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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
James M. GowerN/A180,6760.2%2005-11-02
Dr. Donald G. Payan,M.D.N/A58,334less than 0.1%2015-06-10
Flynn James EN/A25,000less than 0.1%2010-11-03
Raul R. RodriguezN/A23,607less than 0.1%2004-08-31
Bradford S. GoodwinN/A10,000less than 0.1%2007-08-09
Dr. Robin D.G. Cooper,PhD,D.Sc.N/A9,000less than 0.1%2005-12-07
James H. WelchN/A3,757less than 0.1%2004-09-02
Dr. Walter H. Moos,PhDN/A2,222less than 0.1%2007-06-26
Dr. Elliott B. Grossbard,M.D.N/A2,000less than 0.1%2007-05-29
Dr. Jean Deleage,PhDN/A697less than 0.1%2005-11-02

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
PAYAN DONALD GEVP, Pres. Discovery&Research2015-06-10Sell41,66658,334$3.68153.33-39.458,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2015-04-01Sell10,00058,334$3.7537.5-40.5358,334 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.220.45575 (Direct)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2014-12-18Sell1,000575$2.222.220.45575 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-09-03Sell20,00068,334$2.5651.2-12.8968,334 (Direct)
PAYAN DONALD GEVP, Pres. Discovery&Research2014-02-24Sell20,00088,334$3.7174.2-39.8988,334 (Direct)
BVF PARTNERS L P/IL10% Owner2013-11-19Sell484,6226,962,123$2.641279.4-15.53
6,962,123 (See Explanation of Responses)
BVF PARTNERS L P/IL10% Owner2013-06-07Buy32,7006,962,123$3.47113.47-35.73
6,962,123 (See Explanation of Responses)
VANCE DOLLYEVP Corp. Affairs, G.C., Sect.2012-09-13Sell4,1511,103$10.4343.29-78.621,103 (Direct)
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-12Sell23,3020$10.67248.63-79.1Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-09-10Sell51,6980$10.54544.9-78.84Link
Maynard Ryan DEVP & CFO
(Click for the stocks that their CFOs have bought)
2012-08-07Sell1,7000$10.6118.04-78.98Link
PAYAN DONALD GEVP, Pres. Discovery&Research2012-06-19Sell10,000108,334$8.787-74.37108,334 (Direct)
Flynn James E2011-05-26Buy650,0006,742,289$85200-72.1325,000 (Direct)
470,425 (Through Deerfield Special Situations Fund, L.P.)
762,700 (Through Deerfield Special Situations Fund International Limited)
2,279,997 (Through Deerfield Partners, L.P.)
3,204,167 (Through Deerfield International Limited)
Flynn James E2010-11-03Sell7,7116,092,289$7.5558.22-70.46Link
Goodwin Bradford SDirector2007-08-09Buy10,00010,000$9.9399.3-77.54
Grossbard Elliott BSr. VP Medical Development2007-05-29Buy2,0002,000$9.6819.36-76.96
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-12-07Buy1,0009,000$8.128.12-72.54Link
DELEAGE JEANDirector2005-07-27Sell171,99711,604$20.333496.7-89.03Link
DELEAGE JEANDirector2005-07-25Sell6,40017,707$20.37130.37-89.05Link
DELEAGE JEANDirector2005-07-21Sell58617,934$20.7512.16-89.25Link
DELEAGE JEANDirector2005-07-20Sell148,04317,955$20.753071.89-89.25Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-05-10Sell15,0004,385$19.71295.65-88.69Link
VANCE DOLLYVP Intel. Prop.& Gen.Counsel2005-03-30Buy1,0004,385$15.9915.99-86.05Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2005-02-08Buy5008,000$18.789.39-88.13Link
FRAZIER ALAN DDirector2005-01-25Sell2,33210,905$19.144.54-88.32Link
HENNER DENNISDirector2005-01-05Sell17,2530$23.26401.3-90.41Link
HENNER DENNISDirector2004-11-23Sell868,05517,253$23.4920390.61-90.51Link
SIMON NICHOLAS J IIIDirector2004-11-23Sell868,0550$23.4920390.61-90.51Link
DELEAGE JEANDirector2004-11-05Sell126,05023,207$26.113291.17-91.46Link
DELEAGE JEANDirector2004-10-21Sell177,60027,680$25.054448.88-91.1Link
DELEAGE JEANDirector2004-10-19Sell46,35033,981$26.291218.54-91.52Link
DELEAGE JEANDirector2004-09-30Sell25,6250$24.79635.24-91Link
SIMON NICHOLAS J IIIDirector2004-09-17Sell14,9560$32.33483.53-93.1Link
WELCH JAMES HCFO, VP & Secretary
(Click for the stocks that their CFOs have bought)
