245 (Direct)
BIENAIME JEAN JACQUESCEO2015-05-21Sell1,500267,652$126.1189.2-45.75235,894 (Direct)
31,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2015-05-18Sell34,07841,507$1304430.1-47.3841,507 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-05-18Sell2,05975,585$124.77256.9-45.1775,585 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-18Sell1,86476,746$124.78232.6-45.1876,746 (Direct)
Davis George EricSVP, General Counsel2015-05-18Sell2,55869,226$125.26320.4-45.3969,226 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-13Sell1,43480,646$121.37174-43.6480,646 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-11Sell2,86983,646$121.64349-43.7683,646 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-05-06Sell34,01942,645$119.144053-42.5842,645 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-01Sell41489,646$114.5947.4-40.389,646 (Direct)
BIENAIME JEAN JACQUESCEO2015-05-01Sell26,723281,912$114.983072.6-40.5248,654 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-04-01Sell26,052284,509$120.533140-43.24251,251 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-20Sell1,000288,015$126.4126.4-45.88254,757 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-17Sell2,000289,015$124.17248.3-44.91254,757 (Direct)
34,258 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2015-03-16Sell41,31588,635$123.575105.3-44.6488,635 (Direct)
Davis George EricSVP, General Counsel2015-03-13Sell15,00073,846$120.871813.1-43.473,846 (Direct)
BIENAIME JEAN JACQUESCEO2015-03-10Sell21,021291,015$112.392362.6-39.13254,757 (Direct)
36,258 (Shares held by Bienaime Family Trust)
BAFFI ROBERTEVP, Technical Operations2015-03-05Sell14,051133,635$116.371635.1-41.21109,700 (Direct)
23,935 (Shares held by Baffi Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-05Sell10,000297,036$113.71137-39.83254,757 (Direct)
42,279 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-04Sell13,916257,436$107.921501.8-36.61215,157 (Direct)
42,279 (Shares held by Bienaime Family Trust)
LAPALME PIERREDirector2015-03-03Sell20,00031,650$106.572131.4-35.8130,150 (Direct)
1,500 (Shares held by spouse)
Mueller BrianVP, Corporate Controller2015-03-03Sell7,0008,800$109.46766.2-37.58,800 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-03-02Sell15,50068,676$1071658.5-36.0768,676 (Direct)
Davis George EricSVP, General Counsel2015-03-02Sell23,00064,246$108.312491.1-36.8464,246 (Direct)
BIENAIME JEAN JACQUESCEO2015-01-09Sell2,000268,352$94.14188.3-27.33225,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-12-24Sell5,000270,352$88.73443.7-22.9227,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-12-10Sell2,000272,352$95190-27.99229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
LEWIS ALANDirector2014-12-04Sell7,50021,400$89.9674.3-23.921,400 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-12-03Sell12,00031,590$91.011092.1-24.8331,590 (Direct)
Mueller BrianVP, Corporate Controller2014-12-02Sell11,9504,593$90.911086.4-24.754,593 (Direct)
Mueller BrianVP, Corporate Controller2014-11-26Sell3,4004,593$88.97302.5-23.114,593 (Direct)
Davis George EricSVP, General Counsel2014-11-25Sell20,00064,426$89.751795-23.7864,426 (Direct)
BIENAIME JEAN JACQUESCEO2014-11-25Sell2,000272,352$90180-23.99229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-12Sell1,000271,352$85.5185.5-20228,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-12Sell1,000271,352$81.5181.5-16.07228,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-10Sell4,000272,352$87348-21.37229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2014-11-10Sell20,00076,550$86.551731-20.9676,550 (Direct)
BIENAIME JEAN JACQUESCEO2014-11-03Sell3,000272,352$85.33256-19.83229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-11-03Sell4731,590$83.543.9-18.1131,590 (Direct)
BAFFI ROBERTEVP, Technical Operations2014-10-30Sell75,425123,089$81.346135.1-15.999,200 (Direct)
23,889 (Shares Owned by Baffi Family Trust)
Davis George EricSVP, General Counsel2014-10-30Sell15,00064,426$83.21248-17.7864,426 (Direct)
BIENAIME JEAN JACQUESCEO2014-10-24Sell2,000323,547$80160-14.49229,157 (Direct)
48,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-10-21Sell2,000323,547$75150-8.79229,157 (Direct)
48,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
Davis George EricSVP, General Counsel2014-09-19Sell17,53664,426$69.751223.1-1.9264,426 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-09-03Sell4168,733$70.612.9-3.1268,733 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-09-02Sell16,00068,676$69.831117.3-2.0368,676 (Direct)
BIENAIME JEAN JACQUESCEO2014-08-20Sell5,000326,547$70350-2.27229,157 (Direct)
51,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2014-08-05Sell10,00076,550$656505.2576,550 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-08-01Sell2,22968,676$61.76137.710.7768,676 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-07-02Sell2,22970,905$64142.76.8970,905 (Direct)
BIENAIME JEAN JACQUESCEO2014-06-04Sell2,000275,352$61.2122.411.78229,157 (Direct)
46,195 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-06-02Sell37720,190$57.8321.818.320,190 (Direct)
BIENAIME JEAN JACQUESCEO2014-05-22Sell1,000226,452$56.8856.920.27180,257 (Direct)
46,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-05-21Sell1,545227,452$56.1986.821.75180,257 (Direct)
47,195 (Shares held by Bienaime Family Trust)
