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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Christopher M. Starr,PhDN/A295,1760.17%2005-12-01
Jean-Jacques BienaimeCEO170,6820.1%2016-11-21
Dr. Robert A. Baffi,PhDEVP, Technical Operations128,742less than 0.1%2016-06-03
Dr. Henry J. Fuchs,M.D.President, Worldwide R&D113,878less than 0.1%2016-11-25
Mr. Fredric D. PriceN/A79,285less than 0.1%2004-05-06
G. Eric DavisEVP, General Counsel70,798less than 0.1%2016-10-07
Mr. Stephen AselageN/A59,030less than 0.1%2012-07-02
Jeff AjerEVP, Chief Commercial Officer41,342less than 0.1%2016-09-27
Jeffrey H. CooperN/A41,089less than 0.1%2012-04-30
Dr. Emil D. Kakkis,M.D.N/A39,621less than 0.1%2009-03-02

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
FUCHS HENRY JPresident, Worldwide R&D2016-11-25Sell15,000113,878$87.41311-5.31113,878 (Direct)
BIENAIME JEAN JACQUESCEO
(Click for the stocks that their CEOs have bought)
2016-11-22Sell139,487353,483$86.6212082.36-4.46170,682 (Direct)
182,801 (Shares held by Jean-Jacques Bienaime Family Trust)
Davis George EricEVP, General Counsel2016-11-18Sell5,00070,798$90.42452.1-8.4770,798 (Direct)
BIENAIME JEAN JACQUESCEO2016-11-16Sell41,670349,126$90.973790.72-9.02323,368 (Direct)
25,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2016-11-09Sell20,00023,100$90.611812.2-8.6623,100 (Direct)
LAWLIS V BRYANDirector2016-11-09Sell7,50013,860$95712.5-12.8813,860 (Direct)
BIENAIME JEAN JACQUESCEO2016-11-08Sell140,000349,126$82.6711573.80.11323,368 (Direct)
25,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2016-10-28Sell120,000349,126$81.397561.8323,368 (Direct)
25,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2016-10-17Sell41,666349,126$84.393516.19-1.93323,368 (Direct)
25,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2016-10-14Sell64,125349,126$86.965576.31-4.83323,368 (Direct)
25,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2016-09-29Sell53,125404,342$93.654975.16-11.63378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertEVP, Chief Commercial Officer2016-09-27Sell18,46741,342$95.611765.63-13.4441,342 (Direct)
BIENAIME JEAN JACQUESCEO2016-09-16Sell137,368404,342$95.3413096.67-13.19378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2016-08-26Sell15,000113,878$95.061425.9-12.94113,878 (Direct)
BIENAIME JEAN JACQUESCEO2016-08-16Sell41,666404,342$91.493812.02-9.54378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2016-08-01Sell4,00042,944$99.33397.32-16.6842,944 (Direct)
Davis George EricEVP, General Counsel2016-08-01Sell2,16771,158$100216.7-17.2471,158 (Direct)
Mueller BrianVP, Corporate Controller2016-08-01Sell28714,260$10028.7-17.2414,260 (Direct)
LAWLIS V BRYANDirector2016-07-27Sell1,10013,860$95.39104.93-13.2413,860 (Direct)
LAWLIS V BRYANDirector2016-07-22Sell6,40013,860$95.01608.06-12.8913,860 (Direct)
BIENAIME JEAN JACQUESCEO2016-07-18Sell41,666404,342$92.723863.27-10.74378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
Davis George EricEVP, General Counsel2016-07-07Sell2,16770,669$90195.03-8.0470,669 (Direct)
LAWLIS V BRYANDirector2016-06-20Sell55013,860$82.7745.52-0.0113,860 (Direct)
BIENAIME JEAN JACQUESCEO2016-06-16Sell41,666404,342$80.553356.22.74378,584 (Direct)
25,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2016-06-06Sell1,64946,944$89.14146.99-7.1646,944 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2016-05-31Sell20,84150,394$89.881873.19-7.9250,394 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2016-05-26Sell15,000115,914$87.811317.15-5.75115,914 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2016-05-23Sell3,76958,644$87.07328.17-4.9558,644 (Direct)
BAFFI ROBERTEVP, Technical Operations2016-05-18Sell5,000162,062$87.05435.25-4.93130,386 (Direct)
31,676 (Shares held by Baffi Family Trust)
Davis George EricEVP, General Counsel2016-05-10Sell14,65875,540$85.111247.54-2.7675,540 (Direct)
BIENAIME JEAN JACQUESCEO2016-05-05Sell50,000415,914$80.154007.53.26390,156 (Direct)
0 (Shares held in irrevocable trust for Guillaume Bienaime)
0 (Shares held in irrevocable trust for Pierre Bienaime)
0 (Shares held in irrevocable trust for Paul Bienaime)
0 (Shares held in irrevocable trust for Marc Bienaime)
0 (Shares held in irrevocable trust for Aurelie Mitsuki Bienaime & Anais Kimiko Bienaime)
25,758 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertEVP, Chief Commercial Officer2016-05-03Sell41563,072$86.0335.7-3.863,072 (Direct)
BIENAIME JEAN JACQUESCEO2016-05-02Sell36,500421,393$85.013102.87-2.65395,635 (Direct)
25,758 (Shares held by Bienaime Family Trust)
Davis George EricEVP, General Counsel2016-03-14Sell1,99676,190$86.21172.08-476,190 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Officer2016-03-04Sell1,25546,882$88.42110.97-6.446,882 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2016-03-02Sell4,62349,688$86.12398.13-3.949,688 (Direct)
BIENAIME JEAN JACQUESCEO2016-03-01Sell10,000366,258$84.28842.8-1.8340,500 (Direct)
25,758 (Shares held by Bienaime Family Trust)
GREY MICHAEL GDirector2016-02-22Sell7,50026,250$806003.4526,250 (Direct)
Davis George EricSVP, General Counsel2015-12-16Sell1,36266,156$100136.2-17.2466,156 (Direct)
BIENAIME JEAN JACQUESCEO2015-11-30Sell1,000254,512$94.7494.74-12.65228,754 (Direct)
25,758 (Shares held by Bienaime Family Trust)
LAWLIS V BRYANDirector2015-11-16Sell8,55011,850$106.9914-22.5811,850 (Direct)
GREY MICHAEL GDirector2015-11-16Sell7,50026,250$104.27782.03-20.6326,250 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-11-16Sell20,00028,229$104.32086-20.6528,229 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-11-02Sell2635,605$117.563.06-29.635,605 (Direct)
BIENAIME JEAN JACQUESCEO2015-10-15Sell1,000255,512$108.24108.24-23.54228,754 (Direct)
26,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-09-14Sell1,000256,512$131.43131.43-37.03228,754 (Direct)
27,758 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-08-12Sell1,500257,512$134.72202.08-38.57228,754 (Direct)
28,758 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-07-20Sell3,00035,605$150450-44.8335,605 (Direct)
BIENAIME JEAN JACQUESCEO2015-07-07Sell1,500259,012$139.07208.61-40.49228,754 (Direct)
30,258 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2015-06-05Sell1,64928,229$122.3201.67-32.3328,229 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-06-05Sell1,86472,846$122.32228-32.3472,846 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-06-04Sell1,36235,605$122.35166.64-32.3635,605 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-06-01Sell5,52331,679$124.73688.88-33.6531,679 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-06-01Sell37738,455$123.7646.66-33.1338,455 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-05-26Sell1,62539,245$126.55205.64-34.639,245 (Direct)
