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Also traded in: Germany

GuruFocus Financial Strength Rank measures how strong a company’s financial situation is. It is based on these factors

1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.

A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.

Financial Strength : 6/10

vs
industry
vs
history
Cash-to-Debt 4.18
ALNY's Cash-to-Debt is ranked lower than
61% of the 610 Companies
in the Global Biotechnology industry.

( Industry Median: 49.39 vs. ALNY: 4.18 )
Ranked among companies with meaningful Cash-to-Debt only.
ALNY' s Cash-to-Debt Range Over the Past 10 Years
Min: 4.18  Med: No Debt Max: No Debt
Current: 4.18
Equity-to-Asset 0.73
ALNY's Equity-to-Asset is ranked higher than
62% of the 483 Companies
in the Global Biotechnology industry.

( Industry Median: 0.63 vs. ALNY: 0.73 )
Ranked among companies with meaningful Equity-to-Asset only.
ALNY' s Equity-to-Asset Range Over the Past 10 Years
Min: -0.76  Med: 0.55 Max: 0.91
Current: 0.73
-0.76
0.91
Interest Coverage N/A
ALNY's Interest Coverage is ranked lower than
54% of the 485 Companies
in the Global Biotechnology industry.

( Industry Median: 10000.00 vs. ALNY: N/A )
Ranked among companies with meaningful Interest Coverage only.
ALNY' s Interest Coverage Range Over the Past 10 Years
Min: N/A  Med: No Debt Max: No Debt
Current: N/A
N/A
No Debt
Piotroski F-Score: 1
Altman Z-Score: 4.67
Beneish M-Score: -2.05
WACC vs ROIC
25.60%
-128.90%
WACC
ROIC
GuruFocus Profitability Rank ranks how profitable a company is and how likely the company’s business will stay that way. It is based on these factors:

1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
••3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank•

The maximum rank is 10. A rank of 7 or higher means a higher profitability and may stay that way. A rank of 3 or lower indicates that the company has had trouble to make a profit.

Profitability Rank is not directly related to the Financial Strength Rank. But if a company is consistently profitable, its financial strength will be stronger.

Profitability & Growth : 1/10

vs
industry
vs
history
Operating Margin % -900.33
ALNY's Operating Margin % is ranked lower than
78% of the 503 Companies
in the Global Biotechnology industry.

( Industry Median: -50.65 vs. ALNY: -900.33 )
Ranked among companies with meaningful Operating Margin % only.
ALNY' s Operating Margin % Range Over the Past 10 Years
Min: -900.33  Med: -188.54 Max: -28.95
Current: -900.33
-900.33
-28.95
Net Margin % -869.63
ALNY's Net Margin % is ranked lower than
78% of the 503 Companies
in the Global Biotechnology industry.

( Industry Median: -43.94 vs. ALNY: -869.63 )
Ranked among companies with meaningful Net Margin % only.
ALNY' s Net Margin % Range Over the Past 10 Years
Min: -869.63  Med: -163.4 Max: -27.3
Current: -869.63
-869.63
-27.3
ROE % -37.37
ALNY's ROE % is ranked lower than
58% of the 544 Companies
in the Global Biotechnology industry.

( Industry Median: -24.74 vs. ALNY: -37.37 )
Ranked among companies with meaningful ROE % only.
ALNY' s ROE % Range Over the Past 10 Years
Min: -84.12  Med: -39.64 Max: -13.08
Current: -37.37
-84.12
-13.08
ROA % -30.78
ALNY's ROA % is ranked lower than
56% of the 616 Companies
in the Global Biotechnology industry.

( Industry Median: -21.99 vs. ALNY: -30.78 )
Ranked among companies with meaningful ROA % only.
ALNY' s ROA % Range Over the Past 10 Years
Min: -48.05  Med: -23.41 Max: -5.01
Current: -30.78
-48.05
-5.01
ROC (Joel Greenblatt) % -687.45
ALNY's ROC (Joel Greenblatt) % is ranked lower than
62% of the 585 Companies
in the Global Biotechnology industry.

( Industry Median: -218.94 vs. ALNY: -687.45 )
Ranked among companies with meaningful ROC (Joel Greenblatt) % only.
ALNY' s ROC (Joel Greenblatt) % Range Over the Past 10 Years
Min: -2120.98  Med: -554.62 Max: -149.42
Current: -687.45
-2120.98
-149.42
3-Year Revenue Growth Rate -10.40
ALNY's 3-Year Revenue Growth Rate is ranked lower than
67% of the 435 Companies
in the Global Biotechnology industry.

