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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Jean-Jacques BienaimeCEO378,5840.23%2016-08-16
Dr. Christopher M. Starr,PhDN/A295,1760.18%2005-12-01
Dr. Robert A. Baffi,PhDEVP, Technical Operations128,742less than 0.1%2016-06-03
Dr. Henry J. Fuchs,M.D.EVP, Chief Medical Officer113,878less than 0.1%2016-06-03
Mr. Fredric D. PriceN/A79,285less than 0.1%2004-05-06
G. Eric DavisEVP, General Counsel71,158less than 0.1%2016-08-01
Jeff AjerEVP, Chief Commercial Officer59,809less than 0.1%2016-06-03
Mr. Stephen AselageN/A59,030less than 0.1%2012-07-02
Mr. Daniel K. SpiegelmanEVP, CFO42,944less than 0.1%2016-08-01
Jeffrey H. CooperN/A41,089less than 0.1%2012-04-30

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
BIENAIME JEAN JACQUESCEO
(Click for the stocks that their CEOs have bought)
2016-08-16Sell41,666404,342$91.493812.023.8378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2016-08-01Sell4,00042,944$99.33397.32-4.3942,944 (Direct)
Davis George EricEVP, General Counsel2016-08-01Sell2,16771,158$100216.7-5.0371,158 (Direct)
Mueller BrianVP, Corporate Controller2016-08-01Sell28714,260$10028.7-5.0314,260 (Direct)
LAWLIS V BRYANDirector2016-07-27Sell1,10013,860$95.39104.93-0.4413,860 (Direct)
LAWLIS V BRYANDirector2016-07-22Sell6,40013,860$95.01608.06-0.0413,860 (Direct)
BIENAIME JEAN JACQUESCEO2016-07-18Sell41,666404,342$92.723863.272.43378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
Davis George EricEVP, General Counsel2016-07-07Sell2,16770,669$90195.035.5270,669 (Direct)
LAWLIS V BRYANDirector2016-06-20Sell55013,860$82.7745.5214.7413,860 (Direct)
BIENAIME JEAN JACQUESCEO2016-06-16Sell41,666404,342$80.553356.217.9378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2016-06-06Sell1,64946,944$89.14146.996.5446,944 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2016-05-31Sell20,84150,394$89.881873.195.6650,394 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2016-05-26Sell15,000115,914$87.811317.158.15115,914 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2016-05-23Sell3,76958,644$87.07328.179.0758,644 (Direct)
BAFFI ROBERTEVP, Technical Operations2016-05-18Sell5,000162,062$87.05435.259.1130,386 (Direct)
31,676 (Shares held by Baffi Family Trust)
Davis George EricEVP, General Counsel2016-05-10Sell14,65875,540$85.111247.5411.5975,540 (Direct)
BIENAIME JEAN JACQUESCEO2016-05-05Sell50,000415,914$80.154007.518.49390,156 (Direct)
0 (Shares held in irrevocable trust for Guillaume Bienaime)
0 (Shares held in irrevocable trust for Pierre Bienaime)
0 (Shares held in irrevocable trust for Paul Bienaime)
0 (Shares held in irrevocable trust for Marc Bienaime)
0 (Shares held in irrevocable trust for Aurelie Mitsuki Bienaime & Anais Kimiko Bienaime)
25,758 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertEVP, Chief Commercial Officer2016-05-03Sell41563,072$86.0335.710.3963,072 (Direct)
BIENAIME JEAN JACQUESCEO2016-05-02Sell36,500421,393$85.013102.8711.72395,635 (Direct)
25,758 (Shares held by Bienaime Family Trust)
Davis George EricEVP, General Counsel2016-03-14Sell1,99676,190$86.21172.0810.1676,190 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Officer2016-03-04Sell1,25546,882$88.42110.977.4146,882 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2016-03-02Sell4,62349,688$86.12398.1310.2849,688 (Direct)
BIENAIME JEAN JACQUESCEO2016-03-01Sell10,000366,258$84.28842.812.68340,500 (Direct)
25,758 (Shares held by Bienaime Family Trust)
GREY MICHAEL GDirector2016-02-22Sell7,50026,250$8060018.7126,250 (Direct)
Davis George EricSVP, General Counsel2015-12-16Sell1,36266,156$100136.2-5.0366,156 (Direct)
BIENAIME JEAN JACQUESCEO2015-11-30Sell1,000254,512$94.7494.740.24228,754 (Direct)
25,758 (Shares held by Bienaime Family Trust)
LAWLIS V BRYANDirector2015-11-16Sell8,55011,850$106.9914-11.1611,850 (Direct)
GREY MICHAEL GDirector2015-11-16Sell7,50026,250$104.27782.03-8.9226,250 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-11-16Sell20,00028,229$104.32086-8.9528,229 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-11-02Sell2635,605$117.563.06-19.2235,605 (Direct)
BIENAIME JEAN JACQUESCEO2015-10-15Sell1,000255,512$108.24108.24-12.26228,754 (Direct)
26,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-09-14Sell1,000256,512$131.43131.43-27.74228,754 (Direct)
27,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-08-12Sell1,500257,512$134.72202.08-29.51228,754 (Direct)
28,758 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-07-20Sell3,00035,605$150450-36.6935,605 (Direct)
BIENAIME JEAN JACQUESCEO2015-07-07Sell1,500259,012$139.07208.61-31.71228,754 (Direct)
30,258 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2015-06-05Sell1,64928,229$122.3201.67-22.3528,229 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-06-05Sell1,86472,846$122.32228-22.3672,846 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-06-04Sell1,36235,605$122.35166.64-22.3835,605 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-06-01Sell5,52331,679$124.73688.88-23.8631,679 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-06-01Sell37738,455$123.7646.66-23.2638,455 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-05-26Sell1,62539,245$126.55205.64-24.9539,245 (Direct)
BIENAIME JEAN JACQUESCEO2015-05-21Sell1,500267,652$126.1189.15-24.69235,894 (Direct)
31,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2015-05-18Sell34,07841,507$1304430.14-26.9541,507 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-05-18Sell2,05975,585$124.77256.9-23.8875,585 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-18Sell1,86476,746$124.78232.59-23.8976,746 (Direct)
Davis George EricSVP, General Counsel2015-05-18Sell2,55869,226$125.26320.42-24.1869,226 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-13Sell1,43480,646$121.37174.04-21.7580,646 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-11Sell2,86983,646$121.64348.99-21.9383,646 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-05-06Sell34,01942,645$119.144053.02-20.2942,645 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-01Sell41489,646$114.5947.44-17.1289,646 (Direct)
BIENAIME JEAN JACQUESCEO2015-05-01Sell26,723281,912$114.983072.61-17.4248,654 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-04-01Sell26,052284,509$120.533140.05-21.21251,251 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-20Sell1,000288,015$126.4126.4-24.87254,757 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-17Sell2,000289,015$124.17248.34-23.52254,757 (Direct)
