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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Clay B. Siegall,PhDPresident and CEO556,1150.4%2016-05-17
Franklin M. BergerN/A204,7200.15%2014-02-21
Todd E. SimpsonCFO194,6750.14%2015-09-29
Dr. Marc E. Lippman,M.D.N/A128,650less than 0.1%2015-05-15
Dr. Vaughn B. Himes,PhDEVP, Proc Svcs & Tech Ops111,248less than 0.1%2015-12-18
Dr. Felix J. Baker,PhDDirector, 10% Owner107,504less than 0.1%2016-03-17
Eric L. DobmeierCOO90,117less than 0.1%2015-12-31
Jonathan G. DrachmanCMO & EVP, R & D82,724less than 0.1%2015-08-20
Christopher S. BoernerN/A72,358less than 0.1%2014-08-24
Tim J. CarrollN/A62,861less than 0.1%2005-05-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2016-05-17Sell7,618584,060$35.16267.812.12556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$4032-1.45556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.29.14556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.210.98556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.523.77107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.522.8107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.921.44107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.273.96107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.772147424.08107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.733.4107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.633.04107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.129.54107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.739.1510,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.6-1.376,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.8-1.43556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414472-10.29107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.3-13.17556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5-13.737,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.1-8.22107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7-7.2580,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.7-9.5223,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.4-8.62643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.6-4.55611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6-7.38107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.2-1.74611,323 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.3-6.19611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.2-6.1998,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.5-6.1982,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7-6.1943,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.8-6.19179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02252-6.1976,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4-15.97557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5-16.02557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72170-13.78557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1-7.23107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4-2.3882,777 (Direct)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9-3.03557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.510.85107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.91.9933,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.657337.5667,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.313.73107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.613.15107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.416.21107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.423.96559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.423.73107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.816.56107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.25.0667,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.614.0676,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2-7.33559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8-9.4891,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55161-9.48168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8-9.48559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.2-9.4867,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7-9.4866,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.4-9.4872,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.3-2.38525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.5-1.2576,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.6-1.79525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.16208453.376,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.213.0876,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.07646015.776,997 (Direct)
390,944 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535012.6355,519 (Direct)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.516.0876,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.7-9.04955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8-25.47955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.8-28.346,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.1-25.9748,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6-24.2144,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.975197-24.15955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.922684-17.7477,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9-13.8449,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.27730.381,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7-0.6176,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.9-8.7376,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.5-4.441,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.32.051,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7-10.141,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.8-15.04133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.643198-7.55135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.8-10.21977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.8-7.222,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.3-4.9155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.1-3.641,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1-3.64125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1-3.64127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171-3.6446,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2-3.6447,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.1-1.521,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.15.26113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.220.961,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.820.3713,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.122.7733,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.816.351,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.56.0510,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.516.0876,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.27.761,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.110.951,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.717.2933,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.626.51112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.828.2113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296832.82122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.71274937.31,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.745.0918,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.233.131,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.431.0157,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.240.7957,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.1319963.371,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.95127258122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.7118566.33113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.77171652.9757,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.654.0457,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.455.1457,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.856.491,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.255.5657,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.954995857,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.667.1101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.554.531,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.357.6269,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.448.251,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.936.9233,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.538.3270,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.132.557,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.5421948.531,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.746.1670,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.851.7950,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.364.1843,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.551.621,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.255.441,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.3663455.4468,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.560.950,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$2424064.2517,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.9780471.6250,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.275.217,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.7515899.5911,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.183.0117,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.799.5931,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.7579099.5931,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.897.5968,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.9102.0517,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.9108.7917,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.299.2931,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.7579099.5931,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.3112.0517,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.9112.8572,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.1112.7468,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.7579099.5930,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73251135.621,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9117.9115,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.6146.841,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.480.081,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.279.5959,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.191.5559,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.9753579.4349,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.395.631,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.695.921,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.3130.8
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.5130.8
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.4156.31
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7156.31
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.7126.941,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.990.8950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.396.71163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.197950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.797.18,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$202097.1950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$207297.122,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.697.499,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.2100.41Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.2102.15Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.2110.693,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376109.68Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1111.489,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356121.46Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356121.463,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.911925,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5127.2945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8122.219,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5126.16Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.8129.85Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1132.7Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95202132.57Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5158.15Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803145.45Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640146.38Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818179.77Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.1154.32Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.9154.32
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5143.03Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.3149.34Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5168.16Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.8132.57Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.8163.68Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.9230.15Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.4230.15Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8215.61Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.8229.87Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.7229.87Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.9194.84Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132230.7Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.3208.21Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.3208.21Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.8204.4Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.5256.42Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.7256.42Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.6227.14Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7231.26Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.3243.68Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.1266.7Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.6266.7Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.8216.12Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6218.93Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.3233.78Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.7328.01
