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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Fred A. MiddletonDirector, 10% Owner70,3990.19%2013-06-21
Dr. Gary W. Pace,PhDDirector20,692less than 0.1%2015-06-03
James S. (Jim) ScibettaSVP, CFO10,504less than 0.1%2015-09-11
Dr. Taunia Markvicka, Pharm.D.SVP, Chief Commercial Officer8,579less than 0.1%2015-03-17
Ms. Kristen Marie WilliamsN/A7,500less than 0.1%2015-06-03
Ms. Lauren RikerExecutive Director, Finance5,980less than 0.1%2015-06-03
Mr. Dennis L. WingerDirector4,645less than 0.1%2015-06-03
Mark A. KronenfeldDirector3,850less than 0.1%2015-06-03
Paul J. HastingsDirector2,853less than 0.1%2015-11-20
John P. Longenecker,PhDDirector2,300less than 0.1%2016-01-12

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Braunstein ScottSVP, Strategy & Corp. Dev.2016-01-29Buy2,0002,000$58.92117.8-4.482,000 (Direct)
Jones James BSVP & Chief Medical Officer2016-01-27Buy5001,500$62.531.3-9.951,500 (Direct)
STACK DAVID MCEO and Chairman
(Click for the stocks that their CEOs have bought)
2016-01-15Sell15,00020,089$63.84957.6-11.84285 (Direct)
18,596 (By Stack Schroon Mohawk FLP)
1,208 (By LCK Investment LLC)
LONGENECKER JOHN P PHDDirector2016-01-12Buy3002,300$66.5520-15.432,300 (Direct)
Jones James BSVP & Chief Medical Officer2016-01-12Buy1,0001,000$6666-14.731,000 (Direct)
HASTINGS PAUL JDirector2015-11-20Sell3,0002,853$60180-6.22,853 (Direct)
STACK DAVID MPresident, CEO and Chairman2015-10-15Sell15,00019,980$37.57563.649.8176 (Direct)
18,596 (By Stack Schroon Mohawk FLP)
1,208 (By LCK Investment LLC)
Scibetta James SSVP, CFO2015-09-11Buy5,00010,504$61.37306.9-8.2910,504 (Direct)
HASTINGS PAUL JDirector2015-08-17Sell3,0002,853$60.02180.1-6.232,853 (Direct)
STACK DAVID MPresident, CEO and Chairman2015-07-15Sell15,00019,980$67.781016.7-16.97176 (Direct)
18,596 (By Stack Schroon Mohawk FLP)
1,208 (By LCK Investment LLC)
STACK DAVID MPresident, CEO and Chairman2015-04-15Sell25,00019,863$90.52262.5-37.8159 (Direct)
18,596 (By Stack Schroon Mohawk FLP)
1,208 (By LCK Investment LLC)
HASTINGS PAUL JDirector2015-04-10Sell2,500853$88220-36.05853 (Direct)
Riker Lauren BullaroExecutive Director, Finance2015-03-16Sell5,0002,230$95.34476.7-40.972,230 (Direct)
PACE GARY WDirector2015-03-13Buy1,00018,692$93.8393.8-40.0218,692 (Direct)
LONGENECKER JOHN P PHDDirector2015-03-12Sell3,0000$95.28285.8-40.93Link
Scibetta James SSVP, CFO2015-02-06Sell15,0005,230$111.221668.3-49.45,230 (Direct)
STACK DAVID MPresident, CEO and Chairman2015-01-15Sell15,00019,863$97.521462.8-42.291,267 (Direct)
18,596 (Stack Schroon Mohawk FLP)
HASTINGS PAUL JDirector2015-01-12Sell2,500853$94.06235.2-40.17853 (Direct)
LONGENECKER JOHN P PHDDirector2014-12-29Sell1,0000$93.3293.3-39.69Link
WINGER DENNIS LDirector2014-12-05Buy2,6452,645$94.54250.1-40.472,645 (Direct)
Scibetta James SSVP, CFO2014-11-07Sell15,0005,000$87.181307.7-35.445,000 (Direct)
Markvicka TauniaSVP, Chief Commercial Officer2014-11-07Buy230230$86.6219.9-35.03
230 (By spouse)
Kronenfeld Mark A.Director2014-11-03Buy8501,850$90.4876.9-37.81,850 (Direct)
STACK DAVID MPresident, CEO and Chairman2014-10-15Sell15,00019,804$99.491492.4-43.431,208 (Direct)
18,596 (Stack Schroon Mohawk FLP)
HASTINGS PAUL JDirector2014-10-10Sell2,500853$94.87237.2-40.68853 (Direct)
LONGENECKER JOHN P PHDDirector2014-09-29Sell1,0000$96.496.4-41.62Link
Wicki AndreasDirector2014-08-29Sell21,4941,100,100$108.112323.7-47.94
1,100,100 (See footnote.)