34,258 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2015-03-16Sell41,31588,635$123.575105.29-23.1488,635 (Direct)
Davis George EricSVP, General Counsel2015-03-13Sell15,00073,846$120.871813.05-21.4373,846 (Direct)
BIENAIME JEAN JACQUESCEO2015-03-10Sell21,021291,015$112.392362.55-15.5254,757 (Direct)
36,258 (Shares held by Bienaime Family Trust)
BAFFI ROBERTEVP, Technical Operations2015-03-05Sell14,051133,635$116.371635.11-18.39109,700 (Direct)
23,935 (Shares held by Baffi Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-05Sell10,000297,036$113.71137-16.47254,757 (Direct)
42,279 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-04Sell13,916257,436$107.921501.81-12215,157 (Direct)
42,279 (Shares held by Bienaime Family Trust)
LAPALME PIERREDirector2015-03-03Sell20,00031,650$106.572131.4-10.8830,150 (Direct)
1,500 (Shares held by spouse)
Mueller BrianVP, Corporate Controller2015-03-03Sell7,0008,800$109.46766.22-13.248,800 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-03-02Sell15,50068,676$1071658.5-11.2468,676 (Direct)
Davis George EricSVP, General Counsel2015-03-02Sell23,00064,246$108.312491.13-12.3264,246 (Direct)
BIENAIME JEAN JACQUESCEO2015-01-09Sell2,000268,352$94.14188.280.88225,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-12-24Sell5,000270,352$88.73443.657.03227,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-12-10Sell2,000272,352$95190-0.03229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
LEWIS ALANDirector2014-12-04Sell7,50021,400$89.9674.255.6421,400 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-12-03Sell12,00031,590$91.011092.124.3531,590 (Direct)
Mueller BrianVP, Corporate Controller2014-12-02Sell11,9504,593$90.911086.374.474,593 (Direct)
Mueller BrianVP, Corporate Controller2014-11-26Sell3,4004,593$88.97302.56.744,593 (Direct)
Davis George EricSVP, General Counsel2014-11-25Sell20,00064,426$89.7517955.8264,426 (Direct)
BIENAIME JEAN JACQUESCEO2014-11-25Sell2,000272,352$901805.52229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-12Sell1,000271,352$85.5185.5111.06228,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-12Sell1,000271,352$81.5181.5116.51228,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-10Sell4,000272,352$873489.16229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2014-11-10Sell20,00076,550$86.5517319.7376,550 (Direct)
BIENAIME JEAN JACQUESCEO2014-11-03Sell3,000272,352$85.33255.9911.3229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-11-03Sell4731,590$83.543.9313.6831,590 (Direct)
BAFFI ROBERTEVP, Technical Operations2014-10-30Sell75,425123,089$81.346135.0716.7699,200 (Direct)
23,889 (Shares Owned by Baffi Family Trust)
Davis George EricSVP, General Counsel2014-10-30Sell15,00064,426$83.2124814.1564,426 (Direct)
BIENAIME JEAN JACQUESCEO2014-10-24Sell2,000323,547$8016018.71229,157 (Direct)
48,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-10-21Sell2,000323,547$7515026.63229,157 (Direct)
48,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
Davis George EricSVP, General Counsel2014-09-19Sell17,53664,426$69.751223.1436.1664,426 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-09-03Sell4168,733$70.612.934.568,733 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-09-02Sell16,00068,676$69.831117.283668,676 (Direct)
BIENAIME JEAN JACQUESCEO2014-08-20Sell5,000326,547$7035035.67229,157 (Direct)
51,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2014-08-05Sell10,00076,550$6565046.1176,550 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-08-01Sell2,22968,676$61.76137.6653.7768,676 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-07-02Sell2,22970,905$64142.6648.3970,905 (Direct)
BIENAIME JEAN JACQUESCEO2014-06-04Sell2,000275,352$61.2122.455.18229,157 (Direct)
46,195 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-06-02Sell37720,190$57.8321.864.2220,190 (Direct)
BIENAIME JEAN JACQUESCEO2014-05-22Sell1,000226,452$56.8856.8866.97180,257 (Direct)
46,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-05-21Sell1,545227,452$56.1986.8169.02180,257 (Direct)
47,195 (Shares held by Bienaime Family Trust)
LAWLIS V BRYANDirector2014-05-16Sell1,7009,700$56.8796.6866.999,700 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-16Sell1,86460,950$56.86105.9967.0260,950 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-16Sell1,00420,980$56.9157.1466.8820,980 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-13Sell47823,080$58.1827.8163.2323,080 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-13Sell1,43464,850$58.2383.563.0964,850 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-13Sell1,43463,415$58.2383.563.0963,415 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-09Sell3,47967,850$57.91201.476467,850 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-09Sell62124,080$57.9635.9963.8524,080 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-01Sell66625,380$59.5539.6659.4825,380 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-01Sell71573,850$59.6742.6659.1673,850 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-03-06Sell17,37025,380$78.631365.820.7825,380 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-03-03Sell8,00064,273$80.32642.5618.2464,273 (Direct)
BIENAIME JEAN JACQUESCEO2014-02-20Sell8,000301,260$8064018.71194,520 (Direct)
46,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Davis George EricSVP, General Counsel2014-02-20Sell20,00060,656$80160018.7160,656 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-02-03Sell10,00042,350$67.767740.2842,350 (Direct)
BIENAIME JEAN JACQUESCEO2014-01-10Sell5,000166,480$7035035.67
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2014-01-06Sell10,000171,480$67.41674.140.88
60,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2014-01-02Sell5,000166,480$68.9344.537.84
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
FUCHS HENRY JEVP, Chief Medical Officer2014-01-02Sell91642,350$68.9763.1837.742,350 (Direct)
BIENAIME JEAN JACQUESCEO2013-12-24Sell10,000171,480$68.71687.138.22
60,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
GREY MICHAEL GDirector2013-12-11Sell30,00023,050$69.662089.836.3323,050 (Direct)
LAWLIS V BRYANDirector2013-12-09Sell2,90011,400$69.76202.336.1411,400 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-12-09Sell13,02614,880$69.55905.9636.5514,880 (Direct)
LEWIS ALANDirector2013-12-09Sell22,50019,300$69.911572.9835.8519,300 (Direct)