( Industry Median: 4.20 vs. ALNY: -10.40 )
Ranked among companies with meaningful 3-Year Revenue Growth Rate only.
ALNY' s 3-Year Revenue Growth Rate Range Over the Past 10 Years
Min: 0  Med: -8.15 Max: 108
Current: -10.4
0
108
3-Year EBITDA Growth Rate 52.70
ALNY's 3-Year EBITDA Growth Rate is ranked higher than
90% of the 469 Companies
in the Global Biotechnology industry.

( Industry Median: 1.30 vs. ALNY: 52.70 )
Ranked among companies with meaningful 3-Year EBITDA Growth Rate only.
ALNY' s 3-Year EBITDA Growth Rate Range Over the Past 10 Years
Min: -64.8  Med: 3.5 Max: 65.3
Current: 52.7
-64.8
65.3
3-Year EPS without NRI Growth Rate 48.90
ALNY's 3-Year EPS without NRI Growth Rate is ranked higher than
90% of the 459 Companies
in the Global Biotechnology industry.

( Industry Median: -2.90 vs. ALNY: 48.90 )
Ranked among companies with meaningful 3-Year EPS without NRI Growth Rate only.
ALNY' s 3-Year EPS without NRI Growth Rate Range Over the Past 10 Years
Min: -66.7  Med: 6.6 Max: 52.8
Current: 48.9
-66.7
52.8
GuruFocus has detected 3 Warning Signs with Alnylam Pharmaceuticals Inc $ALNY.
More than 500,000 people have already joined GuruFocus to track the stocks they follow and exchange investment ideas.
» ALNY's 10-Y Financials

Financials


Revenue & Net Income
Cash & Debt
Operating Cash Flow & Free Cash Flow
Operating Cash Flow & Net Income

» Details

Guru Trades

Q1 2016

ALNY Guru Trades in Q1 2016

Jim Simons 214,000 sh (New)
Vanguard Health Care Fund 8,512,270 sh (+12.25%)
John Griffin 1,075,000 sh (unchged)
John Paulson 12,300 sh (unchged)
Mairs and Power Sold Out
George Soros Sold Out
» More
Q2 2016

ALNY Guru Trades in Q2 2016

Dodge & Cox 2,516,669 sh (New)
John Paulson 19,300 sh (+56.91%)
John Griffin 1,320,000 sh (+22.79%)
Vanguard Health Care Fund 8,512,270 sh (unchged)
Jim Simons 18,673 sh (-91.27%)
» More
Q3 2016

ALNY Guru Trades in Q3 2016

Dodge & Cox 5,276,068 sh (+109.64%)
Vanguard Health Care Fund 8,512,270 sh (unchged)
John Griffin 1,320,000 sh (unchged)
John Paulson 19,300 sh (unchged)
Jim Simons Sold Out
» More
Q4 2016

ALNY Guru Trades in Q4 2016

Dodge & Cox 9,204,950 sh (+74.47%)
Vanguard Health Care Fund 8,549,357 sh (+0.44%)
John Paulson 19,300 sh (unchged)
John Griffin 1,320,000 sh (unchged)
» More
» Details

Insider Trades

Latest Guru Trades with ALNY

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Business Description

Industry: Biotechnology » Biotechnology    NAICS: 325412    SIC: 2834
Compare:NAS:TECH, NAS:ARIA, NAS:BLUE, NAS:ACAD, NAS:RARE, OTCPK:GLPGF, NAS:CBPO, NAS:ICPT, OTCPK:BTGGF, NAS:IONS, NAS:CLVS, NAS:SAGE, OTCPK:ABCZF, NAS:LGND, NAS:NKTR, NAS:AGIO, NAS:ONCE, NYSE:CBM, NAS:EXEL, NAS:ARRY » details
Traded in other countries:DUL.Germany,
Alnylam Pharmaceuticals Inc is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi.