Wicki AndreasDirector2014-08-27Sell55,8132,244,794$108.086032.3-47.93
1,121,594 (See footnote.)
1,123,200 (See footnote)
Wicki AndreasDirector2014-08-11Sell150,0002,392,600$101.2515187.5-44.41
1,177,407 (See footnote.)
1,215,193 (See footnote)
Scibetta James SSVP, CFO2014-08-08Sell15,0005,000$99.631494.5-43.515,000 (Direct)
PATOU GARYChief Medical Officer2014-08-07Sell20,000702$100.262005.2-43.87
702 (See Footnote)
STACK DAVID MPresident, CEO and Chairman2014-07-15Sell15,00019,804$86.751301.3-35.121,208 (Direct)
18,596 (Stack Schroon Mohawk FLP)
PATOU GARYChief Medical Officer2014-07-14Sell29,700702$86.962582.7-35.28
702 (See Footnote)
HASTINGS PAUL JDirector2014-07-10Sell2,500853$84.41211-33.33853 (Direct)
LONGENECKER JOHN P PHDDirector2014-06-30Sell1,0000$91.691.6-38.56Link
Wicki AndreasDirector2014-06-09Sell68,0001,327,407$85.435809.2-34.12
1,327,407 (See footnote.)
Wicki AndreasDirector2014-06-06Sell67,9001,395,407$82.625609.9-31.88
1,395,407 (See footnote.)
Wicki AndreasDirector2014-06-03Sell68,0001,463,307$80.695486.9-30.25
1,463,307 (See footnote.)
Wicki AndreasDirector2014-05-27Sell64,4001,531,307$77.935018.7-27.78
1,531,307 (See footnote.)
Wicki AndreasDirector2014-05-21Sell3,6001,595,707$77.8280.1-27.66
1,595,707 (See footnote.)
PATOU GARYChief Medical Officer2014-05-12Sell30,000702$74.392231.7-24.34
702 (See footnote)
STACK DAVID MPresident, CEO and Chairman2014-05-09Sell25,00019,804$73.941848.5-23.881,208 (Direct)
18,596 (See Footnote)
Brege LauraDirector2014-05-09Sell10,0000$73.85738.5-23.79Link
Scibetta James SSVP, CFO2014-05-08Sell15,0005,000$75.051125.8-25.015,000 (Direct)
Wicki AndreasDirector2014-05-08Sell23,2201,599,307$75.761759.1-25.71
1,599,307 (See footnote.)
Wicki AndreasDirector2014-05-07Sell44,7801,622,527$75.783393.4-25.73
1,622,527 (See footnote.)
LONGENECKER JOHN P PHDDirector2014-03-28Sell1,0000$64.6364.6-12.92Link
Wicki AndreasDirector2014-03-06Sell24,8871,667,307$80.161994.9-29.79
1,667,307 (See footnote.)
