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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
David E. RobinsonN/A411,7251.97%2004-08-19
Mr. John L. HigginsCEO125,6640.6%2016-03-07
Dr. Martin D. MeglassonN/A102,2500.49%2010-05-11
Paul V. MaierN/A84,9510.41%2006-11-20
Mr. Matthew W. FoehrPresident and COO83,0370.4%2016-08-05
David M. KnottN/A66,1520.32%2015-08-17
Mr. Jason M. AryehDirector58,9590.28%2016-05-23
Todd C. DavisN/A56,2090.27%2016-05-23
Dr. John W. Kozarich,PhDDirector39,3170.19%2016-09-01
Mr. Sunil PatelN/A38,6470.19%2016-05-23

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
HIGGINS JOHN LCEO
(Click for the stocks that their CEOs have bought)
2016-09-22Sell3,000122,664$117.34352.02-2.68122,664 (Direct)
KOZARICH JOHN WDirector2016-09-07Sell1,00039,983$115115-0.739,983 (Direct)
KOZARICH JOHN WDirector2016-09-01Sell1,66639,317$105.4175.68.3439,317 (Direct)
FOEHR MATTHEW WPresident and COO2016-08-05Sell12,50083,037$122.141526.75-6.5183,037 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2016-08-05Sell22,06737,927$123.162717.77-7.2837,927 (Direct)
KOZARICH JOHN WDirector2016-08-01Sell1,00040,983$137.57137.57-16.9940,983 (Direct)
KOZARICH JOHN WDirector2016-07-01Sell1,00041,983$121.4121.4-5.9441,983 (Direct)
KOZARICH JOHN WDirector2016-06-01Sell1,00042,983$117.42117.42-2.7542,983 (Direct)
Herman Melanie JDirector of Accounting2016-05-18Sell3343,297$120.540.25-5.243,297 (Direct)
Aryeh JasonDirector2016-05-06Sell25,000274,069$119.22980-4.258,337 (Direct)
210,707 (Indirect)
5,025 (by Trust)
KOZARICH JOHN WDirector2016-05-02Sell1,00043,711$121.57121.57-6.0743,711 (Direct)
KOZARICH JOHN WDirector2016-04-06Sell5,00044,711$115575-0.744,711 (Direct)
FOEHR MATTHEW WPresident and COO2016-03-17Sell6,40078,912$96.7618.8818.0978,912 (Direct)
Aryeh JasonDirector2016-03-08Sell6,129299,069$101.18620.1312.8658,337 (Direct)
235,707 (Indirect)
5,025 (by Trust)
HIGGINS JOHN LCEO2016-03-07Sell10,833125,664$102.471110.0611.44125,664 (Direct)
KOZARICH JOHN WDirector2016-01-20Sell1,66649,711$94.94158.1720.2849,711 (Direct)
Aryeh JasonDirector2015-11-11Sell3,000305,198$101.49304.4712.5158,337 (Direct)
241,836 (Indirect)
5,025 (by Trust)
Herman Melanie JDirector of Accounting2015-11-11Sell7,7193,151$101779.6213.063,151 (Direct)
KNOTT DAVID MDirector2015-08-17Sell4,0001,265,918$95.98383.9218.9766,152 (Direct)
969,300 (By Knott Partners, L.P.)
196,186 (By Shoshone Partners, L.P.)
30,771 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
1,843 (By immediate family member)
KNOTT DAVID MDirector2015-08-13Sell49,8001,269,918$96.264793.7518.6370,152 (Direct)
969,300 (By Knott Partners, L.P.)
196,186 (By Shoshone Partners, L.P.)
30,771 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
1,843 (By immediate family member)
KNOTT DAVID MDirector2015-08-07Sell2001,319,718$99.0219.815.3270,152 (Direct)
40,596 (By Knott Partners Offshore Master Fund, L.P.)
972,100 (By Knott Partners, L.P.)
233,361 (By Shoshone Partners, L.P.)
