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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2017-04-04Sell44073,597$1.080.48-6.4873,597 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2017-03-10Sell1,149,40010,466,700$1.161333.3-12.93
10,466,700 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-03-07Sell192,80011,616,100$1.08208.22-6.48
11,616,100 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-03-02Sell160,10011,808,900$1.13180.91-10.62
11,808,900 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-02-27Sell333,00011,969,000$1.14379.62-11.4
11,969,000 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-02-22Sell161,80012,302,000$1.11179.6-9.01
12,302,000 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-02-16Sell305,09012,463,800$1.1335.6-8.18
12,463,800 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-02-13Sell176,41012,768,890$1.11195.82-9.01
12,768,890 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-02-08Sell563,52712,945,300$1.06597.34-4.72
12,945,300 (See Footnote(,))
NORTH TIDE CAPITAL, LLC10% Owner2017-02-03Sell78,63313,508,827$1.1288.07-9.82
13,508,827 (See Footnote(,))
Varghese Santosh TChief Medical Officer2017-01-28Sell42974,037$1.110.48-9.0174,037 (Direct)
Varghese Santosh TChief Medical Officer2016-12-31Sell13,79074,466$1.1215.44-9.8274,466 (Direct)
Varghese Santosh TChief Medical Officer, 10% Owner2016-10-01Sell71088,256$1.140.81-11.488,256 (Direct)
Varghese Santosh TChief Medical Officer2016-08-02Sell12,55988,966$1.0713.44-5.6188,966 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2016-07-01Sell366101,525$1.210.44-16.53101,525 (Direct)
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.54-38.79101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43.02-27.86
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.46-21.71
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.24-9.82
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.21605-16.53
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.486.32102,220 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.85-54.0959,893 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.73-54.0935,373 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.33-56.4741,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.38-56.4763,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.28-56.4749,118 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.31-63.6756,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.75-63.6772,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.66-63.6731,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.31-63.6765,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.92-66.7830,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-67.63
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.47-66.78
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.28-65.17
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049.04-66.7844,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.75-66.7846,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-83.363,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.19-88.24
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.32-91.55Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-91.5610,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-92.144,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-93.1281,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.75-95.1345,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165.04-95.166,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.24-95.6353,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72408.96-95.555,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.59-95.3753,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-95.355,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-95.3540,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-96.674,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.75-96.7437,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510.05-96.67Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-96.67Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-96.67119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.76-96.672,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-96.677,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-96.47,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-96.39119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-96.2937,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-96.1837,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-9637,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-9697,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-95.967,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-95.99119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.48-95.0348,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.15-95.031,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.18-94.9961,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.58-95.18Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-95.3Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.15-95.25Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-95.96118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-95.67,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-95.12118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.28-95.127,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.33-95.1216,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-95.12Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.17-91.5896,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.63-91.58123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.48-91.4Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-91.2216,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.37-89.7716,800 (Direct)
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.52-89.41Link
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.92-89.19Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.36-89.41Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-89.12Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.48-89.15Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.92-88.97Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-91.69Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-92.23Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.08-89.09Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.51-90.68Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-90.39Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.71-91.62Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-91.19Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-91.01Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-91.65Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.49-83.89Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.53-85.1Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.88-86.59Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.25-86.53Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-85.51
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-85.51
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-85.51Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-85.57
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-85.57
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-85.57Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-83.17
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-83.17
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-83.17
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.73-83.22
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-83.44
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.44-82.94
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-84.27
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.55-88.78
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-88.19
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.41-88.09
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-84.46
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.75-75.78
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.54-75.78
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-75.78
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-84.46
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.67-83.14
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-83.17
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.41-80.94
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-81.02
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.08-81.02
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.13-76.12
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.32-76.12
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.14-76.12
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.53-81.64
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.68-80.2
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.75-80.39
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-80.61
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-80.94
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-80.91
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-80.43
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-80.23
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5382.95-81.74
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.15-82.03
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-81.9
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-74.75
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184.05-75.31
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-70.29Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.62-56.28Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.19-56.28Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.63-66.33Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.92-56.09Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.31-56.09Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.49-56.09Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.36-71.87Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.16-71.87Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.63-71.87Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.95-71.87Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.18-68.73Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-68.73Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.71-68.73Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.86-81.37Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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