Alnylam Pharmaceuticals Inc was originally incorporated in Delaware under the name Alnylam Holding Co. on May 8, 2003. It is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The Company's research and development is focused on use of its proprietary N-acetylgalactosamine, or GalNAc-conjugate for delivery of small interfering RNAs, or "siRNAs" - the molecules that mediate RNAi - toward liver-expressed genes involved in the cause or pathway of human diseases. It is also focused on clinical indications where there are high unmet medical needs, early biomarkers for the assessment of clinical activity in Phase 1 clinical studies, and a definable path for drug development, regulatory approval and commercialization. The Company operates in a single reporting segment, the discovery, development and commercialization of RNAi therapeutics. Its competitors include paten, Kyowa Hakko Kirin, Marina Biotech, Inc., Arrowhead and its subsidiary, Calando Pharmaceuticals, Inc., or Calando, Quark Pharmaceuticals, Inc., or Quark, Silence Therapeutics plc, Tekmira, Sylentis, S.A.U., or Sylentis, Dicerna Pharmaceuticals, Inc. and Arcturus Therapeutics, among others. The research, testing, manufacture and marketing of drug products and their delivery systems are extensively regulated in the United States and the rest of the world.

Top Ranked Articles about Alnylam Pharmaceuticals Inc

Weekly Top Insider Buys Highlight for Week of Oct. 14 Top insider buys of the week, including Monsanto, Alnylam Pharmaceuticals, Synergy Resources and Ferrellgas Partners
Largest Insider buys for Monsanto (NYSE:MON), Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), Synergy Resources Corp. (SYRG) and Ferrellgas Partners LP (NYSE:FGP). Read more...
Low Valuation Ratios Lead to Strong Portfolio Returns Backtesting Ben Graham’s Lost Formula strategy
Known as the “Father of Value Investing,” Benjamin Graham intelligently invested money in the stock market. Read more...

Ratios

vs
industry
vs
history
PB Ratio 4.64
ALNY's PB Ratio is ranked lower than
56% of the 556 Companies
in the Global Biotechnology industry.

( Industry Median: 3.85 vs. ALNY: 4.64 )
Ranked among companies with meaningful PB Ratio only.
ALNY' s PB Ratio Range Over the Past 10 Years
Min: 2.07  Med: 4.71 Max: 21.37
Current: 4.64
2.07
21.37
PS Ratio 90.16
ALNY's PS Ratio is ranked lower than
86% of the 477 Companies
in the Global Biotechnology industry.

( Industry Median: 9.96 vs. ALNY: 90.16 )
Ranked among companies with meaningful PS Ratio only.
ALNY' s PS Ratio Range Over the Past 10 Years
Min: 3.09  Med: 20.67 Max: 222.15
Current: 90.16
3.09
222.15
Current Ratio 5.10
ALNY's Current Ratio is ranked higher than
65% of the 585 Companies
in the Global Biotechnology industry.

( Industry Median: 3.45 vs. ALNY: 5.10 )
Ranked among companies with meaningful Current Ratio only.
ALNY' s Current Ratio Range Over the Past 10 Years
Min: 1.88  Med: 4.77 Max: 17.8
Current: 5.1
1.88
17.8
Quick Ratio 5.10
ALNY's Quick Ratio is ranked higher than
66% of the 583 Companies
in the Global Biotechnology industry.

( Industry Median: 3.24 vs. ALNY: 5.10 )
Ranked among companies with meaningful Quick Ratio only.
ALNY' s Quick Ratio Range Over the Past 10 Years
Min: 1.88  Med: 4.77 Max: 17.8
Current: 5.1
1.88
17.8
Days Sales Outstanding 180.60
ALNY's Days Sales Outstanding is ranked lower than
89% of the 405 Companies
in the Global Biotechnology industry.

( Industry Median: 62.87 vs. ALNY: 180.60 )
Ranked among companies with meaningful Days Sales Outstanding only.
ALNY' s Days Sales Outstanding Range Over the Past 10 Years
Min: 0.57  Med: 34.48 Max: 288.31
Current: 180.6
0.57
288.31

Buy Back

vs
industry
vs
history
3-Year Average Share Buyback Ratio -10.50
ALNY's 3-Year Average Share Buyback Ratio is ranked higher than
51% of the 503 Companies
in the Global Biotechnology industry.