BIENAIME JEAN JACQUESCEO2015-05-21Sell1,500267,652$126.1189.15-34.37235,894 (Direct)
31,758 (Shares held by Bienaime Family Trust)
SPIEGELMAN DANIEL KEVP, CFO2015-05-18Sell34,07841,507$1304430.14-36.3441,507 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-05-18Sell2,05975,585$124.77256.9-33.6775,585 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-18Sell1,86476,746$124.78232.59-33.6876,746 (Direct)
Davis George EricSVP, General Counsel2015-05-18Sell2,55869,226$125.26320.42-33.9369,226 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-13Sell1,43480,646$121.37174.04-31.8180,646 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-11Sell2,86983,646$121.64348.99-31.9683,646 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2015-05-06Sell34,01942,645$119.144053.02-30.5442,645 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2015-05-01Sell41489,646$114.5947.44-27.7889,646 (Direct)
BIENAIME JEAN JACQUESCEO2015-05-01Sell26,723281,912$114.983072.61-28.02248,654 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-04-01Sell26,052284,509$120.533140.05-31.34251,251 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-20Sell1,000288,015$126.4126.4-34.53254,757 (Direct)
33,258 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-17Sell2,000289,015$124.17248.34-33.35254,757 (Direct)
34,258 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2015-03-16Sell41,31588,635$123.575105.29-33.0388,635 (Direct)
Davis George EricSVP, General Counsel2015-03-13Sell15,00073,846$120.871813.05-31.5373,846 (Direct)
BIENAIME JEAN JACQUESCEO2015-03-10Sell21,021291,015$112.392362.55-26.36254,757 (Direct)
36,258 (Shares held by Bienaime Family Trust)
BAFFI ROBERTEVP, Technical Operations2015-03-05Sell14,051133,635$116.371635.11-28.88109,700 (Direct)
23,935 (Shares held by Baffi Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-05Sell10,000297,036$113.71137-27.21254,757 (Direct)
42,279 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2015-03-04Sell13,916257,436$107.921501.81-23.31215,157 (Direct)
42,279 (Shares held by Bienaime Family Trust)
LAPALME PIERREDirector2015-03-03Sell20,00031,650$106.572131.4-22.3430,150 (Direct)
1,500 (Shares held by spouse)
Mueller BrianVP, Corporate Controller2015-03-03Sell7,0008,800$109.46766.22-24.398,800 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2015-03-02Sell15,50068,676$1071658.5-22.6568,676 (Direct)
Davis George EricSVP, General Counsel2015-03-02Sell23,00064,246$108.312491.13-23.5964,246 (Direct)
BIENAIME JEAN JACQUESCEO2015-01-09Sell2,000268,352$94.14188.28-12.09225,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-12-24Sell5,000270,352$88.73443.65-6.73227,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-12-10Sell2,000272,352$95190-12.88229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
LEWIS ALANDirector2014-12-04Sell7,50021,400$89.9674.25-7.9421,400 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-12-03Sell12,00031,590$91.011092.12-9.0631,590 (Direct)
Mueller BrianVP, Corporate Controller2014-12-02Sell11,9504,593$90.911086.37-8.964,593 (Direct)
Mueller BrianVP, Corporate Controller2014-11-26Sell3,4004,593$88.97302.5-6.984,593 (Direct)
Davis George EricSVP, General Counsel2014-11-25Sell20,00064,426$89.751795-7.7964,426 (Direct)
BIENAIME JEAN JACQUESCEO2014-11-25Sell2,000272,352$90180-8.04229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-12Sell1,000271,352$85.5185.51-3.22228,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-12Sell1,000271,352$81.5181.511.53228,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-11-10Sell4,000272,352$87348-4.87229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2014-11-10Sell20,00076,550$86.551731-4.3876,550 (Direct)
BIENAIME JEAN JACQUESCEO2014-11-03Sell3,000272,352$85.33255.99-3.01229,157 (Direct)
43,195 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-11-03Sell4731,590$83.543.93-0.9331,590 (Direct)
BAFFI ROBERTEVP, Technical Operations2014-10-30Sell75,425123,089$81.346135.071.7599,200 (Direct)
23,889 (Shares Owned by Baffi Family Trust)
Davis George EricSVP, General Counsel2014-10-30Sell15,00064,426$83.21248-0.5364,426 (Direct)
BIENAIME JEAN JACQUESCEO2014-10-24Sell2,000323,547$801603.45229,157 (Direct)
48,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-10-21Sell2,000323,547$7515010.35229,157 (Direct)
48,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
Davis George EricSVP, General Counsel2014-09-19Sell17,53664,426$69.751223.1418.6564,426 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-09-03Sell4168,733$70.612.917.2168,733 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-09-02Sell16,00068,676$69.831117.2818.5268,676 (Direct)
BIENAIME JEAN JACQUESCEO2014-08-20Sell5,000326,547$7035018.23229,157 (Direct)
51,195 (Shares owned by Bienaime Family Trust)
46,195 (Shares held by Bienaime Family Trust)
FUCHS HENRY JEVP, Chief Medical Officer2014-08-05Sell10,00076,550$6565027.3276,550 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-08-01Sell2,22968,676$61.76137.663468,676 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-07-02Sell2,22970,905$64142.6629.3170,905 (Direct)
BIENAIME JEAN JACQUESCEO2014-06-04Sell2,000275,352$61.2122.435.23229,157 (Direct)
46,195 (Shares held by Bienaime Family Trust)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-06-02Sell37720,190$57.8321.843.1120,190 (Direct)
BIENAIME JEAN JACQUESCEO2014-05-22Sell1,000226,452$56.8856.8845.5180,257 (Direct)
46,195 (Shares held by Bienaime Family Trust)
BIENAIME JEAN JACQUESCEO2014-05-21Sell1,545227,452$56.1986.8147.29180,257 (Direct)
47,195 (Shares held by Bienaime Family Trust)
LAWLIS V BRYANDirector2014-05-16Sell1,7009,700$56.8796.6845.529,700 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-16Sell1,86460,950$56.86105.9945.5560,950 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-16Sell1,00420,980$56.9157.1445.4220,980 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-13Sell47823,080$58.1827.8142.2523,080 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-13Sell1,43464,850$58.2383.542.1364,850 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-13Sell1,43463,415$58.2383.542.1363,415 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-09Sell3,47967,850$57.91201.4742.9167,850 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-09Sell62124,080$57.9635.9942.7924,080 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-05-01Sell66625,380$59.5539.6638.9825,380 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-05-01Sell71573,850$59.6742.6638.773,850 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2014-03-06Sell17,37025,380$78.631365.85.2525,380 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2014-03-03Sell8,00064,273$80.32642.563.0464,273 (Direct)
