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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Clay B. Siegall,PhDPresident and CEO556,1150.4%2015-12-03
Franklin M. BergerDirector204,7200.15%2014-02-21
Todd E. SimpsonCFO194,6750.14%2015-09-29
Dr. Marc E. Lippman,M.D.Director128,650less than 0.1%2015-05-15
Dr. Vaughn B. Himes,PhDEVP, Proc Svcs & Tech Ops111,248less than 0.1%2015-12-18
Dr. Felix J. Baker,PhDDirector, 10% Owner107,504less than 0.1%2015-11-18
Eric L. DobmeierCOO90,117less than 0.1%2015-12-31
Jonathan G. DrachmanCMO & EVP, R & D82,724less than 0.1%2015-08-20
Christopher S. BoernerExecutive Vice President, Comm72,358less than 0.1%2014-08-24
Tim J. CarrollCFO62,861less than 0.1%2005-05-03

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.6-28.2976,212 (Direct)
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-12-03Sell3,720584,060$39.99148.8-28.38556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414472-34.82107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.3-36.92556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5-37.337,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.1-33.32107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7-32.6180,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.7-34.2723,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.4-33.61643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.6-30.65611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6-32.71107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.2-28.61611,323 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.3-31.84611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.2-31.8498,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.5-31.8482,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7-31.8443,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.8-31.84179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02252-31.8476,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4-38.95557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5-38.99557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72170-37.36557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1-32.6107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4-29.0782,777 (Direct)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9-29.54557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5-19.46107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.9-25.933,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.65733-21.8667,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3-17.37107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6-17.8107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4-15.57107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.4-9.94559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4-10.11107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8-15.32107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.2-23.6767,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6-17.1376,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2-32.68559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8-34.2491,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55161-34.24168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8-34.24559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.2-34.2467,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7-34.2466,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.4-34.2472,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.3-29.07525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.5-28.2676,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.6-28.65525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620845-24.9576,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2-17.8476,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460-15.9476,997 (Direct)
390,944 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$35350-18.1755,519 (Direct)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.5-15.6776,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.7-33.92955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8-45.85955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.8-47.9146,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.1-46.2248,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6-44.9344,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.975197-44.89955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.922684-40.2377,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9-37.449,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2773-27.071,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7-27.7976,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.9-33.6976,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.5-30.571,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.3-25.861,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7-34.721,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.8-38.28133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.643198-32.83135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.8-34.76977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.8-32.5822,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.3-30.9155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.1-29.991,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1-29.99125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1-29.99127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171-29.9946,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2-29.9947,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.1-28.451,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1-23.52113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.2-12.121,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.8-12.5513,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.1-10.8133,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.8-15.471,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.5-22.9510,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.5-15.6776,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.2-21.711,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.1-19.391,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.7-14.7933,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.6-8.09112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.8-6.86113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.682968-3.5122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712749-0.241,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.75.4118,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.2-3.281,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.4-4.8257,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.22.2957,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.1319918.691,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.95127214.79122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.7118520.84113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.77171611.1457,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.611.9257,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.412.7157,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.813.71,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.213.0257,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.9549914.7957,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.621.41101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.512.271,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.314.5169,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.47.711,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.9-0.5233,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.50.4970,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.1-3.7357,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.542197.911,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.76.1970,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.810.2850,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.319.2843,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.510.151,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.212.931,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.3663412.9368,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.516.950,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$2424019.3317,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.9780424.6850,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.227.2917,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.7515845.0111,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.132.9617,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.745.0131,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.7579045.0131,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.843.5668,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.946.817,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.951.6917,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.244.7931,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.7579045.0131,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.354.0617,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.954.6472,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.154.5668,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.7579045.0130,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.7325171.191,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.958.3215,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.679.341,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.430.841,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.230.4859,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.139.1659,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.9753530.3649,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.342.131,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.642.351,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.367.68
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.567.68
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.486.22
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.786.22
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.764.881,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.938.63950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.342.91163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.143.13950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.743.28,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$202043.2950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$207243.222,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.643.499,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.245.6Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.246.87Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.253.073,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.837652.34Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.153.659,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.835660.9Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.835660.93,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.959.1125,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.565.07945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.861.449,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.564.31Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.867Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.169.07Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.9520268.97Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.587.56Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.0680378.33Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$1664079Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818103.26Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.184.77Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.984.77
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.576.57Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.381.15Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.594.83Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.868.97Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.891.57Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.9139.87Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.4139.87Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8129.3Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.8139.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.7139.67Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.9114.21Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132140.27Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.3123.92Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.3123.92Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.8121.16Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.5158.95Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.7158.95Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.6137.68Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7140.67Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.3149.69Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.1166.42Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.6166.42Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.8129.67Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6131.72Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.3142.51Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.7210.97
