Orbimed Advisors Llc Buys Anthem, Alexion Pharmaceuticals, Aetna, Sells WellCare Health Plans, Molina Healthcare, Express Scripts Holding Co

• New Purchases: ANTM, MNTA, BGNE, SEM, CRSP, TSRO, ROKA, PTCT, CLSD, NVLN,
• Added Positions: ALXN, AET, HUM, SGYP, MRK, PFE, HCA, LLY, VRTX, GWPH,
• Reduced Positions: MOH, ZBH, ABBV, GILD, BLUE, ILMN, TEVA, UNH, IRWD, BMY,
• Sold Out: WCG, ESRX, IPXL, EXEL, OPHT, CI, CYNA, SRPT, ARWR, SAGE,

For the details of ORBIMED ADVISORS LLC's stock buys and sells, go to http://www.gurufocus.com/StockBuy.php?GuruName=ORBIMED+ADVISORS+LLC

1. Alexion Pharmaceuticals Inc (ALXN) - 3,388,386 shares, 5.33% of the total portfolio. Shares added by 28.44%
2. Celgene Corp (CELG) - 3,106,777 shares, 4.62% of the total portfolio. Shares added by 5.37%
3. Boston Scientific Corp (BSX) - 16,506,900 shares, 4.59% of the total portfolio. Shares reduced by 4.09%
4. Amgen Inc (AMGN) - 2,331,800 shares, 4.38% of the total portfolio. Shares reduced by 4.31%
5. Biogen Inc (BIIB) - 1,281,200 shares, 4.31% of the total portfolio. Shares reduced by 3.95%

Orbimed Advisors Llc initiated holdings in Anthem Inc. The purchase prices were between $117.42 and $147.66, with an estimated average price of $133.9. The stock is now traded at around $164.60. The impact to the portfolio due to this purchase was 1.89%. The holdings were 1,021,600 shares as of 2016-12-31.

Orbimed Advisors Llc initiated holdings in Momenta Pharmaceuticals Inc. The purchase prices were between $10.8 and $15.7, with an estimated average price of $13.21. The stock is now traded at around $13.45. The impact to the portfolio due to this purchase was 0.57%. The holdings were 2,951,968 shares as of 2016-12-31.

Orbimed Advisors Llc initiated holdings in BeiGene Ltd. The purchase prices were between $26.95 and $36.9, with an estimated average price of $31.43. The stock is now traded at around $36.21. The impact to the portfolio due to this purchase was 0.35%. The holdings were 903,700 shares as of 2016-12-31.

Orbimed Advisors Llc initiated holdings in Select Medical Holdings Corp. The purchase prices were between $11.2 and $14.05, with an estimated average price of $12.92. The stock is now traded at around $12.96. The impact to the portfolio due to this purchase was 0.14%. The holdings were 831,900 shares as of 2016-12-31.

Orbimed Advisors Llc initiated holdings in CRISPR Therapeutics AG. The purchase prices were between $13.82 and $23.07, with an estimated average price of $18.69. The stock is now traded at around $20.42. The impact to the portfolio due to this purchase was 0.1%. The holdings were 372,191 shares as of 2016-12-31.

Orbimed Advisors Llc initiated holdings in Tesaro Inc. The purchase prices were between $98.87 and $148.5, with an estimated average price of $126.14. The stock is now traded at around $154.90. The impact to the portfolio due to this purchase was 0.08%. The holdings were 47,200 shares as of 2016-12-31.

Orbimed Advisors Llc added to the holdings in Alexion Pharmaceuticals Inc by 28.44%. The purchase prices were between $110.01 and $135.59, with an estimated average price of $122.36. The stock is now traded at around $118.53. The impact to the portfolio due to this purchase was 1.18%. The holdings were 3,388,386 shares as of 2016-12-31.

Orbimed Advisors Llc added to the holdings in Aetna Inc by 591.17%. The purchase prices were between $105.2 and $134.9, with an estimated average price of $119.72. The stock is now traded at around $127.01. The impact to the portfolio due to this purchase was 1.09%. The holdings were 805,900 shares as of 2016-12-31.

