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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Clay B. Siegall,PhDPresident and CEO638,8350.45%2016-09-08
Todd E. SimpsonCFO209,4450.15%2016-08-27
Franklin M. BergerN/A204,7200.15%2014-02-21
Dr. Vaughn B. Himes,PhDEVP, Proc Svcs & Tech Ops135,3790.1%2016-08-31
Dr. Marc E. Lippman,M.D.N/A132,350less than 0.1%2016-05-20
Jonathan G. DrachmanCMO & EVP, R & D113,255less than 0.1%2016-08-27
Dr. Felix J. Baker,PhDDirector, 10% Owner107,504less than 0.1%2016-09-09
Eric L. DobmeierCOO87,767less than 0.1%2016-09-14
Christopher S. BoernerN/A72,358less than 0.1%2014-08-24
Tim J. CarrollN/A62,861less than 0.1%2005-05-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
DRACHMAN JONATHAN GCMO & EVP, R & D2016-09-22Sell2,249113,255$56.75127.63-1.83113,255 (Direct)
DOBMEIER ERICCOO2016-09-14Sell22,91887,767$54.041238.493.0987,767 (Direct)
BAKER FELIXDirector, 10% Owner2016-09-13Buy447,31144,233,991$50.7122683.149.86107,504 (Direct)
4,693,991 (See footnote(,,,))
39,432,496 (See Footnote(,,,))
BAKER FELIXDirector, 10% Owner2016-09-08Buy414,01643,696,884$48.4320050.7915.03107,504 (Direct)
4,559,012 (See footnote(,,,))
39,030,368 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2016-09-08Sell31,269638,835$50.081565.9511.24638,835 (Direct)
0 (by Trust)
SIEGALL CLAY BPresident and CEO2016-09-06Sell11,653644,983$45.4529.0522.71617,038 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-09-06Sell5,39751,576$46.01248.3221.0851,576 (Direct)
DOBMEIER ERICCOO2016-08-23Sell12,58958,767$48604.2716.0658,767 (Direct)
Cline Darren SEVP, Commercial2016-08-22Sell1,77440,973$46.5982.6519.5840,973 (Direct)
DOBMEIER ERICCOO2016-08-22Sell5,41167,525$46.59252.119.5867,525 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-08-22Sell3,99184,255$46.59185.9419.5884,255 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2016-08-22Sell3,991108,779$46.59185.9419.58108,779 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-22Sell23,381560,679$46.591089.3219.58532,734 (Direct)
27,945 (by Trust)
SIMPSON TODD ECFO2016-08-22Sell3,991191,445$46.59185.9419.58191,445 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-08Sell11,660584,060$47.19550.2418.05556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-27Sell4,042584,060$45.2182.723.25556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9937.35556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.627.8556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6132.4242,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3537.86556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7638.96556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8558.45556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403239.28556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1654.24556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1856.84556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4774.91107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5173.55107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8671.63107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17145.85107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.0475.35107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.7188.53107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.5988.02107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.1483.08107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.6696.6510,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5739.4876,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7639.31556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.9926.79107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.2722.71556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5321.9637,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.129.71107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7131.0880,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.727.8623,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3929.14643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5534.89611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6430.9107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1738.86611,323 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.332.58611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1932.5898,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4932.5882,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7532.5843,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7732.58179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9932.5876,212 (Direct)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1932.5898,340 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7532.5843,482 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4118.76557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5218.68557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.9921.85557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1531.11107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4537.9682,777 (Direct)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9137.05557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5356.66107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8844.1433,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573352.0167,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3560.73107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6259.9107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4264.24107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.3775.19559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4274.86107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8464.73107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.248.4867,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6561.276,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2230.96559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8227.9291,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9627.92168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8327.92559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1527.9267,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7227.9266,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3527.9272,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2637.96525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4739.5576,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5738.79525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9845.9976,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2359.8176,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0563.5276,997 (Direct)
390,944 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535059.1755,519 (Direct)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4564.0576,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.728.54955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.835.33955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.831.3346,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.084.6248,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.637.1144,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.9751977.2955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.92268416.2677,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9521.7749,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9641.861,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7140.4776,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8628.9976,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.535.051,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2644.211,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7426.991,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.820.06133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319830.65135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.826.9977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.831.1422,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2834.4155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0836.181,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1536.18125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1536.18127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0236.1846,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2536.1847,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0639.171,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1448.76113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1870.941,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7570.1113,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.173.533,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7664.431,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4849.8810,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4564.0576,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1652.31,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0656.81,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6965.7533,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.678.79112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.8381.17113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296887.7122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.9894.041,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.7105.0418,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.2288.151,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.3685.1457,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.2198.9657,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.05130.871,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.03123.29122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185135.06113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.97116.1857,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.6117.757,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.4119.2457,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.82121.161,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.2119.8557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.95499123.2957,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64136.16101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.46118.381,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.25122.7569,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.37109.511,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.993.533,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.595.4770,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.0787.2657,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.96109.911,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.65106.5670,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.8114.5250,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25132.0343,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.5114.271,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.22119.681,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.36634119.6868,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.5127.3950,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$24240132.1317,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95142.5350,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24147.617,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158182.0811,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1158.6417,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74182.0831,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790182.0831,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75179.2568,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86185.5517,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85195.0717,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2181.6531,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790182.0831,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35199.6817,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92200.8172,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12200.6568,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790182.0830,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95232.991,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9207.9615,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55248.841,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35154.51,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15153.859,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.09170.759,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97153.5749,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.25176.481,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6176.891,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28226.17
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51226.17
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39262.22
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7262.22
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73220.731,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9169.65950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28177.99163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09178.41950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7178.558,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020178.55950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072178.5522,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57179.119,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23183.22Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19185.69Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16197.763,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376196.33Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1198.879,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356212.98Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356212.983,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.87209.525,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5221.1945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8214.049,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5219.62Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75224.84Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1228.87Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96228.67Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5264.83Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803246.89Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640248.19Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818295.39Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05259.42Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95259.42
