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GuruFocus Financial Strength Rank measures how strong a company’s financial situation is. It is based on these factors

1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.

A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.

Financial Strength : 9/10

vs
industry
vs
history
Cash to Debt No Debt
ALNY's Cash to Debt is ranked higher than
80% of the 1250 Companies
in the Global Biotechnology industry.

( Industry Median: 67.35 vs. ALNY: No Debt )
ALNY' s 10-Year Cash to Debt Range
Min: 3.29   Max: No Debt
Current: No Debt

Equity to Asset 0.92
ALNY's Equity to Asset is ranked higher than
94% of the 937 Companies
in the Global Biotechnology industry.

( Industry Median: 0.68 vs. ALNY: 0.92 )
ALNY' s 10-Year Equity to Asset Range
Min: -0.99   Max: 0.92
Current: 0.92

-0.99
0.92
Interest Coverage No Debt
ALNY's Interest Coverage is ranked higher than
87% of the 582 Companies
in the Global Biotechnology industry.

( Industry Median: 10000.00 vs. ALNY: No Debt )
ALNY' s 10-Year Interest Coverage Range
Min: 9999.99   Max: 9999.99
Current: No Debt

F-Score: 3
Z-Score: 54.92
M-Score: -3.98
GuruFocus Profitability Rank ranks how profitable a company is and how likely the company’s business will stay that way. It is based on these factors:

1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
••3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank•

The maximum rank is 10. A rank of 7 or higher means a higher profitability and may stay that way. A rank of 3 or lower indicates that the company has had trouble to make a profit.

Profitability Rank is not directly related to the Financial Strength Rank. But if a company is consistently profitable, its financial strength will be stronger.

Profitability & Growth : 2/10

vs
industry
vs
history
Operating margin (%) -1040.04
ALNY's Operating margin (%) is ranked higher than
58% of the 1026 Companies
in the Global Biotechnology industry.

( Industry Median: -75.73 vs. ALNY: -1040.04 )
ALNY' s 10-Year Operating margin (%) Range
Min: -14236.93   Max: -28.95
Current: -1040.04

-14236.93
-28.95
Net-margin (%) -993.24
ALNY's Net-margin (%) is ranked higher than
57% of the 1026 Companies
in the Global Biotechnology industry.

( Industry Median: -78.15 vs. ALNY: -993.24 )
ALNY' s 10-Year Net-margin (%) Range
Min: -14223.3   Max: -27.3
Current: -993.24

-14223.3
-27.3
ROE (%) -55.10
ALNY's ROE (%) is ranked higher than
67% of the 1147 Companies
in the Global Biotechnology industry.

( Industry Median: -34.77 vs. ALNY: -55.10 )
ALNY' s 10-Year ROE (%) Range
Min: -336.03   Max: -13.08
Current: -55.1

-336.03
-13.08
ROA (%) -46.80
ALNY's ROA (%) is ranked higher than
65% of the 1253 Companies
in the Global Biotechnology industry.

( Industry Median: -27.49 vs. ALNY: -46.80 )
ALNY' s 10-Year ROA (%) Range
Min: -97.61   Max: -5.01
Current: -46.8

-97.61
-5.01
ROC (Joel Greenblatt) (%) -2289.78
ALNY's ROC (Joel Greenblatt) (%) is ranked higher than
63% of the 1227 Companies
in the Global Biotechnology industry.

( Industry Median: -437.61 vs. ALNY: -2289.78 )
ALNY' s 10-Year ROC (Joel Greenblatt) (%) Range
Min: -1053.7   Max: -168.68
Current: -2289.78

-1053.7
-168.68
Revenue Growth (3Y)(%) -31.40
ALNY's Revenue Growth (3Y)(%) is ranked higher than
65% of the 728 Companies
in the Global Biotechnology industry.

( Industry Median: -2.20 vs. ALNY: -31.40 )
ALNY' s 10-Year Revenue Growth (3Y)(%) Range
Min: 0   Max: 108
Current: -31.4

0
108
EBITDA Growth (3Y)(%) 12.90
ALNY's EBITDA Growth (3Y)(%) is ranked higher than
88% of the 714 Companies
in the Global Biotechnology industry.

( Industry Median: -5.80 vs. ALNY: 12.90 )
ALNY' s 10-Year EBITDA Growth (3Y)(%) Range
Min: -64.8   Max: 36.5
Current: 12.9

-64.8
36.5
EPS Growth (3Y)(%) 11.70
ALNY's EPS Growth (3Y)(%) is ranked higher than
87% of the 729 Companies
in the Global Biotechnology industry.

