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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Clay B. Siegall,PhDPresident and CEO556,1150.4%2016-06-06
Franklin M. BergerN/A204,7200.15%2014-02-21
Todd E. SimpsonCFO194,6750.14%2015-09-29
Dr. Marc E. Lippman,M.D.N/A132,350less than 0.1%2016-05-20
Dr. Vaughn B. Himes,PhDEVP, Proc Svcs & Tech Ops111,248less than 0.1%2015-12-18
Dr. Felix J. Baker,PhDDirector, 10% Owner107,504less than 0.1%2016-05-20
Eric L. DobmeierCOO90,117less than 0.1%2015-12-31
Jonathan G. DrachmanCMO & EVP, R & D88,246less than 0.1%2016-06-02
Christopher S. BoernerN/A72,358less than 0.1%2014-08-24
Tim J. CarrollN/A62,861less than 0.1%2005-05-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2016-06-06Sell22,083584,060$43.59962.6-8.3556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.61-4.9942,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.35-1.09556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.76-0.3556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8513.68556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$4032-0.08556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1610.66556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1812.53556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4725.49107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5124.52107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8623.14107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.1776.39107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.0425.81107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.7135.26107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.5934.9107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.1431.35107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.6641.0910,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.570.0876,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.76-0.05556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.99-9.04107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.27-11.96556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.53-12.537,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.1-6.94107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.71-5.9580,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.7-8.2623,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.39-7.35643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.55-3.22611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.64-6.09107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.17-0.37611,323 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.3-4.88611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.19-4.8898,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.49-4.8882,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.75-4.8843,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.77-4.88179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.99-4.8876,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.41-14.79557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.52-14.85557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.99-12.58557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.15-5.93107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.45-1.0282,777 (Direct)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.91-1.67557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5312.4107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.883.4233,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.657339.0667,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3515.32107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6214.72107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4217.84107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.3725.69559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4225.46107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8418.18107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.26.5367,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6515.6576,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.22-6.04559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.82-8.2291,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.96-8.22168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.83-8.22559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.15-8.2267,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.72-8.2266,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.35-8.2272,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.26-1.02525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.470.1376,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.57-0.42525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.984.7476,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2314.6676,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0517.3276,997 (Direct)
390,944 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535014.255,519 (Direct)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4517.776,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.7-7.78955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.83-24.43955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.83-27.346,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.08-24.9448,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.63-23.1544,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.975197-23.09955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.922684-16.5977,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.95-12.6349,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.961.781,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.710.7876,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.86-7.4676,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.5-3.11,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.263.471,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.74-8.891,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.8-13.86133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.643198-6.26135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.8-8.95977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.8-5.9122,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.28-3.57155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.08-2.31,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.15-2.3125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.15-2.3127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.02-2.346,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.25-2.347,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.06-0.151,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.146.73113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1822.641,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7522.0513,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.124.4833,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7617.981,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.487.5310,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4517.776,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.169.271,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0612.51,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6918.9233,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.628.27112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.8329.98113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296834.67122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.9839.221,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.747.1118,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.2234.991,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.3632.8357,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.2142.7557,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.0565.641,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.0360.2122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.7118568.65113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.9755.157,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.656.1957,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.457.357,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.8258.671,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.257.7357,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.9549960.257,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.6469.44101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.4656.681,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.2559.8269,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.3750.321,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.938.8333,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.540.2570,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.0734.3557,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.9650.61,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.6548.270,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.853.9150,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.2566.4743,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.553.731,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.2257.611,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.3663457.6168,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.563.1450,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$2424066.5417,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.9574.0150,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.2477.6417,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158102.3811,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.185.5617,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74102.3831,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790102.3831,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75100.3568,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86104.8717,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85111.7117,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2102.0731,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790102.3831,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35115.0117,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92115.8272,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12115.768,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790102.3830,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95138.911,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9120.9515,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55150.281,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.3582.591,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.1582.159,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.0994.2259,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.9781.9349,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.2598.361,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.698.661,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28134.02
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51134.02
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39159.88
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7159.88
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73130.111,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.993.47950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.2899.45163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.0999.75950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.799.858,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$202099.85950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$207299.8522,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57100.259,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23103.2Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19104.97Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16113.633,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376112.61Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1114.439,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356124.55Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356124.553,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.87122.0625,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5130.37945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8125.319,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5129.32Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75133.06Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1135.95Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96135.81Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5161.76Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803148.88Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640149.81Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818183.68Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05157.87Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95157.87
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5146.42Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25152.81Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5171.9Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75135.81Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75167.36Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88234.76Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44234.76Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8220.02Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79234.48Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72234.48Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85198.95Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01235.32Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26212.51Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32212.51Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75208.65Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49261.39Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67261.39Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58231.7Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7235.88Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26248.47Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09271.81Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58271.81Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75220.53Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6223.38Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25238.44Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66333.98
