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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Thomas J. Schall, PhDN/A2,139,6674.83%2015-12-31
Mr. Thomas A. EdwardsDirector91,9770.21%2016-05-17
Dr. Roger C. Lucas, PhDN/A67,0270.15%2015-05-21
Dr. Petrus (Pirow) Bekker, M.D.,PhDN/A53,5940.12%2013-08-07
Dr. Joseph M. FeczkoN/A37,027less than 0.1%2015-05-21
Dr. Juan C. Jaen, PhDN/A30,000less than 0.1%2013-03-07
Dr. Ira KleinN/A16,216less than 0.1%2015-05-21
James L. TyreeN/A14,324less than 0.1%2015-05-21
Mr. Geoffrey M. ParkerDirector13,514less than 0.1%2016-05-13
Dr. Markus J. Cappel, PhDN/A12,500less than 0.1%2015-03-05

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Edwards Thomas A.Director2016-05-17Buy50,00091,977$4.05202.57.991,977 (Direct)
Edwards Thomas A.Director2016-05-16Buy25,00041,977$4.05101.37.941,977 (Direct)
Parker Geoffrey M.Director2016-05-13Buy40,000118,114$4.03161.28.4413,514 (Direct)
99,600 (Geoffrey M Parker & Jill Gofen Parker Trustees of Geoffrey M Parker & Jill G Parker Revocable Trust)
5,000 (By Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
KANAYA SUSAN MSVP, Finance, CFO and Sec.
(Click for the stocks that their CFOs have bought)
2016-01-22Sell25,7640$4.04104.18.17Link
KANAYA SUSAN MSVP, Finance, CFO and Sec.
(Click for the stocks that their CFOs have bought)
2016-01-20Sell21,4050$4.0887.37.11Link
Parker Geoffrey M.Director2016-01-11Buy20,00078,114$4.6392.6-5.6213,514 (Direct)
59,600 (Geoffrey M Parker & Jill Gofen Parker Trustees of Geoffrey M Parker & Jill G Parker Revocable Trust)
5,000 (By Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
KANAYA SUSAN MSVP, Finance, CFO and Sec.
(Click for the stocks that their CFOs have bought)
2016-01-08Sell10,2240$5.1252.3-14.65Link
KANAYA SUSAN MSVP, Finance, CFO and Sec.
(Click for the stocks that their CFOs have bought)
2016-01-06Sell47,6070$6.98332.3-37.39Link
Parker Geoffrey M.Director2015-12-11Buy20,00058,114$7.25145-39.7213,514 (Direct)
39,600 (Geoffrey M Parker & Jill Gofen Parker Trustees of Geoffrey M Parker & Jill G Parker Revocable Trust)
5,000 (By Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
BIOTECHNOLOGY VALUE FUND L P2015-11-04Sell360,0001,251,914$72520-37.57
1,251,914 (See Explanation of Reponses)
BIOTECHNOLOGY VALUE FUND L P2015-11-02Sell50,0001,251,914$6.97348.5-37.3
1,251,914 (See Explanation of Reponses)
BVF PARTNERS L P/IL10% Owner2015-06-10Sell955,7001,251,914$98601.3-51.44
1,251,914 (See Explanation of Reponses)
Parker Geoffrey M.Director2015-05-27Sell13,51338,114$7.51101.5-41.8113,514 (Direct)
19,600 (By Geoffrey M Parker and Jill Gofen Parker Trustees of Geoffrey M Parker and Jill G Parker Revocable)
5,000 (By Delaware Charter Guarantee & Trust Company, Trustee FBO Mr. Geoffrey Monroe Parker IRA)
Tyree James LDirector2015-05-22Sell12,70314,324$7.4594.6-41.3414,324 (Direct)
KLEIN IRADirector2015-05-22Sell10,81116,216$7.4480.4-41.2616,216 (Direct)
Schall Thomas J.President and CEO
(Click for the stocks that their CEOs have bought)
2015-04-01Sell24,2672,148,667$7.5182-41.732,148,667 (Direct)
Schall Thomas J.President and CEO2015-03-25Sell9002,148,667$7.576.8-42.272,148,667 (Direct)
Schall Thomas J.President and CEO2015-03-24Sell50,3712,148,667$7.84394.9-44.262,148,667 (Direct)
Schall Thomas J.President and CEO2015-03-19Sell18,1462,148,667$8.34151.3-47.62,148,667 (Direct)
Schall Thomas J.President and CEO2015-03-17Sell31,3162,148,667$8.55267.8-48.892,148,667 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2015-03-09Sell34,12512,500$7.81266.5-44.0512,500 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2015-03-04Sell40,87512,500$7.98326.2-45.2412,500 (Direct)
