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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Mr. William C. Mills,IIIN/A396,3501.81%2016-04-15
Bevil J. HoggN/A304,4371.39%2010-03-11
Douglas M. BruceN/A243,5731.11%2012-02-14
Mr. Martin C. StammerN/A121,0500.55%2016-08-23
Mr. Michael P. KaminskiN/A107,3690.49%2013-04-01
Melissa WalkerN/A81,4410.37%2010-02-17
James M. StolzeN/A81,3040.37%2009-06-10
Frank ChengN/A74,8850.34%2016-08-23
David W. BenferN/A68,7140.31%2016-05-24
David GiffinN/A68,6570.31%2016-08-23

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
MIDDLETON FRED ADirector2015-06-15Sell26,0641,414,232$1.5740.92-64.9746,810 (Direct)
1,107,189 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-12Sell16,2731,440,296$1.6126.2-65.8446,810 (Direct)
1,133,253 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
MIDDLETON FRED ADirector2015-06-09Sell106,8761,456,569$1.65176.35-66.6746,810 (Direct)
1,149,526 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Benfer DavidDirector2015-03-13Buy3,00044,990$1.955.85-71.7942,290 (Direct)
2,700 (Spouse)
MESSEY ROBERT JDirector2015-03-04Sell1,41035,818$2.333.29-76.3935,818 (Direct)
0 (By Trust)
Mills William C. IIICEO
(Click for the stocks that their CEOs have bought)
2014-12-12Buy10,000239,711$1.4514.5-62.07239,711 (Direct)
Mills William C. IIICEO2014-12-05Buy10,000229,711$1.4314.3-61.54229,711 (Direct)
Mills William C. IIICEO2014-08-11Buy10,000219,711$2.7527.5-80219,711 (Direct)
MIDDLETON FRED ADirector2013-08-23Sell14,6001,592,107$3.6753.58-85.0175,472 (Direct)
0 (Middleton McNeil Retirement Trust)
1,256,402 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
40,673 (Sanderling Ventures Management VI)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
Alafi Christopher D10% Owner2013-08-20Sell261,2411,307,043$3.74977.04-85.2924,593 (Direct)
1,266,628 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
222 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2013-08-07Sell78,9741,296,592$10.13800.01-94.5788,072 (Direct)
960,764 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
6,358 (Sanderling VI Limited Partnership)
5,335 (Sanderling VI Beteiligungs GmbH & Co. KG)
28,117 (Sanderling Ventures Management VI)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
MIDDLETON FRED ADirector2012-11-30Buy24,3601,101,114$1.5337.27-64.0576,072 (Direct)
782,272 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
28,117 (Sanderling Ventures Management VI)
3,060 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,275 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,956 (Sanderling V Limited Partnership)
67,790 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,451 (Sanderling Venture Partners IV Co-Investment Fund)
82 (Sanderling Ventures Management V)
79 (Middleton McNeil Retirement Trust)
Benfer DavidDirector2012-05-31Buy3,0006,935$2.57.5-784,910 (Direct)
2,025 (Spouse)
Duggan Samuel W IICFO2012-05-11Buy5,00015,000$3.517.5-84.2910,000 (Direct)
5,000 (Samuel W. Duggan II Trust U/A DTD 4/21/2000)
Kelley William MDirector2011-12-09Buy2,0004,260$9.418.8-94.153,860 (Direct)
400 (Med Tech Partners)
MIDDLETON FRED ADirector2011-09-15Buy485484,541$13.86.69-96.0131,976 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-09-12Buy6,447437,788$13.486.39-95.922,829 (Direct)
399,137 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
Alafi Christopher DDirector2011-09-09Buy3,553431,342$13.347.26-95.8622,829 (Direct)
392,691 (Alafi Capital Company LLC)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
3,000 (by Mother)
MIDDLETON FRED ADirector2011-09-01Buy1,712484,056$13.723.45-95.9931,491 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Kaminski Michael PPresident and CEO2011-09-01Buy1,04012,927$14.314.87-96.1512,557 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Cheng FrankSenior VP, Marketing and BD2011-08-19Buy1,5003,930$9.914.85-94.443,930 (Direct)
Giffin DavidVP, Human Resources2011-08-18Buy9524,477$10.510-94.764,477 (Direct)
Duros Karen WitteSr. VP, Gen. Counsel & Sec.2011-08-16Buy1,0002,620$11.611.6-95.262,620 (Direct)
Kaminski Michael PPresident and CEO2011-08-11Buy1,27111,887$11.815-95.3411,517 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
Kaminski Michael PPresident and CEO2011-06-15Buy50010,616$30.115.05-98.1710,246 (Direct)
70 (By Cynthia B. Kaminski Revocable Trust)
300 (Immediate Family Members)
MIDDLETON FRED ADirector2011-06-14Buy1,000482,344$3030-98.1729,779 (Direct)
158,161 (Sanderling Venture Partners VI Co-Investment Fund, L.P.)