1,666 (By Managed Account C)
1,843 (By immediate family member)
HIGGINS JOHN LCEO2015-08-06Sell4,666121,378$110.79516.953.07121,378 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2015-07-10Sell14,06727,454$99.141394.615.1827,454 (Direct)
FOEHR MATTHEW WPresident and COO2015-06-26Sell12,50072,628$100.971262.1313.0972,628 (Direct)
FOEHR MATTHEW WPresident and COO2015-06-22Sell23,04670,128$96.452222.7918.3970,128 (Direct)
Herman Melanie JInterim CFO2015-06-10Sell4,1252,986$93.5385.6922.132,986 (Direct)
HIGGINS JOHN LCEO2015-06-09Sell10,000126,044$92.88928.822.94126,044 (Direct)
Aryeh JasonDirector2015-06-04Sell1,640308,198$92.6815223.2158,337 (Direct)
244,836 (Indirect)
5,025 (by Trust)
Aryeh JasonDirector2015-05-20Sell9,240309,838$87.34807.0230.7458,337 (Direct)
246,476 (Indirect)
5,025 (by Trust)
DeSilva Nishan MVP, Finance & Strategy and CFO2015-05-14Sell68,36322,282$83.915736.3436.0922,282 (Direct)
Patel SunilDirector2015-03-19Sell4,59137,100$74.42341.6653.4437,100 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2015-03-16Sell11,26425,989$74.54839.6253.1925,989 (Direct)
Herman Melanie JDirector of Accounting2015-03-02Sell5352,986$60.6932.4788.152,986 (Direct)
Herman Melanie JDirector of Accounting2015-02-19Sell5103,521$57.8429.597.423,521 (Direct)
DeSilva Nishan MVP, Corporate Development2015-02-10Sell2,30022,282$56.34129.58102.6822,282 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2014-12-31Buy12627,433$45.235.7152.4727,433 (Direct)
FOEHR MATTHEW WEVP and COO2014-12-31Buy4655,016$45.232.08152.4755,016 (Direct)
Herman Melanie JDirector of Accounting2014-12-31Buy1032,831$45.234.66152.472,831 (Direct)
KOZARICH JOHN WDirector2014-10-15Buy2,00049,286$45.6891.36149.9849,286 (Direct)
FOEHR MATTHEW WEVP and COO2014-10-10Buy8554,970$44.913.82154.2654,970 (Direct)
Aryeh JasonDirector2014-10-09Buy11,000321,436$42.99472.89165.6260,695 (Direct)
255,716 (Indirect)
5,025 (by Trust)
Sabba Stephen LDirector2014-10-09Buy2,00023,697$43.1286.24164.8223,697 (Direct)
KNOTT DAVID MDirector2014-10-09Buy4,0001,318,993$43.01172.04165.569,227 (Direct)
972,100 (By Knott Partners, L.P.)
233,361 (By Shoshone Partners, L.P.)
40,796 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
1,843 (By immediate family member)
HIGGINS JOHN LPresident & CEO2014-08-15Buy1,000120,099$54.9754.97107.73120,099 (Direct)
Herman Melanie JDirector of Accounting2014-06-30Buy982,728$43.794.29160.772,728 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2014-06-30Buy32927,307$43.7914.41160.7727,307 (Direct)
FOEHR MATTHEW WEVP and COO2014-06-30Buy42853,885$43.7918.74160.7753,885 (Direct)
Herman Melanie JDirector of Accounting2014-06-09Sell1,1002,630$69.6876.6563.882,630 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2014-05-27Sell7,16626,978$66.9479.4170.6926,978 (Direct)
BVF PARTNERS L P/IL2014-03-25Sell78,226360,300$70.095482.8662.92
230,125 (By Biotechnology Value Fund, L.P.)
130,175 (By Biotechnology Value Fund II, L.P.)
Davis Todd CDirector2014-03-19Sell7,50032,536$79.57596.7843.5132,536 (Direct)
LAMATTINA JOHN LDirector2014-03-18Sell5,00021,356$78.83394.1544.8621,356 (Direct)
Sabba Stephen LDirector2014-02-27Sell50020,546$72.2536.1358.0520,546 (Direct)
BVF PARTNERS L P/IL10% Owner2014-02-20Sell422,9002,203,260$73.8131214.2554.71
279,842 (By Biotechnology Value Fund, L.P.)
158,684 (By Biotechnology Value Fund II, L.P.)
1,685,344 (By BVF Investments, L.L.C.)
79,390 (By Investment 10, L.L.C.)
KNOTT DAVID MDirector2014-02-20Sell9001,313,509$72.9765.6756.4963,743 (Direct)
1,843 (By immediate family member)
972,100 (By Knott Partners, L.P.)
233,361 (By Shoshone Partners, L.P.)