LAWLIS V BRYANDirector2014-05-16Sell1,7009,700$56.8796.720.299,700 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-16Sell1,86460,950$56.8610620.3160,950 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-16Sell1,00420,980$56.9157.120.2120,980 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-13Sell47823,080$58.1827.817.5823,080 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-13Sell1,43464,850$58.2383.517.4864,850 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-13Sell1,43463,415$58.2383.517.4863,415 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-09Sell3,47967,850$57.91201.518.1367,850 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-09Sell62124,080$57.963618.0324,080 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-01Sell66625,380$59.5539.714.8825,380 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-01Sell71573,850$59.6742.714.6573,850 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-03-06Sell17,37025,380$78.631365.8-1325,380 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-03-03Sell8,00064,273$80.32642.6-14.8364,273 (Direct)
BIENAIME JEAN JACQUESCEO2014-02-20Sell8,000301,260$80640-14.49194,520 (Direct)
46,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Davis George EricSVP, General Counsel2014-02-20Sell20,00060,656$801600-14.4960,656 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-02-03Sell10,00042,350$67.76771.0542,350 (Direct)
BIENAIME JEAN JACQUESCEO2014-01-10Sell5,000166,480$70350-2.27
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2014-01-06Sell10,000171,480$67.41674.11.48
60,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2014-01-02Sell5,000166,480$68.9344.5-0.71
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
FUCHS HENRY JEVP, Chief Medical Officer2014-01-02Sell91642,350$68.9763.2-0.8142,350 (Direct)
BIENAIME JEAN JACQUESCEO2013-12-24Sell10,000171,480$68.71687.1-0.44
60,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
GREY MICHAEL GDirector2013-12-11Sell30,00023,050$69.662089.8-1.7923,050 (Direct)
LAWLIS V BRYANDirector2013-12-09Sell2,90011,400$69.76202.3-1.9411,400 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-12-09Sell13,02614,880$69.55906-1.6414,880 (Direct)
LEWIS ALANDirector2013-12-09Sell22,50019,300$69.911573-2.1519,300 (Direct)
BIENAIME JEAN JACQUESCEO2013-12-05Sell5,000166,480$69.7348.5-1.85
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-12-02Sell9,00037,950$70.14631.3-2.4737,950 (Direct)
BIENAIME JEAN JACQUESCEO2013-11-05Sell5,000105,740$62.36311.89.7
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-11-01Sell9914,880$63.166.38.3114,880 (Direct)
BIENAIME JEAN JACQUESCEO2013-10-31Sell10,000105,740$62.72627.29.07
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-10-16Sell2,000105,740$67.73135.51
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-10-10Sell3,000105,740$66.76200.32.47
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
FUCHS HENRY JEVP, Chief Medical Officer2013-09-19Sell10,00043,266$80.19801.9-14.6943,266 (Direct)
BIENAIME JEAN JACQUESCEO2013-09-16Sell2,000108,740$73.08146.2-6.39
48,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BAFFI ROBERTEVP, Technical Operations2013-09-09Sell20,00062,262$731460-6.2962,262 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-09-05Sell10,00043,266$70700-2.2743,266 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2013-09-04Sell9,00037,950$69621-0.8637,950 (Direct)
BIENAIME JEAN JACQUESCEO2013-08-15Sell1,000108,740$64.3664.46.29
48,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-07-01Sell4,06637,950$59.78243.114.4437,950 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-07-01Sell10,00043,266$6060014.0243,266 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-06-03Sell49314,880$58.3428.817.2614,880 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-06-03Sell1,09843,266$58.326417.343,266 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-05-23Sell20,60944,364$66.291366.23.244,364 (Direct)
Wood MarkVP, Human Resources2013-05-22Sell3,10320,277$67.12208.31.9220,277 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-21Sell2,000216,510$64.14128.36.66115,770 (Direct)
40,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-05-16Sell12,000242,119$67.9814.80.75125,901 (Direct)
30,609 (Shares held by Bienaime Family Trust)
25,609 (Shares held by Bienaime Family Trust()
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Mueller BrianVP, Corporate Controller2013-05-14Sell4,9476,660$70.35348-2.766,660 (Direct)
Davis George EricSVP, General Counsel2013-05-14Sell20,00041,708$70.341406.8-2.7441,708 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-05-14Sell20,00050,262$701400-2.2750,262 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-14Sell25,00080,609$70.941773.5-3.57
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-05-14Sell15,00080,609$70.171052.6-2.51
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Davis George EricSVP, General Counsel2013-05-13Sell2,59041,708$69.29179.5-1.2741,708 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-13Sell15,800168,710$68.771086.6-0.5288,101 (Direct)
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-13Sell1,2487,270$69.2686.4-1.237,270 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-13Sell15,800168,710$68.771086.6-0.5288,101 (Direct)
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-09Sell8119,270$6653.53.659,270 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-08Sell4,000185,383$65.87263.53.86111,838 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Mueller BrianVP, Corporate Controller2013-05-03Sell16,8319,403$66.171113.73.399,403 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-03Sell8,000192,862$67.24537.91.74119,317 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BAFFI ROBERTEVP, Technical Operations2013-05-03Sell20,00061,393$6713402.153,155 (Direct)
8,238 (Shares held by Baffi Family Trust)
