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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
James M. GowerN/A180,6760.2%2005-11-02
Dr. Donald G. Payan,M.D.EVP, Pres. Discovery&Research58,334less than 0.1%2015-06-10
Flynn James E25,000less than 0.1%2010-11-03
Raul R. RodriguezEVP, COO23,607less than 0.1%2004-08-31
Bradford S. GoodwinN/A10,000less than 0.1%2007-08-09
Dr. Robin D.G. Cooper,PhD,D.Sc.Sr. V.P. Pharmaceutical Scs.9,000less than 0.1%2005-12-07
James H. WelchCFO, VP & Secretary3,757less than 0.1%2004-09-02
Dr. Walter H. Moos,PhDN/A2,222less than 0.1%2007-06-26
Dr. Elliott B. Grossbard,M.D.N/A2,000less than 0.1%2007-05-29
Dr. Jean Deleage,PhDDirector697less than 0.1%2005-11-02

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
PAYAN DONALD GEVP, Pres. Discovery&Research2015-06-10Sell41,66658,334$3.68153.3-34.7858,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-04-01Sell10,00058,334$3.7537.5-3658,334 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.28.11575 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.28.11575 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-09-03Sell20,00068,334$2.5651.2-6.2568,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-02-24Sell20,00088,334$3.7174.2-35.3188,334 (Direct)
BVF PARTNERS L P/IL10% Owner2013-11-19Sell484,6226,962,123$2.641279.4-9.09
6,962,123 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy32,7006,962,123$3.47113.5-30.84
6,962,123 (See Explanation of Responses)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2012-09-13Sell4,1511,103$10.4343.3-76.991,103 (Direct)
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-12Sell23,3020$10.67248.6-77.51Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-10Sell51,6980$10.54544.9-77.23Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-08-07Sell1,7000$10.6118-77.38Link
PAYAN DONALD GEVP, Pres. Discovery&Research2012-06-19Sell10,000108,334$8.787-72.41108,334 (Direct)
Flynn James E2011-05-26Buy650,0006,742,289$85200-7025,000 (Direct)
470,425 (Through Deerfield Special Situations Fund, L.P.)
762,700 (Through Deerfield Special Situations Fund International Limited)
2,279,997 (Through Deerfield Partners, L.P.)
3,204,167 (Through Deerfield International Limited)
Flynn James E2010-11-03Sell7,7116,092,289$7.5558.2-68.21Link
Goodwin Bradford SDirector2007-08-09Buy10,00010,000$9.9399.3-75.83
Grossbard Elliott BSr. VP Medical Development2007-05-29Buy2,0002,000$9.6819.4-75.21
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-12-07Buy1,0009,000$8.128.1-70.44Link
DELEAGE JEANDirector2005-07-27Sell171,99711,604$20.333496.7-88.19Link
DELEAGE JEANDirector2005-07-25Sell6,40017,707$20.37130.4-88.22Link
DELEAGE JEANDirector2005-07-21Sell58617,934$20.7512.2-88.43Link
DELEAGE JEANDirector2005-07-20Sell148,04317,955$20.753071.9-88.43Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-05-10Sell15,0004,385$19.71295.7-87.82Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-03-30Buy1,0004,385$15.9916-84.99Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-02-08Buy5008,000$18.789.4-87.22Link
FRAZIER ALAN DDirector2005-01-25Sell2,33210,905$19.144.5-87.43Link
HENNER DENNISDirector2005-01-05Sell17,2530$23.26401.3-89.68Link
HENNER DENNISDirector2004-11-23Sell868,05517,253$23.4920390.6-89.78Link
SIMON NICHOLAS J IIIDirector2004-11-23Sell868,0550$23.4920390.6-89.78Link
DELEAGE JEANDirector2004-11-05Sell126,05023,207$26.113291.2-90.81Link
DELEAGE JEANDirector2004-10-21Sell177,60027,680$25.054448.9-90.42Link
DELEAGE JEANDirector2004-10-19Sell46,35033,981$26.291218.5-90.87Link
DELEAGE JEANDirector2004-09-30Sell25,6250$24.79635.2-90.32Link
SIMON NICHOLAS J IIIDirector2004-09-17Sell14,9560$32.33483.5-92.58Link
WELCH JAMES HCFO, VP & Secretary
(Click for the stocks that their CFOs have bought)