BIENAIME JEAN JACQUESCEO2014-02-20Sell8,000301,260$806403.45194,520 (Direct)
46,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Davis George EricSVP, General Counsel2014-02-20Sell20,00060,656$8016003.4560,656 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2014-02-03Sell10,00042,350$67.767722.2542,350 (Direct)
BIENAIME JEAN JACQUESCEO2014-01-10Sell5,000166,480$7035018.23
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2014-01-06Sell10,000171,480$67.41674.122.77
60,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2014-01-02Sell5,000166,480$68.9344.520.12
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
FUCHS HENRY JEVP, Chief Medical Officer2014-01-02Sell91642,350$68.9763.1819.9942,350 (Direct)
BIENAIME JEAN JACQUESCEO2013-12-24Sell10,000171,480$68.71687.120.45
60,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
GREY MICHAEL GDirector2013-12-11Sell30,00023,050$69.662089.818.8123,050 (Direct)
LAWLIS V BRYANDirector2013-12-09Sell2,90011,400$69.76202.318.6411,400 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-12-09Sell13,02614,880$69.55905.9618.9914,880 (Direct)
LEWIS ALANDirector2013-12-09Sell22,50019,300$69.911572.9818.3819,300 (Direct)
BIENAIME JEAN JACQUESCEO2013-12-05Sell5,000166,480$69.7348.518.74
55,740 (Shares Held in Bienaime Family Trust)
50,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-12-02Sell9,00037,950$70.14631.2617.9937,950 (Direct)
BIENAIME JEAN JACQUESCEO2013-11-05Sell5,000105,740$62.36311.832.71
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-11-01Sell9914,880$63.166.2531.0314,880 (Direct)
BIENAIME JEAN JACQUESCEO2013-10-31Sell10,000105,740$62.72627.231.95
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-10-16Sell2,000105,740$67.73135.4622.19
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-10-10Sell3,000105,740$66.76200.2823.97
45,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
FUCHS HENRY JEVP, Chief Medical Officer2013-09-19Sell10,00043,266$80.19801.93.243,266 (Direct)
BIENAIME JEAN JACQUESCEO2013-09-16Sell2,000108,740$73.08146.1613.25
48,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BAFFI ROBERTEVP, Technical Operations2013-09-09Sell20,00062,262$73146013.3762,262 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-09-05Sell10,00043,266$7070018.2343,266 (Direct)
SPIEGELMAN DANIEL KEVP, CFO2013-09-04Sell9,00037,950$6962119.9437,950 (Direct)
BIENAIME JEAN JACQUESCEO2013-08-15Sell1,000108,740$64.3664.3628.59
48,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-07-01Sell4,06637,950$59.78243.0738.4437,950 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-07-01Sell10,00043,266$6060037.9343,266 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-06-03Sell49314,880$58.3428.7641.8614,880 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-06-03Sell1,09843,266$58.3264.0441.9143,266 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-05-23Sell20,60944,364$66.291366.1724.8544,364 (Direct)
Wood MarkVP, Human Resources2013-05-22Sell3,10320,277$67.12208.2723.320,277 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-21Sell2,000216,510$64.14128.2829.03115,770 (Direct)
40,740 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-05-16Sell12,000242,119$67.9814.821.89125,901 (Direct)
30,609 (Shares held by Bienaime Family Trust)
25,609 (Shares held by Bienaime Family Trust()
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Mueller BrianVP, Corporate Controller2013-05-14Sell4,9476,660$70.35348.0217.646,660 (Direct)
Davis George EricSVP, General Counsel2013-05-14Sell20,00041,708$70.341406.817.6641,708 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-05-14Sell20,00050,262$70140018.2350,262 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-14Sell25,00080,609$70.941773.516.66
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BIENAIME JEAN JACQUESCEO2013-05-14Sell15,00080,609$70.171052.5517.94
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Davis George EricSVP, General Counsel2013-05-13Sell2,59041,708$69.29179.4619.4441,708 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-13Sell15,800168,710$68.771086.5720.3488,101 (Direct)
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-13Sell1,2487,270$69.2686.4419.497,270 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-13Sell15,800168,710$68.771086.5720.3488,101 (Direct)
20,609 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-09Sell8119,270$6653.5325.399,270 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-08Sell4,000185,383$65.87263.4825.64111,838 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Mueller BrianVP, Corporate Controller2013-05-03Sell16,8319,403$66.171113.7125.079,403 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-03Sell8,000192,862$67.24537.9223.08119,317 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
BAFFI ROBERTEVP, Technical Operations2013-05-03Sell20,00061,393$67134023.5253,155 (Direct)
8,238 (Shares held by Baffi Family Trust)
Davis George EricSVP, General Counsel2013-05-03Sell5,85447,058$67.19393.3323.1747,058 (Direct)
BIENAIME JEAN JACQUESCEO2013-05-02Sell3,000192,862$64.99194.9727.34119,317 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
SPIEGELMAN DANIEL KEVP, CFO2013-05-01Sell28,00033,000$64.421803.7628.4733,000 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-05-01Sell79710,570$64.5251.4228.2710,570 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2013-04-30Sell20,00044,589$63.291265.830.7644,589 (Direct)
Wood MarkVP, Human Resources2013-04-22Sell3,10223,245$65.57203.426.2223,245 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-04-19Sell5,00010,570$6532527.3210,570 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-04-10Sell20,00060,588$64128029.3152,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
BIENAIME JEAN JACQUESCEO2013-03-26Sell12,000192,946$60.68728.1636.39119,401 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
Wood MarkVP, Human Resources2013-03-22Sell3,10323,245$60.21186.8337.4523,245 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-03-18Sell20,00060,588$61.021220.435.6352,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
GREY MICHAEL GDirector2013-03-06Sell15,00019,650$60.61909.1536.5519,650 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-03-04Sell4,00010,570$6024037.9310,570 (Direct)
Davis George EricSVP, General Counsel2013-03-04Sell4,00046,200$60.18240.7237.5246,200 (Direct)
Mueller BrianVP, Corporate Controller2013-03-01Sell7,03813,279$59.76420.5938.4913,279 (Direct)
BIENAIME JEAN JACQUESCEO2013-03-01Sell11,000192,946$59.01649.1140.25119,401 (Direct)
13,545 (Shares held by Bienaime Family Trust)