Orbimed Advisors Llc added to the holdings in Humana Inc by 97.50%. The purchase prices were between $165.31 and $216.76, with an estimated average price of $190.72. The stock is now traded at around $206.63. The impact to the portfolio due to this purchase was 1.08%. The holdings were 836,400 shares as of 2016-12-31.

Orbimed Advisors Llc added to the holdings in Synergy Pharmaceuticals Inc by 205.21%. The purchase prices were between $4.14 and $6.09, with an estimated average price of $5.23. The stock is now traded at around $4.69. The impact to the portfolio due to this purchase was 0.96%. The holdings were 18,241,398 shares as of 2016-12-31.

Orbimed Advisors Llc added to the holdings in Merck & Co Inc by 31.61%. The purchase prices were between $58.43 and $64.96, with an estimated average price of $61.33. The stock is now traded at around $63.34. The impact to the portfolio due to this purchase was 0.84%. The holdings were 4,615,200 shares as of 2016-12-31.

Orbimed Advisors Llc added to the holdings in Pfizer Inc by 46.31%. The purchase prices were between $29.89 and $33.9, with an estimated average price of $32.18. The stock is now traded at around $34.16. The impact to the portfolio due to this purchase was 0.68%. The holdings were 5,167,900 shares as of 2016-12-31.

Orbimed Advisors Llc sold out the holdings in WellCare Health Plans Inc. The sale prices were between $113.51 and $141.4, with an estimated average price of $127.37.

Orbimed Advisors Llc sold out the holdings in Express Scripts Holding Co. The sale prices were between $65.09 and $77.14, with an estimated average price of $71.67.

Orbimed Advisors Llc sold out the holdings in Impax Laboratories Inc. The sale prices were between $12.75 and $24.23, with an estimated average price of $17.1.

Orbimed Advisors Llc sold out the holdings in Exelixis Inc. The sale prices were between $10.2 and $18.25, with an estimated average price of $14.43.

Orbimed Advisors Llc sold out the holdings in Ophthotech Corp. The sale prices were between $4.82 and $45.3, with an estimated average price of $29.68.

Orbimed Advisors Llc sold out the holdings in Cigna Corp. The sale prices were between $116.03 and $140, with an estimated average price of $130.85.

Orbimed Advisors Llc reduced to the holdings in Molina Healthcare Inc by 81.17%. The sale prices were between $47.53 and $59.6, with an estimated average price of $54.7. The stock is now traded at around $45.74. The impact to the portfolio due to this sale was -1.43%. Orbimed Advisors Llc still held 496,200 shares as of 2016-12-31.

Orbimed Advisors Llc reduced to the holdings in Zimmer Biomet Holdings Inc by 93.17%. The sale prices were between $97.99 and $132.74, with an estimated average price of $110.4. The stock is now traded at around $121.19. The impact to the portfolio due to this sale was -1%. Orbimed Advisors Llc still held 49,000 shares as of 2016-12-31.

Orbimed Advisors Llc reduced to the holdings in AbbVie Inc by 30.85%. The sale prices were between $55.78 and $64, with an estimated average price of $61.04. The stock is now traded at around $65.98. The impact to the portfolio due to this sale was -0.94%. Orbimed Advisors Llc still held 2,925,000 shares as of 2016-12-31.

Orbimed Advisors Llc reduced to the holdings in Gilead Sciences Inc by 47.53%. The sale prices were between $71.61 and $78.47, with an estimated average price of $74.33. The stock is now traded at around $67.10. The impact to the portfolio due to this sale was -0.87%. Orbimed Advisors Llc still held 1,055,100 shares as of 2016-12-31.

Orbimed Advisors Llc reduced to the holdings in bluebird bio Inc by 76.07%. The sale prices were between $41.3 and $78.95, with an estimated average price of $61.3. The stock is now traded at around $91.20. The impact to the portfolio due to this sale was -0.7%. Orbimed Advisors Llc still held 283,800 shares as of 2016-12-31.

Orbimed Advisors Llc reduced to the holdings in Illumina Inc by 63.23%. The sale prices were between $122.02 and $186.17, with an estimated average price of $138.55. The stock is now traded at around $170.81. The impact to the portfolio due to this sale was -0.65%. Orbimed Advisors Llc still held 182,200 shares as of 2016-12-31.