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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Clay B. Siegall,PhDPresident and CEO556,1150.4%2016-04-25
Franklin M. BergerN/A204,7200.15%2014-02-21
Todd E. SimpsonCFO194,6750.14%2015-09-29
Dr. Marc E. Lippman,M.D.N/A128,650less than 0.1%2015-05-15
Dr. Vaughn B. Himes,PhDEVP, Proc Svcs & Tech Ops111,248less than 0.1%2015-12-18
Dr. Felix J. Baker,PhDDirector, 10% Owner107,504less than 0.1%2016-03-17
Eric L. DobmeierCOO90,117less than 0.1%2015-12-31
Jonathan G. DrachmanCMO & EVP, R & D82,724less than 0.1%2015-08-20
Christopher S. BoernerN/A72,358less than 0.1%2014-08-24
Tim J. CarrollN/A62,861less than 0.1%2005-05-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2016-04-25Sell800584,060$4032-9.08556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.20.69556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.22.39556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.514.19107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.513.3107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.912.05107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.260.5107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.772147414.48107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.723.08107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.622.75107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.119.52107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.728.3810,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.6-8.9476,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.8-9.05556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414472-17.23107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.3-19.89556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5-20.3837,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.1-15.32107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7-14.4280,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.7-16.5323,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.4-15.69643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.6-11.94611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6-14.54107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.2-9.35611,323 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.3-13.45611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.2-13.4598,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.5-13.4582,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7-13.4543,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.8-13.45179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02252-13.4576,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4-22.47557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5-22.52557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72170-20.45557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1-14.4107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4-9.9382,777 (Direct)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9-10.53557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.52.28107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.9-5.933,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.65733-0.7667,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.34.93107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.64.39107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.47.22107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.414.37559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.414.16107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.87.54107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.2-3.0767,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.65.2476,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2-14.5559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8-16.4991,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55161-16.49168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8-16.49559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.2-16.4967,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7-16.4966,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.4-16.4972,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.3-9.93525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.5-8.8976,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.6-9.39525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620845-4.6976,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.24.3376,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.0764606.7576,997 (Direct)
390,944 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$353503.9155,519 (Direct)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.57.176,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.7-16.08955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8-31.23955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.8-33.8546,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.1-31.748,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6-30.0744,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.975197-30.02955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.922684-24.177,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9-20.549,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2773-7.381,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7-8.376,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.9-15.7976,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.5-11.831,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.3-5.851,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7-17.11,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.8-21.62133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.643198-14.7135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.8-17.15977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.8-14.3822,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.3-12.26155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.1-11.11,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1-11.1125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1-11.1127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171-11.146,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2-11.147,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.1-9.141,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1-2.88113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.211.61,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.811.0513,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.113.2733,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.87.351,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.5-2.1510,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.57.176,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.2-0.571,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.12.361,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.78.2133,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.616.72112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.818.28113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296822.54122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.71274926.681,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.733.8618,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.222.831,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.420.8757,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.229.8957,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.1319950.731,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.95127245.77122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.7118553.46113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.77171641.1357,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.642.1357,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.443.1357,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.844.381,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.243.5357,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.9549945.7757,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.654.18101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.542.571,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.345.4269,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.436.781,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.926.3333,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.527.6170,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.122.2557,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.5421937.041,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.734.8570,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.840.0550,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.351.4843,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.539.881,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.243.411,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.3663443.4168,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.548.4550,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$2424051.5417,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.9780458.3450,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.261.6417,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.7515884.1511,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.168.8517,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.784.1531,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.7579084.1531,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.882.3168,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.986.4217,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.992.6417,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.283.8731,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.7579084.1531,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.395.6417,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.996.3872,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.196.2868,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.7579084.1530,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73251117.391,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9101.0515,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.6127.741,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.466.151,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.265.6959,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.176.7259,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.9753565.5449,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.380.51,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.680.771,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.3112.94
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.5112.94
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.4136.48
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7136.48
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.7109.381,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.976.04950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.381.49163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.181.76950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.781.858,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$202081.85950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$207281.8522,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.682.219,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.284.9Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.286.51Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.294.393,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.837693.46Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.195.129,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356104.33Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356104.333,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.9102.0625,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5109.63945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8105.029,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5108.66Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.8112.07Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1114.7Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95202114.57Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5138.18Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803126.46Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640127.31Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818158.13Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.1134.65Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.9134.65
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5124.23Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.3130.04Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5147.41Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.8114.57Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.8143.28Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.9204.61Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.4204.61Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8191.19Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.8204.35Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.7204.35Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.9172.03Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132205.12Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.3184.36Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.3184.36Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.8180.85Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.5228.84Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.7228.84Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.6201.83Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7205.63Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.3217.09Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.1238.33Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.6238.33Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.8191.66Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6194.26Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.3207.96Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.7294.9