40,796 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
KNOTT DAVID MDirector2014-02-18Sell41,9001,314,409$75.713172.2550.8363,743 (Direct)
233,361 (By Shoshone Partners, L.P.)
40,796 (By Knott Partners Offshore Master Fund, L.P.)
972,100 (By Knott Partners, L.P.)
1,666 (By Managed Account C)
2,743 (By immediate family member)
FOEHR MATTHEW WEVP and COO2014-02-14Sell22,50053,457$79.541789.6543.5653,457 (Direct)
Aryeh JasonDirector2014-02-14Sell40,320280,984$76.443082.0649.3931,243 (Direct)
244,716 (Indirect)
5,025 (by Trust)
Berkman Charles SVP, Gen. Counsel & Secretary2014-02-12Sell14,88131,645$74.51108.6353.2831,645 (Direct)
HIGGINS JOHN LPresident & CEO2014-02-12Sell16,875119,099$751265.6352.25119,099 (Direct)
Sharp John PVP Finance and CFO2014-02-12Sell86,95317,667$74.746498.8752.7817,667 (Direct)
HIGGINS JOHN LPresident & CEO2014-01-16Sell15,000111,099$6496078.42111,099 (Direct)
FOEHR MATTHEW WEVP and COO2013-12-31Buy8445,013$33.922.85236.6545,013 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2013-12-31Buy20927,145$33.927.09236.6527,145 (Direct)
FOEHR MATTHEW WEVP and COO2013-12-12Sell6,00044,929$53.4320.4113.8444,929 (Direct)
Sharp John PVP Finance and CFO2013-12-12Sell70017,667$53.4437.41113.6817,667 (Direct)
Sharp John PVP Finance and CFO2013-12-06Sell6,00017,667$56.08336.48103.6217,667 (Direct)
Sharp John PVP Finance and CFO2013-11-18Sell1,12323,667$5359.52115.4523,667 (Direct)
HIGGINS JOHN LPresident & CEO2013-10-18Sell10,000117,099$55550107.62117,099 (Direct)
BVF PARTNERS L P/IL10% Owner2013-09-23Sell359,0232,163,412$44.515976.52156.61
2,163,412 (See Explanation of Responses)
KNOTT DAVID MDirector2013-09-12Sell160,0001,356,309$46.787484.8144.163,743 (Direct)
51,396 (By Knott Partners Offshore Master Fund, L.P.)
972,100 (By Knott Partners, L.P.)
264,661 (By Shoshone Partners, L.P.)
1,666 (By Managed Account C)
2,743 (By immediate family member)
Berkman Charles SVP, Gen. Counsel & Secretary2013-08-30Sell28,32326,936$47.541346.48140.226,936 (Direct)
Sharp John PVP Finance and CFO2013-08-16Sell7,50024,166$42.75320.63167.1124,166 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2013-08-16Sell14,58317,928$42.63621.67167.8617,928 (Direct)
HIGGINS JOHN LPresident & CEO2013-08-16Sell10,000116,581$42.85428.5166.49116,581 (Direct)
DeSilva Nishan MVP, Corporate Development2013-06-28Buy16915,659$17.362.93557.7815,659 (Direct)
FOEHR MATTHEW WEVP and COO2013-06-28Buy1,05944,929$17.3618.38557.7844,929 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2013-06-28Buy81513,644$17.3614.15557.7813,644 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2013-05-10Sell4,00012,829$26.66106.64328.3212,829 (Direct)
BVF PARTNERS L P/IL10% Owner2013-01-23Buy39,600272,475$19.78783.29477.3
272,475 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2012-12-14Buy5,386444,151$18.63100.34512.94
444,151 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2012-12-06Buy50,100444,151$17.94898.79536.51
444,151 (See Explanation of Responses)
HIGGINS JOHN LPresident & CEO2012-12-05Buy2,000112,025$18.0336.06533.33112,025 (Direct)
FOEHR MATTHEW WEVP and COO2012-12-05Buy37037,870$17.996.66534.7437,870 (Direct)
KNOTT DAVID MDirector2012-11-30Sell20,0001,511,991$19.9398473.8259,425 (Direct)
211,396 (By Knott Partners Offshore Master Fund, L.P.)
972,100 (By Knott Partners, L.P.)
264,661 (By Shoshone Partners, L.P.)
1,666 (By Managed Account C)
2,743 (By immediate family member)
KNOTT DAVID MDirector2012-11-28Sell100,0001,531,991$19.541954484.3959,425 (Direct)
231,396 (By Knott Partners Offshore Master Fund, L.P.)
