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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
James M. GowerN/A180,6760.19%2005-11-02
Dr. Donald G. Payan,M.D.N/A58,334less than 0.1%2015-06-10
Flynn James EN/A25,000less than 0.1%2010-11-03
Raul R. RodriguezN/A23,607less than 0.1%2004-08-31
Bradford S. GoodwinN/A10,000less than 0.1%2007-08-09
Dr. Robin D.G. Cooper,PhD,D.Sc.N/A9,000less than 0.1%2005-12-07
James H. WelchN/A3,757less than 0.1%2004-09-02
Dr. Walter H. Moos,PhDN/A2,222less than 0.1%2007-06-26
Dr. Elliott B. Grossbard,M.D.N/A2,000less than 0.1%2007-05-29
Dr. Jean Deleage,PhDN/A697less than 0.1%2005-11-02

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
PAYAN DONALD GEVP, Pres. Discovery&Research2015-06-10Sell41,66658,334$3.68153.33-21.4758,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-04-01Sell10,00058,334$3.7537.5-22.9358,334 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.2230.18575 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.2230.18575 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-09-03Sell20,00068,334$2.5651.212.8968,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-02-24Sell20,00088,334$3.7174.2-22.188,334 (Direct)
BVF PARTNERS L P/IL10% Owner2013-11-19Sell484,6226,962,123$2.641279.49.47
6,962,123 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy32,7006,962,123$3.47113.47-16.71
6,962,123 (See Explanation of Responses)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2012-09-13Sell4,1511,103$10.4343.29-72.291,103 (Direct)
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-12Sell23,3020$10.67248.63-72.91Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-10Sell51,6980$10.54544.9-72.58Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-08-07Sell1,7000$10.6118.04-72.76Link
PAYAN DONALD GEVP, Pres. Discovery&Research2012-06-19Sell10,000108,334$8.787-66.78108,334 (Direct)
Flynn James E2011-05-26Buy650,0006,742,289$85200-63.8825,000 (Direct)
470,425 (Through Deerfield Special Situations Fund, L.P.)
762,700 (Through Deerfield Special Situations Fund International Limited)
2,279,997 (Through Deerfield Partners, L.P.)
3,204,167 (Through Deerfield International Limited)
Flynn James E2010-11-03Sell7,7116,092,289$7.5558.22-61.72Link
Goodwin Bradford SDirector2007-08-09Buy10,00010,000$9.9399.3-70.9
Grossbard Elliott BSr. VP Medical Development2007-05-29Buy2,0002,000$9.6819.36-70.14
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-12-07Buy1,0009,000$8.128.12-64.41Link
DELEAGE JEANDirector2005-07-27Sell171,99711,604$20.333496.7-85.78Link
DELEAGE JEANDirector2005-07-25Sell6,40017,707$20.37130.37-85.81Link
DELEAGE JEANDirector2005-07-21Sell58617,934$20.7512.16-86.07Link
DELEAGE JEANDirector2005-07-20Sell148,04317,955$20.753071.89-86.07Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-05-10Sell15,0004,385$19.71295.65-85.34Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-03-30Buy1,0004,385$15.9915.99-81.93Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-02-08Buy5008,000$18.789.39-84.61Link
FRAZIER ALAN DDirector2005-01-25Sell2,33210,905$19.144.54-84.87Link
HENNER DENNISDirector2005-01-05Sell17,2530$23.26401.3-87.58Link
HENNER DENNISDirector2004-11-23Sell868,05517,253$23.4920390.61-87.7Link
SIMON NICHOLAS J IIIDirector2004-11-23Sell868,0550$23.4920390.61-87.7Link
DELEAGE JEANDirector2004-11-05Sell126,05023,207$26.113291.17-88.93Link
DELEAGE JEANDirector2004-10-21Sell177,60027,680$25.054448.88-88.46Link
DELEAGE JEANDirector2004-10-19Sell46,35033,981$26.291218.54-89.01Link
DELEAGE JEANDirector2004-09-30Sell25,6250$24.79635.24-88.34Link
SIMON NICHOLAS J IIIDirector2004-09-17Sell14,9560$32.33483.53-91.06Link
WELCH JAMES HCFO, VP & Secretary
(Click for the stocks that their CFOs have bought)
2004-09-02Sell10,0003,757$20.23202.3-85.71Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-09-01Sell85,0271,687,072$20.751764.31-86.07Link