Duliege Anne-MarieEVP, Chief of Strategic Dev.2014-11-18Sell4,9700$4.7123.4-7.22Link
Schall Thomas J.President and CEO2014-05-01Sell27,7262,148,667$5.59155-21.822,148,667 (Direct)
Schall Thomas J.President and CEO2014-04-29Sell32,2742,148,667$5.38173.6-18.772,148,667 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2014-04-22Sell20,96212,500$8.17171.3-46.5112,500 (Direct)
Schall Thomas J.President and CEO2014-03-17Sell20,0002,148,707$7.25145-39.722,148,707 (Direct)
Schall Thomas J.President and CEO2014-02-18Sell20,0002,148,707$7.05141-38.012,148,707 (Direct)
Parker Geoffrey M.Director2013-12-06Buy20,00024,600$5.15103-15.159,600 (Direct)
15,000 (By Geoffrey M Parker and Jill Gofen Parker Trustees of Geoffrey M Parker and Jill G Parker Revocable)
BVF PARTNERS L P/IL10% Owner2013-12-05Buy189,8003,750,277$5.01950.9-12.77
3,750,277 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-11-06Buy136,0663,750,277$4.92669.4-11.18
3,750,277 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-11-01Buy336,2253,750,277$4.991677.8-12.42
3,750,277 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-10-09Buy1,289,3543,750,277$5.346885.2-18.16
3,750,277 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-10-03Buy109,4253,750,277$5.49600.7-20.4
3,750,277 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-09-13Buy325,6353,750,277$5.951937.5-26.55
3,750,277 (See Explanation of Responses)
FECZKO JOSEPH MDirector2013-09-13Buy10,00010,000$6.0360.3-27.5310,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-08-13Sell5,45918,750$12.970.4-66.1218,750 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-08-07Sell5,00053,594$13.2666.3-67.0453,594 (Direct)
LUCAS ROGER CDirector2013-08-05Sell5,00040,000$13.4267.1-67.4440,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-08-01Sell6,25018,750$13.8286.4-68.3818,750 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-07-17Sell5,45925,000$14.5279.3-69.925,000 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-07-17Sell10,00053,594$14.54145.4-69.9453,594 (Direct)
Schall Thomas J.President and CEO2013-07-16Sell22,0892,148,687$14.39317.9-69.632,148,687 (Direct)
LUCAS ROGER CDirector2013-07-03Sell5,00045,000$13.4367.2-67.4645,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-07-02Sell6,25025,000$13.8886.8-68.5225,000 (Direct)
Schall Thomas J.President and CEO2013-07-01Sell3112,170,776$14.54.5-69.862,170,776 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2013-06-28Sell36,9420$14.31528.6-69.46Link
Bekker PetrusSVP of Medical & Clinical2013-06-27Sell5,00053,594$1470-68.7953,594 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-06-21Sell6,25031,250$1381.3-66.3831,250 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-06-18Sell1,78337,500$12.4722.2-64.9637,500 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-06-17Sell5,00053,594$1260-63.5853,594 (Direct)
LUCAS ROGER CDirector2013-06-03Sell5,00050,000$13.3266.6-67.1950,000 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2013-05-30Sell12,7700$14.28182.4-69.4Link
Cappel Markus J.Chief Bus. Officer & Treasurer2013-05-28Sell3,67637,500$14.151.8-69.0137,500 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-05-24Sell4,80053,594$1467.2-68.7953,594 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-05-20Sell20053,594$142.8-68.7953,594 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-05-17Sell15,00053,594$13.97209.6-68.7253,594 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-05-15Sell15,66837,500$14.08220.6-68.9637,500 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2013-05-15Sell7990$14.3811.5-69.61Link
LUCAS ROGER CDirector2013-05-15Sell5,00055,000$14.1170.6-69.0355,000 (Direct)
