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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Paul R. Schimmel,PhDN/A665,1061.98%2007-06-14
ProfessorDr. Alexander Rich,M.D.N/A436,5001.3%2008-09-09
Dr. Walter C. Herlihy,PhDN/A262,4300.78%2015-05-12
Dr. James R. Rusche,PhDN/A100,5160.3%2016-02-26
Dr. Daniel P. Witt,PhDN/A77,9990.23%2014-06-20
Mr. Tony J. HuntN/A73,3420.22%2016-05-05
Ms. Karen A. DawesN/A42,7460.13%2016-05-11
Dr. Alfred L. Goldberg,PhDN/A40,3310.12%2015-05-21
Dr. Glenn L. Cooper,M.D.N/A37,0940.11%2016-05-11
Howard Benjamin,PhDVP Business Development28,626less than 0.1%2016-05-24

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Benjamin HowardVP Business Development2016-05-11Sell2,88918,626$26.7277.19-11.4118,626 (Direct)
Benjamin HowardVP Business Development2015-06-09Sell35,00011,554$38.141334.9-37.9411,554 (Direct)
RUSCHE JAMES RSenior Vice President2015-05-15Sell15,00096,849$41.32619.8-42.7296,849 (Direct)
HERLIHY WALTER CPRESIDENT, CEO
(Click for the stocks that their CEOs have bought)
2015-05-12Sell45,431262,430$38.971770.45-39.26262,430 (Direct)
HERLIHY WALTER CPRESIDENT, CEO2015-05-11Sell104,569307,861$37.943967.35-37.61307,861 (Direct)
RYAN THOMAS F JRDirector2015-05-08Sell20,00020,312$37.19743.8-36.3520,312 (Direct)
HERLIHY WALTER CPRESIDENT AND CEO2015-03-23Sell24,536422,430$31.78779.75-25.52422,430 (Direct)
HERLIHY WALTER CPRESIDENT AND CEO2015-03-19Sell49,695446,966$33.081643.91-28.45446,966 (Direct)
RYAN THOMAS F JRDirector2015-03-19Sell10,00040,312$32.62326.2-27.4440,312 (Direct)
RUSCHE JAMES RSenior Vice President2015-03-19Sell14,650111,849$33.3487.85-28.92111,849 (Direct)
Benjamin HowardVP Business Development2015-03-18Sell15,79546,554$32.63515.39-27.4646,554 (Direct)
HERLIHY WALTER CPRESIDENT, CEO2014-11-19Sell51,386496,661$23.431203.971.02496,661 (Direct)
RYAN THOMAS F JRDirector2014-11-13Sell10,00050,312$23.81238.1-0.5950,312 (Direct)
Benjamin HowardVP Business Development2014-11-11Sell30,00043,851$23.56706.80.4743,851 (Direct)
GRIFFITH MICHAEL ADirector2014-11-10Sell23,3421,932$22.9534.533.361,932 (Direct)
Benjamin HowardVP Business Development2014-08-13Sell40,00073,851$20.34813.616.3773,851 (Direct)
RYAN THOMAS F JRDirector2014-06-27Sell10,00050,312$22.41224.15.6250,312 (Direct)
RYAN THOMAS F JRDirector2014-06-24Sell10,00050,312$21.78217.88.6850,312 (Direct)
HERLIHY WALTER CPRESIDENT, CEO2014-06-11Sell60,335539,477$20.111213.3417.7539,477 (Direct)
RUSCHE JAMES RSenior Vice President2014-06-09Sell30,000121,270$20.19605.717.24121,270 (Direct)
WITT DANIEL PSenior Vice President2014-06-06Sell47,70910,000$20.56980.915.1310,000 (Direct)
RYAN THOMAS F JRDirector2014-06-05Sell45,00050,312$20.56925.215.1350,312 (Direct)
RUSCHE JAMES RSenior Vice President2014-04-15Buy25,000151,270$3.0576.25676.07151,270 (Direct)
WITT DANIEL PSenior Vice President2014-04-15Buy10,00057,709$3.0530.5676.0757,709 (Direct)
RUSCHE JAMES RSenior Vice President2013-08-08Sell30,000137,270$10.01300.3136.46137,270 (Direct)
DAWES KAREN ADirector2013-06-21Buy1,00033,880$7.77.7207.433,880 (Direct)
RYAN THOMAS F JRDirector2013-05-17Sell21,00048,380$8.97188.37163.8848,380 (Direct)
0 (by Thomas F. Ryan Jr., trustee for child)
0 (by Thomas F. Ryan Jr., trustee for grandchild)
RYAN THOMAS F JRDirector2013-05-15Sell86,03958,999$9.01775.21162.7158,999 (Direct)