2004-09-02Sell10,0003,757$20.23202.3-88.14Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-09-01Sell85,0271,687,072$20.751764.3-88.43Link
HENNER DENNISDirector, 10% Owner2004-09-01Sell85,0271,688,641$20.751764.3-88.43Link
EVNIN LUKE10% Owner2004-09-01Sell85,8531,687,072$20.741780.6-88.43Link
MPM BIOVENTURES III QP LP10% Owner2004-09-01Sell85,8531,687,072$20.741780.6-88.43Link
RODRIGUEZ RAUL REVP, COO2004-08-31Sell11,00023,607$20.85229.4-88.49Link
HENNER DENNISDirector, 10% Owner2004-08-20Sell32,4991,773,668$21.83709.5-89.01Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-20Sell33,4211,772,099$21.83729.6-89.01Link
EVNIN LUKE10% Owner2004-08-20Sell32,4991,772,925$21.83709.5-89.01Link
MPM BIOVENTURES III QP LP10% Owner2004-08-20Sell32,4991,772,925$21.83709.5-89.01Link
EVNIN LUKE10% Owner2004-08-18Sell18,9991,805,424$22.26422.9-89.22Link
HENNER DENNISDirector, 10% Owner2004-08-18Sell18,9991,806,167$22.26422.9-89.22Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-18Sell18,9991,805,520$22.26422.9-89.22Link
MPM BIOVENTURES III QP LP10% Owner2004-08-18Sell18,9991,805,424$22.26422.9-89.22Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-13Sell10,0001,824,519$22.3223-89.24Link
EVNIN LUKE10% Owner2004-08-13Sell10,0001,824,423$22.3223-89.24Link
MPM BIOVENTURES III QP LP10% Owner2004-08-13Sell10,0001,824,423$22.3223-89.24Link
HENNER DENNISDirector, 10% Owner2004-08-13Sell10,0001,825,166$22.3223-89.24Link
STEINMETZ MICHAEL10% Owner2004-08-02Sell1,9681,833,597$18.6836.8-87.15Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-07-16Buy2,5007,500$11.4628.7-79.06Link
EVNIN LUKE10% Owner2004-07-02Sell7,8471,833,597$14.88116.8-83.87Link
GALAKATOS NICHOLAS10% Owner2004-07-02Sell1,6521,833,597$15.3325.3-84.34Link
GADICKE ANSBERT10% Owner2004-07-02Sell2,4631,833,597$14.5935.9-83.55Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-28Sell2,8771,834,519$15.8345.5-84.84Link
HENNER DENNISDirector, 10% Owner2004-06-28Sell2,8771,835,166$15.8345.5-84.84Link
MPM BIOVENTURES III QP LP10% Owner2004-06-28Sell2,8771,849,800$15.8345.5-84.84Link
EVNIN LUKE10% Owner2004-06-28Sell2,8771,849,800$15.8345.5-84.84Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.6-84.67Link
MPM BIOVENTURES III QP LP10% Owner2004-06-25Sell124,3073,336,463$15.661946.6-84.67Link
HENNER DENNISDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.6-84.67Link
EVNIN LUKE10% Owner2004-06-25Sell124,3073,336,463$15.661946.6-84.67Link
MPM BIOVENTURES III QP LP10% Owner2004-06-23Sell30,1933,460,770$15.51468.3-84.53Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.3-84.53Link
HENNER DENNISDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.3-84.53Link
EVNIN LUKE10% Owner2004-06-23Sell30,1933,460,770$15.51468.3-84.53Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.5-86.67Link
MPM BIOVENTURES III QP LP10% Owner2004-06-02Sell2,0303,490,963$1836.5-86.67Link
HENNER DENNISDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.5-86.67Link
EVNIN LUKE10% Owner2004-06-02Sell2,0303,490,963$1836.5-86.67Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.5-86.64Link
MPM BIOVENTURES III QP LP10% Owner2004-06-01Sell13,9503,492,993$17.96250.5-86.64Link
HENNER DENNISDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.5-86.64Link
EVNIN LUKE10% Owner2004-06-01Sell13,9503,492,993$17.96250.5-86.64Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.1-86.55Link
MPM BIOVENTURES III QP LP10% Owner2004-05-27Sell26,0153,506,943$17.84464.1-86.55Link
HENNER DENNISDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.1-86.55Link
EVNIN LUKE10% Owner2004-05-27Sell26,0153,506,943$17.84464.1-86.55Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.3-86.17Link
MPM BIOVENTURES III QP LP10% Owner2004-05-24Sell3,3003,532,958$17.3557.3-86.17Link
EVNIN LUKE10% Owner2004-05-24Sell3,3003,532,958$17.3557.3-86.17Link