STACK DAVID MPresident and CEO2013-12-30Sell15,00021,583$55.84837.60.792,987 (Direct)
18,596 (See Footnote)
LONGENECKER JOHN P PHDDirector2013-12-30Sell2,5000$55.55138.91.31Link
Scibetta James SCFO2013-12-30Sell10,0005,000$55.55555.51.315,000 (Direct)
Markvicka TauniaVice President, Commercial2013-11-06Sell50,0000$51.14255710.05Link
PATOU GARYChief Medical Officer2013-10-01Sell20,000115$48.92978.415.04
115 (See Footnote)
Scibetta James SCFO2013-09-30Sell10,0005,000$46.74467.420.415,000 (Direct)
LONGENECKER JOHN P PHDDirector2013-09-30Sell2,5000$46.74116.920.41Link
STACK DAVID MPresident and CEO2013-09-30Sell15,00021,169$47.05705.819.622,573 (Direct)
18,596 (See Footnote)
Markvicka TauniaVice President, Commercial2013-09-25Sell10,0000$4747019.74Link
Wicki AndreasDirector2013-09-11Sell17,7833,399,485$37.25662.451.09
1,707,291 (See footnote.)
1,692,194 (See foootnote.)
Kronenfeld Mark A.Director2013-09-11Buy1,0001,000$37.013752.071,000 (Direct)
Markvicka TauniaVice President, Commercial2013-08-14Sell14,7000$37543.952.11Link
Wicki AndreasDirector2013-07-22Sell75,9581,630,944$35.062663.160.52
1,630,944 (See footnote.)
Wicki AndreasDirector2013-07-18Sell25,5603,417,846$33.4585568.25
1,710,944 (See footnote.)
1,706,902 (See footnote)
Wicki AndreasDirector2013-07-16Sell48,4823,465,274$33.281613.569.11
1,732,812 (See footnote.)
1,732,462 (See footnote)
Markvicka TauniaVice President, Commercial2013-07-12Sell29,7540$32952.175.88Link
Wicki AndreasDirector2013-07-11Sell80,0001,780,944$31.482518.478.78
1,780,944 (See footnote.)
Wicki AndreasDirector2013-07-05Sell44,0211,860,944$30.81355.882.73
1,860,944 (See footnote.)
Wicki AndreasDirector2013-07-03Sell114,4481,904,965$30.213457.586.3
1,904,965 (See footnote.)
PATOU GARYChief Medical Officer2013-07-02Sell40,000115$29.441177.691.17
115 (See Footnote)
LONGENECKER JOHN P PHDDirector2013-06-28Sell2,0000$28.0956.2100.36Link
Scibetta James SCFO2013-06-28Sell10,0005,000$28.05280.5100.645,000 (Direct)
STACK DAVID MPresident and CEO2013-06-28Sell15,00021,169$28.7343195.892,573 (Direct)
18,596 (See Footnote)
MIDDLETON FRED ADirector2013-06-24Sell75,90070,399$29.13221193.270,399 (Direct)
0 (See footnote)
MIDDLETON FRED ADirector2013-06-20Sell144,100146,299$29.32422591.9570,399 (Direct)
30,798 (See footnotes(F3,F8))
45,102 (See footnotes(F6,F8))
Wicki AndreasDirector2013-06-19Sell35,4072,019,413$29.91058.788.23
2,019,413 (See footnote.)
Wicki AndreasDirector2013-06-17Sell50,1452,054,820$29.861497.388.48
2,054,820 (See footnote.)
EVNIN LUKEDirector2013-06-13Sell22,746824,255$30.0768487.16
824,255 (See Footnote)
Pratt JohnGeneral Manager, San Diego2013-06-13Sell21,0320$3063187.6Link
Wicki AndreasDirector2013-06-12Sell4,4092,104,965$30132.387.6
2,104,965 (See footnote.)
Pratt JohnGeneral Manager, San Diego2013-06-11Sell18,3430$30550.387.6Link
Wicki AndreasDirector2013-06-11Sell11,5002,109,374$3034587.6
2,109,374 (See footnote.)
Wicki AndreasDirector2013-06-05Sell15,5002,120,874$30.2646985.99
2,120,874 (See footnote.)
