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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Mr. William C. Mills,IIIN/A396,3501.81%2016-04-15
Bevil J. HoggN/A304,4371.39%2010-03-11
Douglas M. BruceN/A243,5731.11%2012-02-14
Mr. Martin C. StammerN/A121,0500.55%2016-08-23
Mr. Michael P. KaminskiN/A107,3690.49%2013-04-01
Melissa WalkerN/A81,4410.37%2010-02-17
James M. StolzeN/A81,3040.37%2009-06-10
Frank ChengN/A74,8850.34%2016-08-23
David W. BenferN/A68,7140.31%2016-05-24
David GiffinN/A68,6570.31%2016-08-23

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Mills William C. IIICEO
(Click for the stocks that their CEOs have bought)
2014-12-12Buy10,000239,711$1.4514.5-55.86239,711 (Direct)
Mills William C. IIICEO2014-12-05Buy10,000229,711$1.4314.3-55.24229,711 (Direct)
Mills William C. IIICEO2014-08-11Buy10,000219,711$2.7527.5-76.73219,711 (Direct)
MIDDLETON FRED ADirector2013-08-23Sell14,6001,592,107$3.6753.58-82.5675,472 (Direct)
0 (Middleton McNeil Retirement Trust)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Alafi Christopher D10% Owner2013-08-20Sell261,2411,307,043$3.74977.04-82.8924,593 (Direct)
1,266,628 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
222 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2013-08-07Sell78,9741,296,592$10.13800.01-93.6888,072 (Direct)
960,764 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
28,117 (Sanderling Ventures Management VI)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
MIDDLETON FRED ADirector2012-11-30Buy24,3601,101,114$1.5337.27-58.1776,072 (Direct)
782,272 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
28,117 (Sanderling Ventures Management VI)
3,060 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
Benfer DavidDirector2012-05-31Buy3,0006,935$2.57.5-74.44,910 (Direct)
2,025 (Spouse)
Duggan Samuel W IICFO2012-05-11Buy5,00015,000$3.517.5-81.7110,000 (Direct)
5,000 (Samuel W. Duggan II Trust U/A DTD 4/21/2000)
Kelley William MDirector2011-12-09Buy2,0004,260$9.418.8-93.193,860 (Direct)
400 (Med Tech Partners)
MIDDLETON FRED ADirector2011-09-15Buy485484,541$13.86.69-95.3631,976 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-09-12Buy6,447437,788$13.486.39-95.2222,829 (Direct)
399,137 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
Alafi Christopher DDirector2011-09-09Buy3,553431,342$13.347.26-95.1922,829 (Direct)
392,691 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2011-09-01Buy1,712484,056$13.723.45-95.3331,491 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Kaminski Michael PPresident and CEO2011-09-01Buy1,04012,927$14.314.87-95.5212,557 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Cheng FrankSenior VP, Marketing and BD2011-08-19Buy1,5003,930$9.914.85-93.543,930 (Direct)
Giffin DavidVP, Human Resources2011-08-18Buy9524,477$10.510-93.94,477 (Direct)
Duros Karen WitteSr. VP, Gen. Counsel & Sec.2011-08-16Buy1,0002,620$11.611.6-94.482,620 (Direct)
Kaminski Michael PPresident and CEO2011-08-11Buy1,27111,887$11.815-94.5811,517 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Kaminski Michael PPresident and CEO2011-06-15Buy50010,616$30.115.05-97.8710,246 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
MIDDLETON FRED ADirector2011-06-14Buy1,000482,344$3030-97.8729,779 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-06-03Buy5,000427,788$33.5167.5-98.0922,829 (Direct)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
389,137 (Alafi Capital Company LLC)
3,000 (by Mother)
