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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Jay Venkatesan, M.D.N/A3,826,7234.03%2014-09-23
Dr. Lynn Kirkpatrick,PhDN/A800,2390.84%2007-12-10
Dr. Christopher S. Henney, PhDN/A135,8070.14%2014-06-12
Dr. Richard L. Jackson,PhDN/A59,557less than 0.1%2015-06-12
Mr. Daniel K. SpiegelmanN/A52,675less than 0.1%2015-06-12
W. Vickery StoughtonN/A46,692less than 0.1%2014-06-06
Gary ChristiansonN/A20,462less than 0.1%2014-12-16
Ms. Julie M. EastlandN/A20,016less than 0.1%2013-12-12
Dr. Douglas E. Williams,PhDN/A19,961less than 0.1%2013-06-09
Mr. Ted W. Love,M.D.N/A13,005less than 0.1%2015-09-05

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Venkatesan JayEVP and General Manager2014-09-23Buy250,000250,000$2500-54.5
250,000 (By Ayer Special Situations Fund I, LP)
BVF PARTNERS L P/IL10% Owner2013-11-01Buy129,0002,670,520$1.78229.62-48.88
2,670,520 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-08-08Buy258,3612,591,160$1.65426.3-44.85
2,591,160 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-08-01Buy338,0872,413,220$1.74588.27-47.7
2,413,220 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy214,4672,377,517$1.81388.19-49.72
2,377,517 (See Explanation of Responses)
Ayer Capital Management, LP10% Owner2011-06-23Sell28,9002,985,238$8.74252.59-89.59
2,985,238 (See footnote)
Karan Shashi K.Corporate Controller2010-09-28Buy5,10010,100$3.4117.39-73.31Link
Karan Shashi K.Corporate Controller2009-08-18Buy5,0005,000$5.0725.35-82.05Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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