Davis George EricSVP, General Counsel2013-05-03Sell5,85447,058$67.19393.31.8247,058 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-02Sell3,000192,862$64.991955.26119,317 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-05-01Sell28,00033,000$64.421803.86.1933,000 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-01Sell79710,570$64.5251.46.0310,570 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-04-30Sell20,00044,589$63.291265.88.0944,589 (Direct)
Wood MarkVP, Human Resources2013-04-22Sell3,10223,245$65.57203.44.3323,245 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-04-19Sell5,00010,570$653255.2510,570 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-04-10Sell20,00060,588$6412806.8952,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
BIENAIME JEAN JACQUESCEO2013-03-26Sell12,000192,946$60.68728.212.74119,401 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Wood MarkVP, Human Resources2013-03-22Sell3,10323,245$60.21186.813.6223,245 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-03-18Sell20,00060,588$61.021220.412.1152,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
GREY MICHAEL GDirector2013-03-06Sell15,00019,650$60.61909.212.8719,650 (Direct)
Davis George EricSVP, General Counsel2013-03-04Sell4,00046,200$60.18240.713.6846,200 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-03-04Sell4,00010,570$6024014.0210,570 (Direct)
Mueller BrianVP, Corporate Controller2013-03-01Sell7,03813,279$59.76420.614.4713,279 (Direct)
BIENAIME JEAN JACQUESCEO2013-03-01Sell11,000192,946$59.01649.115.93119,401 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
LEWIS ALANDirector2013-02-27Sell22,50015,900$56.571272.820.9315,900 (Direct)
BIENAIME JEAN JACQUESCEO2013-02-27Sell1,500133,946$56.4684.721.17120,401 (Direct)
13,545 (Shares hold by Bienaime Family Trust)
Davis George EricSVP, General Counsel2013-02-27Sell8,00046,200$56.9455.220.2346,200 (Direct)
LAPALME PIERREDirector2013-02-26Sell29,90026,150$55.341654.723.6224,650 (Direct)
1,500 (Shares held by spouse)
Wood MarkVP, Human Resources2013-02-22Sell3,10323,245$55.22171.323.8923,245 (Direct)
MEIER RICHARD ADirector2013-02-19Sell5,00018,650$57.5287.518.9718,650 (Direct)
BIENAIME JEAN JACQUESCEO2013-02-04Sell2,000153,691$55.77111.522.66153,691 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-23Sell14,000153,691$55.06770.824.25153,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-01-22Sell19,575100,413$551076.624.38100,413 (Direct)
Wood MarkVP, Human Resources2013-01-22Sell46,74925,646$54.992570.724.425,646 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-01-22Sell3,00010,570$5516524.3810,570 (Direct)
MEIER RICHARD ADirector2013-01-22Sell5,00018,650$5527524.3818,650 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-18Sell5,000167,691$5427026.69167,691 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-04Sell3,000167,691$52.24156.730.95167,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-01-03Sell20,000100,413$53106029.08100,413 (Direct)
MEIER RICHARD ADirector2013-01-02Sell10,00018,650$51.25512.533.4818,650 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-31Sell5,000167,691$48.62243.140.7167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-27Sell17,000167,691$48.37822.341.43167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-21Sell9,000167,691$48.57437.140.85167,691 (Direct)
Wood MarkVP, Human Resources2012-12-17Sell10,41525,646$49.17512.139.1325,646 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-12Sell5,000167,691$5025036.82167,691 (Direct)
MEIER RICHARD ADirector2012-12-11Sell5,00018,650$49.71248.637.6218,650 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-10Sell6,000167,691$47.53285.243.93167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-04Sell5,000167,691$47.94239.742.7167,691 (Direct)
MEIER RICHARD ADirector2012-11-29Sell5,00018,650$49.17245.939.1318,650 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2012-11-28Sell5,91610,570$48.31285.841.6110,570 (Direct)
Wood MarkVP, Human Resources2012-11-23Sell2,66532,364$48.92130.439.8432,364 (Direct)
Davis George EricSVP, General Counsel2012-11-19Sell7,36351,322$48.5357.141.0551,322 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-16Sell8,000167,691$48.05384.442.37167,691 (Direct)
Mueller BrianVP, Corporate Controller2012-11-15Sell15,81215,340$50790.636.8215,340 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-11-15Sell20,000100,413$51102034.14100,413 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-14Sell4,000167,691$48.519441.05167,691 (Direct)
HERON ELAINE JDirector2012-11-12Sell1,87514,025$48.3390.641.5514,025 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2012-11-12Sell26510,570$48.1112.742.1910,570 (Direct)
Davis George EricSVP, General Counsel2012-11-12Sell99,07551,322$48.454800.241.251,322 (Direct)
HERON ELAINE JDirector2012-11-09Sell135,00015,900$46.796316.746.2115,900 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-09Sell7,000167,691$47.62333.343.66167,691 (Direct)
LEWIS ALANDirector2012-11-07Sell15,00015,900$46.870246.1815,900 (Direct)
Mueller BrianVP, Corporate Controller2012-11-05Sell8,00015,340$47.03376.245.4615,340 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-11-05Sell60,000100,413$47.332839.844.54100,413 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-11-05Sell10,00052,277$4646048.7252,277 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-11-01Sell5,00052,277$37.08185.484.4952,277 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-31Sell4,000174,691$37.96151.880.22174,691 (Direct)
Wood MarkVP, Human Resources2012-10-22Sell2,66532,364$41.86111.663.4332,364 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-22Sell3,000175,691$41.86125.663.43175,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-19Sell2,000175,691$42.7285.460.14175,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-10-16Sell20,000100,413$4386059.09100,413 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-12Sell3,000177,691$41.3212465.56177,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-10-01Sell5,00052,277$39.75198.872.152,277 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-28Sell4,000177,691$40.2160.870.17177,691 (Direct)