Kaminski Michael PPresident and CEO2011-03-07Buy6800$37.125.23-98.27Link
Kaminski Michael PPresident and CEO2010-11-18Buy28011,846$35.69.97-98.2Link
Kaminski Michael PPresident and CEO2010-11-18Buy2807,686$35.69.97-98.2Link
Alafi Christopher DDirector, 10% Owner2010-08-18Buy2,600422,473$32.584.5-98.03Link
MIDDLETON FRED ADirector, 10% Owner2010-08-18Buy2,600458,173$32.584.5-98.03Link
JOHNSTON DANIEL JCFO2010-05-10Buy1,0004,179$40.340.3-98.41Link
Kaminski Michael PPresident and CEO2010-05-10Buy25011,566$41.610.4-98.46Link
Hogg Bevil JDirector2010-03-12Sell3,20030,444$55.3176.96-98.84Link
Alafi Christopher DDirector, 10% Owner2010-03-03Buy5,00022,514$48.3241.5-98.67Link
Walker MelissaSr. VP, Reg., Quality & Compl.2009-12-15Sell2507,924$42.210.55-98.48Link
Hogg Bevil JDirector2009-12-09Sell6,50028,088$36.2235.3-98.23Link
Kaminski Michael PPresident & CEO2009-09-01Buy14170$34.94.92-98.17Link
MIDDLETON FRED ADirector, 10% Owner2009-08-31Buy50025,459$35.417.7-98.19Link
Alafi Christopher DDirector, 10% Owner2009-08-26Buy3,0003,000$34.9104.7-98.17Link
Kaminski Michael PPresident & CEO2009-06-04Buy2309,915$44.410.21-98.56
Alafi Christopher DDirector, 10% Owner2009-05-29Buy1,500389,137$34.551.75-98.14
MIDDLETON FRED ADirector, 10% Owner2009-05-26Buy2,77924,959$34.595.88-98.14
Alafi Christopher DDirector, 10% Owner2009-05-14Buy5,0005,000$34.8174-98.16
Benfer DavidDirector2009-03-13Buy350525$37.913.27-98.31
Walker MelissaSr. VP, Reg., Quality & Compl.2009-03-11Sell2007,649$367.2-98.22
MIDDLETON FRED ADirector, 10% Owner2008-12-29Buy101,2131,627$46.44696.28-98.62
Alafi Christopher DDirector2008-12-29Buy101,213388,037$46.44696.28-98.62
Alafi Christopher DDirector2008-11-20Buy1,000286,824$35.335.3-98.19
MIDDLETON FRED ADirector, 10% Owner2008-11-18Buy2922,179$300.88-97.87
Alafi Christopher DDirector2008-11-18Buy4,408285,824$35.6156.91-98.2
Lele Abhijeet JDirector2008-11-17Buy2,1405,140$25.354.14-97.47
SHIFRIN KEVIN TSr. VP, Marketing & Bus. Dev.2008-11-17Buy7504,270$27.520.63-97.67
MIDDLETON FRED ADirector, 10% Owner2008-06-13Buy1,18020,959$51.160.3-98.75
Alafi Christopher DDirector2008-03-14Buy110279,183$36.13.97-98.23
Alafi Christopher DDirector2008-03-14Buy9,060279,073$36.9334.31-98.27
Kelley William MDirector2008-03-14Buy6001,500$37.122.26-98.27
MIDDLETON FRED ADirector, 10% Owner2008-03-14Buy2,32019,779$36.885.38-98.26
Alafi Christopher DDirector2008-03-13Buy34,500270,013$36.61262.7-98.25
MIDDLETON FRED ADirector, 10% Owner2008-03-12Buy12017,459$37.84.54-98.31
Lele Abhijeet JDirector2008-03-11Buy3,0003,000$35.4106.2-98.19
MIDDLETON FRED ADirector, 10% Owner2008-03-11Buy2,38017,339$34.983.06-98.17
MESSEY ROBERT JDirector2008-03-11Buy1,0001,390$34.634.6-98.15
Benfer DavidDirector2008-03-07Buy600350$38.923.34-98.35
MIDDLETON FRED ADirector, 10% Owner2008-03-07Buy50,000615$391950-98.36
PRYSTOWSKY ERIC NDirector2008-03-05Buy1,0001,000$39.339.3-98.37
ACHARYA ABHIDirector2008-03-05Buy1,0002,111$39.839.8-98.39
Mills William C. IIIDirector2008-03-05Buy5002,500$4020-98.4
Benfer DavidDirector2007-09-10Buy300150$126.537.95-99.49
Kaminski Michael PPresident & COO2007-08-24Sell2,7104,185$130352.3-99.51
MIDDLETON FRED ADirector2007-06-21Sell120$120.41.47-99.47
Walker MelissaSVP, Reg, Quality & Compliance2007-06-15Sell2015,849$121.224.3-99.47
Kaminski Michael PCOO2007-06-06Sell1,7906,895$120.1214.98-99.47
Mills William C. IIIDirector2007-05-15Buy1,0002,000$113.5113.5-99.44
Alafi Christopher DDirector2007-03-15Buy1,000232,925$108.9108.9-99.41
Mills William C. IIIDirector2006-10-19Sell330$1203.95-99.47