Schall Thomas J.President and CEO2013-05-15Sell7,6002,171,087$14.04106.7-68.872,171,087 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-04-11Sell1,50043,750$14.121.2-69.0143,750 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-04-11Sell3,97953,594$14.0355.8-68.8553,594 (Direct)
Schall Thomas J.President and CEO2013-04-11Sell2,5292,178,687$14.0235.5-68.832,178,687 (Direct)
LUCAS ROGER CDirector2013-04-03Sell5,00060,000$13.4967.5-67.6160,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-04-03Sell6,25043,750$13.4784.2-67.5643,750 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-04-02Sell1,02153,594$1414.3-68.7953,594 (Direct)
Schall Thomas J.President and CEO2013-04-02Sell7562,181,216$1410.6-68.792,181,216 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-03-19Sell5,05950,000$13.9670.6-68.750,000 (Direct)
Schall Thomas J.President and CEO2013-03-18Sell16,8012,181,972$14.1236.9-69.012,181,972 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-03-18Sell13,88953,594$13.9193.1-68.5653,594 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2013-03-15Sell1,9890$14.2728.4-69.38Link
Schall Thomas J.President and CEO2013-03-14Sell4,9052,198,773$1468.7-68.792,198,773 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-03-14Sell8,38853,594$14117.4-68.7953,594 (Direct)
Schall Thomas J.President and CEO2013-03-11Sell6,9482,203,678$1497.3-68.792,203,678 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-03-11Sell31,22153,594$13.9434-68.5653,594 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-03-11Sell40050,000$14.165.7-69.1450,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-03-08Sell2,79530,000$13.9739-68.7230,000 (Direct)
Bekker PetrusSVP of Medical & Clinical2013-03-06Sell11,50253,594$13.98160.8-68.7453,594 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-03-06Sell12,20532,795$13.97170.5-68.7232,795 (Direct)
Schall Thomas J.President and CEO2013-03-06Sell5,5412,210,626$14.0177.6-68.812,210,626 (Direct)
LUCAS ROGER CDirector2013-03-04Sell5,00065,000$13.8769.4-68.4965,000 (Direct)
Schall Thomas J.President and CEO2013-03-01Sell15,0002,216,167$13.61204.2-67.892,216,167 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-02-28Sell25,00050,000$13.22330.5-66.9450,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-28Sell12,59945,000$12.79161.1-65.8345,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-26Sell22,50045,000$12.23275.2-64.2745,000 (Direct)
Schall Thomas J.President and CEO2013-02-22Sell7,5002,231,167$12.0690.5-63.762,231,167 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2013-02-22Sell6660$11.917.9-63.31Link
Bekker PetrusSVP of Medical & Clinical2013-02-22Sell15,00053,594$12.07181.1-63.7953,594 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-21Sell22,20145,000$11.9264.2-63.2845,000 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2013-02-21Sell19,3340$11.91230.3-63.31Link
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-15Sell1,94553,000$11.7422.8-62.7853,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-02-13Sell5,45975,000$11.4562.5-61.8375,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-07Sell1,55553,000$11.6518.1-62.4953,000 (Direct)
LUCAS ROGER CDirector2013-02-07Sell1,14370,000$11.2712.9-61.2270,000 (Direct)
LUCAS ROGER CDirector2013-02-06Sell3,85771,143$11.5244.4-62.0771,143 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-04Sell3,87553,000$11.6945.3-62.6253,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-02-01Sell10,00553,000$11.58115.9-62.2653,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-01-29Sell7,69853,000$11.4388-61.7753,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-01-24Sell1,30053,000$11.3514.8-61.553,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-01-18Sell2,75975,000$11.1630.8-60.8475,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2013-01-17Sell2,70075,000$11.1630.1-60.8475,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-01-12Sell3,30553,000$11.3537.5-61.553,000 (Direct)