Wood MarkVP, Human Resources2012-09-24Sell2,66532,364$40.48107.96932,364 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-14Sell4,000177,691$37.91151.680.45177,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-10Sell1,000177,691$38.6238.677.14177,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-09-04Sell5,00052,277$37.76188.881.1752,277 (Direct)
Wood MarkVP, Human Resources2012-08-22Sell2,66532,364$37.93101.180.3632,364 (Direct)
LEWIS ALANDirector2012-08-06Sell40,00015,900$37.571502.882.0915,900 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-08-01Sell5,00052,277$38.63193.277.0952,277 (Direct)
Wood MarkVP, Human Resources2012-07-23Sell2,66632,364$39.25104.674.2932,364 (Direct)
Mueller BrianVP, Corporate Controller2012-07-10Sell2,50015,340$42.5106.360.9615,340 (Direct)
Mueller BrianVP, Corporate Controller2012-07-02Sell2,77015,340$40110.871.0315,340 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-07-02Sell95,34559,030$403813.871.0359,030 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-07-02Sell15,00052,277$40.19602.970.2252,277 (Direct)
Wood MarkVP, Human Resources2012-06-27Sell81232,364$3830.980.0332,364 (Direct)
Wood MarkVP, Human Resources2012-06-22Sell1,85332,364$36.8368.285.7532,364 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-06-01Sell5,00052,277$35.02175.195.3552,277 (Direct)
Wood MarkVP, Human Resources2012-05-22Sell2,66631,114$38.01101.379.9831,114 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-16Sell15,000168,691$38.49577.477.73168,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-05-15Sell1,74152,277$38.6467.377.0452,277 (Direct)
LAWLIS V BRYANDirector2012-05-15Sell8,90013,400$38.51342.777.6413,400 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-05-15Sell10,00059,030$38.64386.477.0459,030 (Direct)
LAWLIS V BRYANDirector2012-05-15Sell8,90010,900$38.51342.777.6410,900 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-14Sell40,500168,691$38.061541.479.74168,691 (Direct)
Cooper Jeffrey HSVP, CFO2012-05-14Sell25,25041,089$38.09961.879.641,089 (Direct)
Wood MarkVP, Human Resources2012-05-11Sell2,43731,114$3892.680.0331,114 (Direct)
Davis George EricSVP, General Counsel2012-05-11Sell42,30951,322$37.911603.980.4551,322 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-05-11Sell26,16059,030$37.82989.480.8859,030 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-08Sell20,000113,191$36.38727.688.04113,191 (Direct)
Mueller BrianVP, Corporate Controller2012-05-08Sell15,70813,684$37.5589.182.4313,684 (Direct)
Mueller BrianVP, Corporate Controller2012-05-08Sell15,70813,684$37.5589.182.4313,684 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-04Sell20,000113,191$36.34726.888.25113,191 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-02Sell30,000113,191$35.241057.294.13113,191 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-05-01Sell5,00030,018$34.9917595.5130,018 (Direct)
BIENAIME JEAN JACQUESCEO2012-04-27Sell22,000112,093$34.99769.895.51112,093 (Direct)
Wood MarkVP, Human Resources2012-04-23Sell1,85320,634$34.546498.0620,634 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-04-20Sell7,69128,920$35269.295.4628,920 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-04-02Sell5,00036,611$34.08170.4100.7336,611 (Direct)
Wood MarkVP, Human Resources2012-03-22Sell1,85520,634$35.6566.191.8920,634 (Direct)
BIENAIME JEAN JACQUESCEO2012-03-09Sell15,000114,093$34.46516.998.52114,093 (Direct)
BIENAIME JEAN JACQUESCEO2012-03-08Sell1,000114,093$353595.46114,093 (Direct)
BIENAIME JEAN JACQUESCEO2012-02-29Sell1,000115,093$36.2636.388.67115,093 (Direct)
LAPALME PIERREDirector2012-02-28Sell20,00022,750$36.01720.289.9821,250 (Direct)
1,500 (Shares held by spouse)
BIENAIME JEAN JACQUESCEO2012-02-27Sell5,000116,093$35.64178.291.95116,093 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-02-24Sell91,31383,493$34.843181.396.3583,493 (Direct)
Mueller BrianVP, Corporate Controller2012-02-24Sell5,0008,300$35.07175.495.078,300 (Direct)
Cooper Jeffrey HSVP, CFO2012-02-24Sell83,03640,104$35.072912.195.0740,104 (Direct)
BIENAIME JEAN JACQUESCEO2012-02-23Sell5,000121,093$35.31176.693.74121,093 (Direct)
Wood MarkVP, Human Resources2012-02-22Sell1,85420,634$35.1465.194.6820,634 (Direct)
Wood MarkVP, Human Resources2012-02-02Sell6,50020,634$3824780.0320,634 (Direct)
Wood MarkVP, Human Resources2012-01-23Sell1,85420,634$34.9664.895.6820,634 (Direct)
Cooper Jeffrey HSVP, CFO2012-01-03Sell2,50040,104$34.7586.996.8640,104 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-01-03Sell2,50036,611$34.7586.996.8636,611 (Direct)
Wood MarkVP, Human Resources2011-12-22Sell1,85420,634$33.7962.6102.4620,634 (Direct)
Wood MarkVP, Human Resources2011-11-22Sell1,85520,634$32.1859.7112.5920,634 (Direct)
Davis George EricSVP, General Counsel2011-11-01Sell26039,651$33.238.6105.8739,651 (Direct)
Cooper Jeffrey HSVP, CFO2011-11-01Sell2,50040,104$33.2683.2105.6840,104 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-10-28Sell16,87546,478$35590.695.4646,478 (Direct)
Wood MarkVP, Human Resources2011-10-24Sell1,85320,634$33.3261.7105.3120,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-10-10Sell18,37939,876$34624.9101.2139,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-10-03Sell2,50036,455$3177.5120.6836,455 (Direct)
Cooper Jeffrey HSVP, CFO2011-09-28Sell18,37939,876$32588.1113.7839,876 (Direct)
BIENAIME JEAN JACQUESCEO2011-09-28Sell1,000126,093$3232113.78126,093 (Direct)
