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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2017-02-06Sell14,465636,435$61.54890.181.93636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-01-06Sell14,465638,835$57.89837.388.36638,835 (Direct)
Cline Darren SEVP, Commercial2016-12-13Sell10,00058,504$63.38633.8-1.0358,504 (Direct)
DOBMEIER ERICCOO2016-12-08Sell12,50087,767$65.92824-4.8487,767 (Direct)
HIMES VAUGHN BChief Technical Officer2016-12-07Sell30,000135,379$65.321959.6-3.97135,379 (Direct)
SIEGALL CLAY BPresident and CEO2016-12-06Sell14,465638,835$66.17957.15-5.2638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-09Sell7,751109,837$66.75517.38-6.02109,837 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-08Buy382,50040,992,596$59.3622705.25.68107,504 (Direct)
40,885,092 (See footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-11-07Sell14,465638,835$58.43845.197.36638,835 (Direct)
LIPPMAN MARC EDirector2016-11-07Sell1,000131,350$57.7557.758.62131,350 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-03Buy198,43345,482,921$56.4311197.5711.16107,504 (Direct)
4,835,170 (See footnote(,,,))
40,540,247 (See Footnote(,,,))
BAKER FELIXDirector, 10% Owner2016-11-03Buy1,030,62945,194,447$56.1357849.2111.76107,504 (Direct)
4,725,543 (See footnote(,,,))
40,361,400 (See Footnote(,,,))
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-01Sell3,418109,837$51.74176.8521.24109,837 (Direct)
SIEGALL CLAY BPresident and CEO2016-10-06Sell14,465638,835$54.41787.0415.29638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-09-22Sell2,249113,255$56.75127.6310.54113,255 (Direct)
DOBMEIER ERICCOO2016-09-14Sell22,91887,767$54.041238.4916.0887,767 (Direct)
BAKER FELIXDirector, 10% Owner2016-09-13Buy447,31144,233,991$50.7122683.1423.7107,504 (Direct)
4,693,991 (See footnote(,,,))
39,432,496 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-08Sell31,269638,835$50.081565.9525.26638,835 (Direct)
0 (by Trust)
BAKER FELIXDirector, 10% Owner2016-09-08Buy414,01643,696,884$48.4320050.7929.53107,504 (Direct)
4,559,012 (See footnote(,,,))
39,030,368 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-06Sell11,653644,983$45.4529.0538.17617,038 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-09-06Sell5,39751,576$46.01248.3236.3451,576 (Direct)
DOBMEIER ERICCOO2016-08-23Sell12,58958,767$48604.2730.6958,767 (Direct)
Cline Darren SEVP, Commercial2016-08-22Sell1,77440,973$46.5982.6534.6440,973 (Direct)
DOBMEIER ERICCOO2016-08-22Sell5,41167,525$46.59252.134.6467,525 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-08-22Sell3,99184,255$46.59185.9434.6484,255 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2016-08-22Sell3,991108,779$46.59185.9434.64108,779 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-22Sell23,381560,679$46.591089.3234.64532,734 (Direct)
27,945 (by Trust)
SIMPSON TODD ECFO2016-08-22Sell3,991191,445$46.59185.9434.64191,445 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-08Sell11,660584,060$47.19550.2432.93556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-27Sell4,042584,060$45.2182.738.78556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9954.66556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.643.91556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6149.1142,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3555.23556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7656.47556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8578.41556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403256.83556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1673.67556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1876.6556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4796.95107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5195.42107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8693.25107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17176.83107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.0497.45107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.71112.28107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.59111.71107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.14106.15107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.66121.4310,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5757.0676,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7656.86556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.9942.76107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.2738.17556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5337.3237,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.146.05107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7147.680,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.743.9823,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3945.41643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5551.89611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6447.39107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1756.36611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1949.2998,340 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7549.2943,482 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.349.29611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1949.2998,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4949.2982,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7549.2943,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7749.29179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9949.2976,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4133.72557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5233.64557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.9937.2557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1547.63107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9154.32557,022 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4555.3582,777 (Direct)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5376.41107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8862.333,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573371.1667,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3580.99107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6280.05107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4284.94107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.3797.26559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4296.89107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8485.48107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.267.1967,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6581.5176,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2247.46559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8244.0491,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9644.04168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8344.04559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1544.0467,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7244.0466,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3544.0472,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2655.35525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4757.1476,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5756.28525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9864.3976,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2379.9576,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0584.1276,997 (Direct)
390,944 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4584.7276,997 (Direct)
3,872,076 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535079.2355,519 (Direct)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.744.74955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.8318.6955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.8314.146,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.0817.848,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.6320.6144,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.97519720.7955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.92268430.9177,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9537.1149,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9659.741,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7158.1776,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8645.2476,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.552.071,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2662.391,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7442.991,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.835.19133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319847.12135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.842.89977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.847.6722,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2851.34155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0853.341,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1553.34125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1553.34127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0253.3446,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2553.3447,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0656.711,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1467.5113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1892.481,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7591.5413,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.195.3633,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7685.151,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4868.7710,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4584.7276,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1671.491,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0676.561,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6986.6433,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.6101.32112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.83104113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.682968111.35122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.98118.51,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.7130.8818,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.22111.851,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.36108.4757,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.21124.0457,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.05159.971,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.03151.42122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185164.68113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.97143.4257,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.6145.1357,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.82149.031,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.4146.8757,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.2147.5557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.95499151.4257,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64165.92101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.46145.91,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.25150.8269,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.37135.921,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.9117.8933,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.5120.1170,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.07110.8657,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.96136.361,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.65132.5970,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.8141.5550,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25161.2743,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.5141.271,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.22147.361,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.36634147.3668,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.5156.0450,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$24240161.3817,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95173.150,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24178.817,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158217.6211,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1191.2317,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74217.6231,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790217.6231,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75214.4468,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86221.5317,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85232.2617,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2217.1431,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790217.6231,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35237.4417,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92238.7172,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12238.5368,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790217.6230,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95274.961,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9246.7715,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55292.81,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35186.571,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15185.7959,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.09204.8159,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97185.5349,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.25211.321,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6211.781,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28267.27
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51267.27
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39307.87
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7307.87
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73261.141,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9203.63950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28213.02163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09213.49950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7213.658,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020213.65950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072213.6522,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57214.289,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23218.91Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19221.69Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16235.283,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376233.67Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1236.539,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356252.42Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356252.423,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.87248.525,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5261.56945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8253.619,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5259.9Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75265.77Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1270.31Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96270.09Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5310.81Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803290.6Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640292.06Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818345.21Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05304.71Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95304.71