10,000 (Held in irrevocable trust for Guillaume Bienaime)
10,000 (Held in irrevocable trust for Pierre Bienaime)
10,000 (Held in irrevocable trust for Paul Bienaime)
10,000 (Held in irrevocable trust for Marc Bienaime)
20,000 (Held in irrevocable trust for Aurelie Mitsuki Bienaime and Anais Kimiko)
LEWIS ALANDirector2013-02-27Sell22,50015,900$56.571272.8346.315,900 (Direct)
BIENAIME JEAN JACQUESCEO2013-02-27Sell1,500133,946$56.4684.6946.58120,401 (Direct)
13,545 (Shares hold by Bienaime Family Trust)
Davis George EricSVP, General Counsel2013-02-27Sell8,00046,200$56.9455.245.4546,200 (Direct)
LAPALME PIERREDirector2013-02-26Sell29,90026,150$55.341654.6749.5524,650 (Direct)
1,500 (Shares held by spouse)
Wood MarkVP, Human Resources2013-02-22Sell3,10323,245$55.22171.3549.8723,245 (Direct)
MEIER RICHARD ADirector2013-02-19Sell5,00018,650$57.5287.543.9318,650 (Direct)
BIENAIME JEAN JACQUESCEO2013-02-04Sell2,000153,691$55.77111.5448.4153,691 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-23Sell14,000153,691$55.06770.8450.31153,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-01-22Sell19,575100,413$551076.6350.47100,413 (Direct)
Wood MarkVP, Human Resources2013-01-22Sell46,74925,646$54.992570.7350.525,646 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2013-01-22Sell3,00010,570$5516550.4710,570 (Direct)
MEIER RICHARD ADirector2013-01-22Sell5,00018,650$5527550.4718,650 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-18Sell5,000167,691$5427053.26167,691 (Direct)
BIENAIME JEAN JACQUESCEO2013-01-04Sell3,000167,691$52.24156.7258.42167,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2013-01-03Sell20,000100,413$53106056.15100,413 (Direct)
MEIER RICHARD ADirector2013-01-02Sell10,00018,650$51.25512.561.4818,650 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-31Sell5,000167,691$48.62243.170.22167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-27Sell17,000167,691$48.37822.2971.1167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-21Sell9,000167,691$48.57437.1370.39167,691 (Direct)
Wood MarkVP, Human Resources2012-12-17Sell10,41525,646$49.17512.1168.3125,646 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-12Sell5,000167,691$5025065.52167,691 (Direct)
MEIER RICHARD ADirector2012-12-11Sell5,00018,650$49.71248.5566.4918,650 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-10Sell6,000167,691$47.53285.1874.12167,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-12-04Sell5,000167,691$47.94239.772.63167,691 (Direct)
MEIER RICHARD ADirector2012-11-29Sell5,00018,650$49.17245.8568.3118,650 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2012-11-28Sell5,91610,570$48.31285.871.3110,570 (Direct)
Wood MarkVP, Human Resources2012-11-23Sell2,66532,364$48.92130.3769.1732,364 (Direct)
Davis George EricSVP, General Counsel2012-11-19Sell7,36351,322$48.5357.1170.6451,322 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-16Sell8,000167,691$48.05384.472.24167,691 (Direct)
Mueller BrianVP, Corporate Controller2012-11-15Sell15,81215,340$50790.665.5215,340 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-11-15Sell20,000100,413$51102062.27100,413 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-14Sell4,000167,691$48.519470.64167,691 (Direct)
HERON ELAINE JDirector2012-11-12Sell1,87514,025$48.3390.6271.2414,025 (Direct)
Ajer Jeffrey RobertSVP, Chief Commercial Of2012-11-12Sell26510,570$48.1112.7572.0210,570 (Direct)
Davis George EricSVP, General Counsel2012-11-12Sell99,07551,322$48.454800.1870.8251,322 (Direct)
HERON ELAINE JDirector2012-11-09Sell135,00015,900$46.796316.6576.8815,900 (Direct)
BIENAIME JEAN JACQUESCEO2012-11-09Sell7,000167,691$47.62333.3473.79167,691 (Direct)
LEWIS ALANDirector2012-11-07Sell15,00015,900$46.870276.8415,900 (Direct)
Mueller BrianVP, Corporate Controller2012-11-05Sell8,00015,340$47.03376.2475.9715,340 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-11-05Sell60,000100,413$47.332839.874.86100,413 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-11-05Sell10,00052,277$4646079.9152,277 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-11-01Sell5,00052,277$37.08185.4123.1952,277 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-31Sell4,000174,691$37.96151.84118.02174,691 (Direct)
Wood MarkVP, Human Resources2012-10-22Sell2,66532,364$41.86111.5697.7132,364 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-22Sell3,000175,691$41.86125.5897.71175,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-19Sell2,000175,691$42.7285.4493.73175,691 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-10-16Sell20,000100,413$4386092.47100,413 (Direct)
BIENAIME JEAN JACQUESCEO2012-10-12Sell3,000177,691$41.32123.96100.29177,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-10-01Sell5,00052,277$39.75198.75108.252,277 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-28Sell4,000177,691$40.2160.8105.87177,691 (Direct)
Wood MarkVP, Human Resources2012-09-24Sell2,66532,364$40.48107.88104.4532,364 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-14Sell4,000177,691$37.91151.64118.31177,691 (Direct)
BIENAIME JEAN JACQUESCEO2012-09-10Sell1,000177,691$38.6238.62114.29177,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-09-04Sell5,00052,277$37.76188.8119.1752,277 (Direct)
Wood MarkVP, Human Resources2012-08-22Sell2,66532,364$37.93101.08118.1932,364 (Direct)
LEWIS ALANDirector2012-08-06Sell40,00015,900$37.571502.8120.2815,900 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-08-01Sell5,00052,277$38.63193.15114.2452,277 (Direct)
Wood MarkVP, Human Resources2012-07-23Sell2,66632,364$39.25104.64110.8532,364 (Direct)
Mueller BrianVP, Corporate Controller2012-07-10Sell2,50015,340$42.5106.2594.7315,340 (Direct)
Mueller BrianVP, Corporate Controller2012-07-02Sell2,77015,340$40110.8106.915,340 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-07-02Sell95,34559,030$403813.8106.959,030 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-07-02Sell15,00052,277$40.19602.85105.9252,277 (Direct)
Wood MarkVP, Human Resources2012-06-27Sell81232,364$3830.86117.7932,364 (Direct)
Wood MarkVP, Human Resources2012-06-22Sell1,85332,364$36.8368.25124.7132,364 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-06-01Sell5,00052,277$35.02175.1136.3252,277 (Direct)
Wood MarkVP, Human Resources2012-05-22Sell2,66631,114$38.01101.33117.7331,114 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-16Sell15,000168,691$38.49577.35115.02168,691 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-05-15Sell1,74152,277$38.6467.27114.1852,277 (Direct)
LAWLIS V BRYANDirector2012-05-15Sell8,90013,400$38.51342.74114.9113,400 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-05-15Sell10,00059,030$38.64386.4114.1859,030 (Direct)