Wood MarkVP, Human Resources2011-09-22Sell1,85420,634$29.9255.5128.6420,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-09-01Sell2,50039,876$29.4173.5132.6139,876 (Direct)
Wood MarkVP, Human Resources2011-08-31Sell83420,634$3025128.0320,634 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-30Sell2,000127,093$29.0158135.82127,093 (Direct)
Wood MarkVP, Human Resources2011-08-22Sell1,02020,634$27.0327.6153.0920,634 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-19Sell2,000127,093$26.7553.5155.74127,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-12Sell3,000127,093$27.181.3152.44127,093 (Direct)
BAFFI ROBERTEVP, Technical Operations2011-08-02Sell18,68783,160$30.55570.9123.9383,160 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-02Sell8,000127,093$30.27242.2126127,093 (Direct)
Cooper Jeffrey HSVP, CFO2011-08-02Sell18,03639,876$30.47549.6124.5239,876 (Direct)
Davis George EricSVP, General Counsel2011-07-29Sell3,80039,651$31117.8120.6839,651 (Direct)
Davis George EricSVP, General Counsel2011-07-22Sell3,80039,651$30.5115.9124.339,651 (Direct)
Wood MarkVP, Human Resources2011-07-22Sell1,85520,634$30.2956.2125.8520,634 (Direct)
Wood MarkVP, Human Resources2011-07-14Sell10,83320,634$30325128.0320,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-07-14Sell18,37839,876$30551.3128.0339,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-14Sell5,00036,455$30150128.0336,455 (Direct)
BIENAIME JEAN JACQUESCEO2011-07-14Sell1,000131,093$3030128.03131,093 (Direct)
Cooper Jeffrey HSVP, CFO2011-07-01Sell2,50039,876$27.568.8148.7639,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-01Sell2,50036,455$27.6869.2147.1536,455 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-01Sell2,50036,455$27.6869.2147.1536,455 (Direct)
Wood MarkVP, Human Resources2011-06-23Sell2,01620,634$25.8652.1164.5420,634 (Direct)
Wood MarkVP, Human Resources2011-06-07Sell45620,005$27.4612.5149.1320,005 (Direct)
BIENAIME JEAN JACQUESCEO2011-06-06Sell2,000132,093$27.3954.8149.76132,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-31Sell710129,093$2819.9144.32129,093 (Direct)
Davis George EricSVP, General Counsel2011-05-31Sell3,80038,151$28.5108.3140.0438,151 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-27Sell290129,803$288.1144.32129,803 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-05-26Sell49,68943,978$271341.6153.3743,978 (Direct)
Cooper Jeffrey HSVP, CFO2011-05-26Sell17,50037,876$27.5481.3148.7637,876 (Direct)
Davis George EricSVP, General Counsel2011-05-26Sell3,80038,151$27.5104.5148.7638,151 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-25Sell1,000103,093$26.9426.9153.93103,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-25Sell1,000130,093$26.9426.9153.93130,093 (Direct)
Wood MarkVP, Human Resources2011-05-24Sell1,64619,211$25.842.5165.1619,211 (Direct)
Wood MarkVP, Human Resources2011-05-13Sell1,03219,211$26.6827.5156.4119,211 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-10Sell40087,593$25.8710.3164.4487,593 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-05Sell20087,993$25.645.1166.8187,993 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-04Sell7,70088,193$26.6204.8157.1888,193 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-05-03Sell10,31131,478$27.15279.9151.9731,478 (Direct)
Davis George EricSVP, General Counsel2011-05-02Sell1,5300$27.0941.4152.53Link
Wood MarkVP, Human Resources2011-04-25Sell1,6460$26.3543.4159.62Link
FUCHS HENRY JEVP, Chief Medical Officer2011-04-20Sell13,1650$27355.5153.37Link
Davis George EricSVP, General Counsel2011-04-13Sell3,8000$26.5100.7158.15Link
Wood MarkVP, Human Resources2011-04-13Sell7080$2618.4163.12Link
FUCHS HENRY JEVP, Chief Medical Officer2011-04-01Sell2,5000$25.4563.6168.8Link
Wood MarkVP, Human Resources2011-03-22Sell9380$23.4222192.1Link
Davis George EricSVP, General Counsel2011-03-09Sell6,0000$24.49146.9179.34Link
FUCHS HENRY JEVP, Chief Medical Officer2011-03-01Sell8340$24.1820.2182.92Link
LAPALME PIERREDirector2011-02-24Sell15,1000$24.95376.7174.19Link
Wood MarkVP, Human Resources2011-02-22Sell1,6450$26.3443.3159.72Link
Wood MarkVP, Human Resources2011-02-01Sell1,33414,243$2634.7163.1214,243 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-02-01Sell83331,000$25.7621.5165.5731,000 (Direct)
Wood MarkVP, Human Resources2011-01-24Sell93814,243$25.7324.1165.8814,243 (Direct)
BIENAIME JEAN JACQUESCEO2011-01-18Sell3,50090,067$26.5893157.37Link
FUCHS HENRY JEVP, Chief Medical Officer2011-01-03Sell83331,000$26.9922.5153.46Link
Wood MarkVP, Human Resources2010-12-22Sell2,47914,243$28.2169.9142.5Link
FUCHS HENRY JEVP, Chief Medical Officer2010-12-20Sell5,00031,000$28140144.32Link
BIENAIME JEAN JACQUESCEO2010-12-13Sell1,00093,567$27.4327.4149.4Link
BIENAIME JEAN JACQUESCEO2010-12-06Sell1,00093,567$27.1727.2151.79Link
BIENAIME JEAN JACQUESCEO2010-12-06Sell2,00093,567$27.1754.3151.79Link
FUCHS HENRY JEVP, Chief Medical Officer2010-12-01Sell83431,000$27.0822.6152.62Link
Cooper Jeffrey HSVP, CFO2010-11-24Sell11,25026,810$27.5309.4148.76Link
Davis George EricSVP, General Counsel2010-11-24Sell5,00027,901$27.5137.5148.76Link
BIENAIME JEAN JACQUESCEO2010-11-23Sell1,00093,567$27.0227153.18Link
Wood MarkVP, Human Resources2010-11-22Sell2,47914,243$26.665.9157.18Link
ASELAGE STEVEEVP, Chief Business Officer2010-11-18Sell39,87529,881$25.841030.4164.74Link
BIENAIME JEAN JACQUESCEO2010-11-18Sell1,00093,567$25.9926163.22Link
BIENAIME JEAN JACQUESCEO2010-11-08Sell2,00093,567$25.7851.6165.36Link
Davis George EricSVP, General Counsel2010-11-04Sell10,37127,901$25.83267.9164.85Link
Davis George EricSVP, General Counsel2010-11-04Sell10,37127,901$25.83267.9164.85Link