EVNIN LUKEDirector2013-06-03Sell82,072847,001$302462.287.622,746 (Direct)
824,255 (See Footnote)
Wicki AndreasDirector2013-06-03Sell1,9002,136,374$305787.6
2,136,374 (See footnote.)
Wicki AndreasDirector2013-05-31Sell5,5332,138,274$3016687.6
2,138,274 (See footnote.)
EVNIN LUKEDirector2013-05-31Sell54,517929,073$301635.587.622,746 (Direct)
906,327 (See Footnote)
EVNIN LUKEDirector2013-05-29Sell215,528983,590$30.866651.282.3722,746 (Direct)
960,844 (See Footnote)
EVNIN LUKEDirector2013-05-22Sell7,3401,199,118$30220.287.622,746 (Direct)
1,176,372 (See Footnote)
Wicki AndreasDirector2013-05-22Sell18,4712,143,807$30554.187.6
2,143,807 (See footnote.)
EVNIN LUKEDirector2013-05-20Sell13,5501,206,458$30406.587.622,746 (Direct)
1,183,712 (See Footnote)
Wicki AndreasDirector2013-05-20Sell14,3742,162,278$30431.287.6
2,162,278 (See footnote.)
HASTINGS PAUL JDirector2013-05-15Buy853853$29.32592.08853 (Direct)
Wicki AndreasDirector2013-04-24Sell16,0472,176,652$30481.487.6
2,176,652 (See footnote.)
EVNIN LUKEDirector2013-04-24Sell114,4181,186,232$303432.587.622,746 (Direct)
1,163,486 (See Footnote)
Wicki AndreasDirector2013-04-15Sell6,4002,192,699$3019287.6
2,192,699 (See footnote.)
EVNIN LUKEDirector2013-04-15Sell12,5751,300,650$30377.387.622,746 (Direct)
1,277,904 (See Footnote)
Wicki AndreasDirector2013-04-12Sell34,8942,199,099$301046.887.6
2,199,099 (See footnote.)
PATOU GARYChief Medical Officer2013-04-12Sell10,000115$3030087.6
115 (See Footnote)
EVNIN LUKEDirector2013-04-12Sell3,4161,337,001$29.3100.192.0822,746 (Direct)
1,314,255 (See Footnote)
PATOU GARYChief Medical Officer2013-04-01Sell30,000115$28.15844.599.93
115 (See Footnote)
LONGENECKER JOHN P PHDDirector2013-03-28Sell2,0000$28.495797.54Link
STACK DAVID MPresident and CEO2013-03-28Sell15,00021,169$28.66429.996.372,573 (Direct)
18,596 (See Footnote)
Scibetta James SCFO2013-03-28Sell10,0005,000$28.49284.997.545,000 (Direct)
Wicki AndreasDirector2013-03-25Sell290,9002,233,993$27.958130.7101.36
2,233,993 (See footnote.)