BIENAIME JEAN JACQUESCEO2013-12-05Sell5,000166,480$69.7348.536.26
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-12-02Sell9,00037,950$70.14631.2635.437,950 (Direct)
BIENAIME JEAN JACQUESCEO2013-11-05Sell5,000105,740$62.36311.852.29
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-11-01Sell9914,880$63.166.2550.3614,880 (Direct)
BIENAIME JEAN JACQUESCEO2013-10-31Sell10,000105,740$62.72627.251.42
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-10-16Sell2,000105,740$67.73135.4640.22
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-10-10Sell3,000105,740$66.76200.2842.26
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
FUCHS HENRY JEVP, Chief Medical Officer2013-09-19Sell10,00043,266$80.19801.918.4343,266 (Direct)
BIENAIME JEAN JACQUESCEO2013-09-16Sell2,000108,740$73.08146.1629.95
48,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BAFFI ROBERTEVP, Technical Operations2013-09-09Sell20,00062,262$73146030.162,262 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-09-05Sell10,00043,266$7070035.6743,266 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2013-09-04Sell9,00037,950$6962137.6437,950 (Direct)
BIENAIME JEAN JACQUESCEO2013-08-15Sell1,000108,740$64.3664.3647.56
48,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-07-01Sell4,06637,950$59.78243.0758.8737,950 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-07-01Sell10,00043,266$6060058.2843,266 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-06-03Sell49314,880$58.3428.7662.7914,880 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-06-03Sell1,09843,266$58.3264.0462.8443,266 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-05-23Sell20,60944,364$66.291366.1743.2644,364 (Direct)
Wood MarkVP, Human Resources2013-05-22Sell3,10320,277$67.12208.2741.4920,277 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-21Sell2,000216,510$64.14128.2848.07115,770 (Direct)
40,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-05-16Sell12,000242,119$67.9814.839.87125,901 (Direct)
30,609 (Shares held by Bienaime Family Trust)
25,609 (Shares held by Bienaime Family Trust()
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Mueller BrianVP, Corporate Controller2013-05-14Sell4,9476,660$70.35348.02356,660 (Direct)
Davis George EricSVP, General Counsel2013-05-14Sell20,00041,708$70.341406.835.0241,708 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-05-14Sell20,00050,262$70140035.6750,262 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-14Sell25,00080,609$70.941773.533.87
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-05-14Sell15,00080,609$70.171052.5535.34
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Davis George EricSVP, General Counsel2013-05-13Sell2,59041,708$69.29179.4637.0641,708 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-13Sell15,800168,710$68.771086.5738.188,101 (Direct)
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-13Sell1,2487,270$69.2686.4437.127,270 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-13Sell15,800168,710$68.771086.5738.188,101 (Direct)
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-09Sell8119,270$6653.5343.899,270 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-08Sell4,000185,383$65.87263.4844.18111,838 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Mueller BrianVP, Corporate Controller2013-05-03Sell16,8319,403$66.171113.7143.529,403 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-03Sell8,000192,862$67.24537.9241.24119,317 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BAFFI ROBERTEVP, Technical Operations2013-05-03Sell20,00061,393$67134041.7553,155 (Direct)
8,238 (Shares held by Baffi Family Trust)
Davis George EricSVP, General Counsel2013-05-03Sell5,85447,058$67.19393.3341.3547,058 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-02Sell3,000192,862$64.99194.9746.13119,317 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-05-01Sell28,00033,000$64.421803.7647.4233,000 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-01Sell79710,570$64.5251.4247.1910,570 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-04-30Sell20,00044,589$63.291265.850.0644,589 (Direct)
Wood MarkVP, Human Resources2013-04-22Sell3,10223,245$65.57203.444.8423,245 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-04-19Sell5,00010,570$6532546.1110,570 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-04-10Sell20,00060,588$64128048.3952,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
BIENAIME JEAN JACQUESCEO2013-03-26Sell12,000192,946$60.68728.1656.51119,401 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Wood MarkVP, Human Resources2013-03-22Sell3,10323,245$60.21186.8357.7323,245 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-03-18Sell20,00060,588$61.021220.455.6452,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
GREY MICHAEL GDirector2013-03-06Sell15,00019,650$60.61909.1556.6919,650 (Direct)
Davis George EricSVP, General Counsel2013-03-04Sell4,00046,200$60.18240.7257.8146,200 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-03-04Sell4,00010,570$6024058.2810,570 (Direct)
Mueller BrianVP, Corporate Controller2013-03-01Sell7,03813,279$59.76420.5958.9213,279 (Direct)
BIENAIME JEAN JACQUESCEO2013-03-01Sell11,000192,946$59.01649.1160.94119,401 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
LEWIS ALANDirector2013-02-27Sell22,50015,900$56.571272.8367.8815,900 (Direct)
BIENAIME JEAN JACQUESCEO2013-02-27Sell1,500133,946$56.4684.6968.21120,401 (Direct)
13,545 (Shares hold by Bienaime Family Trust)
Davis George EricSVP, General Counsel2013-02-27Sell8,00046,200$56.9455.266.9146,200 (Direct)
LAPALME PIERREDirector2013-02-26Sell29,90026,150$55.341654.6771.6124,650 (Direct)
1,500 (Shares held by spouse)
Wood MarkVP, Human Resources2013-02-22Sell3,10323,245$55.22171.3571.9823,245 (Direct)
MEIER RICHARD ADirector2013-02-19Sell5,00018,650$57.5287.565.1718,650 (Direct)
BIENAIME JEAN JACQUESCEO2013-02-04Sell2,000153,691$55.77111.5470.29153,691 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-23Sell14,000153,691$55.06770.8472.48153,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-01-22Sell19,575100,413$551076.6372.67100,413 (Direct)
Wood MarkVP, Human Resources2013-01-22Sell46,74925,646$54.992570.7372.725,646 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-01-22Sell3,00010,570$5516572.6710,570 (Direct)
