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Top Direct Holders

HolderPositionShares% of Shares
Report Date
Dr. John D. MendleinN/A245,9711.04%2015-05-12
John K. ClarkeN/A104,8780.44%2015-05-12
Ms. Melissa A. AshlockN/A68,1640.29%2015-05-06
Mr. Frederic ChereauN/A12,867less than 0.1%2015-05-06
Kathryn E. FalbergN/A12,572less than 0.1%2015-05-06
Amir NashatN/A12,572less than 0.1%2015-05-12
Dr. Paul R. Schimmel,PhDN/A12,572less than 0.1%2015-05-12
Dr. David M. Weiner, M.D.N/A5,028less than 0.1%2015-05-06
Mr. Stan BlackburnN/A2,149less than 0.1%2015-05-06
Mr. Holly D. ChrzanowskiN/A1,885less than 0.1%2015-05-06

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Flynn James E2015-05-12Buy50,000511,528$14700-37.57
255,764 (Through Deerfield Private Design Fund III, L.P.)
255,764 (Through Deerfield Special Situations Fund, L.P.)
AKKARAJU SRINIVASFormer 10% Owner2015-05-12Buy320,0001,866,126$144480-37.57
1,866,126 (By Sofinnova Venture Partners IX, L.P.)
Sofinnova Venture Partners IX,10% Owner2015-05-12Buy320,0001,866,126$144480-37.571,866,126 (Direct)
UPRICHARD DAVID CDirector2013-05-29Sell2,0102,930$74.04148.8-88.22,930 (Direct)
COTTINGHAM JOHN AChief Legal Officer2013-05-28Sell60,00030,755$74.034441.8-88.198,231 (Direct)
20,248 (By Trust)
2,276 (By Employee Benefit Plan Trust)
LORIMIER BRADLEY GDirector2012-12-11Sell20,0008,200$51.061021.2-82.888,200 (Direct)
GRIMM DONALD WDirector2012-11-20Sell12,0520$47.94577.8-81.77Link
RICHARD KELLIChief Accounting Officer2012-11-06Sell6,1945,422$49.19304.7-82.235,422 (Direct)
LEVINE ARNOLD JDirector2012-10-15Sell6,9581,081$48.52337.6-81.991,081 (Direct)
(Click for the stocks that their CEOs have bought)
207,188 (Trust)
LORIMIER BRADLEY GDirector2012-05-01Sell20,0008,200$46.55931-81.228,200 (Direct)
ANDREWS RONALD ASBURYPresident, Medical Sciences2012-04-27Buy3,3303,330$46.49154.8-81.23,330 (Direct)
UPRICHARD DAVID CDirector2012-03-15Sell20052$46.089.2-81.0352 (Direct)
UPRICHARD DAVID CDirector2012-03-09Sell100252$46.64.7-81.24252 (Direct)
UPRICHARD DAVID CDirector2012-03-08Sell200352$46.579.3-81.23352 (Direct)
UPRICHARD DAVID CDirector2012-02-27Sell500552$47.6623.8-81.66552 (Direct)
DITTAMORE RAYMOND VDirector2012-01-25Sell20,0004,052$50.651013-82.744,052 (Direct)
Leddy Peter MichaelSVP, Global Human Resources2011-11-22Sell2,47427,525$36.7490.9-76.2127,525 (Direct)
Stevenson MarkPresident & COO2011-08-22Buy5,00049,699$36.2181-75.8649,699 (Direct)
Pescovitz Ora H.Director2011-08-22Buy5501,133$36.1619.9-75.831,133 (Direct)

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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