( Industry Median: -7.40 vs. ALNY: 11.70 )
ALNY' s 10-Year EPS Growth (3Y)(%) Range
Min: -66.7   Max: 28.6
Current: 11.7

-66.7
28.6
» ALNY's 10-Y Financials

Financials


Revenue & Net Income
Cash & Debt
Oprt. Cash Flow & Free Cash Flow

» Details

Guru Trades

Q4 2013

ALNY Guru Trades in Q4 2013

Vanguard Health Care Fund 4,105,200 sh (+611.72%)
Columbia Wanger 1,910,000 sh (+45.26%)
Steven Cohen 45,435 sh (-30.1%)
» More
Q1 2014

ALNY Guru Trades in Q1 2014

Jim Simons 158,700 sh (New)
George Soros 3,092 sh (New)
Steven Cohen 140,522 sh (+209.28%)
Vanguard Health Care Fund 4,524,800 sh (+10.22%)
Columbia Wanger 902,764 sh (-52.73%)
» More
Q2 2014

ALNY Guru Trades in Q2 2014

Vanguard Health Care Fund 4,973,900 sh (+9.93%)
Jim Simons Sold Out
George Soros Sold Out
Columbia Wanger 784,500 sh (-13.1%)
» More
Q3 2014

ALNY Guru Trades in Q3 2014

Steven Cohen 12,100 sh (New)
Pioneer Investments 324,287 sh (New)
Vanguard Health Care Fund 5,277,100 sh (+6.1%)
Columbia Wanger 554,000 sh (-29.38%)
» More
» Details

Insider Trades

Latest Guru Trades with ALNY

(List those with share number changes of more than 20%, or impact to portfolio more than 0.1%)

GuruDate Trades Impact to Portfolio Price Range * (?) Current Price Change from Average Current Shares
George Soros 2014-06-30 Sold Out $48.87 - $70.76 $ 100.7370%0
George Soros 2014-03-31 New Buy$61.07 - $93.28 $ 100.7330%3092
Vanguard Health Care Fund 2013-12-31 Add 611.72%0.7%$50.79 - $66.91 $ 100.7369%4105200
Vanguard Health Care Fund 2013-09-30 New Buy0.13%$35.84 - $64.07 $ 100.73102%576800
Premium More recent guru trades are included for Premium Members only!!
Premium More recent guru trades are included for USA Subscribe Members only!!
» Interactive Charts

Peter Lynch Chart ( What is Peter Lynch Charts )

Ratios

vs
industry
vs
history
P/B 8.54
ALNY's P/B is ranked higher than
67% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 6.25 vs. ALNY: 8.54 )
ALNY' s 10-Year P/B Range
Min: 1.58   Max: 21.38
Current: 8.54

1.58
21.38
P/S 190.06
ALNY's P/S is ranked higher than
67% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 28.14 vs. ALNY: 190.06 )
ALNY' s 10-Year P/S Range
Min: 3.09   Max: 190.06
Current: 190.06

3.09
190.06
EV-to-EBIT -18.30
ALNY's EV-to-EBIT is ranked higher than
50% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 9999.00 vs. ALNY: -18.30 )
ALNY' s 10-Year EV-to-EBIT Range
Min: -58.7   Max: 0.6
Current: -18.3

-58.7
0.6
Current Ratio 11.31
ALNY's Current Ratio is ranked higher than
89% of the 1242 Companies
in the Global Biotechnology industry.

( Industry Median: 4.73 vs. ALNY: 11.31 )
ALNY' s 10-Year Current Ratio Range
Min: 1.88   Max: 12.38
Current: 11.31

1.88
12.38
Quick Ratio 11.31
ALNY's Quick Ratio is ranked higher than
89% of the 1242 Companies
in the Global Biotechnology industry.

( Industry Median: 4.57 vs. ALNY: 11.31 )
ALNY' s 10-Year Quick Ratio Range
Min: 1.88   Max: 12.38
Current: 11.31

1.88
12.38

Valuation & Return

vs
industry
vs
history
Price/Net Cash 14.05
ALNY's Price/Net Cash is ranked higher than
80% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 53.79 vs. ALNY: 14.05 )
ALNY' s 10-Year Price/Net Cash Range
Min: 3.7   Max: 92.77
Current: 14.05

3.7
92.77
Price/Net Current Asset Value 14.03
ALNY's Price/Net Current Asset Value is ranked higher than
78% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 31.40 vs. ALNY: 14.03 )
ALNY' s 10-Year Price/Net Current Asset Value Range
Min: 3.61   Max: 91.44
Current: 14.03

3.61
91.44
Price/Tangible Book 8.54
ALNY's Price/Tangible Book is ranked higher than
73% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 9.45 vs. ALNY: 8.54 )
ALNY' s 10-Year Price/Tangible Book Range
Min: 2.2   Max: 15.17
Current: 8.54

2.2
15.17
Price/Median PS Value 9.65
ALNY's Price/Median PS Value is ranked higher than
68% of the 1337 Companies
in the Global Biotechnology industry.