3,061 (Sanderling VI Beteiligungs GmbH & Co. KG)
3,647 (Sanderling VI Limited Partnership)
1,612 (Sanderling Ventures Management VI)
78,135 (Sanderling Venture Partners II, L.P.)
1,500 (Sanderling Mgmt. LLC 401K Pension Profit Sharing Plan)
53,276 (Sanderling IV Biomedical Co-Investment Fund, L.P.)
11,097 (Sanderling V Beteiligungs GmbH & Co. KG)
39,716 (Sanderling V Biomedical Co-Investment Fund, L.P.)
11,957 (Sanderling V Limited Partnership)
67,791 (Sanderling Venture Partners V Co-Investment Fund, L.P.)
22,452 (Sanderling Venture Partners iV Co-Investment Fund)
83 (Sanderling Ventures Management V)
80 (Middleton McNeil Retirement Trust)
Alafi Christopher DDirector2011-06-03Buy5,000427,788$33.5167.5-98.3622,829 (Direct)
12,600 (Christopher Alafi Trust)
223 (Alafi Family Foundation)
389,137 (Alafi Capital Company LLC)
3,000 (by Mother)
Kaminski Michael PPresident and CEO2011-03-07Buy6800$37.125.23-98.52Link
Kaminski Michael PPresident and CEO2010-11-18Buy2807,686$35.69.97-98.46Link
Kaminski Michael PPresident and CEO2010-11-18Buy28011,846$35.69.97-98.46Link
Alafi Christopher DDirector, 10% Owner2010-08-18Buy2,600422,473$32.584.5-98.31Link
MIDDLETON FRED ADirector, 10% Owner2010-08-18Buy2,600458,173$32.584.5-98.31Link
JOHNSTON DANIEL JCFO2010-05-10Buy1,0004,179$40.340.3-98.64Link
Kaminski Michael PPresident and CEO2010-05-10Buy25011,566$41.610.4-98.68Link
Hogg Bevil JDirector2010-03-12Sell3,20030,444$55.3176.96-99.01Link
Alafi Christopher DDirector, 10% Owner2010-03-03Buy5,00022,514$48.3241.5-98.86Link
Walker MelissaSr. VP, Reg., Quality & Compl.2009-12-15Sell2507,924$42.210.55-98.7Link
Hogg Bevil JDirector2009-12-09Sell6,50028,088$36.2235.3-98.48Link
Kaminski Michael PPresident & CEO2009-09-01Buy14170$34.94.92-98.42Link
MIDDLETON FRED ADirector, 10% Owner2009-08-31Buy50025,459$35.417.7-98.45Link
Alafi Christopher DDirector, 10% Owner2009-08-26Buy3,0003,000$34.9104.7-98.42Link
Kaminski Michael PPresident & CEO2009-06-04Buy2309,915$44.410.21-98.76
Alafi Christopher DDirector, 10% Owner2009-05-29Buy1,500389,137$34.551.75-98.41
MIDDLETON FRED ADirector, 10% Owner2009-05-26Buy2,77924,959$34.595.88-98.41
Alafi Christopher DDirector, 10% Owner2009-05-14Buy5,0005,000$34.8174-98.42
Benfer DavidDirector2009-03-13Buy350525$37.913.27-98.55
Walker MelissaSr. VP, Reg., Quality & Compl.2009-03-11Sell2007,649$367.2-98.47
MIDDLETON FRED ADirector, 10% Owner2008-12-29Buy101,2131,627$46.44696.28-98.81
Alafi Christopher DDirector2008-12-29Buy101,213388,037$46.44696.28-98.81
Alafi Christopher DDirector2008-11-20Buy1,000286,824$35.335.3-98.44
MIDDLETON FRED ADirector, 10% Owner2008-11-18Buy2922,179$300.88-98.17