HBM Healthcare Investments (Ca10% Owner2013-03-25Sell290,9002,233,993$27.958130.7101.362,233,993 (Direct)
Sanderling Venture Partners VIDirector2013-03-19Sell250,000416,083$28.217052.599.5416,083 (Direct)
HBM BIOVENTURES CAYMAN LTD10% Owner2013-03-19Sell909,1003,433,993$28.0125463.9100.933,433,993 (Direct)
Wicki AndreasDirector2013-03-19Sell909,1003,433,993$28.0125463.9100.93
3,433,993 (See footnote)
EVNIN LUKEDirector2013-03-18Sell500,0002,290,479$28.441422097.89
2,290,479 (See Footnote)
Riker Lauren BullaroExecutive Director, Accounting2013-03-14Sell10,0002,000$3030087.62,000 (Direct)
Pratt JohnGeneral Manager, San Diego2013-03-12Sell9,3750$28.46266.897.75Link
KAILIAN VAUGHN M2013-03-11Sell500,0002,790,479$27.8613930102.01
2,790,479 (See Footnote)
MPM BioVentures IV QP LP2013-03-11Sell500,0002,790,479$27.8613930102.01
2,790,479 (See Footnote)
EVNIN LUKEDirector2013-03-11Sell500,0002,790,479$27.8613930102.01
2,790,479 (See Footnote)
Sanderling Venture Partners VI10% Owner2013-03-11Sell374,511559,453$27.7310385.2102.96559,453 (Direct)
Sanderling Venture Partners VI10% Owner2013-03-11Sell374,51142,833$27.7310385.2102.9642,833 (Direct)
Sanderling Venture Partners VI10% Owner2013-01-24Sell500,00056,896$18.939465197.3156,896 (Direct)
Sanderling Venture Partners VI10% Owner2013-01-24Sell500,00042,833$18.939465197.3142,833 (Direct)
PACE GARY WDirector2012-04-17Buy10,00017,692$9.7597.5477.2317,692 (Direct)
ORBIMED ADVISORS LLC10% Owner2012-03-12Sell100,1002,446,000$11.111112.1406.57
2,446,000 (See footnotes(F2,F5))
ORBIMED ADVISORS LLC10% Owner2012-02-29Sell42,1002,546,100$11.05465.2409.32
2,546,100 (See footnotes(F2,F5))
MPM BioVentures IV QP LP10% Owner2012-02-08Buy535,7140$73750704Link
EVNIN LUKEDirector, 10% Owner2012-02-08Buy535,7140$73750704Link
KAILIAN VAUGHN M10% Owner2012-02-08Buy535,7140$73750704Link
ORBIMED ADVISORS LLC10% Owner2012-02-03Sell143,3002,588,200$10.911563.4415.86
2,588,200 (See footnotes(F2,F5))
MPM BioVentures IV QP LP10% Owner2011-11-21Buy461,5383,290,479$6.53000765.85
3,290,479 (See footnote)
KAILIAN VAUGHN M10% Owner2011-11-21Buy461,5383,290,479$6.53000765.85
3,290,479 (See footnote)
EVNIN LUKEDirector, 10% Owner2011-11-21Buy461,5383,290,479$6.53000765.85
3,290,479 (See footnote)
HBM BIOVENTURES CAYMAN LTD10% Owner2011-11-21Buy307,6923,445,289$6.52000765.853,445,289 (Direct)
Wicki AndreasDirector2011-11-21Buy307,6923,445,289$6.52000765.85
3,445,289 (See footnote)
MIDDLETON FRED ADirector, 10% Owner2011-11-21Buy10,00066,896$6.565765.8510,000 (Direct)
56,896 (See Footnote)
PACE GARY WDirector2011-11-21Buy7,6927,692$6.550765.857,692 (Direct)
ORBIMED ADVISORS LLC10% Owner2011-10-31Sell97,4412,731,500$10.531026.1434.47
2,731,500 (See footnotes(F2,F5))
Scibetta James SCFO2011-02-15Buy5,0000$7.0435.2699.43Link
STACK DAVID MPresident and CEO2011-02-10Buy5,0000$6.633752.73Link
GORDON CARL LDirector2011-02-08Buy535,7140$73750704Link
ORBIMED ADVISORS LLC10% Owner2011-02-08Buy535,7140$73750704Link
Wicki AndreasDirector2011-02-08Buy535,7140$73750704Link
HBM BIOVENTURES CAYMAN LTD10% Owner2011-02-08Buy535,7140$73750704Link
MIDDLETON FRED ADirector2011-02-08Buy267,8570$71875704Link
Sanderling Venture Partners VI10% Owner2011-02-08Buy221,4780$71550.3704Link
Sanderling Venture Partners VI10% Owner2011-02-08Buy46,3790$7324.7704Link
MPM BioVentures IV QP LP10% Owner2011-02-08Buy535,7140$73750704Link
EVNIN LUKEDirector, 10% Owner2011-02-08Buy535,7140$73750704Link
KAILIAN VAUGHN M10% Owner2011-02-08Buy535,7140$73750704Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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