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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2016-12-31Sell13,79074,466$1.1215.445.3674,466 (Direct)
Varghese Santosh TChief Medical Officer, 10% Owner2016-10-01Sell71088,256$1.140.813.5188,256 (Direct)
Varghese Santosh TChief Medical Officer2016-08-02Sell12,55988,966$1.0713.4410.2888,966 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2016-07-01Sell366101,525$1.210.44-2.48101,525 (Direct)
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.54-28.48101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43.02-15.71
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.46-8.53
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.245.36
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.21605-2.48
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.4824.21102,220 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.85-46.3659,893 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.73-46.3635,373 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.33-49.1441,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.38-49.1463,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.28-49.1449,118 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.31-57.5556,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.75-57.5572,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.66-57.5531,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.31-57.5565,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.92-61.1830,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-62.18
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.47-61.18
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.28-59.31
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049.04-61.1844,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.75-61.1846,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-80.563,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.19-86.26
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.32-90.13Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-90.1310,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-90.824,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-91.9681,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.75-94.3145,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165.04-94.2866,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.24-94.953,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72408.96-94.815,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.59-94.5953,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-94.575,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-94.5740,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-96.114,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.75-96.1937,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510.05-96.11Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-96.11Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-96.11119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.76-96.112,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-96.117,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-95.87,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-95.79119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-95.6737,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-95.5437,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-95.3337,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-95.3397,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-95.287,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-95.31119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.48-94.1948,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.15-94.191,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.18-94.1461,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.58-94.37Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-94.51Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.15-94.45Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-95.28118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-94.857,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-94.3118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.28-94.37,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.33-94.316,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-94.3Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.17-90.1796,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.63-90.17123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.48-89.96Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-89.7416,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.37-88.0416,800 (Direct)
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.52-87.63Link
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.92-87.37Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.36-87.63Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-87.28Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.48-87.33Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.92-87.12Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-90.3Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-90.92Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.08-87.26Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.51-89.11Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-88.77Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.71-90.21Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-89.7Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-89.49Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-90.25Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.49-81.18Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.53-82.6Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.88-84.33Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.25-84.27Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.07
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.07
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.07Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.14
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.14
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.14Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-80.33
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-80.33
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-80.33
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.73-80.4
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-80.66
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.44-80.07
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-81.62
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.55-86.89
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-86.2
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.41-86.08
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-81.85
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.75-71.7
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.54-71.7
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-71.7
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-81.85
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.67-80.3
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-80.33
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.41-77.74
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-77.82
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.08-77.82
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.13-72.1
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.32-72.1
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.14-72.1
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.53-78.55
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.68-76.86
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.75-77.09
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-77.35
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-77.74
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-77.69
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-77.13
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-76.91
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5382.95-78.66
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.15-79
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-78.85
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-70.5
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184.05-71.15
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-65.29Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.62-48.92Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.19-48.92Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.63-60.67Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.92-48.7Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.31-48.7Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.49-48.7Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.36-67.13Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.16-67.13Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.63-67.13Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.95-67.13Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.18-63.47Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-63.47Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.71-63.47Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.86-78.23Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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