LAWLIS V BRYANDirector2012-05-15Sell8,90010,900$38.51342.74114.9110,900 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-14Sell40,500168,691$38.061541.43117.45168,691 (Direct)
Cooper Jeffrey HSVP, CFO2012-05-14Sell25,25041,089$38.09961.77117.2741,089 (Direct)
Wood MarkVP, Human Resources2012-05-11Sell2,43731,114$3892.61117.7931,114 (Direct)
Davis George EricSVP, General Counsel2012-05-11Sell42,30951,322$37.911603.93118.3151,322 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2012-05-11Sell26,16059,030$37.82989.37118.8359,030 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-08Sell20,000113,191$36.38727.6127.49113,191 (Direct)
Mueller BrianVP, Corporate Controller2012-05-08Sell15,70813,684$37.5589.05120.6913,684 (Direct)
Mueller BrianVP, Corporate Controller2012-05-08Sell15,70813,684$37.5589.05120.6913,684 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-04Sell20,000113,191$36.34726.8127.74113,191 (Direct)
BIENAIME JEAN JACQUESCEO2012-05-02Sell30,000113,191$35.241057.2134.85113,191 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-05-01Sell5,00030,018$34.99174.95136.5230,018 (Direct)
BIENAIME JEAN JACQUESCEO2012-04-27Sell22,000112,093$34.99769.78136.52112,093 (Direct)
Wood MarkVP, Human Resources2012-04-23Sell1,85320,634$34.5464139.6120,634 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-04-20Sell7,69128,920$35269.19136.4628,920 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-04-02Sell5,00036,611$34.08170.4142.8436,611 (Direct)
Wood MarkVP, Human Resources2012-03-22Sell1,85520,634$35.6566.13132.1520,634 (Direct)
BIENAIME JEAN JACQUESCEO2012-03-09Sell15,000114,093$34.46516.9140.16114,093 (Direct)
BIENAIME JEAN JACQUESCEO2012-03-08Sell1,000114,093$3535136.46114,093 (Direct)
BIENAIME JEAN JACQUESCEO2012-02-29Sell1,000115,093$36.2636.26128.24115,093 (Direct)
LAPALME PIERREDirector2012-02-28Sell20,00022,750$36.01720.2129.8321,250 (Direct)
1,500 (Shares held by spouse)
BIENAIME JEAN JACQUESCEO2012-02-27Sell5,000116,093$35.64178.2132.21116,093 (Direct)
BAFFI ROBERTEVP, Technical Operations2012-02-24Sell91,31383,493$34.843181.34137.5483,493 (Direct)
Mueller BrianVP, Corporate Controller2012-02-24Sell5,0008,300$35.07175.35135.998,300 (Direct)
Cooper Jeffrey HSVP, CFO2012-02-24Sell83,03640,104$35.072912.07135.9940,104 (Direct)
BIENAIME JEAN JACQUESCEO2012-02-23Sell5,000121,093$35.31176.55134.38121,093 (Direct)
Wood MarkVP, Human Resources2012-02-22Sell1,85420,634$35.1465.15135.5220,634 (Direct)
Wood MarkVP, Human Resources2012-02-02Sell6,50020,634$38247117.7920,634 (Direct)
Wood MarkVP, Human Resources2012-01-23Sell1,85420,634$34.9664.82136.7320,634 (Direct)
Cooper Jeffrey HSVP, CFO2012-01-03Sell2,50040,104$34.7586.88138.1640,104 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2012-01-03Sell2,50036,611$34.7586.88138.1636,611 (Direct)
Wood MarkVP, Human Resources2011-12-22Sell1,85420,634$33.7962.65144.9220,634 (Direct)
Wood MarkVP, Human Resources2011-11-22Sell1,85520,634$32.1859.69157.1820,634 (Direct)
Davis George EricSVP, General Counsel2011-11-01Sell26039,651$33.238.64149.0539,651 (Direct)
Cooper Jeffrey HSVP, CFO2011-11-01Sell2,50040,104$33.2683.15148.8340,104 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-10-28Sell16,87546,478$35590.63136.4646,478 (Direct)
Wood MarkVP, Human Resources2011-10-24Sell1,85320,634$33.3261.74148.3820,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-10-10Sell18,37939,876$34624.89143.4139,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-10-03Sell2,50036,455$3177.5166.9736,455 (Direct)
Cooper Jeffrey HSVP, CFO2011-09-28Sell18,37939,876$32588.13158.6339,876 (Direct)
BIENAIME JEAN JACQUESCEO2011-09-28Sell1,000126,093$3232158.63126,093 (Direct)
Wood MarkVP, Human Resources2011-09-22Sell1,85420,634$29.9255.47176.620,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-09-01Sell2,50039,876$29.4173.53181.439,876 (Direct)
Wood MarkVP, Human Resources2011-08-31Sell83420,634$3025.02175.8720,634 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-30Sell2,000127,093$29.0158.02185.28127,093 (Direct)
Wood MarkVP, Human Resources2011-08-22Sell1,02020,634$27.0327.57206.1820,634 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-19Sell2,000127,093$26.7553.5209.38127,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-12Sell3,000127,093$27.181.3205.39127,093 (Direct)
BAFFI ROBERTEVP, Technical Operations2011-08-02Sell18,68783,160$30.55570.89170.983,160 (Direct)
BIENAIME JEAN JACQUESCEO2011-08-02Sell8,000127,093$30.27242.16173.41127,093 (Direct)
Cooper Jeffrey HSVP, CFO2011-08-02Sell18,03639,876$30.47549.56171.6139,876 (Direct)
Davis George EricSVP, General Counsel2011-07-29Sell3,80039,651$31117.8166.9739,651 (Direct)
Davis George EricSVP, General Counsel2011-07-22Sell3,80039,651$30.5115.9171.3439,651 (Direct)
Wood MarkVP, Human Resources2011-07-22Sell1,85520,634$30.2956.19173.2320,634 (Direct)
Wood MarkVP, Human Resources2011-07-14Sell10,83320,634$30324.99175.8720,634 (Direct)
Cooper Jeffrey HSVP, CFO2011-07-14Sell18,37839,876$30551.34175.8739,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-14Sell5,00036,455$30150175.8736,455 (Direct)
BIENAIME JEAN JACQUESCEO2011-07-14Sell1,000131,093$3030175.87131,093 (Direct)
Cooper Jeffrey HSVP, CFO2011-07-01Sell2,50039,876$27.568.75200.9539,876 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-01Sell2,50036,455$27.6869.2198.9936,455 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-07-01Sell2,50036,455$27.6869.2198.9936,455 (Direct)
Wood MarkVP, Human Resources2011-06-23Sell2,01620,634$25.8652.13220.0320,634 (Direct)
Wood MarkVP, Human Resources2011-06-07Sell45620,005$27.4612.52201.3820,005 (Direct)
BIENAIME JEAN JACQUESCEO2011-06-06Sell2,000132,093$27.3954.78202.15132,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-31Sell710129,093$2819.88195.57129,093 (Direct)
Davis George EricSVP, General Counsel2011-05-31Sell3,80038,151$28.5108.3190.3938,151 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-27Sell290129,803$288.12195.57129,803 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-05-26Sell49,68943,978$271341.6206.5243,978 (Direct)
Cooper Jeffrey HSVP, CFO2011-05-26Sell17,50037,876$27.5481.25200.9537,876 (Direct)
Davis George EricSVP, General Counsel2011-05-26Sell3,80038,151$27.5104.5200.9538,151 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-25Sell1,000103,093$26.9426.94207.2103,093 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-25Sell1,000130,093$26.9426.94207.2130,093 (Direct)
Wood MarkVP, Human Resources2011-05-24Sell1,64619,211$25.842.47220.7819,211 (Direct)
Wood MarkVP, Human Resources2011-05-13Sell1,03219,211$26.6827.53210.1919,211 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-10Sell40087,593$25.8710.35219.9187,593 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-05Sell20087,993$25.645.13222.7887,993 (Direct)