MEIER RICHARD ADirector2013-01-22Sell5,00018,650$5527572.6718,650 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-18Sell5,000167,691$5427075.87167,691 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-04Sell3,000167,691$52.24156.7281.8167,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-01-03Sell20,000100,413$53106079.19100,413 (Direct)
MEIER RICHARD ADirector2013-01-02Sell10,00018,650$51.25512.585.3118,650 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-31Sell5,000167,691$48.62243.195.33167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-27Sell17,000167,691$48.37822.2996.34167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-21Sell9,000167,691$48.57437.1395.53167,691 (Direct)
Wood MarkVP, Human Resources2012-12-17Sell10,41525,646$49.17512.1193.1525,646 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-12Sell5,000167,691$5025089.94167,691 (Direct)
MEIER RICHARD ADirector2012-12-11Sell5,00018,650$49.71248.5591.0518,650 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-10Sell6,000167,691$47.53285.1899.81167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-04Sell5,000167,691$47.94239.798.1167,691 (Direct)
MEIER RICHARD ADirector2012-11-29Sell5,00018,650$49.17245.8593.1518,650 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2012-11-28Sell5,91610,570$48.31285.896.5810,570 (Direct)
Wood MarkVP, Human Resources2012-11-23Sell2,66532,364$48.92130.3794.1332,364 (Direct)
Davis George EricSVP, General Counsel2012-11-19Sell7,36351,322$48.5357.1195.8151,322 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-16Sell8,000167,691$48.05384.497.65167,691 (Direct)
Mueller BrianVP, Corporate Controller2012-11-15Sell15,81215,340$50790.689.9415,340 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-11-15Sell20,000100,413$51102086.22100,413 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-14Sell4,000167,691$48.519495.81167,691 (Direct)
HERON ELAINE JDirector2012-11-12Sell1,87514,025$48.3390.6296.514,025 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2012-11-12Sell26510,570$48.1112.7597.410,570 (Direct)
Davis George EricSVP, General Counsel2012-11-12Sell99,07551,322$48.454800.1896.0251,322 (Direct)
HERON ELAINE JDirector2012-11-09Sell135,00015,900$46.796316.65102.9715,900 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-09Sell7,000167,691$47.62333.3499.43167,691 (Direct)
LEWIS ALANDirector2012-11-07Sell15,00015,900$46.8702102.9315,900 (Direct)
Mueller BrianVP, Corporate Controller2012-11-05Sell8,00015,340$47.03376.24101.9315,340 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-11-05Sell60,000100,413$47.332839.8100.65100,413 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-11-05Sell10,00052,277$46460106.4652,277 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-11-01Sell5,00052,277$37.08185.4156.1252,277 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-31Sell4,000174,691$37.96151.84150.18174,691 (Direct)
Wood MarkVP, Human Resources2012-10-22Sell2,66532,364$41.86111.56126.8832,364 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-22Sell3,000175,691$41.86125.58126.88175,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-19Sell2,000175,691$42.7285.44122.31175,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-10-16Sell20,000100,413$43860120.86100,413 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-12Sell3,000177,691$41.32123.96129.84177,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-10-01Sell5,00052,277$39.75198.75138.9252,277 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-28Sell4,000177,691$40.2160.8136.24177,691 (Direct)
Wood MarkVP, Human Resources2012-09-24Sell2,66532,364$40.48107.88134.6132,364 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-14Sell4,000177,691$37.91151.64150.51177,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-10Sell1,000177,691$38.6238.62145.91177,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-09-04Sell5,00052,277$37.76188.8151.5152,277 (Direct)
Wood MarkVP, Human Resources2012-08-22Sell2,66532,364$37.93101.08150.3832,364 (Direct)
LEWIS ALANDirector2012-08-06Sell40,00015,900$37.571502.8152.7815,900 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-08-01Sell5,00052,277$38.63193.15145.8552,277 (Direct)
Wood MarkVP, Human Resources2012-07-23Sell2,66632,364$39.25104.64141.9632,364 (Direct)
Mueller BrianVP, Corporate Controller2012-07-10Sell2,50015,340$42.5106.25123.4615,340 (Direct)
Mueller BrianVP, Corporate Controller2012-07-02Sell2,77015,340$40110.8137.4315,340 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-07-02Sell95,34559,030$403813.8137.4359,030 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-07-02Sell15,00052,277$40.19602.85136.352,277 (Direct)
Wood MarkVP, Human Resources2012-06-27Sell81232,364$3830.86149.9232,364 (Direct)
Wood MarkVP, Human Resources2012-06-22Sell1,85332,364$36.8368.25157.8632,364 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-06-01Sell5,00052,277$35.02175.1171.1952,277 (Direct)
Wood MarkVP, Human Resources2012-05-22Sell2,66631,114$38.01101.33149.8631,114 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-16Sell15,000168,691$38.49577.35146.74168,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-05-15Sell1,74152,277$38.6467.27145.7852,277 (Direct)
LAWLIS V BRYANDirector2012-05-15Sell8,90013,400$38.51342.74146.6113,400 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-05-15Sell10,00059,030$38.64386.4145.7859,030 (Direct)
LAWLIS V BRYANDirector2012-05-15Sell8,90010,900$38.51342.74146.6110,900 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-14Sell40,500168,691$38.061541.43149.53168,691 (Direct)
Cooper Jeffrey HSVP, CFO2012-05-14Sell25,25041,089$38.09961.77149.3341,089 (Direct)
Wood MarkVP, Human Resources2012-05-11Sell2,43731,114$3892.61149.9231,114 (Direct)
Davis George EricSVP, General Counsel2012-05-11Sell42,30951,322$37.911603.93150.5151,322 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-05-11Sell26,16059,030$37.82989.37151.1159,030 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-08Sell20,000113,191$36.38727.6161.05113,191 (Direct)
Mueller BrianVP, Corporate Controller2012-05-08Sell15,70813,684$37.5589.05153.2513,684 (Direct)
Mueller BrianVP, Corporate Controller2012-05-08Sell15,70813,684$37.5589.05153.2513,684 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-04Sell20,000113,191$36.34726.8161.34113,191 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-02Sell30,000113,191$35.241057.2169.49113,191 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-05-01Sell5,00030,018$34.99174.95171.4230,018 (Direct)