HENNER DENNISDirector, 10% Owner2004-09-01Sell85,0271,688,641$20.751764.31-86.07Link
EVNIN LUKE10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-86.07Link
MPM BIOVENTURES III QP LP10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-86.07Link
RODRIGUEZ RAUL REVP, COO2004-08-31Sell11,00023,607$20.85229.35-86.14Link
HENNER DENNISDirector, 10% Owner2004-08-20Sell32,4991,773,668$21.83709.45-86.76Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-20Sell33,4211,772,099$21.83729.58-86.76Link
EVNIN LUKE10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-86.76Link
MPM BIOVENTURES III QP LP10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-86.76Link
EVNIN LUKE10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-87.02Link
HENNER DENNISDirector, 10% Owner2004-08-18Sell18,9991,806,167$22.26422.92-87.02Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-18Sell18,9991,805,520$22.26422.92-87.02Link
MPM BIOVENTURES III QP LP10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-87.02Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-13Sell10,0001,824,519$22.3223-87.04Link
EVNIN LUKE10% Owner2004-08-13Sell10,0001,824,423$22.3223-87.04Link
MPM BIOVENTURES III QP LP10% Owner2004-08-13Sell10,0001,824,423$22.3223-87.04Link
HENNER DENNISDirector, 10% Owner2004-08-13Sell10,0001,825,166$22.3223-87.04Link
STEINMETZ MICHAEL10% Owner2004-08-02Sell1,9681,833,597$18.6836.76-84.53Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-07-16Buy2,5007,500$11.4628.65-74.78Link
EVNIN LUKE10% Owner2004-07-02Sell7,8471,833,597$14.88116.76-80.58Link
GALAKATOS NICHOLAS10% Owner2004-07-02Sell1,6521,833,597$15.3325.33-81.15Link
GADICKE ANSBERT10% Owner2004-07-02Sell2,4631,833,597$14.5935.94-80.19Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-28Sell2,8771,834,519$15.8345.54-81.74Link
HENNER DENNISDirector, 10% Owner2004-06-28Sell2,8771,835,166$15.8345.54-81.74Link
MPM BIOVENTURES III QP LP10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-81.74Link
EVNIN LUKE10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-81.74Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-81.55Link
MPM BIOVENTURES III QP LP10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-81.55Link
HENNER DENNISDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-81.55Link
EVNIN LUKE10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-81.55Link
MPM BIOVENTURES III QP LP10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-81.37Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-81.37Link
HENNER DENNISDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-81.37Link
EVNIN LUKE10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-81.37Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-83.94Link
MPM BIOVENTURES III QP LP10% Owner2004-06-02Sell2,0303,490,963$1836.54-83.94Link
HENNER DENNISDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-83.94Link
EVNIN LUKE10% Owner2004-06-02Sell2,0303,490,963$1836.54-83.94Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-83.91Link
MPM BIOVENTURES III QP LP10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-83.91Link
HENNER DENNISDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-83.91Link
EVNIN LUKE10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-83.91Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-83.8Link
MPM BIOVENTURES III QP LP10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-83.8Link
HENNER DENNISDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-83.8Link
EVNIN LUKE10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-83.8Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-83.34Link
MPM BIOVENTURES III QP LP10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-83.34Link
EVNIN LUKE10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-83.34Link