BIENAIME JEAN JACQUESCEO2011-05-04Sell7,70088,193$26.6204.82211.1388,193 (Direct)
ASELAGE STEVEEVP, Chief Business Officer2011-05-03Sell10,31131,478$27.15279.94204.8331,478 (Direct)
Davis George EricSVP, General Counsel2011-05-02Sell1,5300$27.0941.45205.5Link
Wood MarkVP, Human Resources2011-04-25Sell1,6460$26.3543.37214.08Link
FUCHS HENRY JEVP, Chief Medical Officer2011-04-20Sell13,1650$27355.46206.52Link
Davis George EricSVP, General Counsel2011-04-13Sell3,8000$26.5100.7212.3Link
Wood MarkVP, Human Resources2011-04-13Sell7080$2618.41218.31Link
FUCHS HENRY JEVP, Chief Medical Officer2011-04-01Sell2,5000$25.4563.63225.19Link
Wood MarkVP, Human Resources2011-03-22Sell9380$23.4221.97253.37Link
Davis George EricSVP, General Counsel2011-03-09Sell6,0000$24.49146.94237.93Link
FUCHS HENRY JEVP, Chief Medical Officer2011-03-01Sell8340$24.1820.17242.27Link
LAPALME PIERREDirector2011-02-24Sell15,1000$24.95376.75231.7Link
Wood MarkVP, Human Resources2011-02-22Sell1,6450$26.3443.33214.2Link
Wood MarkVP, Human Resources2011-02-01Sell1,33414,243$2634.68218.3114,243 (Direct)
FUCHS HENRY JEVP, Chief Medical Officer2011-02-01Sell83331,000$25.7621.46221.2731,000 (Direct)
Wood MarkVP, Human Resources2011-01-24Sell93814,243$25.7324.13221.6514,243 (Direct)
BIENAIME JEAN JACQUESCEO2011-01-18Sell3,50090,067$26.5893.03211.36Link
FUCHS HENRY JEVP, Chief Medical Officer2011-01-03Sell83331,000$26.9922.48206.63Link
Wood MarkVP, Human Resources2010-12-22Sell2,47914,243$28.2169.93193.37Link
FUCHS HENRY JEVP, Chief Medical Officer2010-12-20Sell5,00031,000$28140195.57Link
BIENAIME JEAN JACQUESCEO2010-12-13Sell1,00093,567$27.4327.43201.71Link
BIENAIME JEAN JACQUESCEO2010-12-06Sell1,00093,567$27.1727.17204.6Link
BIENAIME JEAN JACQUESCEO2010-12-06Sell2,00093,567$27.1754.34204.6Link
FUCHS HENRY JEVP, Chief Medical Officer2010-12-01Sell83431,000$27.0822.58205.61Link
Cooper Jeffrey HSVP, CFO2010-11-24Sell11,25026,810$27.5309.38200.95Link
Davis George EricSVP, General Counsel2010-11-24Sell5,00027,901$27.5137.5200.95Link
BIENAIME JEAN JACQUESCEO2010-11-23Sell1,00093,567$27.0227.02206.29Link
Wood MarkVP, Human Resources2010-11-22Sell2,47914,243$26.665.94211.13Link
ASELAGE STEVEEVP, Chief Business Officer2010-11-18Sell39,87529,881$25.841030.37220.28Link
BIENAIME JEAN JACQUESCEO2010-11-18Sell1,00093,567$25.9925.99218.43Link
BIENAIME JEAN JACQUESCEO2010-11-08Sell2,00093,567$25.7851.56221.02Link
Davis George EricSVP, General Counsel2010-11-04Sell10,37127,901$25.83267.88220.4Link
Davis George EricSVP, General Counsel2010-11-04Sell10,37127,901$25.83267.88220.4Link
BAFFI ROBERTEVP, Technical Operations2010-11-03Sell2,00067,713$25.2450.48227.89Link
BAFFI ROBERTEVP, Technical Operations2010-11-03Sell2,00067,713$25.2450.48227.89Link
BIENAIME JEAN JACQUESCEO2010-11-03Sell7,50093,567$25.54191.55224.04Link
FUCHS HENRY JEVP, Chief Medical Officer2010-11-01Sell2,43531,000$25.7662.73221.27Link
Wood MarkVP, Human Resources2010-10-29Sell36,75014,243$26955.5218.31Link
Cooper Jeffrey HSVP, CFO2010-10-29Sell28,75026,486$25.32727.95226.86Link
Cooper Jeffrey HSVP, CFO2010-10-25Sell15,20926,486$24365.02244.83Link
Wood MarkVP, Human Resources2010-10-22Sell93714,243$23.5222.04251.87Link
FUCHS HENRY JEVP, Chief Medical Officer2010-10-01Sell83331,000$22.318.58271.12Link
Wood MarkVP, Human Resources2010-09-22Sell93814,243$22.9221.5261.08Link
Cooper Jeffrey HSVP, CFO2010-09-13Sell6,00026,486$22.85137.1262.19Link
BIENAIME JEAN JACQUESCEO2010-09-08Sell1,00095,067$22.2222.22272.46Link
ASELAGE STEVEEVP, Chief Business Officer2010-09-08Sell35,00037,587$22770276.18Link
Wood MarkVP, Human Resources2010-09-07Sell93714,243$21.5120.15284.75Link
BIENAIME JEAN JACQUESCEO2010-09-02Sell4,00095,067$20.9783.88294.66Link
FUCHS HENRY JEVP, Chief Medical Officer2010-09-01Sell83431,000$20.8817.41296.36Link
BIENAIME JEAN JACQUESCEO2010-08-30Sell3,00099,067$20.7162.13299.61Link
BIENAIME JEAN JACQUESCEO2010-08-30Sell3,00099,067$20.7162.13299.61Link
BIENAIME JEAN JACQUESCEO2010-08-27Sell3,00099,067$20.6862.04300.19Link
Davis George EricSVP, General Counsel2010-08-20Sell15,65727,901$20.57322.06302.33Link
Wood MarkVP, Human Resources2010-07-26Sell2,50014,243$2152.5294.1Link
FUCHS HENRY JEVP, Chief Medical Officer2010-07-23Sell83331,000$2016.66313.8Link
Wood MarkVP, Human Resources2010-06-23Sell37214,243$19.797.36318.19Link
Wood MarkVP, Human Resources2010-06-08Sell47014,615$18.878.87338.58Link
FUCHS HENRY JEVP, Chief Medical Officer2010-06-02Sell83431,000$2016.68313.8Link
Wood MarkVP, Human Resources2010-05-13Sell54612,835$21.7511.88280.51Link
Wood MarkVP, Human Resources2010-05-12Sell9388,081$21.4120.08286.55Link
Wood MarkVP, Human Resources2010-05-06Sell3138,081$21.036.58293.53Link
FUCHS HENRY JEVP, Chief Medical Officer2010-05-03Sell2,27520,000$22.851.87262.98Link
Wood MarkVP, Human Resources2010-04-12Sell9378,081$23.8122.31247.59Link
Wood MarkVP, Human Resources2010-04-05Sell3128,081$24.637.68236.01Link
FUCHS HENRY JEVP, Chief Medical Officer2010-04-01Sell5,83320,000$24139.99244.83Link
Wood MarkVP, Human Resources2010-03-12Sell9388,081$22.1720.8273.3Link
BAFFI ROBERTEVP, Technical Operations2010-03-10Sell163,88860,588$22.523690.76267.552,350 (Direct)
8,238 (Shares held by Baffi Family Trust)
ASELAGE STEVEEVP, Chief Business Officer2010-03-08Sell35,50619,855$21.99780.78276.35Link
Wood MarkVP, Human Resources2010-03-08Sell3138,081$22.146.93273.8Link
KLEIN JOSEPH IIIDirector2010-03-08Sell10,00035,000$22.12221.2274.14Link
ASELAGE STEVEEVP, Chief Business Officer2010-03-03Sell10,00031,271$21210294.1Link
Wood MarkVP, Human Resources2010-03-02Sell1,2498,081$2126.23294.1Link
ASELAGE STEVEEVP, Chief Business Officer2010-03-02Sell10,00041,271$21210294.1Link
BIENAIME JEAN JACQUESCEO2010-02-26Buy80048,740$20.0816.06312.15Link
Wood MarkVP, Human Resources2010-02-03Sell3778,081$217.92294.1Link
Wood MarkVP, Human Resources2010-01-21Sell1448,081$21.053.03293.16Link
BIENAIME JEAN JACQUESCEO2010-01-19Sell3,50050,440$20.8973.12296.17Link
Wood MarkVP, Human Resources2010-01-19Sell17,4998,081$21367.48294.1Link
BIENAIME JEAN JACQUESCEO2009-12-22Sell1,50053,940$18.8328.25339.51Link
Davis George EricVP, General Counsel2009-12-02Sell21,00020,453$17.25362.25379.77Link
Wood MarkVP, Human Resources2009-08-28Sell1778,081$16.52.92401.58Link
BIENAIME JEAN JACQUESCEO2009-08-10Sell4,00055,440$15.9563.8418.87Link
Wood MarkVP, Human Resources2009-07-08Sell4568,081$13.896.33495.82
Wood MarkVP, Human Resources2009-06-23Sell3637,287$14.755.35461.08
BIENAIME JEAN JACQUESCEO2009-06-12Buy1,50051,940$14.5221.78469.97
Davis George EricVP, General Counsel2009-06-11Sell2,50016,203$14.4736.18471.94