( Industry Median: 2.20 vs. ALNY: 9.65 )
ALNY' s 10-Year Price/Median PS Value Range
Min: 0.17   Max: 7.48
Current: 9.65

0.17
7.48
Earnings Yield (Greenblatt) -5.50
ALNY's Earnings Yield (Greenblatt) is ranked higher than
75% of the 1221 Companies
in the Global Biotechnology industry.

( Industry Median: -6.20 vs. ALNY: -5.50 )
ALNY' s 10-Year Earnings Yield (Greenblatt) Range
Min: 163.7   Max: 1781.6
Current: -5.5

163.7
1781.6

Business Description

Industry: Biotechnology » Biotechnology
Compare:NVO, AMGN, GILD, BIIB, CELG » details
Traded in other countries:DUL.Germany,
Alnylam Pharmaceuticals Inc is a Delaware corporation that was formed in May 2003. The Company is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. RNAi is a naturally occurring biological pathway within cells for selectively silencing and regulating the expression of specific genes. The Companys core product Alnylam 5x15, was launched in January 2011 and is focused on the development and commercialization of novel RNAi therapeutics as genetic medicines. Its genetic medicine programs are RNAi therapeutics directed towards genetically defined targets for the treatment of diseases with high unmet medical need. The Company is currently advancing the following core programs in clinical or pre-clinical development: patisiran (the International Nonproprietary Name for ALN-TTR02), an intravenously delivered RNAi therapeutic targeting transthyretin, or TTR, in development for the treatment of TTR-mediated amyloidosis, or ATTR, in patients with familial amyloidotic polyneuropathy, or FAP; ALN-TTRsc, a subcutaneously delivered RNAi therapeutic targeting TTR in development for the treatment of ATTR in patients with TTR cardiac amyloidosis, including familial amyloidotic cardiomyopathy, or FAC, and senile systemic amyloidosis, or SSA; ALN-AT3, an RNAi therapeutic targeting antithrombin, or AT, in development for the treatment of hemophilia and rare bleeding disorders, or RBD; ALN-CC5, an RNAi therapeutic targeting complement component C5 in development for the treatment of complement-mediated diseases; ALN-AS1, an RNAi therapeutic targeting aminolevulinate synthase-1, or ALAS-1, in development for the treatment of hepatic porphyrias, including acute intermittent porphyria, or AIP; ALN-PCSsc, an RNAi therapeutic targeting proprotein convertase subtilisin/kexin type 9, or PCSK9, in development for the treatment of hypercholesterolemia; ALN-AAT, an RNAi therapeutic targeting alpha-1-antitrypsin, or AAT, in development for the treatment of AAT deficiency liver disease; ALN-TMP, an RNAi therapeutic targeting transmembrane protease, serine 6, or TMPRSS6, in development for the treatment of beta-thalassemia and iron-overload disorders; ALN-ANG, an RNAi therapeutic targeting angioprotein-like 3, or ANGPTL3, in development for the treatment of genetic forms of mixed hyperlipidemia and severe hypertriglyceridemia; and other yet to be disclosed programs. The Companys product platform provides a capability for an approach to identifying RNAi therapeutic product candidates through sequence selection, potency selection, stabilization by chemical modification, improvement of biodistribution and cellular uptake by various chemical conjugates and formulations. Its competitors include Novartis, Takeda, Kyowa Hakko Kirin, Marina Biotech, Inc., Arrowhead and its subsidiary, Calando, Quark, Silence Therapeutics plc, Tekmira, Sylentis and Dicerna Pharmaceuticals, Inc., Regulus, Rosetta Genomics, Santaris Pharma A/S, or
» More Articles for ALNY

Headlines

Articles On GuruFocus.com
comment on ALNY Mar 09 2013 
comment on ALNY Mar 02 2013 
Weekly CEO Buys Highlight: ULBI, BDE, ALNY, CTTR, GFN Feb 27 2012 
Weekly CEO Buys Highlight: VITC, CTFO, RPM, EFC, ALNY Oct 17 2011 
Alnylam Pharmaceuticals Reports Second Quarter 2009 Financial Results Aug 06 2009 
Alnylam to Webcast Conference Call Discussing Fourth Quarter and 2008 Financial Results Feb 17 2009 

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