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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2017-01-06Sell14,465638,835$57.89837.381.99638,835 (Direct)
Cline Darren SEVP, Commercial2016-12-13Sell10,00058,504$63.38633.8-6.8558,504 (Direct)
DOBMEIER ERICCOO2016-12-08Sell12,50087,767$65.92824-10.4487,767 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-09Sell7,751109,837$66.75517.38-11.55109,837 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-08Buy382,50040,992,596$59.3622705.2-0.54107,504 (Direct)
40,885,092 (See footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-11-07Sell14,465638,835$58.43845.191.04638,835 (Direct)
LIPPMAN MARC EDirector2016-11-07Sell1,000131,350$57.7557.752.23131,350 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-03Buy198,43345,482,921$56.4311197.574.63107,504 (Direct)
4,835,170 (See footnote(,,,))
40,540,247 (See Footnote(,,,))
BAKER FELIXDirector, 10% Owner2016-11-03Buy1,030,62945,194,447$56.1357849.215.18107,504 (Direct)
4,725,543 (See footnote(,,,))
40,361,400 (See Footnote(,,,))
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-01Sell3,418109,837$51.74176.8514.11109,837 (Direct)
SIEGALL CLAY BPresident and CEO2016-10-06Sell14,465638,835$54.41787.048.51638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-09-22Sell2,249113,255$56.75127.634.04113,255 (Direct)
DOBMEIER ERICCOO2016-09-14Sell22,91887,767$54.041238.499.2587,767 (Direct)
BAKER FELIXDirector, 10% Owner2016-09-13Buy447,31144,233,991$50.7122683.1416.43107,504 (Direct)
4,693,991 (See footnote(,,,))
39,432,496 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-08Sell31,269638,835$50.081565.9517.89638,835 (Direct)
0 (by Trust)
BAKER FELIXDirector, 10% Owner2016-09-08Buy414,01643,696,884$48.4320050.7921.91107,504 (Direct)
4,559,012 (See footnote(,,,))
39,030,368 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-06Sell11,653644,983$45.4529.0530.04617,038 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-09-06Sell5,39751,576$46.01248.3228.3251,576 (Direct)
DOBMEIER ERICCOO2016-08-23Sell12,58958,767$48604.272358,767 (Direct)
Cline Darren SEVP, Commercial2016-08-22Sell1,77440,973$46.5982.6526.7240,973 (Direct)
DOBMEIER ERICCOO2016-08-22Sell5,41167,525$46.59252.126.7267,525 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-08-22Sell3,99184,255$46.59185.9426.7284,255 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2016-08-22Sell3,991108,779$46.59185.9426.72108,779 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-22Sell23,381560,679$46.591089.3226.72532,734 (Direct)
27,945 (by Trust)
SIMPSON TODD ECFO2016-08-22Sell3,991191,445$46.59185.9426.72191,445 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-08Sell11,660584,060$47.19550.2425.11556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-27Sell4,042584,060$45.2182.730.62556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9945.56556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.635.44556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6140.3442,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3546.1556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7647.27556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8567.92556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403247.6556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1663.46556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1866.22556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4785.37107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5183.93107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8681.89107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17160.55107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.0485.84107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.7199.8107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.5999.26107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.1494.02107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.66108.410,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5747.8276,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7647.64556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.9934.37107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.2730.04556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5329.2537,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.137.46107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7138.9280,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.735.5123,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3936.86643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5542.95611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6438.72107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1747.16611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1940.598,340 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7540.543,482 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.340.5611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1940.598,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4940.582,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7540.543,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7740.5179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9940.576,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4125.86557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5225.78557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.9929.13557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1538.95107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9145.24557,022 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4546.2182,777 (Direct)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5366.03107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8852.7633,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573361.0967,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3570.34107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6269.46107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4274.06107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.3785.66559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4285.31107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8474.57107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.257.3667,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6570.8376,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2238.79559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8235.5791,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9635.57168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8335.57559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1535.5767,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7235.5766,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3535.5772,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2646.21525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4747.976,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5747.09525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9854.7276,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2369.3676,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0573.2976,997 (Direct)
390,944 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4573.8576,997 (Direct)
3,872,076 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535068.6955,519 (Direct)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.736.23955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8311.63955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.837.3846,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.0810.8748,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6313.5244,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.97519713.6955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.92268423.2177,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9529.0549,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9650.341,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7148.8776,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8636.776,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.543.131,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2652.831,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7434.581,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.827.24133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319838.46135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.834.49977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.838.9822,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2842.44155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0844.321,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1544.32125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1544.32127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0244.3246,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2544.3247,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0647.491,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1457.65113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1881.161,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7580.2713,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.183.8733,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7674.261,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4858.8410,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4573.8576,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1661.41,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0666.171,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6975.6633,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.689.47112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.8392113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296898.92122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.98105.641,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.7117.318,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.2299.391,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.3696.2157,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.21110.8657,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.05144.671,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.03136.63122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185149.11113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.97129.157,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.6130.7257,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.82134.381,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.4132.3557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.2132.9957,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.95499136.6357,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64150.28101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.46131.441,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.25136.0769,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.37122.041,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.9105.0733,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.5107.1670,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.0798.4557,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.96122.461,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.65118.9170,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.8127.3450,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25145.943,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.5127.081,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.22132.811,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.36634132.8168,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.5140.9850,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$2424014617,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95157.0350,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24162.417,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158198.9411,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1174.0917,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74198.9431,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790198.9431,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75195.9468,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86202.6117,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85212.7117,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2198.4831,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790198.9431,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35217.5917,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92218.7972,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12218.6268,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790198.9430,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95252.91,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9226.3715,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55269.691,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35169.711,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15168.9759,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.09186.8859,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97168.7349,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.251931,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6193.441,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28245.67
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51245.67
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39283.88
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7283.88
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73239.91,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9185.77950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28194.61163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09195.05950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7195.28,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020195.2950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072195.222,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57195.799,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23200.15Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19202.77Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16215.553,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376214.04Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1216.749,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356231.69Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356231.693,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.8722825,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5240.29945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8232.819,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5238.73Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75244.26Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1248.52Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96248.32Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5286.64Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803267.62Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640269Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818319.02Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05280.9Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95280.9