HERLIHY WALTER CPRESIDENT, CEO2013-05-15Sell40,000537,793$8.97358.8163.88537,793 (Direct)
RYAN THOMAS F JRDirector2013-05-15Sell1,96162,380$917.6516362,380 (Direct)
Kelly William JChief Accounting Officer2013-05-07Sell20,0000$9.14182.8158.97Link
RUSCHE JAMES RSenior Vice President2012-09-27Sell5,000154,121$5.9529.75297.82154,121 (Direct)
COOPER GLENN L MDDirector2012-09-21Buy10,00026,038$6.0960.9288.6726,038 (Direct)
Kelly William JCFO2012-08-31Sell95,0000$5.52524.4328.8Link
GRIFFITH MICHAEL ADirector2012-08-16Buy2,0002,000$4.889.76385.042,000 (Direct)
DAWES KAREN ADirector2011-08-12Buy10,000150,500$3.4934.9578.22150,500 (Direct)
Goldberg Alfred LewisDirector2011-08-10Buy21,000105,000$3.4372.03590.09105,000 (Direct)
Henry Earl WebbDirector2011-06-15Buy5,0005,000$3.6318.15552.075,000 (Direct)
DAWES KAREN ADirector2011-06-14Buy4,5006,500$3.5716.07563.036,500 (Direct)
RUSCHE JAMES RSenior Vice President2011-03-30Buy5,0005,000$2.6613.3789.855,000 (Direct)
COOPER GLENN L MDDirector2009-11-09Buy5,0005,000$4.9824.9375.3Link
BVF PARTNERS L P/IL2009-07-07Sell451,8002,765,050$5.522493.94328.8
DAWES KAREN ADirector2008-12-01Buy2,00050,000$3.57576.29
RICH ALEXANDERDirector2008-09-09Sell5,000436,500$5.0525.25368.71
WITT DANIEL PVice President2008-03-04Sell5,00039,834$5.4227.1336.72
WITT DANIEL PVice President2008-02-20Sell2,20038,300$5.812.76308.1
WITT DANIEL PVice President2008-02-19Sell14,33485,334$6.2890.02276.91
RUSCHE JAMES RSenior Vice President2007-12-13Sell20,0000$6.14122.8285.5
HERLIHY WALTER CPRESIDENT, CEO, Director2007-12-13Sell50,000452,203$6.13306.5286.13
RUSCHE JAMES RSenior Vice President2007-12-13Sell17,64395,874$6.14108.33285.5
LANDY HALVice President2007-06-19Sell30,0000$3.82114.6519.63
RICH ALEXANDERDirector2007-06-14Sell5,000436,500$3.919.5506.92
RUSCHE JAMES RSenior Vice President2007-06-14Sell7,4440$3.929.03506.92
RICH ALEXANDERDirector2006-09-06Sell5,000436,500$3.3816.9600.3Link
DAWES KAREN ADirector2006-09-01Buy2,0002,000$3.336.66610.81Link
Whitehouse LauraVice President2006-02-28Sell10,0003,457$4.545426Link
HERLIHY WALTER CPRESIDENT, CEO2006-02-21Sell54,000116,668$4.25229.5456.94Link
WITT DANIEL PVice President2006-02-17Sell34,60089,668$4.25147.05456.94Link
RUSCHE JAMES RSenior Vice President2006-02-14Sell30,000103,874$4.16124.8468.99Link
WITT DANIEL PVice President2006-02-14Sell25,40089,668$4.25107.95456.94Link
DAY BARBARA BURNIMFormer Vice President2006-01-24Sell14,5002,000$3.8155.25521.26Link
RYAN THOMAS F JRDirector2005-12-09Buy8,00058,000$2.9523.6702.37Link
DAY BARBARA BURNIMVice President2005-08-25Sell10,0002,000$3.5735.7563.03Link
HERLIHY WALTER CPRESIDENT, CEO2005-08-03Sell17,6000$3.5562.48566.76Link
RUSCHE JAMES RSenior Vice President2005-08-03Sell10,0007,444$3.4534.5586.09Link
Whitehouse LauraVice President2005-08-02Sell2,8253,457$3.18.76663.55Link
RUSCHE JAMES RSenior Vice President2005-07-29Sell10,00093,874$2.9629.6699.66Link
RYAN THOMAS F JRDirector2005-03-10Buy12,00048,000$1.7220.641276.16Link
HERLIHY WALTER CPRESIDENT, CEO2005-02-18Buy10,000170,668$1.9919.91089.45Link
RYAN THOMAS F JRDirector2004-08-13Buy10,00035,000$1.5915.91388.68Link
RYAN THOMAS F JRDirector2003-11-26Buy11,00021,000$4.8453.24389.05Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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