HENNER DENNISDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-83.34Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-05-21Buy5,0005,000$16.6783.35-82.66Link
FRAZIER ALAN DDirector2004-05-20Sell2,333949,280$17.6141.08-83.59Link
HENNER DENNISDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-83.25Link
EVNIN LUKE10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-83.25Link
MPM BIOVENTURES III QP LP10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-83.25Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-83.25Link
DELEAGE JEANDirector, 10% Owner2004-05-07Sell3,10044,573$21.566.65-86.56Link
ALTA PARTNERS II INC10% Owner2004-05-07Sell3,10044,573$21.566.65-86.56Link
ALTA PARTNERS II INC10% Owner2004-05-03Sell95,20044,573$21.312028.71-86.44Link
DELEAGE JEANDirector, 10% Owner2004-05-03Sell95,20044,573$21.312028.71-86.44Link
DELEAGE JEANDirector, 10% Owner2004-04-30Sell8,40044,573$21.25178.5-86.4Link
ALTA PARTNERS II INC10% Owner2004-04-30Sell8,40044,573$21.25178.5-86.4Link
DELEAGE JEANDirector, 10% Owner2004-04-29Sell42,80044,573$21.25909.5-86.4Link
ALTA PARTNERS II INC10% Owner2004-04-29Sell42,80055,006$21.25909.5-86.4Link
DELEAGE JEANDirector, 10% Owner2004-04-27Sell8,90044,573$21.26189.21-86.41Link
ALTA PARTNERS II INC10% Owner2004-04-27Sell8,90055,962$21.26189.21-86.41Link
DELEAGE JEANDirector, 10% Owner2004-04-23Sell13,10044,573$21.32279.29-86.44Link
ALTA PARTNERS II INC10% Owner2004-04-23Sell13,10044,573$21.32279.29-86.44Link
ALTA PARTNERS II INC10% Owner2004-04-22Sell8,80056,454$21.26187.09-86.41Link
DELEAGE JEANDirector, 10% Owner2004-04-22Sell8,80056,454$21.26187.09-86.41Link
EVNIN LUKE10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-86.05Link
MPM BIOVENTURES III QP LP10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-86.05Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-86.05Link
HENNER DENNISDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-86.05Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-85.5Link
EVNIN LUKE10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-85.5Link
MPM BIOVENTURES III QP LP10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-85.5Link
HENNER DENNISDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-85.5Link
DELEAGE JEANDirector, 10% Owner2004-04-07Sell60,30044,573$211266.3-86.24Link
ALTA PARTNERS II INC10% Owner2004-04-07Sell60,30044,573$211266.3-86.24Link
DELEAGE JEANDirector, 10% Owner2004-04-06Sell10,90057,997$21.21231.19-86.37Link
ALTA PARTNERS II INC10% Owner2004-04-06Sell10,90044,573$21.21231.19-86.37Link
FRAZIER ALAN DDirector2004-04-05Sell2,5241,409,965$22.7657.45-87.3Link
ALTA PARTNERS II INC10% Owner2004-03-24Sell7,48744,573$20149.74-85.55Link
DELEAGE JEANDirector, 10% Owner2004-03-24Sell7,48744,573$20149.74-85.55Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-85.55Link
HENNER DENNISDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-85.55Link
MPM BIOVENTURES III QP LP10% Owner2004-03-19Sell17,3344,150,571$20346.68-85.55Link
EVNIN LUKE10% Owner2004-02-19Sell17,3344,150,571$20346.68-85.55Link
FRAZIER HEALTHCARE IV LP10% Owner2004-02-19Sell78,4361,223,647$18.81474.6-84.63Link
FRAZIER ALAN DDirector, 10% Owner2004-02-19Sell78,4361,706,726$18.81474.6-84.63Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-85.55Link
HENNER DENNISDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-85.55Link
MPM BIOVENTURES III QP LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-85.55Link
MPM BIOEQUITIES MASTER FUND LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-85.55Link
ALTA PARTNERS II INC10% Owner2004-02-19Sell111,69644,573$202233.92-85.55Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-85.55Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-85.55Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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