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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
PAYAN DONALD GEVP, Pres. Discovery&Research2016-08-30Sell5,30353,031$421.21-34.25
53,031 (By Family Trust)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-06-10Sell41,66658,334$3.68153.33-28.5358,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-04-01Sell10,00058,334$3.7537.5-29.8758,334 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.2218.47575 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.2218.47575 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-09-03Sell20,00068,334$2.5651.22.7368,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-02-24Sell20,00088,334$3.7174.2-29.1188,334 (Direct)
BVF PARTNERS L P/IL10% Owner2013-11-19Sell484,6226,962,123$2.641279.4-0.38
6,962,123 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy32,7006,962,123$3.47113.47-24.21
6,962,123 (See Explanation of Responses)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2012-09-13Sell4,1511,103$10.4343.29-74.781,103 (Direct)
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-12Sell23,3020$10.67248.63-75.35Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-10Sell51,6980$10.54544.9-75.05Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-08-07Sell1,7000$10.6118.04-75.21Link
PAYAN DONALD GEVP, Pres. Discovery&Research2012-06-19Sell10,000108,334$8.787-69.77108,334 (Direct)
Flynn James E2011-05-26Buy650,0006,742,289$85200-67.1325,000 (Direct)
470,425 (Through Deerfield Special Situations Fund, L.P.)
762,700 (Through Deerfield Special Situations Fund International Limited)
2,279,997 (Through Deerfield Partners, L.P.)
3,204,167 (Through Deerfield International Limited)
Flynn James E2010-11-03Sell7,7116,092,289$7.5558.22-65.17Link
Goodwin Bradford SDirector2007-08-09Buy10,00010,000$9.9399.3-73.51
Grossbard Elliott BSr. VP Medical Development2007-05-29Buy2,0002,000$9.6819.36-72.83
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-12-07Buy1,0009,000$8.128.12-67.61Link
DELEAGE JEANDirector2005-07-27Sell171,99711,604$20.333496.7-87.06Link
DELEAGE JEANDirector2005-07-25Sell6,40017,707$20.37130.37-87.09Link
DELEAGE JEANDirector2005-07-21Sell58617,934$20.7512.16-87.33Link
DELEAGE JEANDirector2005-07-20Sell148,04317,955$20.753071.89-87.33Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-05-10Sell15,0004,385$19.71295.65-86.66Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-03-30Buy1,0004,385$15.9915.99-83.55Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-02-08Buy5008,000$18.789.39-86Link
FRAZIER ALAN DDirector2005-01-25Sell2,33210,905$19.144.54-86.23Link
HENNER DENNISDirector2005-01-05Sell17,2530$23.26401.3-88.69Link
HENNER DENNISDirector2004-11-23Sell868,05517,253$23.4920390.61-88.8Link
SIMON NICHOLAS J IIIDirector2004-11-23Sell868,0550$23.4920390.61-88.8Link
DELEAGE JEANDirector2004-11-05Sell126,05023,207$26.113291.17-89.93Link
DELEAGE JEANDirector2004-10-21Sell177,60027,680$25.054448.88-89.5Link
DELEAGE JEANDirector2004-10-19Sell46,35033,981$26.291218.54-90Link
DELEAGE JEANDirector2004-09-30Sell25,6250$24.79635.24-89.39Link
SIMON NICHOLAS J IIIDirector2004-09-17Sell14,9560$32.33483.53-91.87Link
WELCH JAMES HCFO, VP & Secretary
(Click for the stocks that their CFOs have bought)
2004-09-02Sell10,0003,757$20.23202.3-87Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-09-01Sell85,0271,687,072$20.751764.31-87.33Link
HENNER DENNISDirector, 10% Owner2004-09-01Sell85,0271,688,641$20.751764.31-87.33Link
EVNIN LUKE10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-87.32Link
MPM BIOVENTURES III QP LP10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-87.32Link
RODRIGUEZ RAUL REVP, COO2004-08-31Sell11,00023,607$20.85229.35-87.39Link
HENNER DENNISDirector, 10% Owner2004-08-20Sell32,4991,773,668$21.83709.45-87.95Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-20Sell33,4211,772,099$21.83729.58-87.95Link
EVNIN LUKE10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-87.95Link
MPM BIOVENTURES III QP LP10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-87.95Link
EVNIN LUKE10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-88.19Link
HENNER DENNISDirector, 10% Owner2004-08-18Sell18,9991,806,167$22.26422.92-88.19Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-18Sell18,9991,805,520$22.26422.92-88.19Link
MPM BIOVENTURES III QP LP10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-88.19Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-13Sell10,0001,824,519$22.3223-88.21Link
EVNIN LUKE10% Owner2004-08-13Sell10,0001,824,423$22.3223-88.21Link
MPM BIOVENTURES III QP LP10% Owner2004-08-13Sell10,0001,824,423$22.3223-88.21Link
HENNER DENNISDirector, 10% Owner2004-08-13Sell10,0001,825,166$22.3223-88.21Link
STEINMETZ MICHAEL10% Owner2004-08-02Sell1,9681,833,597$18.6836.76-85.92Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-07-16Buy2,5007,500$11.4628.65-77.05Link
EVNIN LUKE10% Owner2004-07-02Sell7,8471,833,597$14.88116.76-82.33Link
GALAKATOS NICHOLAS10% Owner2004-07-02Sell1,6521,833,597$15.3325.33-82.84Link
GADICKE ANSBERT10% Owner2004-07-02Sell2,4631,833,597$14.5935.94-81.97Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-28Sell2,8771,834,519$15.8345.54-83.39Link
HENNER DENNISDirector, 10% Owner2004-06-28Sell2,8771,835,166$15.8345.54-83.39Link
MPM BIOVENTURES III QP LP10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-83.39Link
EVNIN LUKE10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-83.39Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-83.21Link