( Industry Median: -10.60 vs. ALNY: -10.50 )
Ranked among companies with meaningful 3-Year Average Share Buyback Ratio only.
ALNY' s 3-Year Average Share Buyback Ratio Range Over the Past 10 Years
Min: -331.8  Med: -15.2 Max: -1
Current: -10.5
-331.8
-1

Valuation & Return

vs
industry
vs
history
Price-to-Net-Cash 15.01
ALNY's Price-to-Net-Cash is ranked lower than
69% of the 295 Companies
in the Global Biotechnology industry.

( Industry Median: 7.38 vs. ALNY: 15.01 )
Ranked among companies with meaningful Price-to-Net-Cash only.
ALNY' s Price-to-Net-Cash Range Over the Past 10 Years
Min: 4.44  Med: 11.31 Max: 42.87
Current: 15.01
4.44
42.87
Price-to-Net-Current-Asset-Value 12.97
ALNY's Price-to-Net-Current-Asset-Value is ranked lower than
71% of the 387 Companies
in the Global Biotechnology industry.

( Industry Median: 6.60 vs. ALNY: 12.97 )
Ranked among companies with meaningful Price-to-Net-Current-Asset-Value only.
ALNY' s Price-to-Net-Current-Asset-Value Range Over the Past 10 Years
Min: 4.31  Med: 10.54 Max: 39.45
Current: 12.97
4.31
39.45
Price-to-Tangible-Book 4.64
ALNY's Price-to-Tangible-Book is ranked higher than
53% of the 494 Companies
in the Global Biotechnology industry.

( Industry Median: 4.73 vs. ALNY: 4.64 )
Ranked among companies with meaningful Price-to-Tangible-Book only.
ALNY' s Price-to-Tangible-Book Range Over the Past 10 Years
Min: 2.65  Med: 5.09 Max: 15.16
Current: 4.64
2.65
15.16
Price-to-Median-PS-Value 4.36
ALNY's Price-to-Median-PS-Value is ranked lower than
93% of the 425 Companies
in the Global Biotechnology industry.

( Industry Median: 0.99 vs. ALNY: 4.36 )
Ranked among companies with meaningful Price-to-Median-PS-Value only.
ALNY' s Price-to-Median-PS-Value Range Over the Past 10 Years
Min: 0.2  Med: 1.06 Max: 9.22
Current: 4.36
0.2
9.22
Earnings Yield (Greenblatt) % -11.16
ALNY's Earnings Yield (Greenblatt) % is ranked lower than
63% of the 639 Companies
in the Global Biotechnology industry.

( Industry Median: -6.50 vs. ALNY: -11.16 )
Ranked among companies with meaningful Earnings Yield (Greenblatt) % only.
ALNY' s Earnings Yield (Greenblatt) % Range Over the Past 10 Years
Min: -18.85  Med: 465.9 Max: 1781.6
Current: -11.16
-18.85
1781.6

More Statistics

Revenue (TTM) (Mil) $47.16
EPS (TTM) $ -4.78
Beta3.16
Short Percentage of Float11.10%
52-Week Range $31.38 - 80.11
Shares Outstanding (Mil)86.01

Analyst Estimate

Dec17
Revenue (Mil $)
EPS ($) -4.41
EPS without NRI ($) -4.41
EPS Growth Rate
(Future 3Y To 5Y Estimate)
N/A
Dividends per Share ($)
» More Articles for ALNY

Headlines

Articles On GuruFocus.com
Weekly Top Insider Buys Highlight for Week of Oct. 14 Oct 16 2016 
Low Valuation Ratios Lead to Strong Portfolio Returns Sep 13 2016 
Liberty Broadband, Hanmi Bank Among Popular Micro-Cap Stocks Apr 04 2016 
Weekly Insider Sells Highlights: Facebook, PacWest Bancorp, Waste Management, Alnylam Pharmaceutical Nov 17 2015 
Julian Robertson Boosts His Stakes in JD.com, Netflix Oct 06 2015 
Julian Robertson Adds 16 New Stakes to Portfolio Jun 23 2015 
Gurus Purchase Tekmira Pharmaceuticals in Q1 Jun 19 2015 
Arrowhead Research Making Headway In The RNAi Therapy Platform Mar 09 2015 
Weekly CEO Buys Highlight: ULBI, BDE, ALNY, CTTR, GFN Feb 27 2012 
Weekly CEO Buys Highlight: VITC, CTFO, RPM, EFC, ALNY Oct 17 2011 

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