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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2017-04-05Sell14,465636,435$62.99911.153.73636,435 (Direct)
HIMES VAUGHN BChief Technical Officer2017-03-31Sell10,000151,283$62.75627.54.13151,283 (Direct)
SIEGALL CLAY BPresident and CEO2017-03-06Sell14,465636,435$68.04984.2-3.97636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-02-06Sell14,465636,435$61.54890.186.17636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-01-06Sell14,465638,835$57.89837.3812.87638,835 (Direct)
Cline Darren SEVP, Commercial2016-12-13Sell10,00058,504$63.38633.83.0958,504 (Direct)
DOBMEIER ERICCOO2016-12-08Sell12,50087,767$65.92824-0.8887,767 (Direct)
HIMES VAUGHN BChief Technical Officer2016-12-07Sell30,000135,379$65.321959.60.03135,379 (Direct)
SIEGALL CLAY BPresident and CEO2016-12-06Sell14,465638,835$66.17957.15-1.25638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-09Sell7,751109,837$66.75517.38-2.11109,837 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-08Buy382,50040,992,596$59.3622705.210.07107,504 (Direct)
40,885,092 (See footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-11-07Sell14,465638,835$58.43845.1911.83638,835 (Direct)
LIPPMAN MARC EDirector2016-11-07Sell1,000131,350$57.7557.7513.14131,350 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-03Buy198,43345,482,921$56.4311197.5715.79107,504 (Direct)
4,835,170 (See footnote(,,,))
40,540,247 (See Footnote(,,,))
BAKER FELIXDirector, 10% Owner2016-11-03Buy1,030,62945,194,447$56.1357849.2116.41107,504 (Direct)
4,725,543 (See footnote(,,,))
40,361,400 (See Footnote(,,,))
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-01Sell3,418109,837$51.74176.8526.29109,837 (Direct)
SIEGALL CLAY BPresident and CEO2016-10-06Sell14,465638,835$54.41787.0420.09638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-09-22Sell2,249113,255$56.75127.6315.14113,255 (Direct)
DOBMEIER ERICCOO2016-09-14Sell22,91887,767$54.041238.4920.9187,767 (Direct)
BAKER FELIXDirector, 10% Owner2016-09-13Buy447,31144,233,991$50.7122683.1428.85107,504 (Direct)
4,693,991 (See footnote(,,,))
39,432,496 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-08Sell31,269638,835$50.081565.9530.47638,835 (Direct)
0 (by Trust)
BAKER FELIXDirector, 10% Owner2016-09-08Buy414,01643,696,884$48.4320050.7934.92107,504 (Direct)
4,559,012 (See footnote(,,,))
39,030,368 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-06Sell11,653644,983$45.4529.0543.92617,038 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-09-06Sell5,39751,576$46.01248.3242.0151,576 (Direct)
DOBMEIER ERICCOO2016-08-23Sell12,58958,767$48604.2736.1358,767 (Direct)
Cline Darren SEVP, Commercial2016-08-22Sell1,77440,973$46.5982.6540.2440,973 (Direct)
DOBMEIER ERICCOO2016-08-22Sell5,41167,525$46.59252.140.2467,525 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-08-22Sell3,99184,255$46.59185.9440.2484,255 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2016-08-22Sell3,991108,779$46.59185.9440.24108,779 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-22Sell23,381560,679$46.591089.3240.24532,734 (Direct)
27,945 (by Trust)
SIMPSON TODD ECFO2016-08-22Sell3,991191,445$46.59185.9440.24191,445 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-08Sell11,660584,060$47.19550.2438.46556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-27Sell4,042584,060$45.2182.744.56556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9961.09556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.649.9556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6155.3142,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3561.69556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7662.98556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8585.84556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403263.35556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1680.9556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1883.95556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.47105.15107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.51103.55107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.86101.29107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17188.35107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.04105.67107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.71121.12107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.59120.52107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.14114.72107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.66130.6410,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5763.676,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7663.39556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.9948.7107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.2743.92556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5343.0437,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.152.13107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7153.7480,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.749.9723,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3951.46643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5558.21611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6453.52107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1762.86611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1955.598,340 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7555.543,482 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.355.5611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1955.598,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4955.582,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7555.543,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7755.5179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9955.576,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4139.29557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5239.2557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.9942.91557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1553.78107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9160.74557,022 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4561.8182,777 (Direct)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5383.75107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8869.0633,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573378.2867,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3588.52107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6287.54107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4292.63107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.37105.47559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.42105.08107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8493.2107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.274.1567,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6589.0676,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2253.6559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8250.0391,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9650.03168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8350.03559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1550.0367,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7250.0366,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3550.0372,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2661.81525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4763.6876,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5762.78525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9871.2376,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2387.4476,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0591.7876,997 (Direct)
390,944 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4592.476,997 (Direct)
3,872,076 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535086.6955,519 (Direct)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.750.76955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8323.54955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.8318.8446,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.0822.748,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6325.6344,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.97519725.73955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.92268436.3577,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9542.8249,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9666.391,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7164.7576,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8651.2976,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.558.41,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2669.141,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7448.941,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.840.82133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319853.24135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.848.84977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.853.8122,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2857.64155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0859.721,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1559.72125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1559.72127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0259.7246,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2559.7247,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0663.231,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1474.47113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.18100.491,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7599.5113,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.1103.4933,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7692.861,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4875.7910,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4592.476,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1678.621,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0683.91,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6994.4133,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.6109.69112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.83112.49113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.682968120.15122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.98127.591,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.7140.4918,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.22120.671,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.36117.1557,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.21133.3657,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.05170.781,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.03161.88122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185175.7113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.97153.5557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.6155.3357,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.82159.391,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.4157.1457,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.2157.8557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.95499161.8857,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64176.98101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.46156.131,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.25161.2669,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.37145.731,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.9126.9533,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.5129.2670,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.07119.6357,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.96146.191,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.65142.2770,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.8151.650,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25172.1443,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.5151.311,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.22157.651,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.36634157.6568,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.5166.6950,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$24240172.2517,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95184.4650,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24190.417,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158230.8411,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1203.3417,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74230.8431,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790230.8431,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75227.5268,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86234.9117,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85246.0817,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2230.3331,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790230.8431,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35251.4817,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92252.8172,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12252.6268,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790230.8430,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95290.561,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9261.1915,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55309.141,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35198.491,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15197.6859,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.09217.4959,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97197.4149,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.25224.271,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6224.751,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28282.55
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51282.55
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39324.84
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7324.84
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73276.171,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9216.26950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28226.05163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09226.54950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7226.78,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020226.7950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072226.722,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57227.359,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23232.18Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19235.08Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16249.233,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376247.55Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1250.549,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356267.08Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356267.083,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.8726325,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5276.6945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8268.329,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5274.87Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75280.99Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1285.71Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96285.49Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5327.9Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803306.85Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640308.38Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818363.73Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05321.55Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95321.55
