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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Clay B. Siegall,PhDPresident and CEO556,1150.4%2016-07-06
Franklin M. BergerN/A204,7200.15%2014-02-21
Todd E. SimpsonCFO194,6750.14%2015-09-29
Dr. Marc E. Lippman,M.D.N/A132,350less than 0.1%2016-05-20
Dr. Vaughn B. Himes,PhDEVP, Proc Svcs & Tech Ops111,248less than 0.1%2015-12-18
Dr. Felix J. Baker,PhDDirector, 10% Owner107,504less than 0.1%2016-05-20
Eric L. DobmeierCOO90,117less than 0.1%2015-12-31
Jonathan G. DrachmanCMO & EVP, R & D88,246less than 0.1%2016-06-02
Christopher S. BoernerN/A72,358less than 0.1%2014-08-24
Tim J. CarrollN/A62,861less than 0.1%2005-05-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2016-07-27Sell4,042584,060$45.2182.76.33556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9918.49556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.610.25556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6114.2442,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3518.93556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7619.88556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8536.69556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403220.15556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1633.06556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1835.3556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4750.89107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5149.72107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8648.06107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17112.09107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.0451.27107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.7162.64107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.5962.2107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.1457.94107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.6669.6410,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5720.3376,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7620.18556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.999.38107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.275.86556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.535.2137,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.111.9107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7113.0880,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.710.3123,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3911.4643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5516.37611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6412.92107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1719.79611,323 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.314.37611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1914.3798,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4914.3782,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7514.3743,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7714.37179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9914.3776,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.412.45557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.522.39557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.995.12557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1513.11107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4519.0282,777 (Direct)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9118.23557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5335.15107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8824.3533,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573331.1367,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3538.66107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6237.94107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4241.69107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.3751.13559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4250.85107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8442.11107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.228.0967,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6539.0676,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2212.98559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8210.3691,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9610.36168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8310.36559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1510.3667,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7210.3666,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3510.3672,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2619.02525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4720.3976,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5719.73525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9825.9476,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2337.8776,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0541.0676,997 (Direct)
390,944 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535037.3155,519 (Direct)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4541.5276,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.710.89955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.83-9.13955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.83-12.5946,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.08-9.7548,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.63-7.5944,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.975197-7.52955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.9226840.2977,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.955.0549,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9622.381,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7121.1876,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8611.2876,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.516.511,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2624.411,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.749.551,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.83.58133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319812.71135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.89.48977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.813.1422,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2815.95155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0817.481,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1517.48125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1517.48127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0217.4846,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2517.4847,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0620.061,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1428.33113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1847.471,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7546.7513,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.149.6733,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7641.851,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4829.310,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4541.5276,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1631.381,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0635.271,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6942.9933,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.654.24112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.8356.29113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296861.93122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.9867.41,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.776.8918,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.2262.311,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.3659.7257,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.2171.6457,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.0599.171,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.0392.63122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185102.78113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.9786.557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.687.8157,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.489.1457,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.8290.791,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.289.6657,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.9549992.6357,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64103.73101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.4688.41,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.2592.1669,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.3780.741,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.966.9333,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.568.6370,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.0761.5557,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.9681.091,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.6578.270,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.885.0650,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25100.1743,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.584.851,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.2289.511,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.3663489.5168,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.596.1650,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$24240100.2517,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95109.2350,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24113.617,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158143.3411,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1123.1217,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74143.3431,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790143.3431,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75140.968,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86146.3417,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85154.5617,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2142.9731,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790143.3431,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35158.5317,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92159.572,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12159.3668,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790143.3430,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95187.271,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9165.6715,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55200.941,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35119.551,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15118.9559,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.09133.5359,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97118.7549,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.25138.511,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6138.871,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28181.38
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51181.38
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39212.48
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7212.48
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73176.681,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9132.62950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28139.82163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09140.18950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7140.38,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020140.3950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072140.322,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57140.789,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23144.33Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19146.46Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16156.873,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376155.64Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1157.839,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356170Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.83561703,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.8716725,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5177945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8170.919,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5175.73Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75180.23Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1183.71Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96183.54Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5214.73Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803199.25Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640200.38Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818241.09Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05210.06Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95210.06
