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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
James M. GowerN/A180,6760.19%2005-11-02
Dr. Donald G. Payan,M.D.EVP, Pres. Discovery&Research58,334less than 0.1%2015-06-10
Flynn James EN/A25,000less than 0.1%2010-11-03
Raul R. RodriguezN/A23,607less than 0.1%2004-08-31
Bradford S. GoodwinN/A10,000less than 0.1%2007-08-09
Dr. Robin D.G. Cooper,PhD,D.Sc.N/A9,000less than 0.1%2005-12-07
James H. WelchN/A3,757less than 0.1%2004-09-02
Dr. Walter H. Moos,PhDN/A2,222less than 0.1%2007-06-26
Dr. Elliott B. Grossbard,M.D.N/A2,000less than 0.1%2007-05-29
Dr. Jean Deleage,PhDN/A697less than 0.1%2005-11-02

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
PAYAN DONALD GEVP, Pres. Discovery&Research2016-08-30Sell5,30353,031$421.21-14.25
53,031 (By Family Trust)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-06-10Sell41,66658,334$3.68153.33-6.7958,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-04-01Sell10,00058,334$3.7537.5-8.5358,334 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.2254.5575 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.2254.5575 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-09-03Sell20,00068,334$2.5651.233.9868,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-02-24Sell20,00088,334$3.7174.2-7.5588,334 (Direct)
BVF PARTNERS L P/IL10% Owner2013-11-19Sell484,6226,962,123$2.641279.429.92
6,962,123 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy32,7006,962,123$3.47113.47-1.15
6,962,123 (See Explanation of Responses)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2012-09-13Sell4,1511,103$10.4343.29-67.111,103 (Direct)
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-12Sell23,3020$10.67248.63-67.85Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-10Sell51,6980$10.54544.9-67.46Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-08-07Sell1,7000$10.6118.04-67.67Link
PAYAN DONALD GEVP, Pres. Discovery&Research2012-06-19Sell10,000108,334$8.787-60.57108,334 (Direct)
Flynn James E2011-05-26Buy650,0006,742,289$85200-57.1325,000 (Direct)
470,425 (Through Deerfield Special Situations Fund, L.P.)
762,700 (Through Deerfield Special Situations Fund International Limited)
2,279,997 (Through Deerfield Partners, L.P.)
3,204,167 (Through Deerfield International Limited)
Flynn James E2010-11-03Sell7,7116,092,289$7.5558.22-54.57Link
Goodwin Bradford SDirector2007-08-09Buy10,00010,000$9.9399.3-65.46
Grossbard Elliott BSr. VP Medical Development2007-05-29Buy2,0002,000$9.6819.36-64.57
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-12-07Buy1,0009,000$8.128.12-57.76Link
DELEAGE JEANDirector2005-07-27Sell171,99711,604$20.333496.7-83.13Link
DELEAGE JEANDirector2005-07-25Sell6,40017,707$20.37130.37-83.16Link
DELEAGE JEANDirector2005-07-21Sell58617,934$20.7512.16-83.47Link
DELEAGE JEANDirector2005-07-20Sell148,04317,955$20.753071.89-83.47Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-05-10Sell15,0004,385$19.71295.65-82.6Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-03-30Buy1,0004,385$15.9915.99-78.55Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-02-08Buy5008,000$18.789.39-81.74Link
FRAZIER ALAN DDirector2005-01-25Sell2,33210,905$19.144.54-82.04Link
HENNER DENNISDirector2005-01-05Sell17,2530$23.26401.3-85.25Link
HENNER DENNISDirector2004-11-23Sell868,05517,253$23.4920390.61-85.4Link
SIMON NICHOLAS J IIIDirector2004-11-23Sell868,0550$23.4920390.61-85.4Link
DELEAGE JEANDirector2004-11-05Sell126,05023,207$26.113291.17-86.86Link
DELEAGE JEANDirector2004-10-21Sell177,60027,680$25.054448.88-86.31Link
DELEAGE JEANDirector2004-10-19Sell46,35033,981$26.291218.54-86.95Link
DELEAGE JEANDirector2004-09-30Sell25,6250$24.79635.24-86.16Link
SIMON NICHOLAS J IIIDirector2004-09-17Sell14,9560$32.33483.53-89.39Link
WELCH JAMES HCFO, VP & Secretary
(Click for the stocks that their CFOs have bought)
