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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2017-03-06Sell14,465636,435$68.04984.2-6.39636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-02-06Sell14,465636,435$61.54890.183.49636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-01-06Sell14,465638,835$57.89837.3810.02638,835 (Direct)
Cline Darren SEVP, Commercial2016-12-13Sell10,00058,504$63.38633.80.4958,504 (Direct)
DOBMEIER ERICCOO2016-12-08Sell12,50087,767$65.92824-3.3887,767 (Direct)
HIMES VAUGHN BChief Technical Officer2016-12-07Sell30,000135,379$65.321959.6-2.5135,379 (Direct)
SIEGALL CLAY BPresident and CEO2016-12-06Sell14,465638,835$66.17957.15-3.75638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-09Sell7,751109,837$66.75517.38-4.58109,837 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-08Buy382,50040,992,596$59.3622705.27.29107,504 (Direct)
40,885,092 (See footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-11-07Sell14,465638,835$58.43845.199638,835 (Direct)
LIPPMAN MARC EDirector2016-11-07Sell1,000131,350$57.7557.7510.29131,350 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-03Buy198,43345,482,921$56.4311197.5712.87107,504 (Direct)
4,835,170 (See footnote(,,,))
40,540,247 (See Footnote(,,,))
BAKER FELIXDirector, 10% Owner2016-11-03Buy1,030,62945,194,447$56.1357849.2113.47107,504 (Direct)
4,725,543 (See footnote(,,,))
40,361,400 (See Footnote(,,,))
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-01Sell3,418109,837$51.74176.8523.1109,837 (Direct)
SIEGALL CLAY BPresident and CEO2016-10-06Sell14,465638,835$54.41787.0417.06638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-09-22Sell2,249113,255$56.75127.6312.23113,255 (Direct)
DOBMEIER ERICCOO2016-09-14Sell22,91887,767$54.041238.4917.8687,767 (Direct)
BAKER FELIXDirector, 10% Owner2016-09-13Buy447,31144,233,991$50.7122683.1425.6107,504 (Direct)
4,693,991 (See footnote(,,,))
39,432,496 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-08Sell31,269638,835$50.081565.9527.18638,835 (Direct)
0 (by Trust)
BAKER FELIXDirector, 10% Owner2016-09-08Buy414,01643,696,884$48.4320050.7931.51107,504 (Direct)
4,559,012 (See footnote(,,,))
39,030,368 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-06Sell11,653644,983$45.4529.0540.29617,038 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-09-06Sell5,39751,576$46.01248.3238.4351,576 (Direct)
DOBMEIER ERICCOO2016-08-23Sell12,58958,767$48604.2732.6958,767 (Direct)
Cline Darren SEVP, Commercial2016-08-22Sell1,77440,973$46.5982.6536.740,973 (Direct)
DOBMEIER ERICCOO2016-08-22Sell5,41167,525$46.59252.136.767,525 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-08-22Sell3,99184,255$46.59185.9436.784,255 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2016-08-22Sell3,991108,779$46.59185.9436.7108,779 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-22Sell23,381560,679$46.591089.3236.7532,734 (Direct)
27,945 (by Trust)
SIMPSON TODD ECFO2016-08-22Sell3,991191,445$46.59185.9436.7191,445 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-08Sell11,660584,060$47.19550.2434.97556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-27Sell4,042584,060$45.2182.740.91556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9957.03556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.646.11556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6151.3942,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3557.61556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7658.87556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8581.14556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403259.23556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1676.33556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1879.31556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4799.97107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5198.41107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8696.21107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17181.07107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.04100.47107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.71115.53107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.59114.95107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.14109.3107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.66124.8110,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5759.4676,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7659.26556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.9944.95107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.2740.29556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5339.4337,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.148.29107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7149.8680,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.746.1823,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3947.64643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5554.21611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6449.65107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1758.75611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1951.5798,340 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7551.5743,482 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.351.57611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1951.5798,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4951.5782,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7551.5743,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7751.57179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9951.5776,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4135.77557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5235.68557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.9939.3557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1549.89107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9156.68557,022 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4557.7382,777 (Direct)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5379.11107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8864.7933,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573373.7867,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3583.76107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6282.81107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4287.77107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.37100.28559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4299.91107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8488.32107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.269.7567,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6584.2976,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2249.72559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8246.2591,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9646.25168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8346.25559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1546.2567,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7246.2566,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3546.2572,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2657.73525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4759.5476,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5758.67525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9866.976,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2382.776,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0586.9476,997 (Direct)
390,944 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4587.5476,997 (Direct)
3,872,076 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535081.9755,519 (Direct)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.746.95955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8320.42955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.8315.8446,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.0819.6148,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6322.4644,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.97519722.55955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.92268432.9177,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9539.2149,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9662.181,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7160.5976,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8647.4676,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.554.41,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2664.871,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7445.181,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.837.26133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319849.37135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.845.08977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.849.9322,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2853.66155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0855.681,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1555.68125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1555.68127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0255.6846,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2555.6847,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0659.111,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1470.07113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1895.431,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7594.4713,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.198.3533,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7687.991,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4871.3510,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4587.5476,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1674.111,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0679.261,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6989.533,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.6104.4112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.83107.12113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.682968114.59122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.98121.841,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.7134.4118,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.22115.11,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.36111.6757,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.21127.4657,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.05163.951,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.03155.27122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185168.73113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.97147.1557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.6148.8957,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.82152.841,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.4150.6557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.2151.3457,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.95499155.2757,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64169.99101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.46149.671,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.25154.6669,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.37139.531,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.9121.2233,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.5123.4770,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.07114.0857,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.96139.981,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.65136.1570,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.8145.2450,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25165.2643,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.5144.961,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.22151.141,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.36634151.1468,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.5159.9650,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$24240165.3817,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95177.2750,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24183.0717,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158222.4811,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1195.6817,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74222.4831,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790222.4831,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75219.2568,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86226.4517,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85237.3417,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2221.9931,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790222.4831,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35242.617,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92243.972,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12243.7168,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790222.4830,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95280.691,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9252.0715,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55298.811,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35190.951,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15190.1659,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.09209.4859,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97189.949,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.25216.081,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6216.551,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28272.89
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51272.89
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39314.11
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7314.11
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73266.671,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9208.28950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28217.81163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09218.29950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7218.458,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020218.45950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072218.4522,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57219.099,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23223.79Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19226.62Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16240.413,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376238.78Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1241.689,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356257.81Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356257.813,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.87253.8325,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5267.09945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8259.029,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5265.4Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75271.37Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1275.97Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96275.75Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5317.09Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803296.58Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640298.06Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818352.02Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05310.9Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95310.9