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5196.3Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25203.98Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5226.94Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75183.54Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75221.47Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88302.51Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44302.51Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8284.79Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79302.18Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72302.18Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85259.46Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01303.19Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26275.76Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32275.76Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75271.12Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49334.54Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67334.54Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58298.84Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7303.87Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26319.01Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09347.07Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58347.07Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75285.4Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6288.83Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25306.94Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66421.82
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68394.44
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67394.44
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68394.44
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06394.44
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66394.44
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64316.83
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91275.76
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11283.87
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52277.24
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25277.24
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86278.13
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59278.13
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5292.33
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565325.31
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21342.95
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96363.9
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74363.9
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078345.83
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5344.59
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5344.59
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35344.59
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74363.9
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99362.56
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41373.96
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014373.96
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22375.84
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22375.84
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79375.84
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45377.73
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45377.73
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01377.73
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16508.35
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95508.35
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59508.35
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47516.15
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63497.76
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91495.54
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58497.76
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91495.54
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19497.76
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24497.76
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46432.23
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6432.23
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22433.41
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38433.41
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144433.41
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05434
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1434.59
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56434.59
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34434.59
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45434.59
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82426.97
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06280.52
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72280.52
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1303.53
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95302.85
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61303.87
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38307.29
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23312.53
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14313.95
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38316.46
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24352.54
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66333.36
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04337.31
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74331.42
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68369.79
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258365.7
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5403.77
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39448.63
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09448.63
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35448.63
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18448.63
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71448.63
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57451.15
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1451.15
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39451.15
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19451.15
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55460.79
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447437.58
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441086.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131086.67Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921086.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181092.56Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751092.56Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191092.56Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841086.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181086.67Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61086.67Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011092.56Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031092.56Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231198.92Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721198.92Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431198.92Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991092.56Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121092.56Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831092.56Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151095.52Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821095.52Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251095.52Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131095.52Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031095.52Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691095.52Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311101.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081101.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771101.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.71815.43Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.71815.43Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.91815.43Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81705.03Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76702.34Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88706.38Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.5861.2Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.25903.34Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.54903.34Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.85903.34Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.2903.34Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.74903.34Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.68903.34Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.94903.34Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.54903.34Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571101.5Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641101.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581101.5Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941101.5Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061101.5Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171101.5Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041101.5Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271101.5Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.72868.95Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.65868.95Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.62868.95Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.63868.95Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.47868.95Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.7868.95Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.14868.95Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.97868.95Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.72884.84Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.76884.84Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.27884.84Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.04884.84Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.13884.84Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.04884.84Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.68884.84Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.33884.84Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.56863.13Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.89863.13Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.19863.13Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.02863.13Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.71863.13Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.34868.95Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.04868.95Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.34868.95Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5586.57Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82583.64Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1580.74Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55592.51Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6596.52Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42609.9Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5620.54Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2594.51Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35603.66Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41616.24Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86627.08Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35605.73Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01605.73Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297612Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.61765.95Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.14775.41Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.31790Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.05769.08Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3769.08Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.66769.08Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.15740.21Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.34740.21Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.36740.21Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36583.64Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4582.67Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22578.81Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6575Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69484.67Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85459.49Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3361.23Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3440Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95565.65Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12584.62Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4624.89Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77632.62Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49659.24Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5642.81Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5642.81Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98646.27Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98646.27Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3666.51Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38637.12Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38637.12Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89618.39Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87701Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08641.67Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959714.58Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959714.58Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38694.38Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38694.38Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67677.67Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67677.67Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.29811.95Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8844.2Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.2884.84Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.5922.55Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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