972,100 (By Knott Partners, L.P.)
264,661 (By Shoshone Partners, L.P.)
1,666 (By Managed Account C)
2,743 (By immediate family member)
BVF PARTNERS L P/IL10% Owner2012-10-31Buy16,591741,627$15.19252.02651.74
741,627 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2012-10-31Buy16,5912,068,326$15.19252.02651.74
2,068,326 (See Explanation of Responses)
Berkman Charles SVP, Gen. Counsel & Secretary2012-09-07Sell4,24914,329$18.7779.75508.3614,329 (Direct)
KNOTT DAVID MDirector2012-08-29Buy2,7431,631,991$16.3644.88597.9859,425 (Direct)
2,743 (By immediate family member)
972,100 (By Knott Partners, L.P.)
264,661 (By Shoshone Partners, L.P.)
331,396 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
HIGGINS JOHN LPresident & CEO2012-08-13Buy500110,025$16.398.2596.71110,025 (Direct)
Aryeh JasonDirector2012-06-01Buy700318,379$11.988.39853.1728,318 (Direct)
285,036 (Indirect)
5,025 (by Trust)
KNOTT DAVID MDirector2012-05-24Sell196,0001,666,110$11.622277.52882.754,704 (Direct)
972,100 (By Knott Partners, L.P.)
264,661 (By Shoshone Partners, L.P.)
0 (By Mulsanne Partners, L.P.)
331,396 (By Knott Partners Offshore Master Fund, L.P.)
41,583 (By Managed Account D)
1,666 (By Managed Account C)
Patel SunilDirector2012-05-23Buy1,50029,705$11.3817.07903.4329,705 (Direct)
HIGGINS JOHN LPresident & CEO2012-05-04Buy1,000108,275$12.0412.04848.42108,275 (Direct)
Berkman Charles SVP, Gen. Counsel & Secretary2012-03-08Sell3,60617,328$15.7656.83624.5617,328 (Direct)
BVF PARTNERS L P/IL10% Owner2011-11-21Buy511,0402,793,362$10.655442.58972.21
2,068,326 (See Explanation of Responses)
725,036 (See Explanation of Respones)
Sabba Stephen LDirector2011-11-14Buy2,00012,704$11.623.2884.412,704 (Direct)
KNOTT DAVID MDirector2011-11-10Buy4,0001,694,410$11.5846.32886.154,704 (Direct)
800,000 (By Knott Partners, L.P.)
240,761 (By Shoshone Partners, L.P.)
98,633 (By Mulsanne Partners, L.P.)
407,563 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
62,783 (By Managed Account D)
28,300 (By Managed Account E)
BVF PARTNERS L P/IL10% Owner2011-10-26Buy6,0201,741,800$13.9183.74720.92
1,741,800 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2011-10-21Buy4,6001,738,000$13.9364.08719.74
1,738,000 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2011-10-20Buy14,1001,735,000$13.9195.99721.51
1,735,000 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2011-10-13Buy75,3532,331,053$13.651028.57736.56
1,726,000 (See Explanation of Responses)
605,053 (See Explanation of Respones)
BVF PARTNERS L P/IL10% Owner2011-10-04Buy14,400362,080$12.78184.03793.51
362,080 (See Explanation of Responses)
KNOTT DAVID MDirector2011-09-01Buy10,0001,690,411$15.21152.1650.7650,705 (Direct)
800,000 (By Knott Partners, L.P.)
240,761 (By Shoshone Partners, L.P.)
98,633 (By Mulsanne Partners, L.P.)
407,563 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
62,783 (By Managed Account D)
28,300 (By Managed Account E)
KNOTT DAVID MDirector2011-08-31Buy11,9401,680,411$14.86177.43668.4450,705 (Direct)
794,680 (By Knott Partners, L.P.)
239,261 (By Shoshone Partners, L.P.)
97,933 (By Mulsanne Partners, L.P.)
405,083 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
62,783 (By Managed Account D)
28,300 (By Managed Account E)
KNOTT DAVID MDirector2011-08-29Buy61,5591,668,471$13.08805.19773.0150,705 (Direct)
787,780 (By Knott Partners, L.P.)
237,361 (By Shoshone Partners, L.P.)
97,033 (By Mulsanne Partners, L.P.)