LUCAS ROGER CDirector2013-01-08Sell3,89975,000$11.0843.2-60.5675,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2013-01-04Sell6,01753,000$11.2767.8-61.2253,000 (Direct)
LUCAS ROGER CDirector2013-01-04Sell1,10178,899$11.0912.2-60.678,899 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2012-12-18Sell15,00053,000$11.05165.8-60.4553,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2012-12-18Sell4,84375,000$10.9453-60.0575,000 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2012-12-04Sell5,9270$11.9770.9-63.49Link
LUCAS ROGER CDirector2012-12-04Sell5,00080,000$11.9659.8-63.4680,000 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2012-11-29Sell4,0730$11.8948.4-63.25Link
Cappel Markus J.Chief Bus. Officer & Treasurer2012-11-26Sell20175,000$12.12.4-63.8875,000 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2012-11-23Sell2,18875,000$11.9426.1-63.475,000 (Direct)
Bekker PetrusSVP of Medical & Clinical2012-11-20Sell15,00053,594$11.94179.1-63.453,594 (Direct)
Schall Thomas J.President and CEO2012-11-20Sell2,1002,238,667$12.0125.2-63.612,238,667 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2012-11-20Sell1075,000$12.10.1-63.8875,000 (Direct)
Schall Thomas J.President and CEO2012-11-16Sell20,4002,240,767$12.58256.6-65.262,240,767 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2012-11-14Sell2,00053,000$12.9525.9-66.2553,000 (Direct)
LUCAS ROGER CDirector2012-11-06Sell5,00085,000$11.5958-62.385,000 (Direct)
BVF PARTNERS L P/IL10% Owner2012-11-06Buy40,0003,750,277$12480-63.58
3,750,277 (See Explanation of Responses)
Jaen Juan C.SVP, Drug Discovery & CSO2012-11-06Sell5,83355,000$12.0170.1-63.6155,000 (Direct)
Bekker PetrusSVP of Medical & Clinical2012-11-06Sell9,30062,500$12.01111.7-63.6162,500 (Direct)
Schall Thomas J.President and CEO2012-11-06Sell22,5002,279,167$12.01270.2-63.612,279,167 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2012-11-06Sell3,67675,000$12.144.5-63.8875,000 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2012-11-06Sell16,0290$11.91190.9-63.31Link
BVF PARTNERS L P/IL10% Owner2012-11-06Buy40,000376,150$12480-63.58
376,150 (See Explanation of Responses)
Cappel Markus J.Chief Bus. Officer & Treasurer2012-10-22Sell10,91875,000$10.87118.7-59.875,000 (Direct)
LUCAS ROGER CDirector2012-10-04Sell1,89390,000$11.4721.7-61.990,000 (Direct)
LUCAS ROGER CDirector2012-10-03Sell3,10791,893$11.3835.4-61.691,893 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2012-10-01Sell2,40060,833$11.9828.8-63.5260,833 (Direct)
KANAYA SUSAN MSVP, Finance, CFO and Sec.2012-10-01Sell3,9710$11.8947.2-63.25Link
Schall Thomas J.President and CEO2012-10-01Sell15,0002,301,667$11.53173-62.12,301,667 (Direct)
Cappel Markus J.Chief Bus. Officer & Treasurer2012-09-25Sell5,45975,000$11.8664.7-63.1575,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2012-09-25Sell7,40163,233$11.9688.5-63.4663,233 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2012-09-24Sell3,56670,634$11.9742.7-63.4970,634 (Direct)
Bekker PetrusSVP of Medical & Clinical2012-09-24Sell30062,500$12.023.6-63.6462,500 (Direct)
LUCAS ROGER CDirector2012-09-18Sell5,00095,000$11.8759.4-63.1895,000 (Direct)
Jaen Juan C.SVP, Drug Discovery & CSO2012-09-17Sell80074,200$12.059.6-63.7374,200 (Direct)
Bekker PetrusSVP of Medical & Clinical2012-09-17Sell40062,500$12.124.8-63.9462,500 (Direct)

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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