MPM BIOVENTURES III QP LP10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-83.21Link
HENNER DENNISDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-83.21Link
EVNIN LUKE10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-83.21Link
MPM BIOVENTURES III QP LP10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-83.04Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-83.04Link
HENNER DENNISDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-83.04Link
EVNIN LUKE10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-83.04Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-85.39Link
MPM BIOVENTURES III QP LP10% Owner2004-06-02Sell2,0303,490,963$1836.54-85.39Link
HENNER DENNISDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-85.39Link
EVNIN LUKE10% Owner2004-06-02Sell2,0303,490,963$1836.54-85.39Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-85.36Link
MPM BIOVENTURES III QP LP10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-85.36Link
HENNER DENNISDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-85.36Link
EVNIN LUKE10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-85.36Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-85.26Link
MPM BIOVENTURES III QP LP10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-85.26Link
HENNER DENNISDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-85.26Link
EVNIN LUKE10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-85.26Link
EVNIN LUKE10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-84.84Link
HENNER DENNISDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-84.84Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-84.84Link
MPM BIOVENTURES III QP LP10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-84.84Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-05-21Buy5,0005,000$16.6783.35-84.22Link
FRAZIER ALAN DDirector2004-05-20Sell2,333949,280$17.6141.08-85.07Link
HENNER DENNISDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-84.75Link
EVNIN LUKE10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-84.75Link
MPM BIOVENTURES III QP LP10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-84.75Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-84.75Link
DELEAGE JEANDirector, 10% Owner2004-05-07Sell3,10044,573$21.566.65-87.77Link
ALTA PARTNERS II INC10% Owner2004-05-07Sell3,10044,573$21.566.65-87.77Link
ALTA PARTNERS II INC10% Owner2004-05-03Sell95,20044,573$21.312028.71-87.66Link
DELEAGE JEANDirector, 10% Owner2004-05-03Sell95,20044,573$21.312028.71-87.66Link
DELEAGE JEANDirector, 10% Owner2004-04-30Sell8,40044,573$21.25178.5-87.62Link
ALTA PARTNERS II INC10% Owner2004-04-30Sell8,40044,573$21.25178.5-87.62Link
DELEAGE JEANDirector, 10% Owner2004-04-29Sell42,80044,573$21.25909.5-87.62Link
ALTA PARTNERS II INC10% Owner2004-04-29Sell42,80055,006$21.25909.5-87.62Link
DELEAGE JEANDirector, 10% Owner2004-04-27Sell8,90044,573$21.26189.21-87.63Link
ALTA PARTNERS II INC10% Owner2004-04-27Sell8,90055,962$21.26189.21-87.63Link
DELEAGE JEANDirector, 10% Owner2004-04-23Sell13,10044,573$21.32279.29-87.66Link
ALTA PARTNERS II INC10% Owner2004-04-23Sell13,10044,573$21.32279.29-87.66Link
ALTA PARTNERS II INC10% Owner2004-04-22Sell8,80056,454$21.26187.09-87.63Link
DELEAGE JEANDirector, 10% Owner2004-04-22Sell8,80056,454$21.26187.09-87.63Link
EVNIN LUKE10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-87.3Link
MPM BIOVENTURES III QP LP10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-87.3Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-87.3Link
HENNER DENNISDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-87.3Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-86.8Link
EVNIN LUKE10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-86.8Link
MPM BIOVENTURES III QP LP10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-86.8Link
HENNER DENNISDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-86.8Link
DELEAGE JEANDirector, 10% Owner2004-04-07Sell60,30044,573$211266.3-87.48Link
ALTA PARTNERS II INC10% Owner2004-04-07Sell60,30044,573$211266.3-87.48Link
DELEAGE JEANDirector, 10% Owner2004-04-06Sell10,90057,997$21.21231.19-87.6Link
ALTA PARTNERS II INC10% Owner2004-04-06Sell10,90044,573$21.21231.19-87.6Link
FRAZIER ALAN DDirector2004-04-05Sell2,5241,409,965$22.7657.45-88.44Link
ALTA PARTNERS II INC10% Owner2004-03-24Sell7,48744,573$20149.74-86.85Link
DELEAGE JEANDirector, 10% Owner2004-03-24Sell7,48744,573$20149.74-86.85Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-86.85Link
HENNER DENNISDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-86.85Link
MPM BIOVENTURES III QP LP10% Owner2004-03-19Sell17,3344,150,571$20346.68-86.85Link
EVNIN LUKE10% Owner2004-02-19Sell17,3344,150,571$20346.68-86.85Link
FRAZIER HEALTHCARE IV LP10% Owner2004-02-19Sell78,4361,223,647$18.81474.6-86.01Link
FRAZIER ALAN DDirector, 10% Owner2004-02-19Sell78,4361,706,726$18.81474.6-86.01Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-86.85Link
HENNER DENNISDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-86.85Link
MPM BIOVENTURES III QP LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-86.85Link
MPM BIOEQUITIES MASTER FUND LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-86.85Link
ALTA PARTNERS II INC10% Owner2004-02-19Sell111,69644,573$202233.92-86.85Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-86.85Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-86.85Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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