MEIER RICHARD ADirector2009-06-05Buy2,00010,250$13.727.4504.09
MEIER RICHARD ADirector2009-03-13Buy1,0004,250$11.4511.45622.79
BIENAIME JEAN JACQUESDirector2009-03-05Buy1,00011,917$10.0410.04724.3
KLEIN JOSEPH IIIDirector2009-03-05Buy5,00042,500$10.0750.35721.85
MEIER RICHARD ADirector2009-03-03Buy2,0003,250$10.9321.86657.18
KLEIN JOSEPH IIIDirector2009-03-03Buy5,00037,500$10.5652.8683.71
KAKKIS EMIL DChief Medical Officer2009-03-02Sell7,89739,621$11.792.39607.35
KLEIN JOSEPH IIIDirector2009-02-24Buy10,00032,500$12.08120.8585.1
KAKKIS EMIL DChief Medical Officer2009-02-03Sell17,00039,621$19.14325.38332.39
Wood MarkVP, Human Resources2009-01-22Sell178650$19.293.43329.03
Wood MarkVP, Human Resources2009-01-16Sell2,501650$2152.52294.1
KAKKIS EMIL DChief Medical officer2009-01-02Sell17,00039,621$17.57298.69371.03
Wood MarkVP, Human Resources2008-12-22Sell177650$17.183.04381.72
BIENAIME JEAN JACQUESCEO, Director2008-12-08Sell4,00010,917$1768386.82
BIENAIME JEAN JACQUESCEO, Director2008-12-08Buy4,00014,917$17.268.8381.16
Davis George EricVP, General Counsel2008-12-04Sell7,0008,180$16.3114.1407.73
LAPALME PIERREDirector2008-12-03Buy2,4001,500$15.336.72440.92
KAKKIS EMIL DCHIEF MEDICAL OFFICER2008-12-01Sell17,00039,621$15.87269.79421.49
Wood MarkVP, Human Resources2008-11-28Sell177650$16.52.92401.58
KAKKIS EMIL DChief Medical Officer2008-11-25Sell75,00039,621$15.981198.5417.9
Wood MarkVP, Human Resources2008-10-21Sell177650$20.223.58309.3
KAKKIS EMIL DChief Medical Officer2008-10-01Sell18,000115,304$26.27472.86215.04
Wood MarkVP, Human Resources2008-09-22Sell2,468650$28.0369.18195.26
KAKKIS EMIL DChief Medical Officer2008-09-02Sell18,000115,304$30.19543.42174.13
BAFFI ROBERTSVP, Technical Operations2008-09-02Sell11,52838,434$31.31360.94164.32
Wood MarkVP, Human Resources2008-08-21Sell2,469650$26.164.44217.09
KAKKIS EMIL DChief Medical Officer2008-08-01Sell18,000127,304$32.48584.64154.8
BAFFI ROBERTSVP, Technical Operations2008-07-30Sell9,22848,734$31.69292.44161.15
BAFFI ROBERTSVP, Technical Operations2008-07-30Sell10,30038,434$31.98329.39158.79
Wood MarkVP, Human Resources2008-07-21Sell2,468650$30.2774.71173.41
Davis George EricVP, General Counsel2008-07-15Sell5,00014,994$28140195.57
Wood MarkVP, Human Resources2008-07-08Sell350650$28.029.81195.36
KAKKIS EMIL DChief Medical Officer2008-07-07Sell18,000145,304$28.06505.08194.94
Swiedler Stuart JSVP, Clinical Affairs2008-07-01Sell15,00010,000$28.34425.1192.03
BAFFI ROBERTSVP, Technical Operations2008-06-30Sell3,52836,434$30.01105.88175.77
Wood MarkVP, Human Resources2008-06-23Sell2,2920$32.6174.74153.79
BIENAIME JEAN JACQUESCEO, Director2008-06-05Sell3,0003,567$39117112.21
Wood MarkVP, Human Resources2008-06-04Sell1,3230$37.6649.82119.76
KAKKIS EMIL DChief Medical Officer2008-06-02Sell18,000160,804$37.63677.34119.93
BAFFI ROBERTSVP, Technical Operatons2008-05-30Sell1,10036,434$38.7142.58113.79
BAFFI ROBERTSVP, Technical Operations2008-05-30Sell10,42837,534$38.44400.85115.3
Wood MarkVP, Human Resources2008-05-21Sell1,6670$39.0965.16111.72
BIENAIME JEAN JACQUESCEO, Director2008-05-15Sell5,0003,567$39.11195.55111.61
Davis George EricVP, General Counsel2008-05-13Sell10,0005,807$39.13391.3111.5
BIENAIME JEAN JACQUESCEO, Director2008-05-12Sell13,0003,567$38.91505.83112.7
ASELAGE STEVESVP, Global Commercial Dev.2008-05-06Sell20,00028,665$37.75755119.23
BIENAIME JEAN JACQUESCEO, Director2008-05-05Sell22,5533,567$36.97833.78123.86
KAKKIS EMIL DChief Medical Officer2008-05-01Sell18,000162,804$37.49674.82120.75
Davis George EricVP, General Counsel2008-04-30Sell4005,807$36.7314.69125.32
Davis George EricVP, General Counsel2008-04-30Sell4,6006,207$36.3166.98127.99
Wood MarkVP, Human Resources2008-04-21Sell2,9900$33.99101.63143.48
BAFFI ROBERTSVP, Technical Operations2008-04-02Sell22,96550,477$36.88846.95124.4
BAFFI ROBERTSVP, Technical Operations2008-04-02Sell15,79734,680$37.11586.23123.01
KAKKIS EMIL DChief Medical Officer2008-04-01Sell9,85786,164$35.9353.87130.53
KAKKIS EMIL DChief Medical Officer2008-04-01Sell8,14396,021$35.75291.11131.5
Swiedler Stuart JSVP, Clinical Affairs2008-04-01Sell12,50010,000$36.02450.25129.76
ASELAGE STEVESVP, Global Commercial Dev2008-04-01Sell80532,034$36.0529.02129.57
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell11,30934,680$36.19409.27128.68
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell14,18945,989$35.87508.96130.72
BAFFI ROBERTSVP, Technical Operations2008-03-25Sell9,50060,178$35.52337.44133
Wood MarkVP, Human Resources2008-03-24Sell2,9890$35.05104.76136.12
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell7,57634,680$32.75248.11152.7
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell26,53642,256$32.46861.36154.96
BAFFI ROBERTSVP, Technical Operations2008-03-18Sell12,12868,792$32.13389.67157.58
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell6,64334,680$34.33228.05141.07
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell11,95741,323$33.59401.64146.38
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell12,64353,280$33.15419.12149.65
BAFFI ROBERTSVP, Technical Operations2008-03-14Sell7,00065,923$32.81229.67152.24
HERON ELAINE JDirector2008-03-06Sell3,63830,000$38.34139.48115.86
HERON ELAINE JDirector2008-03-06Sell16,45133,638$38.11626.95117.16
HERON ELAINE JDirector2008-03-06Sell9,91150,089$37.7373.64119.52
KAKKIS EMIL DChief Medical Officer2008-03-06Sell18,00086,164$38.16686.88116.88
GREY MICHAEL GDirector2008-03-05Sell3,5005,000$38.41134.44115.46
GREY MICHAEL GDirector2008-03-05Sell21,5008,500$38.17820.66116.82
HERON ELAINE JDirector2008-03-03Sell20,0000$38.47769.4115.13
Davis George EricVP, General Counsel2008-03-03Sell20,0003,397$38760117.79
ASELAGE STEVESVP, Global Commercial Dev2008-03-03Sell40,00032,034$381520117.79
KLEIN JOSEPH IIIDirector2008-03-03Sell10,00030,000$38.03380.3117.62
KLEIN JOSEPH IIIDirector2008-03-03Sell20,00020,000$37.92758.4118.25
BIENAIME JEAN JACQUESCEO, Director2008-02-29Sell27,1424,071$38.11034.11117.22
LAPALME PIERREDirector2008-02-29Sell5,9756,600$38.43229.62115.35
LAPALME PIERREDirector2008-02-29Sell9,02512,575$37.8341.15118.94
Cooper Jeffrey HSVP, CFO2008-02-29Sell5,9051,005$37.94224.04118.13
Cooper Jeffrey HSVP, CFO2008-02-29Sell49,7206,910$37.621870.47119.99
Wood MarkVP, Human Resources2008-02-21Sell2,9900$36.46109.02126.99
Wood MarkVP, Human Resources2008-01-22Sell2,9900$36.26108.42128.24
BIENAIME JEAN JACQUESCEO, Director2008-01-02Sell15,0007,213$36.07541.05129.44
Swiedler Stuart JSVP, Clinical Affairs2008-01-02Sell12,50010,000$36.08451129.38
ASELAGE STEVESVP, Global Commercial Dev2008-01-02Sell5,0007,034$36.08180.4129.38
Wood MarkVP, Human Resources2007-12-21Sell6,1140$36.06220.47129.51