Alafi Christopher DDirector2008-11-18Buy4,408285,824$35.6156.91-98.46
Lele Abhijeet JDirector2008-11-17Buy2,1405,140$25.354.14-97.83
SHIFRIN KEVIN TSr. VP, Marketing & Bus. Dev.2008-11-17Buy7504,270$27.520.63-98
MIDDLETON FRED ADirector, 10% Owner2008-06-13Buy1,18020,959$51.160.3-98.92
Alafi Christopher DDirector2008-03-14Buy110279,183$36.13.97-98.48
Alafi Christopher DDirector2008-03-14Buy9,060279,073$36.9334.31-98.51
Kelley William MDirector2008-03-14Buy6001,500$37.122.26-98.52
MIDDLETON FRED ADirector, 10% Owner2008-03-14Buy2,32019,779$36.885.38-98.51
Alafi Christopher DDirector2008-03-13Buy34,500270,013$36.61262.7-98.5
MIDDLETON FRED ADirector, 10% Owner2008-03-12Buy12017,459$37.84.54-98.54
Lele Abhijeet JDirector2008-03-11Buy3,0003,000$35.4106.2-98.45
MIDDLETON FRED ADirector, 10% Owner2008-03-11Buy2,38017,339$34.983.06-98.42
MESSEY ROBERT JDirector2008-03-11Buy1,0001,390$34.634.6-98.41
Benfer DavidDirector2008-03-07Buy600350$38.923.34-98.59
MIDDLETON FRED ADirector, 10% Owner2008-03-07Buy50,000615$391950-98.59
PRYSTOWSKY ERIC NDirector2008-03-05Buy1,0001,000$39.339.3-98.6
ACHARYA ABHIDirector2008-03-05Buy1,0002,111$39.839.8-98.62
Mills William C. IIIDirector2008-03-05Buy5002,500$4020-98.63
Benfer DavidDirector2007-09-10Buy300150$126.537.95-99.57
Kaminski Michael PPresident & COO2007-08-24Sell2,7104,185$130352.3-99.58
MIDDLETON FRED ADirector2007-06-21Sell120$120.41.47-99.54
Walker MelissaSVP, Reg, Quality & Compliance2007-06-15Sell2015,849$121.224.3-99.55
Kaminski Michael PCOO2007-06-06Sell1,7906,895$120.1214.98-99.54
Mills William C. IIIDirector2007-05-15Buy1,0002,000$113.5113.5-99.52
Alafi Christopher DDirector2007-03-15Buy1,000232,925$108.9108.9-99.49
Mills William C. IIIDirector2006-10-19Sell330$1203.95-99.54
Mills William C. IIIDirector2006-06-30Sell301,024$104.53.14-99.47Link
Walker MelissaVP, Regulatory & Quality2006-06-15Sell8604,862$9178.26-99.4Link
Sehra RuchirChief Medical Officer2006-06-14Buy1103,635$90.59.96-99.39Link
Hogg Bevil JPresident & CEO2006-06-08Buy1,00036,090$89.689.6-99.39Link
Benfer DavidDirector2006-06-06Buy260560$96.725.14-99.43Link
Kelley William MDirector2006-06-01Buy5001,300$98.949.45-99.44Link
Kaminski Michael PCOO2006-05-24Sell1,0004,185$100.9100.9-99.45Link
Sehra RuchirChief Medical Officer2006-05-16Buy1003,341$105.210.52-99.48Link
MESSEY ROBERT JDirector2006-05-15Buy340410$106.636.24-99.48Link
Hogg Bevil JPresident & CEO2006-04-11Sell1,00030,090$118.1118.1-99.53Link
Hogg Bevil JPresident & CEO2006-04-07Sell7,50031,090$120.9906.75-99.55Link
Mills William C. IIIDirector2006-01-23Sell61,054$152.50.92-99.64Link
Mills William C. IIIDirector2006-01-13Sell301,060$106.43.19-99.48Link