BIENAIME JEAN JACQUESCEO2012-04-27Sell22,000112,093$34.99769.78171.42112,093 (Direct)
Wood MarkVP, Human Resources2012-04-23Sell1,85320,634$34.5464174.9620,634 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-04-20Sell7,69128,920$35269.19171.3428,920 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-04-02Sell5,00036,611$34.08170.4178.6736,611 (Direct)
Wood MarkVP, Human Resources2012-03-22Sell1,85520,634$35.6566.13166.420,634 (Direct)
BIENAIME JEAN JACQUESCEO2012-03-09Sell15,000114,093$34.46516.9175.59114,093 (Direct)
BIENAIME JEAN JACQUESCEO2012-03-08Sell1,000114,093$3535171.34114,093 (Direct)
BIENAIME JEAN JACQUESCEO2012-02-29Sell1,000115,093$36.2636.26161.91115,093 (Direct)
LAPALME PIERREDirector2012-02-28Sell20,00022,750$36.01720.2163.7321,250 (Direct)
1,500 (Shares held by spouse)
BIENAIME JEAN JACQUESCEO2012-02-27Sell5,000116,093$35.64178.2166.47116,093 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-02-24Sell91,31383,493$34.843181.34172.5983,493 (Direct)
Mueller BrianVP, Corporate Controller2012-02-24Sell5,0008,300$35.07175.35170.88,300 (Direct)
Cooper Jeffrey HSVP, CFO2012-02-24Sell83,03640,104$35.072912.07170.840,104 (Direct)
BIENAIME JEAN JACQUESCEO2012-02-23Sell5,000121,093$35.31176.55168.96121,093 (Direct)
Wood MarkVP, Human Resources2012-02-22Sell1,85420,634$35.1465.15170.2620,634 (Direct)
Wood MarkVP, Human Resources2012-02-02Sell6,50020,634$38247149.9220,634 (Direct)
Wood MarkVP, Human Resources2012-01-23Sell1,85420,634$34.9664.82171.6520,634 (Direct)
Cooper Jeffrey HSVP, CFO2012-01-03Sell2,50040,104$34.7586.88173.2940,104 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-01-03Sell2,50036,611$34.7586.88173.2936,611 (Direct)
Wood MarkVP, Human Resources2011-12-22Sell1,85420,634$33.7962.65181.0620,634 (Direct)
Wood MarkVP, Human Resources2011-11-22Sell1,85520,634$32.1859.69195.1220,634 (Direct)
Davis George EricSVP, General Counsel2011-11-01Sell26039,651$33.238.64185.839,651 (Direct)
Cooper Jeffrey HSVP, CFO2011-11-01Sell2,50040,104$33.2683.15185.5440,104 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-10-28Sell16,87546,478$35590.63171.3446,478 (Direct)
Wood MarkVP, Human Resources2011-10-24Sell1,85320,634$33.3261.74185.0220,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-10-10Sell18,37939,876$34624.89179.3239,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-10-03Sell2,50036,455$3177.5206.3536,455 (Direct)
Cooper Jeffrey HSVP, CFO2011-09-28Sell18,37939,876$32588.13196.7839,876 (Direct)
BIENAIME JEAN JACQUESCEO2011-09-28Sell1,000126,093$3232196.78126,093 (Direct)
Wood MarkVP, Human Resources2011-09-22Sell1,85420,634$29.9255.47217.4120,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-09-01Sell2,50039,876$29.4173.53222.9239,876 (Direct)
Wood MarkVP, Human Resources2011-08-31Sell83420,634$3025.02216.5720,634 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-30Sell2,000127,093$29.0158.02227.37127,093 (Direct)
Wood MarkVP, Human Resources2011-08-22Sell1,02020,634$27.0327.57251.3520,634 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-19Sell2,000127,093$26.7553.5255.03127,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-12Sell3,000127,093$27.181.3250.44127,093 (Direct)
BAFFI ROBERTEVP, Technical Operations2011-08-02Sell18,68783,160$30.55570.89210.8783,160 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-02Sell8,000127,093$30.27242.16213.74127,093 (Direct)
Cooper Jeffrey HSVP, CFO2011-08-02Sell18,03639,876$30.47549.56211.6839,876 (Direct)
Davis George EricSVP, General Counsel2011-07-29Sell3,80039,651$31117.8206.3539,651 (Direct)
Davis George EricSVP, General Counsel2011-07-22Sell3,80039,651$30.5115.9211.3839,651 (Direct)
Wood MarkVP, Human Resources2011-07-22Sell1,85520,634$30.2956.19213.5420,634 (Direct)
Wood MarkVP, Human Resources2011-07-14Sell10,83320,634$30324.99216.5720,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-07-14Sell18,37839,876$30551.34216.5739,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-14Sell5,00036,455$30150216.5736,455 (Direct)
BIENAIME JEAN JACQUESCEO2011-07-14Sell1,000131,093$3030216.57131,093 (Direct)
Cooper Jeffrey HSVP, CFO2011-07-01Sell2,50039,876$27.568.75245.3539,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-01Sell2,50036,455$27.6869.2243.136,455 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-01Sell2,50036,455$27.6869.2243.136,455 (Direct)
Wood MarkVP, Human Resources2011-06-23Sell2,01620,634$25.8652.13267.2520,634 (Direct)
Wood MarkVP, Human Resources2011-06-07Sell45620,005$27.4612.52245.8520,005 (Direct)
BIENAIME JEAN JACQUESCEO2011-06-06Sell2,000132,093$27.3954.78246.73132,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-31Sell710129,093$2819.88239.18129,093 (Direct)
Davis George EricSVP, General Counsel2011-05-31Sell3,80038,151$28.5108.3233.2338,151 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-27Sell290129,803$288.12239.18129,803 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-05-26Sell49,68943,978$271341.6251.7443,978 (Direct)
Cooper Jeffrey HSVP, CFO2011-05-26Sell17,50037,876$27.5481.25245.3537,876 (Direct)
Davis George EricSVP, General Counsel2011-05-26Sell3,80038,151$27.5104.5245.3538,151 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-25Sell1,000103,093$26.9426.94252.52103,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-25Sell1,000130,093$26.9426.94252.52130,093 (Direct)
Wood MarkVP, Human Resources2011-05-24Sell1,64619,211$25.842.47268.119,211 (Direct)
Wood MarkVP, Human Resources2011-05-13Sell1,03219,211$26.6827.53255.9619,211 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-10Sell40087,593$25.8710.35267.187,593 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-05Sell20087,993$25.645.13270.487,993 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-04Sell7,70088,193$26.6204.82257.0388,193 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-05-03Sell10,31131,478$27.15279.94249.831,478 (Direct)
Davis George EricSVP, General Counsel2011-05-02Sell1,5300$27.0941.45250.57Link
Wood MarkVP, Human Resources2011-04-25Sell1,6460$26.3543.37260.42Link
FUCHS HENRY JEVP, Chief Medical Officer2011-04-20Sell13,1650$27355.46251.74Link
Davis George EricSVP, General Counsel2011-04-13Sell3,8000$26.5100.7258.38Link
Wood MarkVP, Human Resources2011-04-13Sell7080$2618.41265.27Link
FUCHS HENRY JEVP, Chief Medical Officer2011-04-01Sell2,5000$25.4563.63273.16Link
Wood MarkVP, Human Resources2011-03-22Sell9380$23.4221.97305.51Link