BIENAIME JEAN JACQUESCEO, Director2007-12-17Sell15,0007,213$35.53532.95132.93
Wood MarkVP, Human Resources2007-11-21Sell2,3650$25.8661.16220.03
Wood MarkVP, Human Resources2007-10-22Sell1,5320$25.338.76227.11
Davis George EricVP, General Counsel2007-10-11Sell5,0002,607$27.34136.7202.71
Cooper Jeffrey HSVP, CFO2007-10-08Sell12,3800$26321.88218.31
Wood MarkVP, Human Resources2007-10-08Sell8,3330$26216.66218.31
ASELAGE STEVESVP, Global Commercial Dev2007-10-01Sell5,0004,895$25.09125.45229.85
BIENAIME JEAN JACQUESCEO2007-10-01Sell20,0006,695$25500231.04
Swiedler Stuart JSVP, Clinical Affairs2007-10-01Sell12,50010,000$25.1313.75229.72
Davis George EricVP, General Counsel2007-10-01Sell5,0002,607$25.1125.5229.72
Cooper Jeffrey HSVP, CFO2007-09-26Sell12,5000$24.5306.25237.8
BIENAIME JEAN JACQUESCEO2007-09-25Sell10,0006,695$24240244.83
Wood MarkVP, Human Resources2007-09-21Sell5,9060$23.25137.31255.96
BIENAIME JEAN JACQUESCEO2007-09-19Sell10,0006,695$23230259.83
BAFFI ROBERTSVP, Technical Operations2007-09-14Sell22,70733,124$22.64514.09265.55
BAFFI ROBERTSVP, Technical Operations2007-09-14Sell67,29355,831$22.481512.75268.15
ASELAGE STEVESVP, Global Commercial Dev.2007-09-14Sell10,0004,895$22.4224269.46
Cooper Jeffrey HSVP, CFO2007-09-06Sell13,5360$22.5304.56267.82
Cooper Jeffrey HSVP, CFO2007-08-17Sell20,0000$20.29405.8307.89
BIENAIME JEAN JACQUESCEO2007-08-17Sell10,0006,695$21210294.1
Davis George EricVP, General Counsel2007-08-15Sell4,0002,607$20.2681.04308.49
LEWIS ALANDirector2007-08-10Sell20,00010,000$20.08401.6312.15
ASELAGE STEVESVP, Global Commercial Dev2007-08-10Sell20,0004,895$20.27405.4308.29
Wood MarkVP, Human Resources2007-08-10Sell2,6330$21.0855.5292.6
BIENAIME JEAN JACQUESCEO2007-08-10Sell35,8866,695$20.2724.9309.7
Cooper Jeffrey HSVP, CFO2007-08-08Sell12,5000$21262.5294.1
BIENAIME JEAN JACQUESCEO2007-08-03Sell2,0006,695$18.0336.06359.01
BIENAIME JEAN JACQUESCEO2007-07-05Sell2,0008,695$18.2936.58352.49
Swiedler Stuart JSVP, Clinical Affairs2007-07-02Sell12,50010,000$18.18227.25355.23
BIENAIME JEAN JACQUESCEO2007-06-25Sell2,50010,695$17.6544.13368.9
Wood MarkVP, Human Resources2007-06-07Sell1,0450$17.5418.33371.84
BIENAIME JEAN JACQUESCEO2007-06-04Sell12,50013,195$18.34229.25351.25
BIENAIME JEAN JACQUESCEO2007-05-21Sell2,00015,695$18.5637.12345.91
BIENAIME JEAN JACQUESCEO2007-05-03Sell15,00017,695$16.79251.85392.91
BIENAIME JEAN JACQUESCEO2007-05-02Sell1,50015,142$16.4324.65403.71
BIENAIME JEAN JACQUESCEO2007-04-04Sell6,50016,642$17.87116.16363.12
Swiedler Stuart JSVP, Clinical Affairs2007-04-02Sell12,50010,000$17.3216.25378.38
KLEIN JOSEPH IIIDirector2007-03-07Sell12,0000$16.37196.44405.56
BIENAIME JEAN JACQUESCEO2007-03-02Sell1,50018,142$16.4824.72402.18
Davis George EricVP, General Counsel2007-02-22Sell13,0000$18.37238.81350.52
BIENAIME JEAN JACQUESCEO2007-02-22Sell14,00019,642$17.06238.84385.11
ASELAGE STEVESVP, Global Commercial Ops2007-02-14Sell15,0002,829$20300313.8
Swiedler Stuart JSVP, Clinical Affairs2007-01-03Sell12,50010,000$16.3203.75407.73
LAPALME PIERREDirector2006-12-12Buy2,1005,500$17.8837.55362.86
LAPALME PIERREDirector2006-12-12Buy2,1006,600$17.8837.55362.86
Cooper Jeffrey HChief Financial Officer2006-12-06Sell14,5000$18261359.78
ASELAGE STEVESVP, Global Commercial Ops2006-11-29Sell5,0002,829$17.2386.15380.33
Swiedler Stuart JSVP, Clinical Affairs2006-11-01Sell12,50010,000$15.92199419.85
Cooper Jeffrey HVP, CFO2006-08-29Sell26,0000$16416417.25Link
KLEIN JOSEPH IIIDirector2006-08-09Sell20,00022,000$15.52310.4433.25Link
LAPALME PIERREDirector2006-08-07Buy1,0004,500$15.3515.35439.15Link
Swiedler Stuart JSVP, Clinical Affairs2006-08-01Sell12,50010,000$14.34179.25477.13Link
BIENAIME JEAN JACQUESCEO2006-08-01Buy1,50030,881$14.521.75470.76Link
BIENAIME JEAN JACQUESCEO2006-07-03Buy1,50029,381$14.4421.66473.13Link
BIENAIME JEAN JACQUESCEO2006-06-14Buy2,50027,881$13.2433.1525.08Link
BIENAIME JEAN JACQUESCEO2006-06-01Buy1,50025,381$13.0519.58534.18Link
BIENAIME JEAN JACQUESCEO2006-05-18Buy1,00023,881$1212589.67Link
BIENAIME JEAN JACQUESCEO2006-05-08Buy1,00022,881$12.7812.78547.57Link
BIENAIME JEAN JACQUESCEO2006-05-01Buy1,50018,500$12.5918.89557.35Link
BIENAIME JEAN JACQUESCEO2006-04-03Buy1,50017,000$13.3520.03519.93Link
Cooper Jeffrey HCFO2006-03-16Sell12,5000$14.85185.63457.31Link
Cooper Jeffrey HCFO2006-03-01Sell15,5000$13.25205.38524.6Link
BIENAIME JEAN JACQUESCEO2006-03-01Buy1,50015,500$12.9919.49537.11Link
Cooper Jeffrey HCFO2006-02-27Sell1,0000$13.2513.25524.6Link
LAPALME PIERREDirector2006-02-27Buy3,5003,500$12.9945.47537.11Link
SAGER ERICHDirector2006-02-24Sell11,5003,309$12.64145.36554.75Link
SAGER ERICHDirector2006-02-22Sell1,0003,309$12.212.2578.36Link
Swiedler Stuart JSVP, Clinical Affairs2006-02-01Sell10,00010,000$11.55115.5616.54Link
BIENAIME JEAN JACQUESCEO2006-02-01Buy1,50014,000$11.6717.51609.17Link
SAGER ERICHDirector2006-01-27Sell2,5003,309$12.230.5578.36Link
BIENAIME JEAN JACQUESCEO2006-01-03Buy1,50012,500$10.7916.19667.01Link
BIENAIME JEAN JACQUESCEO2005-12-12Buy1,00011,000$10.2110.21710.58Link
SAGER ERICHDirector2005-12-05Sell7,5003,309$10.780.25673.46Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2005-12-01Sell10,571295,176$10105.71727.6Link
SAGER ERICHDirector2005-12-01Sell22,5000$10.42234.45694.24Link
BIENAIME JEAN JACQUESCEO2005-12-01Buy1,50010,000$9.9414.91732.6Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2005-11-21Sell10,571300,176$10105.71727.6Link
Swiedler Stuart JSVP, Clinical Affairs2005-11-21Sell30,00010,000$10300727.6Link
BIENAIME JEAN JACQUESCEO2005-11-01Buy1,5008,500$8.3712.56888.77Link
BIENAIME JEAN JACQUESCEO2005-10-12Buy5006,500$73.51082.29Link
BIENAIME JEAN JACQUESCEO2005-10-06Buy5006,500$84934.5Link
BIENAIME JEAN JACQUESCEO2005-10-03Buy1,5006,000$8.5112.77872.5Link
BIENAIME JEAN JACQUESCEO2005-09-01Buy4,5004,500$8.5838.61864.57Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-06-03Sell10,000305,176$7.6476.4983.25Link
BAFFI ROBERTSVP, Technical Operations2004-05-10Buy8,00014,931$6.1248.961252.29Link
KAKKIS EMIL DSVP, Business Operations2004-05-06Buy15,00026,110$6.4997.351175.19Link
PRICE FREDRIC DCEO2004-05-06Buy15,00079,285$6.3294.81209.49Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-04-02Sell5,570315,176$844.56934.5Link
STARR CHRISTOPHER MSVP, Chief Scientific Officer2004-04-01Sell5,000315,176$7.5637.8994.71Link
SAGER ERICHDirector2004-01-02Sell20,0003,309$7.81156.2959.67Link
KAKKIS EMIL DSVP, Business Operations2003-12-29Sell10,18711,110$7.5777.12993.26Link
STARR CHRISTOPHER MSr. VP, Scientific Operations2003-08-21Sell33,000320,176$9297819.56Link
WILLIAMS GWYNNDirector2003-07-28Sell68,700812,565$10687727.6Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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