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5302.84Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25313.28Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5344.49Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75285.49Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75337.06Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88447.24Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44447.24Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8423.14Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79446.78Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72446.78Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85388.71Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01448.15Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26410.87Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32410.87Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75404.56Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49490.78Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67490.78Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58442.24Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7449.08Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26469.66Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09507.81Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58507.81Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75423.98Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6428.64Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25453.26Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66609.45
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68572.22
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67572.22
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68572.22
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06572.22
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66572.22
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64466.7
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91410.87
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11421.88
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52412.87
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25412.87
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86414.08
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59414.08
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5433.39
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565478.23
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21502.21
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96530.69
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74530.69
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078506.12
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5504.44
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5504.44
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35504.44
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74530.69
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99528.87
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41544.38
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014544.38
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22546.93
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22546.93
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79546.93
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45549.5
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45549.5
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01549.5
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16727.09
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95727.09
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59727.09
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47737.69
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63712.69
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91709.67
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58712.69
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91709.67
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19712.69
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24712.69
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46623.59
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6623.59
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22625.19
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38625.19
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144625.19
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05626
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1626.81
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56626.81
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34626.81
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45626.81
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82616.45
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06417.34
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72417.34
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1448.61
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95447.69
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61449.08
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38453.73
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23460.86
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14462.79
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38466.2
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24515.25
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66489.18
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04494.54
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74486.54
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68538.71
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258533.14
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5584.91
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39645.89
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09645.89
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35645.89
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18645.89
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71645.89
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57649.31
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1649.31
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39649.31
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19649.31
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55662.43
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447630.87
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441513.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131513.33Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921513.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181521.34Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751521.34Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191521.34Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841513.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181513.33Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61513.33Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011521.34Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031521.34Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231665.95Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721665.95Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431665.95Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991521.34Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121521.34Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831521.34Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151525.37Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821525.37Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251525.37Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131525.37Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031525.37Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691525.37Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311533.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081533.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771533.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.711144.57Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.711144.57Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.911144.57Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81994.47Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76990.82Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88996.31Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.51206.8Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.251264.09Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.541264.09Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.851264.09Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.21264.09Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.741264.09Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.681264.09Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.941264.09Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.541264.09Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571533.5Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641533.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581533.5Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941533.5Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061533.5Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171533.5Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041533.5Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271533.5Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.721217.34Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.651217.34Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.621217.34Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.631217.34Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.471217.34Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.71217.34Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.141217.34Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.971217.34Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.721238.93Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.761238.93Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.271238.93Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.041238.93Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.131238.93Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.041238.93Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.681238.93Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.331238.93Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.561209.42Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.891209.42Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.191209.42Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.021209.42Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.711209.42Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.341217.34Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.041217.34Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.341217.34Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5833.43Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82829.45Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1825.5Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55841.5Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6846.96Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42865.14Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5879.61Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2844.22Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35856.66Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41873.77Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86888.5Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35859.47Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01859.47Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297868Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.611077.3Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.141090.16Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.311110Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.051081.56Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.31081.56Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.661081.56Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.151042.31Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.341042.31Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.361042.31Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36829.45Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4828.13Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22822.88Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6817.7Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69694.89Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85660.65Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3527.06Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3634.16Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95804.99Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12830.77Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4885.52Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77896.04Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49932.23Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5909.89Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5909.89Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98914.6Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98914.6Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3942.11Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38902.15Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38902.15Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89876.68Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87989Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08908.33Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.9591007.46Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.9591007.46Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38980Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38980Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67957.28Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67957.28Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.291139.85Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.81183.69Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.21238.93Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.51290.21Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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