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5243.46Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25252.37Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5278.98Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75228.67Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75272.64Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88366.58Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44366.58Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8346.04Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79366.19Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72366.19Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85316.68Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01367.37Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26335.57Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32335.57Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75330.19Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49403.71Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67403.71Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58362.32Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7368.15Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26385.7Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09418.23Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58418.23Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75346.75Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6350.73Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25371.72Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66504.89
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68473.15
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67473.15
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68473.15
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06473.15
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66473.15
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64383.17
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91335.57
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11344.97
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52337.28
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25337.28
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86338.32
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59338.32
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5354.78
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565393.01
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21413.46
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96437.74
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74437.74
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078416.79
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5415.36
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5415.36
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35415.36
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74437.74
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99436.19
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41449.41
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014449.41
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22451.58
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22451.58
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79451.58
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45453.78
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45453.78
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01453.78
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16605.19
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95605.19
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59605.19
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47614.23
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63592.91
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91590.33
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58592.91
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91590.33
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19592.91
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24592.91
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46516.94
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6516.94
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22518.31
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38518.31
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144518.31
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05519
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1519.69
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56519.69
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34519.69
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45519.69
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82510.86
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06341.09
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72341.09
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1367.76
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95366.97
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61368.15
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38372.12
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23378.2
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14379.84
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38382.76
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24424.58
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66402.34
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04406.92
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74400.09
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68444.57
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258439.83
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5483.96
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39535.96
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09535.96
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35535.96
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18535.96
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71535.96
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57538.88
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1538.88
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39538.88
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19538.88
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55550.06
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447523.15
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441275.56Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131275.56Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921275.56Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181282.38Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751282.38Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191282.38Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841275.56Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181275.56Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61275.56Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011282.38Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031282.38Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231405.68Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721405.68Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431405.68Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991282.38Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121282.38Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831282.38Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151285.82Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821285.82Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251285.82Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131285.82Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031285.82Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691285.82Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311292.75Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081292.75Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771292.75Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.71961.14Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.71961.14Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.91961.14Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81833.17Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76830.05Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88834.73Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.51014.2Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.251063.05Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.541063.05Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.851063.05Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.21063.05Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.741063.05Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.681063.05Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.941063.05Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.541063.05Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571292.75Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641292.75Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581292.75Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941292.75Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061292.75Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171292.75Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041292.75Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271292.75Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.721023.19Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.651023.19Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.621023.19Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.631023.19Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.471023.19Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.71023.19Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.141023.19Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.971023.19Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.721041.6Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.761041.6Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.271041.6Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.041041.6Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.131041.6Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.041041.6Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.681041.6Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.331041.6Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.561016.43Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.891016.43Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.191016.43Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.021016.43Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.711016.43Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.341023.19Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.041023.19Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.341023.19Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5695.86Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82692.46Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1689.09Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55702.74Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6707.39Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42722.9Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5735.23Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2705.06Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35715.67Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41730.25Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86742.81Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35718.06Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01718.06Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297725.33Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.61903.78Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.14914.75Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.31931.67Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.05907.41Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3907.41Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.66907.41Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.15873.95Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.34873.95Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.36873.95Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36692.46Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4691.34Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22686.86Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6682.44Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69577.74Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85548.54Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3434.64Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3525.96Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95671.61Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12693.59Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4740.27Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77749.24Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49780.09Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5761.05Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5761.05Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98765.06Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98765.06Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3788.52Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38754.45Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38754.45Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89732.74Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87828.5Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08759.72Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959844.24Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959844.24Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38820.83Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38820.83Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67801.46Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67801.46Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.29957.12Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8994.5Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.21041.6Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.51085.32Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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