Davis George EricSVP, General Counsel2011-03-09Sell6,0000$24.49146.94287.79Link
FUCHS HENRY JEVP, Chief Medical Officer2011-03-01Sell8340$24.1820.17292.76Link
LAPALME PIERREDirector2011-02-24Sell15,1000$24.95376.75280.64Link
Wood MarkVP, Human Resources2011-02-22Sell1,6450$26.3443.33260.55Link
Wood MarkVP, Human Resources2011-02-01Sell1,33414,243$2634.68265.2714,243 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-02-01Sell83331,000$25.7621.46268.6731,000 (Direct)
Wood MarkVP, Human Resources2011-01-24Sell93814,243$25.7324.13269.114,243 (Direct)
BIENAIME JEAN JACQUESCEO2011-01-18Sell3,50090,067$26.5893.03257.3Link
FUCHS HENRY JEVP, Chief Medical Officer2011-01-03Sell83331,000$26.9922.48251.87Link
Wood MarkVP, Human Resources2010-12-22Sell2,47914,243$28.2169.93236.65Link
FUCHS HENRY JEVP, Chief Medical Officer2010-12-20Sell5,00031,000$28140239.18Link
BIENAIME JEAN JACQUESCEO2010-12-13Sell1,00093,567$27.4327.43246.23Link
BIENAIME JEAN JACQUESCEO2010-12-06Sell1,00093,567$27.1727.17249.54Link
BIENAIME JEAN JACQUESCEO2010-12-06Sell2,00093,567$27.1754.34249.54Link
FUCHS HENRY JEVP, Chief Medical Officer2010-12-01Sell83431,000$27.0822.58250.7Link
Cooper Jeffrey HSVP, CFO2010-11-24Sell11,25026,810$27.5309.38245.35Link
Davis George EricSVP, General Counsel2010-11-24Sell5,00027,901$27.5137.5245.35Link
BIENAIME JEAN JACQUESCEO2010-11-23Sell1,00093,567$27.0227.02251.48Link
Wood MarkVP, Human Resources2010-11-22Sell2,47914,243$26.665.94257.03Link
ASELAGE STEVEEVP, Chief Business Officer2010-11-18Sell39,87529,881$25.841030.37267.53Link
BIENAIME JEAN JACQUESCEO2010-11-18Sell1,00093,567$25.9925.99265.41Link
BIENAIME JEAN JACQUESCEO2010-11-08Sell2,00093,567$25.7851.56268.39Link
Davis George EricSVP, General Counsel2010-11-04Sell10,37127,901$25.83267.88267.67Link
Davis George EricSVP, General Counsel2010-11-04Sell10,37127,901$25.83267.88267.67Link
BIENAIME JEAN JACQUESCEO2010-11-03Sell7,50093,567$25.54191.55271.85Link
BAFFI ROBERTEVP, Technical Operations2010-11-03Sell2,00067,713$25.2450.48276.27Link
BAFFI ROBERTEVP, Technical Operations2010-11-03Sell2,00067,713$25.2450.48276.27Link
FUCHS HENRY JEVP, Chief Medical Officer2010-11-01Sell2,43531,000$25.7662.73268.67Link
Wood MarkVP, Human Resources2010-10-29Sell36,75014,243$26955.5265.27Link
Cooper Jeffrey HSVP, CFO2010-10-29Sell28,75026,486$25.32727.95275.08Link
Cooper Jeffrey HSVP, CFO2010-10-25Sell15,20926,486$24365.02295.71Link
Wood MarkVP, Human Resources2010-10-22Sell93714,243$23.5222.04303.78Link
FUCHS HENRY JEVP, Chief Medical Officer2010-10-01Sell83331,000$22.318.58325.87Link
Wood MarkVP, Human Resources2010-09-22Sell93814,243$22.9221.5314.35Link
Cooper Jeffrey HSVP, CFO2010-09-13Sell6,00026,486$22.85137.1315.62Link
BIENAIME JEAN JACQUESCEO2010-09-08Sell1,00095,067$22.2222.22327.41Link
ASELAGE STEVEEVP, Chief Business Officer2010-09-08Sell35,00037,587$22770331.68Link
Wood MarkVP, Human Resources2010-09-07Sell93714,243$21.5120.15341.52Link
BIENAIME JEAN JACQUESCEO2010-09-02Sell4,00095,067$20.9783.88352.89Link
FUCHS HENRY JEVP, Chief Medical Officer2010-09-01Sell83431,000$20.8817.41354.84Link
BIENAIME JEAN JACQUESCEO2010-08-30Sell3,00099,067$20.7162.13358.57Link
BIENAIME JEAN JACQUESCEO2010-08-30Sell3,00099,067$20.7162.13358.57Link
BIENAIME JEAN JACQUESCEO2010-08-27Sell3,00099,067$20.6862.04359.24Link
Davis George EricSVP, General Counsel2010-08-20Sell15,65727,901$20.57322.06361.69Link
Wood MarkVP, Human Resources2010-07-26Sell2,50014,243$2152.5352.24Link
FUCHS HENRY JEVP, Chief Medical Officer2010-07-23Sell83331,000$2016.66374.85Link
Wood MarkVP, Human Resources2010-06-23Sell37214,243$19.797.36379.89Link
Wood MarkVP, Human Resources2010-06-08Sell47014,615$18.878.87403.29Link
FUCHS HENRY JEVP, Chief Medical Officer2010-06-02Sell83431,000$2016.68374.85Link
Wood MarkVP, Human Resources2010-05-13Sell54612,835$21.7511.88336.64Link
Wood MarkVP, Human Resources2010-05-12Sell9388,081$21.4120.08343.58Link
Wood MarkVP, Human Resources2010-05-06Sell3138,081$21.036.58351.59Link
FUCHS HENRY JEVP, Chief Medical Officer2010-05-03Sell2,27520,000$22.851.87316.54Link
Wood MarkVP, Human Resources2010-04-12Sell9378,081$23.8122.31298.87Link
Wood MarkVP, Human Resources2010-04-05Sell3128,081$24.637.68285.59Link
FUCHS HENRY JEVP, Chief Medical Officer2010-04-01Sell5,83320,000$24139.99295.71Link
Wood MarkVP, Human Resources2010-03-12Sell9388,081$22.1720.8328.37Link
BAFFI ROBERTEVP, Technical Operations2010-03-10Sell163,88860,588$22.523690.76321.7152,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
ASELAGE STEVEEVP, Chief Business Officer2010-03-08Sell35,50619,855$21.99780.78331.88Link
Wood MarkVP, Human Resources2010-03-08Sell3138,081$22.146.93328.95Link
KLEIN JOSEPH IIIDirector2010-03-08Sell10,00035,000$22.12221.2329.34Link
ASELAGE STEVEEVP, Chief Business Officer2010-03-03Sell10,00031,271$21210352.24Link
Wood MarkVP, Human Resources2010-03-02Sell1,2498,081$2126.23352.24Link
ASELAGE STEVEEVP, Chief Business Officer2010-03-02Sell10,00041,271$21210352.24Link
BIENAIME JEAN JACQUESCEO2010-02-26Buy80048,740$20.0816.06372.96Link
Wood MarkVP, Human Resources2010-02-03Sell3778,081$217.92352.24Link
Wood MarkVP, Human Resources2010-01-21Sell1448,081$21.053.03351.16Link
BIENAIME JEAN JACQUESCEO2010-01-19Sell3,50050,440$20.8973.12354.62Link
Wood MarkVP, Human Resources2010-01-19Sell17,4998,081$21367.48352.24Link
BIENAIME JEAN JACQUESCEO2009-12-22Sell1,50053,940$18.8328.25404.35Link
Davis George EricVP, General Counsel2009-12-02Sell21,00020,453$17.25362.25450.55Link
Wood MarkVP, Human Resources2009-08-28Sell1778,081$16.52.92475.58Link
BIENAIME JEAN JACQUESCEO2009-08-10Sell4,00055,440$15.9563.8495.42Link
Wood MarkVP, Human Resources2009-07-08Sell4568,081$13.896.33583.73
Wood MarkVP, Human Resources2009-06-23Sell3637,287$14.755.35543.86
BIENAIME JEAN JACQUESCEO2009-06-12Buy1,50051,940$14.5221.78554.06
Davis George EricVP, General Counsel2009-06-11Sell2,50016,203$14.4736.18556.32
MEIER RICHARD ADirector2009-06-05Buy2,00010,250$13.727.4593.21
MEIER RICHARD ADirector2009-03-13Buy1,0004,250$11.4511.45729.43
BIENAIME JEAN JACQUESDirector2009-03-05Buy1,00011,917$10.0410.04845.92
KLEIN JOSEPH IIIDirector2009-03-05Buy5,00042,500$10.0750.35843.1
MEIER RICHARD ADirector2009-03-03Buy2,0003,250$10.9321.86768.89
KLEIN JOSEPH IIIDirector2009-03-03Buy5,00037,500$10.5652.8799.34
KAKKIS EMIL DChief Medical Officer2009-03-02Sell7,89739,621$11.792.39711.71
KLEIN JOSEPH IIIDirector2009-02-24Buy10,00032,500$12.08120.8686.18