402,843 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
62,783 (By Managed Account D)
28,300 (By Managed Account E)
KNOTT DAVID MDirector2011-08-25Buy55,0001,606,912$12.57691.35808.4350,705 (Direct)
756,180 (By Knott Partners, L.P.)
227,661 (By Shoshone Partners, L.P.)
93,233 (By Mulsanne Partners, L.P.)
386,384 (By Knott Partners Offshore Master Fund, L.P.)
62,783 (By Managed Account D)
28,300 (By Managed Account E)
1,666 (By Managed Account C)
KNOTT DAVID MDirector2011-08-24Buy41,4901,551,912$12.58521.94807.7150,705 (Direct)
736,580 (By Knott Partners, L.P.)
221,861 (By Shoshone Partners, L.P.)
90,733 (By Mulsanne Partners, L.P.)
376,484 (By Knott Partners Offshore Master Fund, L.P.)
45,583 (By Managed Account D)
28,300 (By Managed Account E)
1,666 (By Managed Account C)
KNOTT DAVID MDirector2011-08-22Buy31,2691,510,422$11.96373.98854.7750,705 (Direct)
718,780 (By Knott Partners, L.P.)
216,371 (By Shoshone Partners, L.P.)
88,633 (By Mulsanne Partners, L.P.)
367,084 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
41,483 (By Managed Account D)
25,700 (By Managed Account E)
BVF PARTNERS L P/IL10% Owner2011-08-19Buy37,8711,671,562$11.92451.42857.97
1,671,562 (See Explanation of Responses)
KNOTT DAVID MDirector2011-08-18Buy24,1331,479,153$12.06291.04846.8550,705 (Direct)
702,780 (By Knott Partners, L.P.)
211,571 (By Shoshone Partners, L.P.)
86,633 (By Mulsanne Partners, L.P.)
358,615 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
41,483 (By Managed Account D)
25,700 (By Managed Account E)
KNOTT DAVID MDirector2011-08-15Buy18,3481,455,020$11.98219.81853.1750,705 (Direct)
690,180 (By Knott Partners, L.P.)
207,871 (By Shoshone Partners, L.P.)
85,033 (By Mulsanne Partners, L.P.)
352,382 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
41,483 (By Managed Account D)
25,700 (By Managed Account E)
KNOTT DAVID MDirector2011-08-11Buy145,0001,436,672$10.891579.05948.5850,705 (Direct)
680,480 (By Knott Partners, L.P.)
204,971 (By Shoshone Partners, L.P.)
83,933 (By Mulsanne Partners, L.P.)
41,483 (By Managed Account D)
25,700 (By Managed Account E)
347,734 (By Knott Partners Offshore Master Fund, L.P.)
1,666 (By Managed Account C)
BVF PARTNERS L P/IL10% Owner2011-08-11Buy1,3941,636,862$11.1915.6920.46
1,636,862 (See Explanation of Responses)
Davis Todd CDirector2011-08-10Buy15,00029,201$10.9163.5947.6129,201 (Direct)
Patel SunilDirector2011-08-10Buy5,00025,705$10.7453.7963.2225,705 (Direct)
BVF PARTNERS L P/IL10% Owner2011-08-10Buy599,7003,123,672$10.986584.71939.98
1,635,936 (See Explanation of Responses)
1,487,736 (See Explanation of Respones)
Aryeh JasonDirector2011-08-10Buy2,000309,162$10.5721.14980.3221,801 (Direct)
283,336 (Indirect)
4,025 (by Trust)
Aryeh JasonDirector2011-05-12Buy1,725299,790$10.9618.91941.8814,429 (Direct)
281,336 (Indirect)
4,025 (by Trust)
Aryeh JasonDirector2011-03-16Buy5,5000$9.3951.651116.08Link
Aryeh JasonDirector2011-03-14Buy3,5000$9.6933.921078.43Link
LAMATTINA JOHN LDirector2011-03-11Buy10,0000$9.8981065.2Link