BIENAIME JEAN JACQUESCEO2010-11-03Sell7,50093,567$25.54191.6167.85Link
BAFFI ROBERTEVP, Technical Operations2010-11-03Sell2,00067,713$25.2450.5171.04Link
BAFFI ROBERTEVP, Technical Operations2010-11-03Sell2,00067,713$25.2450.5171.04Link
FUCHS HENRY JEVP, Chief Medical Officer2010-11-01Sell2,43531,000$25.7662.7165.57Link
Wood MarkVP, Human Resources2010-10-29Sell36,75014,243$26955.5163.12Link
Cooper Jeffrey HSVP, CFO2010-10-29Sell28,75026,486$25.32728170.18Link
Cooper Jeffrey HSVP, CFO2010-10-25Sell15,20926,486$24365185.04Link
Wood MarkVP, Human Resources2010-10-22Sell93714,243$23.5222190.86Link
FUCHS HENRY JEVP, Chief Medical Officer2010-10-01Sell83331,000$22.318.6206.77Link
Wood MarkVP, Human Resources2010-09-22Sell93814,243$22.9221.5198.47Link
Cooper Jeffrey HSVP, CFO2010-09-13Sell6,00026,486$22.85137.1199.39Link
BIENAIME JEAN JACQUESCEO2010-09-08Sell1,00095,067$22.2222.2207.88Link
ASELAGE STEVEEVP, Chief Business Officer2010-09-08Sell35,00037,587$22770210.95Link
Wood MarkVP, Human Resources2010-09-07Sell93714,243$21.5120.2218.04Link
BIENAIME JEAN JACQUESCEO2010-09-02Sell4,00095,067$20.9783.9226.23Link
FUCHS HENRY JEVP, Chief Medical Officer2010-09-01Sell83431,000$20.8817.4227.63Link
BIENAIME JEAN JACQUESCEO2010-08-30Sell3,00099,067$20.7162.1230.32Link
BIENAIME JEAN JACQUESCEO2010-08-30Sell3,00099,067$20.7162.1230.32Link
BIENAIME JEAN JACQUESCEO2010-08-27Sell3,00099,067$20.6862230.8Link
Davis George EricSVP, General Counsel2010-08-20Sell15,65727,901$20.57322.1232.57Link
Wood MarkVP, Human Resources2010-07-26Sell2,50014,243$2152.5225.76Link
FUCHS HENRY JEVP, Chief Medical Officer2010-07-23Sell83331,000$2016.7242.05Link
Wood MarkVP, Human Resources2010-06-23Sell37214,243$19.797.4245.68Link
Wood MarkVP, Human Resources2010-06-08Sell47014,615$18.878.9262.53Link
FUCHS HENRY JEVP, Chief Medical Officer2010-06-02Sell83431,000$2016.7242.05Link
Wood MarkVP, Human Resources2010-05-13Sell54612,835$21.7511.9214.53Link
Wood MarkVP, Human Resources2010-05-12Sell9388,081$21.4120.1219.52Link
Wood MarkVP, Human Resources2010-05-06Sell3138,081$21.036.6225.3Link
FUCHS HENRY JEVP, Chief Medical Officer2010-05-03Sell2,27520,000$22.851.9200.04Link
Wood MarkVP, Human Resources2010-04-12Sell9378,081$23.8122.3187.32Link
Wood MarkVP, Human Resources2010-04-05Sell3128,081$24.637.7177.75Link
FUCHS HENRY JEVP, Chief Medical Officer2010-04-01Sell5,83320,000$24140185.04Link
Wood MarkVP, Human Resources2010-03-12Sell9388,081$22.1720.8208.57Link
BAFFI ROBERTEVP, Technical Operations2010-03-10Sell163,88860,588$22.523690.8203.7752,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
ASELAGE STEVEEVP, Chief Business Officer2010-03-08Sell35,50619,855$21.99780.8211.1Link
Wood MarkVP, Human Resources2010-03-08Sell3138,081$22.146.9208.99Link
KLEIN JOSEPH IIIDirector2010-03-08Sell10,00035,000$22.12221.2209.27Link
ASELAGE STEVEEVP, Chief Business Officer2010-03-03Sell10,00031,271$21210225.76Link
Wood MarkVP, Human Resources2010-03-02Sell1,2498,081$2126.2225.76Link
ASELAGE STEVEEVP, Chief Business Officer2010-03-02Sell10,00041,271$21210225.76Link
BIENAIME JEAN JACQUESCEO2010-02-26Buy80048,740$20.0816.1240.69Link
Wood MarkVP, Human Resources2010-02-03Sell3778,081$217.9225.76Link
Wood MarkVP, Human Resources2010-01-21Sell1448,081$21.053224.99Link
BIENAIME JEAN JACQUESCEO2010-01-19Sell3,50050,440$20.8973.1227.48Link
Wood MarkVP, Human Resources2010-01-19Sell17,4998,081$21367.5225.76Link
BIENAIME JEAN JACQUESCEO2009-12-22Sell1,50053,940$18.8328.2263.3Link
Davis George EricVP, General Counsel2009-12-02Sell21,00020,453$17.25362.3296.58Link
Wood MarkVP, Human Resources2009-08-28Sell1778,081$16.52.9314.61Link
BIENAIME JEAN JACQUESCEO2009-08-10Sell4,00055,440$15.9563.8328.9Link
Wood MarkVP, Human Resources2009-07-08Sell4568,081$13.896.3392.51
Wood MarkVP, Human Resources2009-06-23Sell3637,287$14.755.4363.8
BIENAIME JEAN JACQUESCEO2009-06-12Buy1,50051,940$14.5221.8371.14
Davis George EricVP, General Counsel2009-06-11Sell2,50016,203$14.4736.2372.77
MEIER RICHARD ADirector2009-06-05Buy2,00010,250$13.727.4399.34
MEIER RICHARD ADirector2009-03-13Buy1,0004,250$11.4511.5497.47
BIENAIME JEAN JACQUESDirector2009-03-05Buy1,00011,917$10.0410581.37
KLEIN JOSEPH IIIDirector2009-03-05Buy5,00042,500$10.0750.4579.34
MEIER RICHARD ADirector2009-03-03Buy2,0003,250$10.9321.9525.89
KLEIN JOSEPH IIIDirector2009-03-03Buy5,00037,500$10.5652.8547.82
KAKKIS EMIL DChief Medical Officer2009-03-02Sell7,89739,621$11.792.4484.7
KLEIN JOSEPH IIIDirector2009-02-24Buy10,00032,500$12.08120.8466.31
KAKKIS EMIL DChief Medical Officer2009-02-03Sell17,00039,621$19.14325.4257.42
Wood MarkVP, Human Resources2009-01-22Sell178650$19.293.4254.64
Wood MarkVP, Human Resources2009-01-16Sell2,501650$2152.5225.76
KAKKIS EMIL DChief Medical officer2009-01-02Sell17,00039,621$17.57298.7289.36
Wood MarkVP, Human Resources2008-12-22Sell177650$17.183298.2
BIENAIME JEAN JACQUESCEO, Director2008-12-08Sell4,00010,917$1768302.41
BIENAIME JEAN JACQUESCEO, Director2008-12-08Buy4,00014,917$17.268.8297.73
Davis George EricVP, General Counsel2008-12-04Sell7,0008,180$16.3114.1319.69
LAPALME PIERREDirector2008-12-03Buy2,4001,500$15.336.7347.12
KAKKIS EMIL DCHIEF MEDICAL OFFICER2008-12-01Sell17,00039,621$15.87269.8331.06
Wood MarkVP, Human Resources2008-11-28Sell177650$16.52.9314.61
KAKKIS EMIL DChief Medical Officer2008-11-25Sell75,00039,621$15.981198.5328.1
Wood MarkVP, Human Resources2008-10-21Sell177650$20.223.6238.33
KAKKIS EMIL DChief Medical Officer2008-10-01Sell18,000115,304$26.27472.9160.41
Wood MarkVP, Human Resources2008-09-22Sell2,468650$28.0369.2144.06
KAKKIS EMIL DChief Medical Officer2008-09-02Sell18,000115,304$30.19543.4126.6
BAFFI ROBERTSVP, Technical Operations2008-09-02Sell11,52838,434$31.31360.9118.49