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5264Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25273.43Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5301.63Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75248.32Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75294.92Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88394.47Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44394.47Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8372.7Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79394.06Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72394.06Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85341.59Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01395.3Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26361.61Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32361.61Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75355.91Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49433.82Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67433.82Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58389.96Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7396.13Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26414.73Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09449.21Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58449.21Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75373.46Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6377.67Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25399.92Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66541.04
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68507.41
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67507.41
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68507.41
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06507.41
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66507.41
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64412.06
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91361.61
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11371.57
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52363.42
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25363.42
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86364.52
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59364.52
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5381.96
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565422.48
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21444.15
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96469.88
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74469.88
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078447.68
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5446.16
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5446.16
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35446.16
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74469.88
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99468.24
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41482.25
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014482.25
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22484.55
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22484.55
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79484.55
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45486.88
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45486.88
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01486.88
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16647.34
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95647.34
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59647.34
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47656.92
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63634.33
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91631.6
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58634.33
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91631.6
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19634.33
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24634.33
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46553.82
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6553.82
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22555.27
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38555.27
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144555.27
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05556
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1556.73
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56556.73
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34556.73
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45556.73
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82547.37
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06367.46
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72367.46
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1395.72
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95394.89
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61396.13
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38400.34
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23406.78
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14408.53
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38411.61
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24455.93
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66432.37
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04437.22
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74429.98
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68477.13
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258472.09
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5518.87
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39573.97
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09573.97
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35573.97
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18573.97
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71573.97
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57577.06
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1577.06
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39577.06
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19577.06
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55588.91
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447560.4
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441357.78Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131357.78Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921357.78Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181365.01Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751365.01Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191365.01Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841357.78Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181357.78Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61357.78Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011365.01Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031365.01Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231495.68Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721495.68Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431495.68Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991365.01Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121365.01Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831365.01Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151368.66Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821368.66Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251368.66Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131368.66Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031368.66Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691368.66Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311376Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081376Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771376Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.711024.57Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.711024.57Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.911024.57Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81888.94Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76885.64Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88890.6Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.51080.8Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.251132.57Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.541132.57Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.851132.57Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.21132.57Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.741132.57Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.681132.57Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.941132.57Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.541132.57Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571376Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641376Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581376Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941376Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061376Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171376Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041376Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271376Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.721090.32Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.651090.32Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.621090.32Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.631090.32Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.471090.32Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.71090.32Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.141090.32Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.971090.32Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.721109.84Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.761109.84Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.271109.84Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.041109.84Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.131109.84Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.041109.84Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.681109.84Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.331109.84Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.561083.17Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.891083.17Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.191083.17Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.021083.17Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.711083.17Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.341090.32Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.041090.32Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.341090.32Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5743.43Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82739.83Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1736.26Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55750.72Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6755.65Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42772.08Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5785.16Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2753.18Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35764.42Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41779.88Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86793.19Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35766.96Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01766.96Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297774.67Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.61963.78Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.14975.41Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.31993.33Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.05967.63Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3967.63Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.66967.63Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.15932.17Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.34932.17Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.36932.17Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36739.83Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4738.64Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22733.9Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6729.21Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69618.25Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85587.31Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3466.6Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3563.37Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95717.73Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12741.03Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4790.5Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77800Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49832.7Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5812.52Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5812.52Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98816.77Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98816.77Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3841.63Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38805.52Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38805.52Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89782.51Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87884Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08811.11Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959900.68Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959900.68Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38875.87Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38875.87Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67855.34Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67855.34Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.291020.3Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.81059.92Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.21109.84Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.51156.17Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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