Aryeh JasonDirector2011-03-11Buy4,000287,565$9.8439.361060.4714,429 (Direct)
270,111 (Indirect)
3,025 (by Trust)
Aryeh JasonDirector2011-03-10Buy1,5000$10.0815.121032.84Link
KNOTT DAVID MDirector2011-03-03Buy37,4000$11.02412.15936.21Link
KNOTT DAVID MDirector2011-02-28Buy40,0000$10.24081019.51Link
Kazmi SyedVP, Bus. Dev. & Strategic Plan2011-02-28Sell1,1660$10.6912.46968.19Link
KOZARICH JOHN WDirector2011-02-25Buy5,0000$9.9949.951043.04Link
Aryeh JasonDirector2011-02-23Buy5,0000$9.9449.71048.79Link
KNOTT DAVID MDirector2011-02-23Sell88,8000$9.95883.561047.64Link
KOZARICH JOHN WDirector2011-02-17Buy1,0000$9.99.91053.43Link
Patel SunilDirector2011-02-16Buy10,0000$9.2292.21138.5Link
Berkman Charles SVP, Gen. Counsel & Secretary2011-02-16Sell5,0000$9.7548.751071.18Link
KOZARICH JOHN WDirector2010-11-11Buy1,66712,726$9.6161089.48Link
Aryeh JasonDirector2010-06-01Buy833278,566$8.887.41185.93Link
Aryeh JasonDirector2010-05-25Buy1,717273,403$8.6414.841221.65Link
Aryeh JasonDirector2010-05-20Buy99271,686$8.880.881185.93Link
MEGLASSON MARTINV-P, Discovery Research2010-05-11Buy1,04217,042$9.7810.191067.59Link
KOZARICH JOHN WDirector2010-05-10Buy1,6676,730$10.0816.81032.84Link
KNOTT DAVID MDirector2010-03-15Sell63,33310,383$10.8684957.32Link
KNOTT DAVID MDirector2010-03-11Sell31,667408,622$10.23231019.51Link
KNOTT DAVID MDirector2010-03-09Sell81,70810,766$10.32843.221006.49Link
KNOTT DAVID MDirector2010-03-09Sell81,70810,766$10.32843.221006.49Link
HIGGINS JOHN LPresident & CEO2010-02-17Buy1,00073,213$10.0210.021039.62Link
Kazmi SyedVP, Bus. Dev. & Strategic Plan2009-12-24Sell3339,618$12.94.3785.2Link
BVF PARTNERS L P/IL2009-08-24Sell758,7601,769,570$15.4211700.05640.53Link
BVF PARTNERS L P/IL2009-07-01Sell23,7832,528,330$17.82423.82540.8
BVF PARTNERS L P/IL2009-06-29Sell138,2112,552,113$17.522421.45551.77
KNOTT DAVID MDirector2009-04-07Sell73,133416,822$27.62018.48313.73
KNOTT DAVID MDirector2009-04-07Buy137,76719,822$15.62149.16631.99
KNOTT DAVID MDirector2009-04-07Sell87,467416,822$16.81469.44579.7
KNOTT DAVID MDirector2009-04-07Buy87,46720,722$16.81469.44579.7
Dziewanowska Zofia EVP, Clinical Research2009-02-25Sell1,0005,663$15.7215.72626.4
KNOTT DAVID MDirector2009-02-17Sell137,767450,706$27.63802.36313.73
KNOTT DAVID MDirector2009-02-17Buy137,76719,822$15.62149.16631.99
KNOTT DAVID MDirector2009-02-17Sell137,767450,706$15.62149.16631.99
KNOTT DAVID MDirector2009-02-17Buy137,76719,822$15.62149.16631.99
BVF PARTNERS L P/IL2009-01-26Buy7,2892,667,708$1287.47851.59
BVF PARTNERS L P/IL2008-12-05Buy4,7142,256,217$11.8856861.2
BVF PARTNERS L P/IL2008-12-04Buy20,6732,251,503$12.12250.56842.16
BVF PARTNERS L P/IL2008-12-02Buy54,1172,230,830$11.28610.44912.32
BVF PARTNERS L P/IL2008-11-28Buy265,1012,176,713$11.73101.67875.98
BVF PARTNERS L P/IL2008-11-25Buy82,6671,911,613$11.04912.64934.33
BVF PARTNERS L P/IL2008-11-21Buy31,1241,828,946$10.68332.4969.2
BVF PARTNERS L P/IL2008-11-19Buy19,0671,796,288$8.28157.871279.11
BVF PARTNERS L P/IL2008-11-17Buy50,3331,777,222$7.86395.621352.8
BVF PARTNERS L P/IL2008-11-13Buy18,0851,726,888$8.04145.41320.28