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.7194.65
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.7194.65
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.7194.65
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.1194.65
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.7194.65
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.6148.4
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.9123.92
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.1128.75
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.5124.8
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.2124.8
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.9125.33
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.6125.33
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5133.8
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565153.45
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.2163.96
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36220176.45
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.7176.45
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078165.68
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5164.94
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5164.94
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.4164.94
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.7176.45
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39437175.65
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.4182.45
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014182.45
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.2183.56
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.2183.56
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.8183.56
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.5184.69
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.5184.69
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512184.69
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.2262.53
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.931262.53
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.6262.53
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.5267.18
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.6256.22
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.9254.89
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.6256.22
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.9254.89
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.2256.22
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.2256.22
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.5217.17
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6217.17
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.2217.87
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.4217.87
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144217.87
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.1218.22
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1218.58
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.6218.58
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.3218.58
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.5218.58
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.8214.04
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.1126.76
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.7126.76
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1140.47
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93179140.07
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.6140.67
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.4142.71
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.2145.84
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.1146.68
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.4148.18
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.2169.68
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.7158.25
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722160.6
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.7157.09
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.7179.96
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258177.52
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5200.21
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.4226.94
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.1226.94
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.4226.94
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.2226.94
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.7226.94
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.6228.44
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1228.44
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.4228.44
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.2228.44
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.6234.19
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447220.36
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.4607.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.1607.16Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.9607.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.2610.67Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.7610.67Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.2610.67Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.8607.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.2607.16Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.6607.16Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036610.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262610.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.2674.05Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.72674.05Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.4674.05Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0334610.67Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.1610.67Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.8610.67Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.2612.44Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.8612.44Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.3612.44Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.1612.44Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210612.44Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.7612.44Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.3616Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.1616Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.8616Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.7445.52Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.7445.52Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.9445.52Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.8379.73Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.8378.13Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.9380.54Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.5472.8Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.2497.91Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.5497.91Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.9497.91Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.2497.91Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.7497.91Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.7497.91Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.9497.91Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.5497.91Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.6616Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.6616Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.6616Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.9616Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.1616Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.2616Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307616Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$4327616Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.7477.42Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.6477.42Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.6477.42Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.6477.42Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.5477.42Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.7477.42Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.1477.42Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.964477.42Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.7486.89Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.8486.89Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.3486.89Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845486.89Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.1486.89Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840486.89Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.7486.89Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.3486.89Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.6473.95Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.9473.95Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.2473.95Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163473.95Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.7473.95Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.3477.42Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626477.42Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.3477.42Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5309.14Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.8307.4Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1305.67Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.6312.68Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6315.07Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.4323.04Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5329.39Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2313.87Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.4319.33Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.4326.83Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.9333.28Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.4320.56Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824320.56Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297324.3Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.6416.04Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.1421.68Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.3430.37Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121417.9Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3417.9Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.7417.9Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.2400.7Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.3400.7Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.4400.7Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.4307.4Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4306.82Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.2304.52Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6302.25Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.7248.42Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.9233.41Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3174.86Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3221.8Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.9296.68Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.1307.98Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4331.98Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.8336.59Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.5352.45Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5342.66Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5342.66Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4429344.72Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4429344.72Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3356.78Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.4339.26Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.4339.26Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.9328.1Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.9377.33Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.1341.98Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959385.42Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959385.42Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.4373.39Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.4373.39Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.7363.43Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.7363.43Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.3443.45Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8462.67Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.2486.89Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.5509.36Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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