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5292.66Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25302.85Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5333.27Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75275.75Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75326.02Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88433.42Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44433.42Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8409.93Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79432.97Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72432.97Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85376.36Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01434.31Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26397.97Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32397.97Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75391.81Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49475.86Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67475.86Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58428.55Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7435.21Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26455.27Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09492.47Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58492.47Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75410.75Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6415.29Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25439.29Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66591.53
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68555.25
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67555.25
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68555.25
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06555.25
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66555.25
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64452.39
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91397.97
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11408.71
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52399.92
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25399.92
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86401.1
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59401.1
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5419.92
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565463.63
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21487
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96514.77
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74514.77
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078490.82
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5489.18
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5489.18
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35489.18
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74514.77
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99512.99
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41528.11
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014528.11
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22530.59
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22530.59
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79530.59
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45533.1
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45533.1
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01533.1
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16706.2
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95706.2
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59706.2
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47716.54
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63692.16
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91689.22
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58692.16
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91689.22
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19692.16
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24692.16
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46605.32
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6605.32
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22606.88
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38606.88
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144606.88
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05607.67
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1608.45
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56608.45
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34608.45
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45608.45
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82598.36
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06404.28
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72404.28
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1434.76
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95433.86
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61435.21
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38439.75
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23446.7
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14448.58
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38451.91
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24499.72
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66474.3
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04479.53
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74471.72
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68522.58
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258517.15
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5567.61
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39627.05
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09627.05
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35627.05
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18627.05
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71627.05
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57630.39
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1630.39
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39630.39
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19630.39
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55643.17
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447612.42
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441472.59Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131472.59Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921472.59Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181480.4Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751480.4Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191480.4Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841472.59Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181472.59Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61472.59Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011480.4Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031480.4Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231621.35Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721621.35Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431621.35Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991480.4Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121480.4Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831480.4Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151484.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821484.33Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251484.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131484.33Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031484.33Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691484.33Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311492.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081492.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771492.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.711113.14Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.711113.14Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.911113.14Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81966.83Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76963.27Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88968.62Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.51173.8Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.251229.65Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.541229.65Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.851229.65Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.21229.65Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.741229.65Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.681229.65Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.941229.65Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.541229.65Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571492.25Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641492.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581492.25Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941492.25Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061492.25Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171492.25Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041492.25Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271492.25Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.721184.07Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.651184.07Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.621184.07Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.631184.07Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.471184.07Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.71184.07Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.141184.07Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.971184.07Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.721205.12Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.761205.12Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.271205.12Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.041205.12Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.131205.12Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.041205.12Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.681205.12Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.331205.12Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.561176.35Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.891176.35Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.191176.35Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.021176.35Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.711176.35Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.341184.07Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.041184.07Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.341184.07Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5809.86Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82805.97Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1802.12Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55817.72Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6823.04Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42840.77Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5854.87Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2820.38Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35832.5Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41849.18Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86863.54Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35835.24Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01835.24Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297843.56Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.611047.57Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.141060.11Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.311079.44Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.051051.72Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.31051.72Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.661051.72Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.151013.46Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.341013.46Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.361013.46Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36805.97Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4804.69Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22799.58Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6794.52Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69674.82Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85641.44Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3511.23Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3615.62Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95782.13Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12807.26Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4860.63Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77870.88Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49906.16Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5884.39Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5884.39Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98888.98Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98888.98Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3915.79Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38876.84Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38876.84Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89852.02Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87961.5Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08882.87Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959979.49Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959979.49Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38952.73Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38952.73Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67930.58Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67930.58Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.291108.54Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.81151.28Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.21205.12Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.51255.11Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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