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.7274.18
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.7274.18
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.7274.18
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.1274.18
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.7274.18
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.6215.44
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.9184.36
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.1190.5
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.5185.48
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.2185.48
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.9186.15
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.6186.15
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5196.9
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565221.86
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.2235.21
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36220251.06
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.7251.06
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078237.38
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5236.45
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5236.45
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.4236.45
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.7251.06
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39437250.05
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.4258.68
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014258.68
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.2260.1
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.2260.1
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.8260.1
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.5261.53
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.5261.53
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512261.53
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.2360.38
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.931360.38
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.6360.38
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.5366.28
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.6352.36
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.9350.68
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.6352.36
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.9350.68
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.2352.36
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.2352.36
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.5302.77
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6302.77
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.2303.66
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.4303.66
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144303.66
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.1304.11
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1304.56
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.6304.56
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.3304.56
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.5304.56
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.8298.79
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.1187.97
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.7187.97
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1205.37
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93179204.86
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.6205.63
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.4208.22
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.2212.19
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.1213.26
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.4215.16
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.2242.47
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.7227.95
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722230.94
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.7226.48
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.7255.52
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258252.42
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5281.24
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.4315.18
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.1315.18
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.4315.18
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.2315.18
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.7315.18
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.6317.09
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1317.09
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.4317.09
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.2317.09
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.6324.39
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447306.82
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.4798.02Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.1798.02Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.9798.02Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.2802.48Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.7802.48Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.2802.48Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.8798.02Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.2798.02Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.6798.02Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036802.48Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262802.48Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.2882.97Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.72882.97Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.4882.97Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0334802.48Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.1802.48Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.8802.48Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.2804.73Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.8804.73Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.3804.73Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.1804.73Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210804.73Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.7804.73Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.3809.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.1809.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.8809.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.7592.76Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.7592.76Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.9592.76Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.8509.21Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.8507.18Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.9510.23Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.5627.4Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.2659.29Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.5659.29Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.9659.29Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.2659.29Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.7659.29Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.7659.29Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.9659.29Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.5659.29Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.6809.25Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.6809.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.6809.25Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.9809.25Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.1809.25Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.2809.25Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307809.25Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$4327809.25Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.7633.27Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.6633.27Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.6633.27Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.6633.27Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.5633.27Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.7633.27Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.1633.27Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.964633.27Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.7645.29Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.8645.29Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.3645.29Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845645.29Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.1645.29Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840645.29Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.7645.29Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.3645.29Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.6628.86Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.9628.86Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.2628.86Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163628.86Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.7628.86Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.3633.27Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626633.27Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.3633.27Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5419.57Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.8417.35Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1415.16Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.6424.06Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6427.1Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.4437.22Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5445.28Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2425.58Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.4432.5Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.4442.03Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.9450.23Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.4434.07Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824434.07Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297438.81Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.6555.32Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.1562.48Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.3573.52Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121557.69Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3557.69Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.7557.69Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.2535.84Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.3535.84Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.4535.84Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.4417.35Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4416.62Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.2413.7Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6410.81Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.7342.46Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.9323.4Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3249.04Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3308.65Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.9403.74Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.1418.09Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4448.57Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.8454.42Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.5474.57Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5462.13Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5462.13Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4429464.75Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4429464.75Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3480.06Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.4457.82Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.4457.82Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.9443.65Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.9506.17Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.1461.27Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959516.44Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959516.44Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.4501.16Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.4501.16Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.7488.51Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.7488.51Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.3590.13Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8614.54Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.2645.29Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.5673.83Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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