2004-09-02Sell10,0003,757$20.23202.3-88.98Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-09-01Sell85,0271,687,072$20.751764.31-89.25Link
HENNER DENNISDirector, 10% Owner2004-09-01Sell85,0271,688,641$20.751764.31-89.25Link
EVNIN LUKE10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-89.25Link
MPM BIOVENTURES III QP LP10% Owner2004-09-01Sell85,8531,687,072$20.741780.59-89.25Link
RODRIGUEZ RAUL REVP, COO2004-08-31Sell11,00023,607$20.85229.35-89.3Link
HENNER DENNISDirector, 10% Owner2004-08-20Sell32,4991,773,668$21.83709.45-89.78Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-20Sell33,4211,772,099$21.83729.58-89.78Link
EVNIN LUKE10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-89.78Link
MPM BIOVENTURES III QP LP10% Owner2004-08-20Sell32,4991,772,925$21.83709.45-89.78Link
EVNIN LUKE10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-89.98Link
HENNER DENNISDirector, 10% Owner2004-08-18Sell18,9991,806,167$22.26422.92-89.98Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-18Sell18,9991,805,520$22.26422.92-89.98Link
MPM BIOVENTURES III QP LP10% Owner2004-08-18Sell18,9991,805,424$22.26422.92-89.98Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-08-13Sell10,0001,824,519$22.3223-90Link
EVNIN LUKE10% Owner2004-08-13Sell10,0001,824,423$22.3223-90Link
MPM BIOVENTURES III QP LP10% Owner2004-08-13Sell10,0001,824,423$22.3223-90Link
HENNER DENNISDirector, 10% Owner2004-08-13Sell10,0001,825,166$22.3223-90Link
STEINMETZ MICHAEL10% Owner2004-08-02Sell1,9681,833,597$18.6836.76-88.06Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-07-16Buy2,5007,500$11.4628.65-80.54Link
EVNIN LUKE10% Owner2004-07-02Sell7,8471,833,597$14.88116.76-85.01Link
GALAKATOS NICHOLAS10% Owner2004-07-02Sell1,6521,833,597$15.3325.33-85.45Link
GADICKE ANSBERT10% Owner2004-07-02Sell2,4631,833,597$14.5935.94-84.72Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-28Sell2,8771,834,519$15.8345.54-85.91Link
HENNER DENNISDirector, 10% Owner2004-06-28Sell2,8771,835,166$15.8345.54-85.91Link
MPM BIOVENTURES III QP LP10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-85.91Link
EVNIN LUKE10% Owner2004-06-28Sell2,8771,849,800$15.8345.54-85.91Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.76Link
MPM BIOVENTURES III QP LP10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.76Link
HENNER DENNISDirector, 10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.76Link
EVNIN LUKE10% Owner2004-06-25Sell124,3073,336,463$15.661946.65-85.76Link
MPM BIOVENTURES III QP LP10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.62Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.62Link
HENNER DENNISDirector, 10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.62Link
EVNIN LUKE10% Owner2004-06-23Sell30,1933,460,770$15.51468.29-85.62Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.61Link
MPM BIOVENTURES III QP LP10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.61Link
HENNER DENNISDirector, 10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.61Link
EVNIN LUKE10% Owner2004-06-02Sell2,0303,490,963$1836.54-87.61Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.58Link
MPM BIOVENTURES III QP LP10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.58Link
HENNER DENNISDirector, 10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.58Link
EVNIN LUKE10% Owner2004-06-01Sell13,9503,492,993$17.96250.54-87.58Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.5Link
MPM BIOVENTURES III QP LP10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.5Link
HENNER DENNISDirector, 10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.5Link
EVNIN LUKE10% Owner2004-05-27Sell26,0153,506,943$17.84464.11-87.5Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-87.15Link
MPM BIOVENTURES III QP LP10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-87.15Link
EVNIN LUKE10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-87.15Link
HENNER DENNISDirector, 10% Owner2004-05-24Sell3,3003,532,958$17.3557.26-87.15Link
