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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Samuel F. Colin, M.D.N/A500,0000.48%2014-05-01
Mr. Seth H.Z. FischerN/A486,0800.47%2016-09-26
Mr. Svai SanfordN/A128,3590.12%2015-08-03
Neil Gesundheit,M.D.N/A127,6530.12%2005-01-14
Leland F. WilsonN/A119,9250.12%2013-01-25
Mr. Santosh T VargheseVP, Medical & Reg Affairs88,966less than 0.1%2016-08-02
Dr. Ernest Mario,PhDN/A81,125less than 0.1%2013-05-29
Mark B. LoganN/A74,125less than 0.1%2013-01-25
Terry M. NidaN/A65,727less than 0.1%2006-12-01
Mr. John L. SlebirN/A59,893less than 0.1%2015-07-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2016-08-02Sell12,55988,966$1.0713.446.5488,966 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2016-07-01Sell366101,525$1.210.44-5.79101,525 (Direct)
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.54-30.91101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43.02-18.57
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.46-11.63
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.241.79
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.21605-5.79
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.4820102,220 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.33-50.8641,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.38-50.8663,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.28-50.8649,118 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.73-48.1835,373 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.85-48.1859,893 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.31-58.9956,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.75-58.9972,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.66-58.9931,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.31-58.9965,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.92-62.530,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-63.46
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.47-62.5
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.28-60.69
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049.04-62.544,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.75-62.546,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-81.223,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.19-86.73
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.32-90.46Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-90.4710,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-91.134,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-92.2381,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.75-94.5145,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165.04-94.4766,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.24-95.0753,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72408.96-94.985,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.59-94.7753,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-94.755,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-94.7640,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-96.254,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.75-96.3237,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510.05-96.25Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-96.25Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-96.25119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.76-96.252,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-96.257,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-95.947,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-95.93119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-95.8237,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-95.6937,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-95.4937,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-95.4997,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-95.447,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-95.47119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.48-94.3948,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.15-94.391,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.18-94.3461,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.58-94.56Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-94.7Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.15-94.64Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-95.44118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-95.037,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-94.49118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.28-94.497,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.33-94.4916,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-94.49Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.17-90.596,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.63-90.5123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.48-90.3Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-90.0916,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.37-88.4516,800 (Direct)
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.92-87.79Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.36-88.05Link
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.52-88.05Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-87.72Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.48-87.76Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.92-87.55Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-90.63Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-91.23Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.08-87.69Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.51-89.48Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-89.15Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.71-90.54Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-90.05Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-89.85Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-90.58Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.49-81.82Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.53-83.19Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.88-84.86Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.25-84.8Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.64
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.64
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.64Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.71
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.71
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.71Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-81
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-81
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-81
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.73-81.06
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-81.31
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.44-80.74
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-82.24
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.55-87.33
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-86.67
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.41-86.56
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-82.46
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.75-72.66
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.54-72.66
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-72.66
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-82.46
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.67-80.97
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-81
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.08-78.57
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-78.57
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.41-78.49
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.13-73.05
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.32-73.05
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.14-73.05
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.53-79.27
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.68-77.65
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.75-77.86
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-78.12
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-78.49
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-78.45
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-77.91
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-77.69
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5382.95-79.39
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.15-79.72
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-79.57
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-71.5
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184.05-72.13
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-66.47Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.62-50.65Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.19-50.65Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.63-62Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.92-50.43Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.31-50.43Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.49-50.43Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.36-68.25Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.16-68.25Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.63-68.25Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.95-68.25Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.18-64.71Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-64.71Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.71-64.71Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.86-78.97Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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