HENNER DENNISDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.3-86.17Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-05-21Buy5,0005,000$16.6783.4-85.6Link
FRAZIER ALAN DDirector2004-05-20Sell2,333949,280$17.6141.1-86.37Link
HENNER DENNISDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.1-86.09Link
EVNIN LUKE10% Owner2004-05-20Sell139,3133,536,258$17.252403.1-86.09Link
MPM BIOVENTURES III QP LP10% Owner2004-05-20Sell139,3133,536,258$17.252403.1-86.09Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.1-86.09Link
DELEAGE JEANDirector, 10% Owner2004-05-07Sell3,10044,573$21.566.7-88.84Link
ALTA PARTNERS II INC10% Owner2004-05-07Sell3,10044,573$21.566.7-88.84Link
ALTA PARTNERS II INC10% Owner2004-05-03Sell95,20044,573$21.312028.7-88.74Link
DELEAGE JEANDirector, 10% Owner2004-05-03Sell95,20044,573$21.312028.7-88.74Link
DELEAGE JEANDirector, 10% Owner2004-04-30Sell8,40044,573$21.25178.5-88.71Link
ALTA PARTNERS II INC10% Owner2004-04-30Sell8,40044,573$21.25178.5-88.71Link
DELEAGE JEANDirector, 10% Owner2004-04-29Sell42,80044,573$21.25909.5-88.71Link
ALTA PARTNERS II INC10% Owner2004-04-29Sell42,80055,006$21.25909.5-88.71Link
DELEAGE JEANDirector, 10% Owner2004-04-27Sell8,90044,573$21.26189.2-88.71Link
ALTA PARTNERS II INC10% Owner2004-04-27Sell8,90055,962$21.26189.2-88.71Link
DELEAGE JEANDirector, 10% Owner2004-04-23Sell13,10044,573$21.32279.3-88.74Link
ALTA PARTNERS II INC10% Owner2004-04-23Sell13,10044,573$21.32279.3-88.74Link
ALTA PARTNERS II INC10% Owner2004-04-22Sell8,80056,454$21.26187.1-88.71Link
DELEAGE JEANDirector, 10% Owner2004-04-22Sell8,80056,454$21.26187.1-88.71Link
EVNIN LUKE10% Owner2004-04-21Sell158,6983,675,571$20.713286.6-88.41Link
MPM BIOVENTURES III QP LP10% Owner2004-04-21Sell158,6983,675,571$20.713286.6-88.41Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.6-88.41Link
HENNER DENNISDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.6-88.41Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-87.96Link
EVNIN LUKE10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-87.96Link
MPM BIOVENTURES III QP LP10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-87.96Link
HENNER DENNISDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-87.96Link
DELEAGE JEANDirector, 10% Owner2004-04-07Sell60,30044,573$211266.3-88.57Link
ALTA PARTNERS II INC10% Owner2004-04-07Sell60,30044,573$211266.3-88.57Link
DELEAGE JEANDirector, 10% Owner2004-04-06Sell10,90057,997$21.21231.2-88.68Link
ALTA PARTNERS II INC10% Owner2004-04-06Sell10,90044,573$21.21231.2-88.68Link
FRAZIER ALAN DDirector2004-04-05Sell2,5241,409,965$22.7657.4-89.46Link
ALTA PARTNERS II INC10% Owner2004-03-24Sell7,48744,573$20149.7-88Link
DELEAGE JEANDirector, 10% Owner2004-03-24Sell7,48744,573$20149.7-88Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.7-88Link
HENNER DENNISDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.7-88Link
MPM BIOVENTURES III QP LP10% Owner2004-03-19Sell17,3344,150,571$20346.7-88Link
EVNIN LUKE10% Owner2004-02-19Sell17,3344,150,571$20346.7-88Link
FRAZIER HEALTHCARE IV LP10% Owner2004-02-19Sell78,4361,223,647$18.81474.6-87.23Link
FRAZIER ALAN DDirector, 10% Owner2004-02-19Sell78,4361,706,726$18.81474.6-87.23Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.5-88Link
HENNER DENNISDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.5-88Link
MPM BIOVENTURES III QP LP10% Owner2004-02-19Sell172,3734,350,516$203447.5-88Link
MPM BIOEQUITIES MASTER FUND LP10% Owner2004-02-19Sell172,3734,350,516$203447.5-88Link
ALTA PARTNERS II INC10% Owner2004-02-19Sell111,69644,573$202233.9-88Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.9-88Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.9-88Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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