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5286.74Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25296.77Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5326.73Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75270.09Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75319.6Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88425.38Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44425.38Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8402.24Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79424.94Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72424.94Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85369.18Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01426.26Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26390.46Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32390.46Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75384.4Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49467.18Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67467.18Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58420.58Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7427.14Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26446.9Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09483.53Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58483.53Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75403.05Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6407.52Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25431.16Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66581.11
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68545.37
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67545.37
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68545.37
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06545.37
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66545.37
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64444.06
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91390.46
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11401.04
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52392.39
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25392.39
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86393.55
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59393.55
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5412.08
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565455.13
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21478.16
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96505.5
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74505.5
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078481.91
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5480.3
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5480.3
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35480.3
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74505.5
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99503.75
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41518.64
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014518.64
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22521.09
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22521.09
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79521.09
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45523.56
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45523.56
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01523.56
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16694.05
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95694.05
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59694.05
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47704.23
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63680.22
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91677.32
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58680.22
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91677.32
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19680.22
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24680.22
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46594.68
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6594.68
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22596.23
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38596.23
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144596.23
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05597
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1597.78
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56597.78
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34597.78
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45597.78
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82587.83
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06396.67
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72396.67
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1426.7
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95425.82
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61427.14
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38431.61
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23438.45
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14440.31
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38443.59
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24490.68
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66465.64
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04470.79
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74463.11
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68513.2
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258507.85
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5557.55
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39616.1
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09616.1
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35616.1
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18616.1
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71616.1
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57619.38
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1619.38
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39619.38
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19619.38
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55631.97
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447601.68
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441448.89Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131448.89Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921448.89Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181456.58Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751456.58Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191456.58Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841448.89Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181448.89Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61448.89Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011456.58Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031456.58Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231595.41Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721595.41Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431595.41Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991456.58Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121456.58Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831456.58Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151460.45Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821460.45Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251460.45Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131460.45Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031460.45Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691460.45Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311468.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081468.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771468.25Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.711094.86Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.711094.86Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.911094.86Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81950.75Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76947.25Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88952.52Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.51154.6Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.251209.6Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.541209.6Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.851209.6Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.21209.6Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.741209.6Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.681209.6Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.941209.6Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.541209.6Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571468.25Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641468.25Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581468.25Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941468.25Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061468.25Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171468.25Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041468.25Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271468.25Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.721164.72Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.651164.72Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.621164.72Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.631164.72Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.471164.72Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.71164.72Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.141164.72Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.971164.72Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.721185.45Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.761185.45Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.271185.45Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.041185.45Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.131185.45Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.041185.45Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.681185.45Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.331185.45Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.561157.11Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.891157.11Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.191157.11Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.021157.11Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.711157.11Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.341164.72Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.041164.72Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.341164.72Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5796.14Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82792.32Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1788.53Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55803.89Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6809.13Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42826.59Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5840.48Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2806.5Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35818.45Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41834.87Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86849.02Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35821.15Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01821.15Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297829.33Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.611030.27Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.141042.62Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.311061.67Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.051034.36Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.31034.36Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.661034.36Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.15996.68Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.34996.68Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.36996.68Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36792.32Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4791.05Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22786.02Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6781.04Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69663.14Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85630.27Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3502.02Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3604.83Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95768.84Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12793.59Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4846.15Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77856.25Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49891Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5869.55Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5869.55Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98874.07Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98874.07Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3900.48Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38862.12Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38862.12Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89837.67Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87945.5Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08868.06Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959963.22Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959963.22Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38936.86Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38936.86Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67915.05Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67915.05Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.291090.32Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.81132.42Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.21185.45Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.51234.68Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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