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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
James M. GowerN/A180,6760.2%2005-11-02
Dr. Donald G. Payan,M.D.N/A58,334less than 0.1%2015-06-10
Flynn James EN/A25,000less than 0.1%2010-11-03
Raul R. RodriguezN/A23,607less than 0.1%2004-08-31
Bradford S. GoodwinN/A10,000less than 0.1%2007-08-09
Dr. Robin D.G. Cooper,PhD,D.Sc.N/A9,000less than 0.1%2005-12-07
James H. WelchN/A3,757less than 0.1%2004-09-02
Dr. Walter H. Moos,PhDN/A2,222less than 0.1%2007-06-26
Dr. Elliott B. Grossbard,M.D.N/A2,000less than 0.1%2007-05-29
Dr. Jean Deleage,PhDN/A697less than 0.1%2005-11-02

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
PAYAN DONALD GEVP, Pres. Discovery&Research2015-06-10Sell41,66658,334$3.68153.33-37.2358,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-04-01Sell10,00058,334$3.7537.5-38.458,334 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.224.05575 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.224.05575 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-09-03Sell20,00068,334$2.5651.2-9.7768,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-02-24Sell20,00088,334$3.7174.2-37.7488,334 (Direct)
BVF PARTNERS L P/IL10% Owner2013-11-19Sell484,6226,962,123$2.641279.4-12.5
6,962,123 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy32,7006,962,123$3.47113.47-33.43
6,962,123 (See Explanation of Responses)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2012-09-13Sell4,1511,103$10.4343.29-77.851,103 (Direct)
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-12Sell23,3020$10.67248.63-78.35Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-10Sell51,6980$10.54544.9-78.08Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-08-07Sell1,7000$10.6118.04-78.23Link
PAYAN DONALD GEVP, Pres. Discovery&Research2012-06-19Sell10,000108,334$8.787-73.45108,334 (Direct)
Flynn James E2011-05-26Buy650,0006,742,289$85200-71.1325,000 (Direct)
470,425 (Through Deerfield Special Situations Fund, L.P.)
762,700 (Through Deerfield Special Situations Fund International Limited)
2,279,997 (Through Deerfield Partners, L.P.)
3,204,167 (Through Deerfield International Limited)
Flynn James E2010-11-03Sell7,7116,092,289$7.5558.22-69.4Link
Goodwin Bradford SDirector2007-08-09Buy10,00010,000$9.9399.3-76.74
Grossbard Elliott BSr. VP Medical Development2007-05-29Buy2,0002,000$9.6819.36-76.14
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-12-07Buy1,0009,000$8.128.12-71.55Link
DELEAGE JEANDirector2005-07-27Sell171,99711,604$20.333496.7-88.64Link
DELEAGE JEANDirector2005-07-25Sell6,40017,707$20.37130.37-88.66Link
DELEAGE JEANDirector2005-07-21Sell58617,934$20.7512.16-88.87Link
DELEAGE JEANDirector2005-07-20Sell148,04317,955$20.753071.89-88.87Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-05-10Sell15,0004,385$19.71295.65-88.28Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-03-30Buy1,0004,385$15.9915.99-85.55Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-02-08Buy5008,000$18.789.39-87.7Link
FRAZIER ALAN DDirector2005-01-25Sell2,33210,905$19.144.54-87.91Link
HENNER DENNISDirector2005-01-05Sell17,2530$23.26401.3-90.07Link
HENNER DENNISDirector2004-11-23Sell868,05517,253$23.4920390.61-90.17Link
SIMON NICHOLAS J IIIDirector2004-11-23Sell868,0550$23.4920390.61-90.17Link
DELEAGE JEANDirector2004-11-05Sell126,05023,207$26.113291.17-91.15Link
DELEAGE JEANDirector2004-10-21Sell177,60027,680$25.054448.88-90.78Link
DELEAGE JEANDirector2004-10-19Sell46,35033,981$26.291218.54-91.21Link
DELEAGE JEANDirector2004-09-30Sell25,6250$24.79635.24-90.68Link
SIMON NICHOLAS J IIIDirector2004-09-17Sell14,9560$32.33483.53-92.85Link
WELCH JAMES HCFO, VP & Secretary
(Click for the stocks that their CFOs have bought)
2004-09-02Sell10,0003,757$20.23202.3-88.58Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-09-01Sell85,0271,687,072$20.751764.31-88.87Link
HENNER DENNISDirector, 10% Owner2004-09-01Sell85,0271,688,641$20.751764.31-88.87Link
EVNIN LUKE10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-88.86Link
MPM BIOVENTURES III QP LP10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-88.86Link
RODRIGUEZ RAUL REVP, COO2004-08-31Sell11,00023,607$20.85229.35-88.92Link
HENNER DENNISDirector, 10% Owner2004-08-20Sell32,4991,773,668$21.83709.45-89.42Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-20Sell33,4211,772,099$21.83729.58-89.42Link
EVNIN LUKE10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-89.42Link
MPM BIOVENTURES III QP LP10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-89.42Link
EVNIN LUKE10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-89.62Link
HENNER DENNISDirector, 10% Owner2004-08-18Sell18,9991,806,167$22.26422.92-89.62Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-18Sell18,9991,805,520$22.26422.92-89.62Link
MPM BIOVENTURES III QP LP10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-89.62Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-13Sell10,0001,824,519$22.3223-89.64Link
EVNIN LUKE10% Owner2004-08-13Sell10,0001,824,423$22.3223-89.64Link
MPM BIOVENTURES III QP LP10% Owner2004-08-13Sell10,0001,824,423$22.3223-89.64Link
HENNER DENNISDirector, 10% Owner2004-08-13Sell10,0001,825,166$22.3223-89.64Link
STEINMETZ MICHAEL10% Owner2004-08-02Sell1,9681,833,597$18.6836.76-87.63Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-07-16Buy2,5007,500$11.4628.65-79.84Link
EVNIN LUKE10% Owner2004-07-02Sell7,8471,833,597$14.88116.76-84.48Link
GALAKATOS NICHOLAS10% Owner2004-07-02Sell1,6521,833,597$15.3325.33-84.93Link
GADICKE ANSBERT10% Owner2004-07-02Sell2,4631,833,597$14.5935.94-84.17Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-28Sell2,8771,834,519$15.8345.54-85.41Link