Wood MarkVP, Human Resources2008-08-21Sell2,469650$26.164.4162.11
KAKKIS EMIL DChief Medical Officer2008-08-01Sell18,000127,304$32.48584.6110.62
BAFFI ROBERTSVP, Technical Operations2008-07-30Sell9,22848,734$31.69292.4115.87
BAFFI ROBERTSVP, Technical Operations2008-07-30Sell10,30038,434$31.98329.4113.91
Wood MarkVP, Human Resources2008-07-21Sell2,468650$30.2774.7126
Davis George EricVP, General Counsel2008-07-15Sell5,00014,994$28140144.32
Wood MarkVP, Human Resources2008-07-08Sell350650$28.029.8144.15
KAKKIS EMIL DChief Medical Officer2008-07-07Sell18,000145,304$28.06505.1143.8
Swiedler Stuart JSVP, Clinical Affairs2008-07-01Sell15,00010,000$28.34425.1141.39
BAFFI ROBERTSVP, Technical Operations2008-06-30Sell3,52836,434$30.01105.9127.96
Wood MarkVP, Human Resources2008-06-23Sell2,2920$32.6174.7109.78
BIENAIME JEAN JACQUESCEO, Director2008-06-05Sell3,0003,567$3911775.41
Wood MarkVP, Human Resources2008-06-04Sell1,3230$37.6649.881.65
KAKKIS EMIL DChief Medical Officer2008-06-02Sell18,000160,804$37.63677.381.8
BAFFI ROBERTSVP, Technical Operatons2008-05-30Sell1,10036,434$38.7142.676.72
BAFFI ROBERTSVP, Technical Operations2008-05-30Sell10,42837,534$38.44400.977.97
Wood MarkVP, Human Resources2008-05-21Sell1,6670$39.0965.275.01
BIENAIME JEAN JACQUESCEO, Director2008-05-15Sell5,0003,567$39.11195.674.92
Davis George EricVP, General Counsel2008-05-13Sell10,0005,807$39.13391.374.83
BIENAIME JEAN JACQUESCEO, Director2008-05-12Sell13,0003,567$38.91505.875.82
ASELAGE STEVESVP, Global Commercial Dev.2008-05-06Sell20,00028,665$37.7575581.22
BIENAIME JEAN JACQUESCEO, Director2008-05-05Sell22,5533,567$36.97833.885.04
KAKKIS EMIL DChief Medical Officer2008-05-01Sell18,000162,804$37.49674.882.48
Davis George EricVP, General Counsel2008-04-30Sell4005,807$36.7314.786.25
Davis George EricVP, General Counsel2008-04-30Sell4,6006,207$36.316788.46
Wood MarkVP, Human Resources2008-04-21Sell2,9900$33.99101.6101.27
BAFFI ROBERTSVP, Technical Operations2008-04-02Sell22,96550,477$36.88846.985.49
BAFFI ROBERTSVP, Technical Operations2008-04-02Sell15,79734,680$37.11586.284.34
Swiedler Stuart JSVP, Clinical Affairs2008-04-01Sell12,50010,000$36.02450.389.92
KAKKIS EMIL DChief Medical Officer2008-04-01Sell9,85786,164$35.9353.990.56
KAKKIS EMIL DChief Medical Officer2008-04-01Sell8,14396,021$35.75291.191.36
ASELAGE STEVESVP, Global Commercial Dev2008-04-01Sell80532,034$36.052989.76
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell11,30934,680$36.19409.389.03
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell14,18945,989$35.8750990.72
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell9,50060,178$35.52337.492.6
Wood MarkVP, Human Resources2008-03-24Sell2,9890$35.05104.895.18
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell7,57634,680$32.75248.1108.89
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell26,53642,256$32.46861.4110.75
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell12,12868,792$32.13389.7112.92
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell6,64334,680$34.33228.199.27
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell11,95741,323$33.59401.6103.66
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell12,64353,280$33.15419.1106.37
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell7,00065,923$32.81229.7108.5
HERON ELAINE JDirector2008-03-06Sell3,63830,000$38.34139.578.43
HERON ELAINE JDirector2008-03-06Sell16,45133,638$38.11626.979.51
HERON ELAINE JDirector2008-03-06Sell9,91150,089$37.7373.681.46
KAKKIS EMIL DChief Medical Officer2008-03-06Sell18,00086,164$38.16686.979.27
GREY MICHAEL GDirector2008-03-05Sell3,5005,000$38.41134.478.1
GREY MICHAEL GDirector2008-03-05Sell21,5008,500$38.17820.779.22
HERON ELAINE JDirector2008-03-03Sell20,0000$38.47769.477.83
Davis George EricVP, General Counsel2008-03-03Sell20,0003,397$3876080.03
ASELAGE STEVESVP, Global Commercial Dev2008-03-03Sell40,00032,034$38152080.03
KLEIN JOSEPH IIIDirector2008-03-03Sell10,00030,000$38.03380.379.88
KLEIN JOSEPH IIIDirector2008-03-03Sell20,00020,000$37.92758.480.41
BIENAIME JEAN JACQUESCEO, Director2008-02-29Sell27,1424,071$38.11034.179.55
LAPALME PIERREDirector2008-02-29Sell5,9756,600$38.43229.678.01
LAPALME PIERREDirector2008-02-29Sell9,02512,575$37.8341.180.98
Cooper Jeffrey HSVP, CFO2008-02-29Sell5,9051,005$37.9422480.31
Cooper Jeffrey HSVP, CFO2008-02-29Sell49,7206,910$37.621870.581.84
Wood MarkVP, Human Resources2008-02-21Sell2,9900$36.4610987.63
Wood MarkVP, Human Resources2008-01-22Sell2,9900$36.26108.488.67
BIENAIME JEAN JACQUESCEO, Director2008-01-02Sell15,0007,213$36.07541.189.66
Swiedler Stuart JSVP, Clinical Affairs2008-01-02Sell12,50010,000$36.0845189.61
ASELAGE STEVESVP, Global Commercial Dev2008-01-02Sell5,0007,034$36.08180.489.61
Wood MarkVP, Human Resources2007-12-21Sell6,1140$36.06220.589.71
BIENAIME JEAN JACQUESCEO, Director2007-12-17Sell15,0007,213$35.5353392.54
Wood MarkVP, Human Resources2007-11-21Sell2,3650$25.8661.2164.54
Wood MarkVP, Human Resources2007-10-22Sell1,5320$25.338.8170.4
Davis George EricVP, General Counsel2007-10-11Sell5,0002,607$27.34136.7150.22
Cooper Jeffrey HSVP, CFO2007-10-08Sell12,3800$26321.9163.12
Wood MarkVP, Human Resources2007-10-08Sell8,3330$26216.7163.12
ASELAGE STEVESVP, Global Commercial Dev2007-10-01Sell5,0004,895$25.09125.5172.66
BIENAIME JEAN JACQUESCEO2007-10-01Sell20,0006,695$25500173.64
Swiedler Stuart JSVP, Clinical Affairs2007-10-01Sell12,50010,000$25.1313.8172.55
Davis George EricVP, General Counsel2007-10-01Sell5,0002,607$25.1125.5172.55
Cooper Jeffrey HSVP, CFO2007-09-26Sell12,5000$24.5306.3179.22
BIENAIME JEAN JACQUESCEO2007-09-25Sell10,0006,695$24240185.04
Wood MarkVP, Human Resources2007-09-21Sell5,9060$23.25137.3194.24
BIENAIME JEAN JACQUESCEO2007-09-19Sell10,0006,695$23230197.43