COOPER ROBIN D GSr. V.P. Pharmaceutical Scs.2004-05-21Buy5,0005,000$16.6783.35-86.62Link
FRAZIER ALAN DDirector2004-05-20Sell2,333949,280$17.6141.08-87.34Link
HENNER DENNISDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-87.07Link
EVNIN LUKE10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-87.07Link
MPM BIOVENTURES III QP LP10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-87.07Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-05-20Sell139,3133,536,258$17.252403.15-87.07Link
DELEAGE JEANDirector, 10% Owner2004-05-07Sell3,10044,573$21.566.65-89.63Link
ALTA PARTNERS II INC10% Owner2004-05-07Sell3,10044,573$21.566.65-89.63Link
ALTA PARTNERS II INC10% Owner2004-05-03Sell95,20044,573$21.312028.71-89.54Link
DELEAGE JEANDirector, 10% Owner2004-05-03Sell95,20044,573$21.312028.71-89.54Link
DELEAGE JEANDirector, 10% Owner2004-04-30Sell8,40044,573$21.25178.5-89.51Link
ALTA PARTNERS II INC10% Owner2004-04-30Sell8,40044,573$21.25178.5-89.51Link
DELEAGE JEANDirector, 10% Owner2004-04-29Sell42,80044,573$21.25909.5-89.51Link
ALTA PARTNERS II INC10% Owner2004-04-29Sell42,80055,006$21.25909.5-89.51Link
DELEAGE JEANDirector, 10% Owner2004-04-27Sell8,90044,573$21.26189.21-89.51Link
ALTA PARTNERS II INC10% Owner2004-04-27Sell8,90055,962$21.26189.21-89.51Link
DELEAGE JEANDirector, 10% Owner2004-04-23Sell13,10044,573$21.32279.29-89.54Link
ALTA PARTNERS II INC10% Owner2004-04-23Sell13,10044,573$21.32279.29-89.54Link
ALTA PARTNERS II INC10% Owner2004-04-22Sell8,80056,454$21.26187.09-89.51Link
DELEAGE JEANDirector, 10% Owner2004-04-22Sell8,80056,454$21.26187.09-89.51Link
EVNIN LUKE10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-89.23Link
MPM BIOVENTURES III QP LP10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-89.23Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-89.23Link
HENNER DENNISDirector, 10% Owner2004-04-21Sell158,6983,675,571$20.713286.64-89.23Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.81Link
EVNIN LUKE10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.81Link
MPM BIOVENTURES III QP LP10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.81Link
HENNER DENNISDirector, 10% Owner2004-04-12Sell316,3023,834,269$19.936303.9-88.81Link
DELEAGE JEANDirector, 10% Owner2004-04-07Sell60,30044,573$211266.3-89.38Link
ALTA PARTNERS II INC10% Owner2004-04-07Sell60,30044,573$211266.3-89.38Link
DELEAGE JEANDirector, 10% Owner2004-04-06Sell10,90057,997$21.21231.19-89.49Link
ALTA PARTNERS II INC10% Owner2004-04-06Sell10,90044,573$21.21231.19-89.49Link
FRAZIER ALAN DDirector2004-04-05Sell2,5241,409,965$22.7657.45-90.2Link
ALTA PARTNERS II INC10% Owner2004-03-24Sell7,48744,573$20149.74-88.85Link
DELEAGE JEANDirector, 10% Owner2004-03-24Sell7,48744,573$20149.74-88.85Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-88.85Link
HENNER DENNISDirector, 10% Owner2004-03-19Sell17,3344,150,571$20346.68-88.85Link
MPM BIOVENTURES III QP LP10% Owner2004-03-19Sell17,3344,150,571$20346.68-88.85Link
EVNIN LUKE10% Owner2004-02-19Sell17,3344,150,571$20346.68-88.85Link
FRAZIER HEALTHCARE IV LP10% Owner2004-02-19Sell78,4361,223,647$18.81474.6-88.14Link
FRAZIER ALAN DDirector, 10% Owner2004-02-19Sell78,4361,706,726$18.81474.6-88.14Link
SIMON NICHOLAS J IIIDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-88.85Link
HENNER DENNISDirector, 10% Owner2004-02-19Sell172,3734,167,905$203447.46-88.85Link
MPM BIOVENTURES III QP LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-88.85Link
MPM BIOEQUITIES MASTER FUND LP10% Owner2004-02-19Sell172,3734,350,516$203447.46-88.85Link
ALTA PARTNERS II INC10% Owner2004-02-19Sell111,69644,573$202233.92-88.85Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-88.85Link
DELEAGE JEANDirector, 10% Owner2004-02-19Sell111,69644,573$202233.92-88.85Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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