Mills William C. IIIDirector2006-06-30Sell301,024$104.53.14-99.39Link
Walker MelissaVP, Regulatory & Quality2006-06-15Sell8604,862$9178.26-99.3Link
Sehra RuchirChief Medical Officer2006-06-14Buy1103,635$90.59.96-99.29Link
Hogg Bevil JPresident & CEO2006-06-08Buy1,00036,090$89.689.6-99.29Link
Benfer DavidDirector2006-06-06Buy260560$96.725.14-99.34Link
Kelley William MDirector2006-06-01Buy5001,300$98.949.45-99.35Link
Kaminski Michael PCOO2006-05-24Sell1,0004,185$100.9100.9-99.37Link
Sehra RuchirChief Medical Officer2006-05-16Buy1003,341$105.210.52-99.39Link
MESSEY ROBERT JDirector2006-05-15Buy340410$106.636.24-99.4Link
Hogg Bevil JPresident & CEO2006-04-11Sell1,00030,090$118.1118.1-99.46Link
Hogg Bevil JPresident & CEO2006-04-07Sell7,50031,090$120.9906.75-99.47Link
Mills William C. IIIDirector2006-01-23Sell61,054$152.50.92-99.58Link
Mills William C. IIIDirector2006-01-13Sell301,060$106.43.19-99.4Link
Mills William C. IIIDirector2006-01-10Sell181,090$911.67-99.3Link
Mills William C. IIIDirector2005-12-28Sell561,108$90.75.11-99.29Link
Mills William C. IIIDirector2005-12-20Sell601,164$83.35-99.23Link
ALAFI MOSHE10% Owner2005-12-06Buy3,210224,245$72.1231.46-99.11Link
Alafi Christopher DDirector, 10% Owner2005-12-06Buy2,339239,838$72.6169.83-99.12Link
ALAFI CAPITAL CO LLC10% Owner2005-12-06Buy2,339224,245$72.6169.83-99.12Link
ALAFI CAPITAL CO LLC10% Owner2005-12-05Buy871221,906$70.761.57-99.09Link
Sehra RuchirVP of Clinical Affairs2005-12-05Buy502,550$70.93.55-99.1Link
Alafi Christopher DDirector, 10% Owner2005-12-02Buy131237,499$719.29-99.1Link
Benfer DavidDirector2005-11-28Buy200300$7014-99.09Link
MIDDLETON FRED ADirector2005-11-18Buy380250,513$63.224.02-98.99Link
Mills William C. IIIDirector2005-09-12Sell121,224$90.11.08-99.29Link
Kelley William MDirector2005-08-23Buy400800$85.334.12-99.25Link
Kelley William MDirector2005-08-15Buy400400$93.537.4-99.32Link
Kaminski Michael PCOO2005-08-15Buy252,275$90.42.26-99.29Link
Mills William C. IIIDirector2005-08-12Sell301,236$81.32.44-99.21Link
Mills William C. IIIDirector2005-07-29Sell261,266$101.12.65-99.37Link
Mills William C. IIIDirector2005-07-26Sell821,293$887.18-99.27Link
Mills William C. IIIDirector2005-07-21Sell221,374$84.31.83-99.24Link
Mills William C. IIIDirector2005-07-19Sell41,396$850.36-99.25Link
Mills William C. IIIDirector2005-07-18Sell41,400$840.34-99.24Link
Mills William C. IIIDirector2005-07-13Sell521,404$83.14.32-99.23Link
Mills William C. IIIDirector2005-07-11Sell131,456$83.81.08-99.24Link
Mills William C. IIIDirector2005-07-06Sell671,469$81.85.44-99.22Link
Mills William C. IIIDirector2005-07-01Sell121,536$80.10.95-99.2Link
Mills William C. IIIDirector2005-06-28Sell41,547$800.3-99.2Link
Mills William C. IIIDirector2005-06-24Sell81,551$800.61-99.2Link
Johnson Gregory RDirector2005-06-15Buy50062,607$79.539.75-99.19Link
MIDDLETON FRED ADirector2005-06-08Buy583250,133$71.941.9-99.11Link
Mills William C. IIIDirector2005-05-19Sell151,552$801.18-99.2Link
MIDDLETON FRED ADirector2005-05-17Buy100319,850$77.97.79-99.18Link
Mills William C. IIIDirector2005-05-12Sell71,566$800.58-99.2Link
Mills William C. IIIDirector2005-05-09Sell111,574$80.10.87-99.2Link
MIDDLETON FRED ADirector2004-08-27Buy817323,522$77.163.01-99.17Link
Bruce Douglas MichaelSr. V.P., R & D2004-08-17Buy1010$800.8-99.2Link
Parker David JDirector2004-08-17Buy150150$8012-99.2Link
Mills William C. IIIDirector2004-08-17Buy1,0001,582$8080-99.2Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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