KAKKIS EMIL DChief Medical Officer2009-02-03Sell17,00039,621$19.14325.38396.19
Wood MarkVP, Human Resources2009-01-22Sell178650$19.293.43392.33
Wood MarkVP, Human Resources2009-01-16Sell2,501650$2152.52352.24
KAKKIS EMIL DChief Medical officer2009-01-02Sell17,00039,621$17.57298.69440.52
Wood MarkVP, Human Resources2008-12-22Sell177650$17.183.04452.79
BIENAIME JEAN JACQUESCEO, Director2008-12-08Sell4,00010,917$1768458.65
BIENAIME JEAN JACQUESCEO, Director2008-12-08Buy4,00014,917$17.268.8452.15
Davis George EricVP, General Counsel2008-12-04Sell7,0008,180$16.3114.1482.64
LAPALME PIERREDirector2008-12-03Buy2,4001,500$15.336.72520.72
KAKKIS EMIL DCHIEF MEDICAL OFFICER2008-12-01Sell17,00039,621$15.87269.79498.42
Wood MarkVP, Human Resources2008-11-28Sell177650$16.52.92475.58
KAKKIS EMIL DChief Medical Officer2008-11-25Sell75,00039,621$15.981198.5494.31
Wood MarkVP, Human Resources2008-10-21Sell177650$20.223.58369.68
KAKKIS EMIL DChief Medical Officer2008-10-01Sell18,000115,304$26.27472.86261.52
Wood MarkVP, Human Resources2008-09-22Sell2,468650$28.0369.18238.82
KAKKIS EMIL DChief Medical Officer2008-09-02Sell18,000115,304$30.19543.42214.57
BAFFI ROBERTSVP, Technical Operations2008-09-02Sell11,52838,434$31.31360.94203.32
Wood MarkVP, Human Resources2008-08-21Sell2,469650$26.164.44263.87
KAKKIS EMIL DChief Medical Officer2008-08-01Sell18,000127,304$32.48584.64192.4
BAFFI ROBERTSVP, Technical Operations2008-07-30Sell9,22848,734$31.69292.44199.68
BAFFI ROBERTSVP, Technical Operations2008-07-30Sell10,30038,434$31.98329.39196.97
Wood MarkVP, Human Resources2008-07-21Sell2,468650$30.2774.71213.74
Davis George EricVP, General Counsel2008-07-15Sell5,00014,994$28140239.18
Wood MarkVP, Human Resources2008-07-08Sell350650$28.029.81238.94
KAKKIS EMIL DChief Medical Officer2008-07-07Sell18,000145,304$28.06505.08238.45
Swiedler Stuart JSVP, Clinical Affairs2008-07-01Sell15,00010,000$28.34425.1235.11
BAFFI ROBERTSVP, Technical Operations2008-06-30Sell3,52836,434$30.01105.88216.46
Wood MarkVP, Human Resources2008-06-23Sell2,2920$32.6174.74191.23
BIENAIME JEAN JACQUESCEO, Director2008-06-05Sell3,0003,567$39117143.51
Wood MarkVP, Human Resources2008-06-04Sell1,3230$37.6649.82152.18
KAKKIS EMIL DChief Medical Officer2008-06-02Sell18,000160,804$37.63677.34152.38
BAFFI ROBERTSVP, Technical Operatons2008-05-30Sell1,10036,434$38.7142.58145.34
BAFFI ROBERTSVP, Technical Operations2008-05-30Sell10,42837,534$38.44400.85147.06
Wood MarkVP, Human Resources2008-05-21Sell1,6670$39.0965.16142.95
BIENAIME JEAN JACQUESCEO, Director2008-05-15Sell5,0003,567$39.11195.55142.83
Davis George EricVP, General Counsel2008-05-13Sell10,0005,807$39.13391.3142.7
BIENAIME JEAN JACQUESCEO, Director2008-05-12Sell13,0003,567$38.91505.83144.08
ASELAGE STEVESVP, Global Commercial Dev.2008-05-06Sell20,00028,665$37.75755151.58
BIENAIME JEAN JACQUESCEO, Director2008-05-05Sell22,5533,567$36.97833.78156.88
KAKKIS EMIL DChief Medical Officer2008-05-01Sell18,000162,804$37.49674.82153.32
Davis George EricVP, General Counsel2008-04-30Sell4005,807$36.7314.69158.56
Davis George EricVP, General Counsel2008-04-30Sell4,6006,207$36.3166.98161.63
Wood MarkVP, Human Resources2008-04-21Sell2,9900$33.99101.63179.41
BAFFI ROBERTSVP, Technical Operations2008-04-02Sell22,96550,477$36.88846.95157.51
BAFFI ROBERTSVP, Technical Operations2008-04-02Sell15,79734,680$37.11586.23155.91
Swiedler Stuart JSVP, Clinical Affairs2008-04-01Sell12,50010,000$36.02450.25163.66
KAKKIS EMIL DChief Medical Officer2008-04-01Sell9,85786,164$35.9353.87164.54
KAKKIS EMIL DChief Medical Officer2008-04-01Sell8,14396,021$35.75291.11165.65
ASELAGE STEVESVP, Global Commercial Dev2008-04-01Sell80532,034$36.0529.02163.44
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell11,30934,680$36.19409.27162.42
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell14,18945,989$35.87508.96164.76
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell9,50060,178$35.52337.44167.37
Wood MarkVP, Human Resources2008-03-24Sell2,9890$35.05104.76170.96
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell7,57634,680$32.75248.11189.98
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell26,53642,256$32.46861.36192.58
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell12,12868,792$32.13389.67195.58
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell6,64334,680$34.33228.05176.64
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell11,95741,323$33.59401.64182.73
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell12,64353,280$33.15419.12186.49
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell7,00065,923$32.81229.67189.45
HERON ELAINE JDirector2008-03-06Sell3,63830,000$38.34139.48147.7
HERON ELAINE JDirector2008-03-06Sell16,45133,638$38.11626.95149.2
HERON ELAINE JDirector2008-03-06Sell9,91150,089$37.7373.64151.91
KAKKIS EMIL DChief Medical Officer2008-03-06Sell18,00086,164$38.16686.88148.87
GREY MICHAEL GDirector2008-03-05Sell3,5005,000$38.41134.44147.25
GREY MICHAEL GDirector2008-03-05Sell21,5008,500$38.17820.66148.81
HERON ELAINE JDirector2008-03-03Sell20,0000$38.47769.4146.87
Davis George EricVP, General Counsel2008-03-03Sell20,0003,397$38760149.92
ASELAGE STEVESVP, Global Commercial Dev2008-03-03Sell40,00032,034$381520149.92
KLEIN JOSEPH IIIDirector2008-03-03Sell10,00030,000$38.03380.3149.72
KLEIN JOSEPH IIIDirector2008-03-03Sell20,00020,000$37.92758.4150.45
BIENAIME JEAN JACQUESCEO, Director2008-02-29Sell27,1424,071$38.11034.11149.27
LAPALME PIERREDirector2008-02-29Sell5,9756,600$38.43229.62147.12
LAPALME PIERREDirector2008-02-29Sell9,02512,575$37.8341.15151.24
Cooper Jeffrey HSVP, CFO2008-02-29Sell5,9051,005$37.94224.04150.32
Cooper Jeffrey HSVP, CFO2008-02-29Sell49,7206,910$37.621870.47152.45
Wood MarkVP, Human Resources2008-02-21Sell2,9900$36.46109.02160.48
Wood MarkVP, Human Resources2008-01-22Sell2,9900$36.26108.42161.91
BIENAIME JEAN JACQUESCEO, Director2008-01-02Sell15,0007,213$36.07541.05163.29
Swiedler Stuart JSVP, Clinical Affairs2008-01-02Sell12,50010,000$36.08451163.22
ASELAGE STEVESVP, Global Commercial Dev2008-01-02Sell5,0007,034$36.08180.4163.22
Wood MarkVP, Human Resources2007-12-21Sell6,1140$36.06220.47163.37
BIENAIME JEAN JACQUESCEO, Director2007-12-17Sell15,0007,213$35.53532.95167.3
Wood MarkVP, Human Resources2007-11-21Sell2,3650$25.8661.16267.25
Wood MarkVP, Human Resources2007-10-22Sell1,5320$25.338.76275.38
Davis George EricVP, General Counsel2007-10-11Sell5,0002,607$27.34136.7247.37