BVF PARTNERS L P/IL2008-11-11Buy79,8081,708,803$8.28660.811279.11
MEGLASSON MARTINV-P, Discovery Research2008-05-09Buy5006,083$20.1610.08466.42
KNOTT DAVID MDirector, 10% Owner2008-05-09Sell85,38438,237$20.41741.82459.76
KNOTT DAVID MDirector, 10% Owner2008-05-09Buy85,3844,600$20.41741.82459.76
KOZARICH JOHN WDirector2008-03-05Buy5003,396$21.9610.98419.99
KOZARICH JOHN WDirector2007-11-20Buy3332,896$25.688.56344.67
MEGLASSON MARTINV-P, Discovery Research2007-08-30Buy3332,250$37.1412.38207.46
KOZARICH JOHN WDirector2007-08-29Buy1672,563$36.846.14209.96
HIGGINS JOHN LPresident & CEO2007-08-13Buy33325,667$35.1611.72224.77
KOZARICH JOHN WDirector2007-08-13Buy3332,396$36.0612.02216.67
HIGGINS JOHN LPresident & CEO2007-06-15Buy33325,333$40.213.4184.06
KNOTT DAVID MDirector2007-06-15Sell66,68388,103$40.982732.68178.65
KNOTT DAVID MDirector2007-06-15Buy66,68396,887$40.982732.68178.65
Aryeh JasonDirector2007-05-30Buy1,3922,025$38.8854.11193.7
GROVES ERIC SV-P, Project Management2006-12-15Sell8,333855$67.38561.569.47
MEGLASSON MARTINV-P, Discovery Research2006-12-15Sell88683$67.3859.6669.47
PETTTIT WILLIAM ASr. V-P, HR and Administration2006-12-15Sell5,000148$67.5337.569.17
NEGRO-VILAR ANDRESExe V-P, R & D, CSO2006-12-14Sell1,9441,206$66.3128.9172.23
Loeb Daniel SDirector2006-12-13Buy58,3331,287,899$64.92378775.89
PETTTIT WILLIAM ASr. V-P, HR and Administration2006-12-12Sell7,634148$63.6485.5279.54
NEGRO-VILAR ANDRESExe V-P, R & D, CSO2006-12-11Sell5,0001,206$64.56322.876.87
MAIER PAUL VSr. V-P, CFO2006-11-20Sell4,50314,159$68.58308.7966.51
BROADDUS WARNER RV-P, Gen. Counsel & Secy.2006-11-20Sell5,3650$68.16365.6667.53
MAIER PAUL VSr. V-P, CFO2006-11-17Sell6,50714,159$68.1443.1367.68
MAIER PAUL VSr. V-P, CFO2006-11-17Sell6,35818,721$68.82437.5665.93
MAIER PAUL VSr. V-P, CFO2006-11-16Sell3,9190$67.92266.268.12
MAIER PAUL VSr. V-P, CFO2006-11-16Sell5,20914,159$68.22355.3867.39
MEGLASSON MARTINV-P, Discovery Research2004-11-11Buy8383$52.924.41115.78Link
MAIER PAUL VSr. V-P, CFO2004-07-01Sell6679,327$102.1868.1211.75Link
LITALIEN JAMES JSr. V-P, Reg Affairs & Comp.2004-06-02Sell1020$125.0412.73-8.68Link
MAIER PAUL VSr. V-P, CFO2004-06-01Sell1,0009,921$122.16122.16-6.52Link
LITALIEN JAMES JSr. V-P, Reg Affairs & Comp.2004-06-01Sell5650$124.570.32-8.28Link
LITALIEN JAMES JSr. V-P, Reg Affairs & Comp.2004-05-28Sell6670$122.0481.36-6.43Link
CROSS ALEXANDER DDirector2004-05-27Sell3335,083$12642-9.37Link
MAIER PAUL VSr. V-P, CFO2004-05-26Sell33310,921$11739-2.4Link
CROSS ALEXANDER DDirector2004-05-26Sell6675,416$11778-2.4Link
MAIER PAUL VSr. V-P, CFO2004-05-17Sell66711,254$104.5869.729.19Link
PETTTIT WILLIAM ASr. V-P, HR and Administration2004-03-18Sell3,33385$111.12370.42.76Link
ROCCA MICHAEL ADirector2004-01-02Sell1,4861,333$90133.726.88Link
JOHNSON IRVING SDirector2003-12-01Sell1,3533,822$83.28112.6937.12Link
JOHNSON IRVING SDirector2003-11-20Sell1,8713,822$72134.7458.6Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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