HENNER DENNISDirector, 10% Owner2004-06-28Sell2,8771,835,166$15.8345.54-85.41Link
MPM BIOVENTURES III QP LP10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-85.41Link
EVNIN LUKE10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-85.41Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.25Link
MPM BIOVENTURES III QP LP10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.25Link
HENNER DENNISDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.25Link
EVNIN LUKE10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.25Link
MPM BIOVENTURES III QP LP10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.11Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.11Link
HENNER DENNISDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.11Link
EVNIN LUKE10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.11Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.17Link
MPM BIOVENTURES III QP LP10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.17Link
HENNER DENNISDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.17Link
EVNIN LUKE10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.17Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.14Link
MPM BIOVENTURES III QP LP10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.14Link
HENNER DENNISDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.14Link
EVNIN LUKE10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.14Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.05Link
MPM BIOVENTURES III QP LP10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.05Link
HENNER DENNISDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.05Link
EVNIN LUKE10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.05Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-86.69Link
MPM BIOVENTURES III QP LP10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-86.69Link
EVNIN LUKE10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-86.69Link
HENNER DENNISDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-86.69Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-05-21Buy5,0005,000$16.6783.35-86.14Link
FRAZIER ALAN DDirector2004-05-20Sell2,333949,280$17.6141.08-86.88Link
HENNER DENNISDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-86.61Link
EVNIN LUKE10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-86.61Link
MPM BIOVENTURES III QP LP10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-86.61Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-86.61Link
DELEAGE JEANDirector, 10% Owner2004-05-07Sell3,10044,573$21.566.65-89.26Link
ALTA PARTNERS II INC10% Owner2004-05-07Sell3,10044,573$21.566.65-89.26Link
ALTA PARTNERS II INC10% Owner2004-05-03Sell95,20044,573$21.312028.71-89.16Link
DELEAGE JEANDirector, 10% Owner2004-05-03Sell95,20044,573$21.312028.71-89.16Link
DELEAGE JEANDirector, 10% Owner2004-04-30Sell8,40044,573$21.25178.5-89.13Link
ALTA PARTNERS II INC10% Owner2004-04-30Sell8,40044,573$21.25178.5-89.13Link
DELEAGE JEANDirector, 10% Owner2004-04-29Sell42,80044,573$21.25909.5-89.13Link
ALTA PARTNERS II INC10% Owner2004-04-29Sell42,80055,006$21.25909.5-89.13Link
DELEAGE JEANDirector, 10% Owner2004-04-27Sell8,90044,573$21.26189.21-89.13Link
ALTA PARTNERS II INC10% Owner2004-04-27Sell8,90055,962$21.26189.21-89.13Link
DELEAGE JEANDirector, 10% Owner2004-04-23Sell13,10044,573$21.32279.29-89.17Link
ALTA PARTNERS II INC10% Owner2004-04-23Sell13,10044,573$21.32279.29-89.17Link
ALTA PARTNERS II INC10% Owner2004-04-22Sell8,80056,454$21.26187.09-89.13Link
DELEAGE JEANDirector, 10% Owner2004-04-22Sell8,80056,454$21.26187.09-89.13Link
EVNIN LUKE10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-88.85Link
MPM BIOVENTURES III QP LP10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-88.85Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-88.85Link
HENNER DENNISDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-88.85Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.41Link
EVNIN LUKE10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.41Link
MPM BIOVENTURES III QP LP10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.41Link
HENNER DENNISDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.41Link
DELEAGE JEANDirector, 10% Owner2004-04-07Sell60,30044,573$211266.3-89Link
ALTA PARTNERS II INC10% Owner2004-04-07Sell60,30044,573$211266.3-89Link
DELEAGE JEANDirector, 10% Owner2004-04-06Sell10,90057,997$21.21231.19-89.11Link
ALTA PARTNERS II INC10% Owner2004-04-06Sell10,90044,573$21.21231.19-89.11Link
FRAZIER ALAN DDirector2004-04-05Sell2,5241,409,965$22.7657.45-89.85Link
ALTA PARTNERS II INC10% Owner2004-03-24Sell7,48744,573$20149.74-88.45Link
DELEAGE JEANDirector, 10% Owner2004-03-24Sell7,48744,573$20149.74-88.45Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-88.45Link
HENNER DENNISDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-88.45Link
MPM BIOVENTURES III QP LP10% Owner2004-03-19Sell17,3344,150,571$20346.68-88.45Link
EVNIN LUKE10% Owner2004-02-19Sell17,3344,150,571$20346.68-88.45Link
FRAZIER HEALTHCARE IV LP10% Owner2004-02-19Sell78,4361,223,647$18.81474.6-87.71Link
FRAZIER ALAN DDirector, 10% Owner2004-02-19Sell78,4361,706,726$18.81474.6-87.71Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-88.45Link
HENNER DENNISDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-88.45Link
MPM BIOVENTURES III QP LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-88.45Link
MPM BIOEQUITIES MASTER FUND LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-88.45Link
ALTA PARTNERS II INC10% Owner2004-02-19Sell111,69644,573$202233.92-88.45Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-88.45Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-88.45Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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