2004-09-02Sell10,0003,757$20.23202.3-83.04Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-09-01Sell85,0271,687,072$20.751764.31-83.47Link
HENNER DENNISDirector, 10% Owner2004-09-01Sell85,0271,688,641$20.751764.31-83.47Link
EVNIN LUKE10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-83.46Link
MPM BIOVENTURES III QP LP10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-83.46Link
RODRIGUEZ RAUL REVP, COO2004-08-31Sell11,00023,607$20.85229.35-83.55Link
HENNER DENNISDirector, 10% Owner2004-08-20Sell32,4991,773,668$21.83709.45-84.29Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-20Sell33,4211,772,099$21.83729.58-84.29Link
EVNIN LUKE10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-84.29Link
MPM BIOVENTURES III QP LP10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-84.29Link
EVNIN LUKE10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-84.59Link
HENNER DENNISDirector, 10% Owner2004-08-18Sell18,9991,806,167$22.26422.92-84.59Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-18Sell18,9991,805,520$22.26422.92-84.59Link
MPM BIOVENTURES III QP LP10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-84.59Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-13Sell10,0001,824,519$22.3223-84.62Link
EVNIN LUKE10% Owner2004-08-13Sell10,0001,824,423$22.3223-84.62Link
MPM BIOVENTURES III QP LP10% Owner2004-08-13Sell10,0001,824,423$22.3223-84.62Link
HENNER DENNISDirector, 10% Owner2004-08-13Sell10,0001,825,166$22.3223-84.62Link
STEINMETZ MICHAEL10% Owner2004-08-02Sell1,9681,833,597$18.6836.76-81.64Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-07-16Buy2,5007,500$11.4628.65-70.07Link
EVNIN LUKE10% Owner2004-07-02Sell7,8471,833,597$14.88116.76-76.95Link
GALAKATOS NICHOLAS10% Owner2004-07-02Sell1,6521,833,597$15.3325.33-77.63Link
GADICKE ANSBERT10% Owner2004-07-02Sell2,4631,833,597$14.5935.94-76.49Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-28Sell2,8771,834,519$15.8345.54-78.33Link
HENNER DENNISDirector, 10% Owner2004-06-28Sell2,8771,835,166$15.8345.54-78.33Link
MPM BIOVENTURES III QP LP10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-78.33Link
EVNIN LUKE10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-78.33Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-78.1Link
MPM BIOVENTURES III QP LP10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-78.1Link
HENNER DENNISDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-78.1Link
EVNIN LUKE10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-78.1Link
MPM BIOVENTURES III QP LP10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-77.89Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-77.89Link
HENNER DENNISDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-77.89Link
EVNIN LUKE10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-77.89Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-80.94Link
MPM BIOVENTURES III QP LP10% Owner2004-06-02Sell2,0303,490,963$1836.54-80.94Link
HENNER DENNISDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-80.94Link
EVNIN LUKE10% Owner2004-06-02Sell2,0303,490,963$1836.54-80.94Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-80.9Link
MPM BIOVENTURES III QP LP10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-80.9Link
HENNER DENNISDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-80.9Link
EVNIN LUKE10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-80.9Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-80.77Link
MPM BIOVENTURES III QP LP10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-80.77Link
HENNER DENNISDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-80.77Link
EVNIN LUKE10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-80.77Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-80.23Link
MPM BIOVENTURES III QP LP10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-80.23Link
EVNIN LUKE10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-80.23Link