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.7305.56
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.7305.56
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.7305.56
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.1305.56
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.7305.56
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.6241.89
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.9208.21
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.1214.86
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.5209.42
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.2209.42
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.9210.15
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.6210.15
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5221.8
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565248.85
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.2263.32
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36220280.5
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.7280.5
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078265.68
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5264.66
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5264.66
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.4264.66
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.7280.5
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39437279.4
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.4288.76
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014288.76
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.2290.3
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.2290.3
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.8290.3
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.5291.85
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.5291.85
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512291.85
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.2398.99
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.931398.99
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.6398.99
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.5405.38
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.6390.3
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.9388.48
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.6390.3
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.9388.48
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.2390.3
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.2390.3
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.5336.54
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6336.54
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.2337.51
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.4337.51
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144337.51
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.1338
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1338.49
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.6338.49
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.3338.49
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.5338.49
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.8332.24
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.1212.11
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.7212.11
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1230.98
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93179230.43
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.6231.26
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.4234.07
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.2238.37
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.1239.53
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.4241.59
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.2271.19
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.7255.46
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722258.69
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.7253.86
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.7285.34
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258281.98
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5313.21
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.4350
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.1350
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.4350
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.2350
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.7350
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.6352.06
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1352.06
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.4352.06
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.2352.06
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.6359.98
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447340.94
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.4873.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.1873.33Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.9873.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.2878.16Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.7878.16Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.2878.16Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.8873.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.2873.33Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.6873.33Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036878.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262878.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.2965.41Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.72965.41Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.4965.41Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0334878.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.1878.16Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.8878.16Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.2880.6Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.8880.6Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.3880.6Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.1880.6Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210880.6Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.7880.6Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.3885.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.1885.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.8885.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.7650.86Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.7650.86Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.9650.86Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.8560.3Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.8558.1Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.9561.41Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.5688.4Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.2722.96Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.5722.96Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.9722.96Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.2722.96Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.7722.96Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.7722.96Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.9722.96Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.5722.96Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.6885.5Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.6885.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.6885.5Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.9885.5Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.1885.5Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.2885.5Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307885.5Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$4327885.5Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.7694.76Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.6694.76Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.6694.76Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.6694.76Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.5694.76Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.7694.76Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.1694.76Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.964694.76Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.7707.79Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.8707.79Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.3707.79Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845707.79Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.1707.79Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840707.79Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.7707.79Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.3707.79Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.6689.98Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.9689.98Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.2689.98Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163689.98Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.7689.98Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.3694.76Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626694.76Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.3694.76Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5463.14Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.8460.74Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1458.36Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.6468.01Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6471.3Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.4482.27Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5491Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2469.65Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.4477.16Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.4487.48Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.9496.37Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.4478.85Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824478.85Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297484Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.6610.27Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.1618.03Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.3630Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121612.84Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3612.84Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.7612.84Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.2589.16Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.3589.16Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.4589.16Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.4460.74Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4459.94Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.2456.78Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6453.65Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.7379.56Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.9358.91Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3278.31Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3342.92Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.9445.98Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.1461.54Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4494.57Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.8500.91Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.5522.75Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5509.27Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5509.27Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4429512.11Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4429512.11Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3528.71Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.4504.6Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.4504.6Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.9489.24Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.9557Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.1508.33Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959568.14Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959568.14Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.4551.57Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.4551.57Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.7537.86Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.7537.86Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.3648.01Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8674.46Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.2707.79Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.5738.72Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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