Cooper Jeffrey HSVP, CFO2007-10-08Sell12,3800$26321.88265.27
Wood MarkVP, Human Resources2007-10-08Sell8,3330$26216.66265.27
ASELAGE STEVESVP, Global Commercial Dev2007-10-01Sell5,0004,895$25.09125.45278.52
BIENAIME JEAN JACQUESCEO2007-10-01Sell20,0006,695$25500279.88
Swiedler Stuart JSVP, Clinical Affairs2007-10-01Sell12,50010,000$25.1313.75278.37
Davis George EricVP, General Counsel2007-10-01Sell5,0002,607$25.1125.5278.37
Cooper Jeffrey HSVP, CFO2007-09-26Sell12,5000$24.5306.25287.63
BIENAIME JEAN JACQUESCEO2007-09-25Sell10,0006,695$24240295.71
Wood MarkVP, Human Resources2007-09-21Sell5,9060$23.25137.31308.47
BIENAIME JEAN JACQUESCEO2007-09-19Sell10,0006,695$23230312.91
BAFFI ROBERTSVP, Technical Operations2007-09-14Sell22,70733,124$22.64514.09319.48
BAFFI ROBERTSVP, Technical Operations2007-09-14Sell67,29355,831$22.481512.75322.46
ASELAGE STEVESVP, Global Commercial Dev.2007-09-14Sell10,0004,895$22.4224323.97
Cooper Jeffrey HSVP, CFO2007-09-06Sell13,5360$22.5304.56322.09
Cooper Jeffrey HSVP, CFO2007-08-17Sell20,0000$20.29405.8368.06
BIENAIME JEAN JACQUESCEO2007-08-17Sell10,0006,695$21210352.24
Davis George EricVP, General Counsel2007-08-15Sell4,0002,607$20.2681.04368.76
LEWIS ALANDirector2007-08-10Sell20,00010,000$20.08401.6372.96
ASELAGE STEVESVP, Global Commercial Dev2007-08-10Sell20,0004,895$20.27405.4368.52
Wood MarkVP, Human Resources2007-08-10Sell2,6330$21.0855.5350.52
BIENAIME JEAN JACQUESCEO2007-08-10Sell35,8866,695$20.2724.9370.15
Cooper Jeffrey HSVP, CFO2007-08-08Sell12,5000$21262.5352.24
BIENAIME JEAN JACQUESCEO2007-08-03Sell2,0006,695$18.0336.06426.73
BIENAIME JEAN JACQUESCEO2007-07-05Sell2,0008,695$18.2936.58419.25
Swiedler Stuart JSVP, Clinical Affairs2007-07-02Sell12,50010,000$18.18227.25422.39
BIENAIME JEAN JACQUESCEO2007-06-25Sell2,50010,695$17.6544.13438.07
Wood MarkVP, Human Resources2007-06-07Sell1,0450$17.5418.33441.45
BIENAIME JEAN JACQUESCEO2007-06-04Sell12,50013,195$18.34229.25417.83
BIENAIME JEAN JACQUESCEO2007-05-21Sell2,00015,695$18.5637.12411.69
BIENAIME JEAN JACQUESCEO2007-05-03Sell15,00017,695$16.79251.85465.63
BIENAIME JEAN JACQUESCEO2007-05-02Sell1,50015,142$16.4324.65478.03
BIENAIME JEAN JACQUESCEO2007-04-04Sell6,50016,642$17.87116.16431.45
Swiedler Stuart JSVP, Clinical Affairs2007-04-02Sell12,50010,000$17.3216.25448.96
KLEIN JOSEPH IIIDirector2007-03-07Sell12,0000$16.37196.44480.15
BIENAIME JEAN JACQUESCEO2007-03-02Sell1,50018,142$16.4824.72476.27
Davis George EricVP, General Counsel2007-02-22Sell13,0000$18.37238.81416.98
BIENAIME JEAN JACQUESCEO2007-02-22Sell14,00019,642$17.06238.84456.68
ASELAGE STEVESVP, Global Commercial Ops2007-02-14Sell15,0002,829$20300374.85
Swiedler Stuart JSVP, Clinical Affairs2007-01-03Sell12,50010,000$16.3203.75482.64
LAPALME PIERREDirector2006-12-12Buy2,1005,500$17.8837.55431.15
LAPALME PIERREDirector2006-12-12Buy2,1006,600$17.8837.55431.15
Cooper Jeffrey HChief Financial Officer2006-12-06Sell14,5000$18261427.61
ASELAGE STEVESVP, Global Commercial Ops2006-11-29Sell5,0002,829$17.2386.15451.19
Swiedler Stuart JSVP, Clinical Affairs2006-11-01Sell12,50010,000$15.92199496.55
Cooper Jeffrey HVP, CFO2006-08-29Sell26,0000$16416493.56Link
KLEIN JOSEPH IIIDirector2006-08-09Sell20,00022,000$15.52310.4511.92Link
LAPALME PIERREDirector2006-08-07Buy1,0004,500$15.3515.35518.7Link
Swiedler Stuart JSVP, Clinical Affairs2006-08-01Sell12,50010,000$14.34179.25562.27Link
BIENAIME JEAN JACQUESCEO2006-08-01Buy1,50030,881$14.521.75554.97Link
BIENAIME JEAN JACQUESCEO2006-07-03Buy1,50029,381$14.4421.66557.69Link
BIENAIME JEAN JACQUESCEO2006-06-14Buy2,50027,881$13.2433.1617.3Link
BIENAIME JEAN JACQUESCEO2006-06-01Buy1,50025,381$13.0519.58627.74Link
BIENAIME JEAN JACQUESCEO2006-05-18Buy1,00023,881$1212691.42Link
BIENAIME JEAN JACQUESCEO2006-05-08Buy1,00022,881$12.7812.78643.11Link
BIENAIME JEAN JACQUESCEO2006-05-01Buy1,50018,500$12.5918.89654.33Link
BIENAIME JEAN JACQUESCEO2006-04-03Buy1,50017,000$13.3520.03611.39Link
Cooper Jeffrey HCFO2006-03-16Sell12,5000$14.85185.63539.53Link
Cooper Jeffrey HCFO2006-03-01Sell15,5000$13.25205.38616.75Link
BIENAIME JEAN JACQUESCEO2006-03-01Buy1,50015,500$12.9919.49631.1Link
Cooper Jeffrey HCFO2006-02-27Sell1,0000$13.2513.25616.75Link
LAPALME PIERREDirector2006-02-27Buy3,5003,500$12.9945.47631.1Link
SAGER ERICHDirector2006-02-24Sell11,5003,309$12.64145.36651.34Link
SAGER ERICHDirector2006-02-22Sell1,0003,309$12.212.2678.44Link
Swiedler Stuart JSVP, Clinical Affairs2006-02-01Sell10,00010,000$11.55115.5722.25Link
BIENAIME JEAN JACQUESCEO2006-02-01Buy1,50014,000$11.6717.51713.8Link
SAGER ERICHDirector2006-01-27Sell2,5003,309$12.230.5678.44Link
BIENAIME JEAN JACQUESCEO2006-01-03Buy1,50012,500$10.7916.19780.17Link
BIENAIME JEAN JACQUESCEO2005-12-12Buy1,00011,000$10.2110.21830.17Link
SAGER ERICHDirector2005-12-05Sell7,5003,309$10.780.25787.57Link
BIENAIME JEAN JACQUESCEO2005-12-01Buy1,50010,000$9.9414.91855.43Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2005-12-01Sell10,571295,176$10105.71849.7Link
SAGER ERICHDirector2005-12-01Sell22,5000$10.42234.45811.42Link
Swiedler Stuart JSVP, Clinical Affairs2005-11-21Sell30,00010,000$10300849.7Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2005-11-21Sell10,571300,176$10105.71849.7Link
BIENAIME JEAN JACQUESCEO2005-11-01Buy1,5008,500$8.3712.561034.65Link
BIENAIME JEAN JACQUESCEO2005-10-12Buy5006,500$73.51256.71Link
BIENAIME JEAN JACQUESCEO2005-10-06Buy5006,500$841087.13Link
BIENAIME JEAN JACQUESCEO2005-10-03Buy1,5006,000$8.5112.771015.98Link
BIENAIME JEAN JACQUESCEO2005-09-01Buy4,5004,500$8.5838.611006.88Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-06-03Sell10,000305,176$7.6476.41143.06Link
BAFFI ROBERTSVP, Technical Operations2004-05-10Buy8,00014,931$6.1248.961451.8Link
KAKKIS EMIL DSVP, Business Operations2004-05-06Buy15,00026,110$6.4997.351363.33Link
PRICE FREDRIC DCEO2004-05-06Buy15,00079,285$6.3294.81402.69Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-04-02Sell5,570315,176$844.561087.13Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-04-01Sell5,000315,176$7.5637.81156.22Link
SAGER ERICHDirector2004-01-02Sell20,0003,309$7.81156.21116.01Link
KAKKIS EMIL DSVP, Business Operations2003-12-29Sell10,18711,110$7.5777.121154.56Link
STARR CHRISTOPHER MSr. VP, Scientific Operations2003-08-21Sell33,000320,176$9297955.22Link
WILLIAMS GWYNNDirector2003-07-28Sell68,700812,565$10687849.7Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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