BAFFI ROBERTSVP, Technical Operations2007-09-14Sell22,70733,124$22.64514.1202.16
BAFFI ROBERTSVP, Technical Operations2007-09-14Sell67,29355,831$22.481512.7204.31
ASELAGE STEVESVP, Global Commercial Dev.2007-09-14Sell10,0004,895$22.4224205.4
Cooper Jeffrey HSVP, CFO2007-09-06Sell13,5360$22.5304.6204.04
Cooper Jeffrey HSVP, CFO2007-08-17Sell20,0000$20.29405.8237.16
BIENAIME JEAN JACQUESCEO2007-08-17Sell10,0006,695$21210225.76
Davis George EricVP, General Counsel2007-08-15Sell4,0002,607$20.2681237.66
LEWIS ALANDirector2007-08-10Sell20,00010,000$20.08401.6240.69
ASELAGE STEVESVP, Global Commercial Dev2007-08-10Sell20,0004,895$20.27405.4237.49
Wood MarkVP, Human Resources2007-08-10Sell2,6330$21.0855.5224.53
BIENAIME JEAN JACQUESCEO2007-08-10Sell35,8866,695$20.2724.9238.66
Cooper Jeffrey HSVP, CFO2007-08-08Sell12,5000$21262.5225.76
BIENAIME JEAN JACQUESCEO2007-08-03Sell2,0006,695$18.0336.1279.42
BIENAIME JEAN JACQUESCEO2007-07-05Sell2,0008,695$18.2936.6274.03
Swiedler Stuart JSVP, Clinical Affairs2007-07-02Sell12,50010,000$18.18227.3276.29
BIENAIME JEAN JACQUESCEO2007-06-25Sell2,50010,695$17.6544.1287.59
Wood MarkVP, Human Resources2007-06-07Sell1,0450$17.5418.3290.02
BIENAIME JEAN JACQUESCEO2007-06-04Sell12,50013,195$18.34229.3273.01
BIENAIME JEAN JACQUESCEO2007-05-21Sell2,00015,695$18.5637.1268.59
BIENAIME JEAN JACQUESCEO2007-05-03Sell15,00017,695$16.79251.9307.44
BIENAIME JEAN JACQUESCEO2007-05-02Sell1,50015,142$16.4324.6316.37
BIENAIME JEAN JACQUESCEO2007-04-04Sell6,50016,642$17.87116.2282.82
Swiedler Stuart JSVP, Clinical Affairs2007-04-02Sell12,50010,000$17.3216.3295.43
KLEIN JOSEPH IIIDirector2007-03-07Sell12,0000$16.37196.4317.9
BIENAIME JEAN JACQUESCEO2007-03-02Sell1,50018,142$16.4824.7315.11
Davis George EricVP, General Counsel2007-02-22Sell13,0000$18.37238.8272.4
BIENAIME JEAN JACQUESCEO2007-02-22Sell14,00019,642$17.06238.8301
ASELAGE STEVESVP, Global Commercial Ops2007-02-14Sell15,0002,829$20300242.05
Swiedler Stuart JSVP, Clinical Affairs2007-01-03Sell12,50010,000$16.3203.8319.69
LAPALME PIERREDirector2006-12-12Buy2,1005,500$17.8837.5282.61
LAPALME PIERREDirector2006-12-12Buy2,1006,600$17.8837.5282.61
Cooper Jeffrey HChief Financial Officer2006-12-06Sell14,5000$18261280.06
ASELAGE STEVESVP, Global Commercial Ops2006-11-29Sell5,0002,829$17.2386.2297.04
Swiedler Stuart JSVP, Clinical Affairs2006-11-01Sell12,50010,000$15.92199329.71
Cooper Jeffrey HVP, CFO2006-08-29Sell26,0000$16416327.56Link
KLEIN JOSEPH IIIDirector2006-08-09Sell20,00022,000$15.52310.4340.79Link
LAPALME PIERREDirector2006-08-07Buy1,0004,500$15.3515.4345.67Link
Swiedler Stuart JSVP, Clinical Affairs2006-08-01Sell12,50010,000$14.34179.3377.06Link
BIENAIME JEAN JACQUESCEO2006-08-01Buy1,50030,881$14.521.8371.79Link
BIENAIME JEAN JACQUESCEO2006-07-03Buy1,50029,381$14.4421.7373.75Link
BIENAIME JEAN JACQUESCEO2006-06-14Buy2,50027,881$13.2433.1416.69Link
BIENAIME JEAN JACQUESCEO2006-06-01Buy1,50025,381$13.0519.6424.21Link
BIENAIME JEAN JACQUESCEO2006-05-18Buy1,00023,881$1212470.08Link
BIENAIME JEAN JACQUESCEO2006-05-08Buy1,00022,881$12.7812.8435.29Link
BIENAIME JEAN JACQUESCEO2006-05-01Buy1,50018,500$12.5918.9443.37Link
BIENAIME JEAN JACQUESCEO2006-04-03Buy1,50017,000$13.3520412.43Link
Cooper Jeffrey HCFO2006-03-16Sell12,5000$14.85185.6360.67Link
Cooper Jeffrey HCFO2006-03-01Sell15,5000$13.25205.4416.3Link
BIENAIME JEAN JACQUESCEO2006-03-01Buy1,50015,500$12.9919.5426.64Link
Cooper Jeffrey HCFO2006-02-27Sell1,0000$13.2513.3416.3Link
LAPALME PIERREDirector2006-02-27Buy3,5003,500$12.9945.5426.64Link
SAGER ERICHDirector2006-02-24Sell11,5003,309$12.64145.4441.22Link
SAGER ERICHDirector2006-02-22Sell1,0003,309$12.212.2460.74Link
Swiedler Stuart JSVP, Clinical Affairs2006-02-01Sell10,00010,000$11.55115.5492.29Link
BIENAIME JEAN JACQUESCEO2006-02-01Buy1,50014,000$11.6717.5486.2Link
SAGER ERICHDirector2006-01-27Sell2,5003,309$12.230.5460.74Link
BIENAIME JEAN JACQUESCEO2006-01-03Buy1,50012,500$10.7916.2534.01Link
BIENAIME JEAN JACQUESCEO2005-12-12Buy1,00011,000$10.2110.2570.03Link
SAGER ERICHDirector2005-12-05Sell7,5003,309$10.780.3539.35Link
BIENAIME JEAN JACQUESCEO2005-12-01Buy1,50010,000$9.9414.9588.23Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2005-12-01Sell10,571295,176$10105.7584.1Link
SAGER ERICHDirector2005-12-01Sell22,5000$10.42234.5556.53Link
Swiedler Stuart JSVP, Clinical Affairs2005-11-21Sell30,00010,000$10300584.1Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2005-11-21Sell10,571300,176$10105.7584.1Link
BIENAIME JEAN JACQUESCEO2005-11-01Buy1,5008,500$8.3712.6717.32Link
BIENAIME JEAN JACQUESCEO2005-10-12Buy5006,500$73.5877.29Link
BIENAIME JEAN JACQUESCEO2005-10-06Buy5006,500$84755.13Link
BIENAIME JEAN JACQUESCEO2005-10-03Buy1,5006,000$8.5112.8703.88Link
BIENAIME JEAN JACQUESCEO2005-09-01Buy4,5004,500$8.5838.6697.32Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-06-03Sell10,000305,176$7.6476.4795.42Link
BAFFI ROBERTSVP, Technical Operations2004-05-10Buy8,00014,931$6.12491017.81Link
KAKKIS EMIL DSVP, Business Operations2004-05-06Buy15,00026,110$6.4997.4954.08Link
PRICE FREDRIC DCEO2004-05-06Buy15,00079,285$6.3294.8982.44Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-04-02Sell5,570315,176$844.6755.13Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-04-01Sell5,000315,176$7.5637.8804.89Link
SAGER ERICHDirector2004-01-02Sell20,0003,309$7.81156.2775.93Link
KAKKIS EMIL DSVP, Business Operations2003-12-29Sell10,18711,110$7.5777.1803.7Link
STARR CHRISTOPHER MSr. VP, Scientific Operations2003-08-21Sell33,000320,176$9297660.11Link
WILLIAMS GWYNNDirector2003-07-28Sell68,700812,565$10687584.1Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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