HENNER DENNISDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-80.23Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-05-21Buy5,0005,000$16.6783.35-79.42Link
FRAZIER ALAN DDirector2004-05-20Sell2,333949,280$17.6141.08-80.52Link
HENNER DENNISDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-80.12Link
EVNIN LUKE10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-80.12Link
MPM BIOVENTURES III QP LP10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-80.12Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-80.12Link
DELEAGE JEANDirector, 10% Owner2004-05-07Sell3,10044,573$21.566.65-84.05Link
ALTA PARTNERS II INC10% Owner2004-05-07Sell3,10044,573$21.566.65-84.05Link
ALTA PARTNERS II INC10% Owner2004-05-03Sell95,20044,573$21.312028.71-83.9Link
DELEAGE JEANDirector, 10% Owner2004-05-03Sell95,20044,573$21.312028.71-83.9Link
DELEAGE JEANDirector, 10% Owner2004-04-30Sell8,40044,573$21.25178.5-83.86Link
ALTA PARTNERS II INC10% Owner2004-04-30Sell8,40044,573$21.25178.5-83.86Link
DELEAGE JEANDirector, 10% Owner2004-04-29Sell42,80044,573$21.25909.5-83.86Link
ALTA PARTNERS II INC10% Owner2004-04-29Sell42,80055,006$21.25909.5-83.86Link
DELEAGE JEANDirector, 10% Owner2004-04-27Sell8,90044,573$21.26189.21-83.87Link
ALTA PARTNERS II INC10% Owner2004-04-27Sell8,90055,962$21.26189.21-83.87Link
DELEAGE JEANDirector, 10% Owner2004-04-23Sell13,10044,573$21.32279.29-83.91Link
ALTA PARTNERS II INC10% Owner2004-04-23Sell13,10044,573$21.32279.29-83.91Link
ALTA PARTNERS II INC10% Owner2004-04-22Sell8,80056,454$21.26187.09-83.87Link
DELEAGE JEANDirector, 10% Owner2004-04-22Sell8,80056,454$21.26187.09-83.87Link
EVNIN LUKE10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-83.44Link
MPM BIOVENTURES III QP LP10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-83.44Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-83.44Link
HENNER DENNISDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-83.44Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-82.79Link
EVNIN LUKE10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-82.79Link
MPM BIOVENTURES III QP LP10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-82.79Link
HENNER DENNISDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-82.79Link
DELEAGE JEANDirector, 10% Owner2004-04-07Sell60,30044,573$211266.3-83.67Link
ALTA PARTNERS II INC10% Owner2004-04-07Sell60,30044,573$211266.3-83.67Link
DELEAGE JEANDirector, 10% Owner2004-04-06Sell10,90057,997$21.21231.19-83.83Link
ALTA PARTNERS II INC10% Owner2004-04-06Sell10,90044,573$21.21231.19-83.83Link
FRAZIER ALAN DDirector2004-04-05Sell2,5241,409,965$22.7657.45-84.93Link
ALTA PARTNERS II INC10% Owner2004-03-24Sell7,48744,573$20149.74-82.85Link
DELEAGE JEANDirector, 10% Owner2004-03-24Sell7,48744,573$20149.74-82.85Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-82.85Link
HENNER DENNISDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-82.85Link
MPM BIOVENTURES III QP LP10% Owner2004-03-19Sell17,3344,150,571$20346.68-82.85Link
EVNIN LUKE10% Owner2004-02-19Sell17,3344,150,571$20346.68-82.85Link
FRAZIER HEALTHCARE IV LP10% Owner2004-02-19Sell78,4361,223,647$18.81474.6-81.76Link
FRAZIER ALAN DDirector, 10% Owner2004-02-19Sell78,4361,706,726$18.81474.6-81.76Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-82.85Link
HENNER DENNISDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-82.85Link
MPM BIOVENTURES III QP LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-82.85Link
MPM BIOEQUITIES MASTER FUND LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-82.85Link
ALTA PARTNERS II INC10% Owner2004-02-19Sell111,69644,573$202233.92-82.85Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-82.85Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-82.85Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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