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68311.21
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67311.21
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68311.21
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06311.21
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66311.21
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64246.66
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91212.51
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11219.25
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52213.74
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25213.74
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86214.48
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59214.48
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5226.29
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565253.72
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21268.39
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96285.81
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74285.81
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078270.78
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5269.75
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5269.75
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35269.75
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74285.81
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99284.7
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41294.18
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014294.18
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22295.74
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22295.74
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79295.74
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45297.32
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45297.32
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01297.32
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16405.95
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95405.95
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59405.95
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47412.44
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63397.14
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91395.29
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58397.14
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91395.29
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19397.14
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24397.14
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46342.64
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6342.64
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22343.62
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38343.62
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144343.62
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05344.11
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1344.61
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56344.61
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34344.61
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45344.61
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82338.27
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06216.47
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72216.47
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1235.6
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95235.04
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61235.88
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38238.73
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23243.09
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14244.27
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38246.36
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24276.37
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66260.41
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04263.69
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74258.8
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68290.71
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258287.31
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5318.97
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39356.28
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09356.28
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35356.28
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18356.28
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71356.28
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57358.37
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1358.37
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39358.37
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19358.37
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55366.39
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447347.09
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.44886.91Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.13886.91Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.92886.91Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.18891.81Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.75891.81Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.19891.81Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.84886.91Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.18886.91Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.6886.91Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.01891.81Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.03891.81Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.23980.27Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.72980.27Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.43980.27Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.99891.81Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.12891.81Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.83891.81Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.15894.28Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.82894.28Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.25894.28Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.13894.28Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.03894.28Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.69894.28Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.31899.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.08899.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.77899.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.71661.33Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.71661.33Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.91661.33Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81569.51Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76567.28Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88570.64Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.5699.4Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.25734.45Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.54734.45Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.85734.45Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.2734.45Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.74734.45Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.68734.45Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.94734.45Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.54734.45Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.57899.25Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.64899.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.58899.25Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.94899.25Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.06899.25Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.17899.25Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.04899.25Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$4327899.25Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.72705.85Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.65705.85Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.62705.85Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.63705.85Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.47705.85Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.7705.85Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.14705.85Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.97705.85Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.72719.06Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.76719.06Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.27719.06Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.04719.06Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.13719.06Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.04719.06Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.68719.06Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.33719.06Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.56701Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.89701Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.19701Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.02701Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.71701Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.34705.85Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.04705.85Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.34705.85Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5471Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82468.56Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1466.15Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55475.94Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6479.28Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42490.4Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5499.25Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2477.6Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35485.21Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41495.68Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86504.69Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35486.93Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01486.93Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297492.15Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.61620.18Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.14628.05Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.31640.19Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.05622.78Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3622.78Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.66622.78Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.15598.78Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.34598.78Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.36598.78Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36468.56Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4467.76Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22464.55Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6461.38Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69386.25Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85365.31Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3283.59Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3349.1Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95453.6Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12469.37Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4502.87Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77509.3Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49531.44Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5517.77Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5517.77Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98520.65Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98520.65Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3537.48Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38513.04Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38513.04Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89497.46Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87566.17Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08516.82Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959577.46Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959577.46Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38560.66Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38560.66Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67546.76Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67546.76Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.29658.44Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8685.27Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.2719.06Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.5750.43Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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