Mills William C. IIIDirector2006-01-10Sell181,090$911.67-99.4Link
Mills William C. IIIDirector2005-12-28Sell561,108$90.75.11-99.39Link
Mills William C. IIIDirector2005-12-20Sell601,164$83.35-99.34Link
ALAFI MOSHE10% Owner2005-12-06Buy3,210224,245$72.1231.46-99.24Link
Alafi Christopher DDirector, 10% Owner2005-12-06Buy2,339239,838$72.6169.83-99.24Link
ALAFI CAPITAL CO LLC10% Owner2005-12-06Buy2,339224,245$72.6169.83-99.24Link
ALAFI CAPITAL CO LLC10% Owner2005-12-05Buy871221,906$70.761.57-99.22Link
Sehra RuchirVP of Clinical Affairs2005-12-05Buy502,550$70.93.55-99.22Link
Alafi Christopher DDirector, 10% Owner2005-12-02Buy131237,499$719.29-99.23Link
Benfer DavidDirector2005-11-28Buy200300$7014-99.21Link
MIDDLETON FRED ADirector2005-11-18Buy380250,513$63.224.02-99.13Link
Mills William C. IIIDirector2005-09-12Sell121,224$90.11.08-99.39Link
Kelley William MDirector2005-08-23Buy400800$85.334.12-99.36Link
Kelley William MDirector2005-08-15Buy400400$93.537.4-99.41Link
Kaminski Michael PCOO2005-08-15Buy252,275$90.42.26-99.39Link
Mills William C. IIIDirector2005-08-12Sell301,236$81.32.44-99.32Link
Mills William C. IIIDirector2005-07-29Sell261,266$101.12.65-99.46Link
Mills William C. IIIDirector2005-07-26Sell821,293$887.18-99.38Link
Mills William C. IIIDirector2005-07-21Sell221,374$84.31.83-99.35Link
Mills William C. IIIDirector2005-07-19Sell41,396$850.36-99.35Link
Mills William C. IIIDirector2005-07-18Sell41,400$840.34-99.35Link
Mills William C. IIIDirector2005-07-13Sell521,404$83.14.32-99.34Link
Mills William C. IIIDirector2005-07-11Sell131,456$83.81.08-99.34Link
Mills William C. IIIDirector2005-07-06Sell671,469$81.85.44-99.33Link
Mills William C. IIIDirector2005-07-01Sell121,536$80.10.95-99.31Link
Mills William C. IIIDirector2005-06-28Sell41,547$800.3-99.31Link
Mills William C. IIIDirector2005-06-24Sell81,551$800.61-99.31Link
Johnson Gregory RDirector2005-06-15Buy50062,607$79.539.75-99.31Link
MIDDLETON FRED ADirector2005-06-08Buy583250,133$71.941.9-99.24Link
Mills William C. IIIDirector2005-05-19Sell151,552$801.18-99.31Link
MIDDLETON FRED ADirector2005-05-17Buy100319,850$77.97.79-99.29Link
Mills William C. IIIDirector2005-05-12Sell71,566$800.58-99.31Link
Mills William C. IIIDirector2005-05-09Sell111,574$80.10.87-99.31Link
MIDDLETON FRED ADirector2004-08-27Buy817323,522$77.163.01-99.29Link
Bruce Douglas MichaelSr. V.P., R & D2004-08-17Buy1010$800.8-99.31Link
Parker David JDirector2004-08-17Buy150150$8012-99.31Link
Mills William C. IIIDirector2004-08-17Buy1,0001,582$8080-99.31Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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