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GuruFocus Financial Strength Rank measures how strong a company’s financial situation is. It is based on these factors

1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.

A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.

Financial Strength : 4/10

vs
industry
vs
history
Cash to Debt 5.67
FOLD's Cash to Debt is ranked higher than
67% of the 896 Companies
in the Global Biotechnology industry.

( Industry Median: 171.30 vs. FOLD: 5.67 )
FOLD' s 10-Year Cash to Debt Range
Min: 5.67   Max: No Debt
Current: 5.67

Equity to Asset 0.36
FOLD's Equity to Asset is ranked higher than
55% of the 759 Companies
in the Global Biotechnology industry.

( Industry Median: 0.67 vs. FOLD: 0.36 )
FOLD' s 10-Year Equity to Asset Range
Min: 0.36   Max: 0.84
Current: 0.36

0.36
0.84
F-Score: 2
Z-Score: -4.21
M-Score: 24.74
GuruFocus Profitability Rank ranks how profitable a company is and how likely the company’s business will stay that way. It is based on these factors:

1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
••3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank•

The maximum rank is 10. A rank of 7 or higher means a higher profitability and may stay that way. A rank of 3 or lower indicates that the company has had trouble to make a profit.

Profitability Rank is not directly related to the Financial Strength Rank. But if a company is consistently profitable, its financial strength will be stronger.

Profitability & Growth : 1/10

vs
industry
vs
history
Operating margin (%) -17680.72
FOLD's Operating margin (%) is ranked lower than
53% of the 781 Companies
in the Global Biotechnology industry.

( Industry Median: -66.98 vs. FOLD: -17680.72 )
FOLD' s 10-Year Operating margin (%) Range
Min: -17680.72   Max: -11.42
Current: -17680.72

-17680.72
-11.42
Net-margin (%) -16427.82
FOLD's Net-margin (%) is ranked lower than
52% of the 781 Companies
in the Global Biotechnology industry.

( Industry Median: -56.37 vs. FOLD: -16427.82 )
FOLD' s 10-Year Net-margin (%) Range
Min: -16427.82   Max: -10.2
Current: -16427.82

-16427.82
-10.2
ROE (%) -130.34
FOLD's ROE (%) is ranked higher than
52% of the 808 Companies
in the Global Biotechnology industry.

( Industry Median: -21.52 vs. FOLD: -130.34 )
FOLD' s 10-Year ROE (%) Range
Min: -150.08   Max: -9.14
Current: -130.34

-150.08
-9.14
ROA (%) -46.75
FOLD's ROA (%) is ranked higher than
61% of the 890 Companies
in the Global Biotechnology industry.

( Industry Median: -18.90 vs. FOLD: -46.75 )
FOLD' s 10-Year ROA (%) Range
Min: -1350.9   Max: -7.69
Current: -46.75

-1350.9
-7.69
ROC (Joel Greenblatt) (%) -1557.79
FOLD's ROC (Joel Greenblatt) (%) is ranked higher than
60% of the 868 Companies
in the Global Biotechnology industry.

( Industry Median: -189.80 vs. FOLD: -1557.79 )
FOLD' s 10-Year ROC (Joel Greenblatt) (%) Range
Min: -2144.32   Max: -167.08
Current: -1557.79

-2144.32
-167.08
Revenue Growth (%) -30.70
FOLD's Revenue Growth (%) is ranked higher than
62% of the 589 Companies
in the Global Biotechnology industry.

( Industry Median: -0.40 vs. FOLD: -30.70 )
FOLD' s 10-Year Revenue Growth (%) Range
Min: 0   Max: -2.6
Current: -30.7

EBITDA Growth (%) -14.80
FOLD's EBITDA Growth (%) is ranked higher than
70% of the 597 Companies
in the Global Biotechnology industry.

( Industry Median: -10.60 vs. FOLD: -14.80 )
FOLD' s 10-Year EBITDA Growth (%) Range
Min: 0   Max: 82.8
Current: -14.8

0
82.8
EPS Growth (%) -16.30
FOLD's EPS Growth (%) is ranked higher than
71% of the 617 Companies
in the Global Biotechnology industry.

( Industry Median: -12.60 vs. FOLD: -16.30 )
FOLD' s 10-Year EPS Growth (%) Range
Min: -85.2   Max: 59.5
Current: -16.3

-85.2
59.5
» FOLD's 10-Y Financials

Financials


Revenue & Net Income
Cash & Debt
Oprt. Cash Flow & Free Cash Flow

» Details

Guru Trades

Q1 2013

FOLD Guru Trades in Q1 2013

Jim Simons 67,843 sh (New)
RS Investment Management 2,599,787 sh (+26.71%)
» More
Q2 2013

FOLD Guru Trades in Q2 2013

Chuck Royce 715,700 sh (New)
Jim Simons 173,644 sh (+155.95%)
RS Investment Management 2,522,419 sh (-2.98%)
» More
Q3 2013

FOLD Guru Trades in Q3 2013

Jim Simons 302,600 sh (+74.26%)
RS Investment Management 2,794,439 sh (+10.78%)
Chuck Royce 515,700 sh (-27.94%)
» More
Q4 2013

FOLD Guru Trades in Q4 2013

Jim Simons 399,401 sh (+31.99%)
RS Investment Management 2,797,339 sh (+0.1%)
Chuck Royce 355,700 sh (-31.03%)
» More
» Details

Insider Trades

Latest Guru Trades with FOLD



No Insider Trades Found!
» Interactive Charts

Peter Lynch Chart ( What is Peter Lynch Charts )

Ratios

vs
industry
vs
history
P/B 2.60
FOLD's P/B is ranked higher than
76% of the 787 Companies
in the Global Biotechnology industry.

( Industry Median: 4.51 vs. FOLD: 2.60 )
FOLD' s 10-Year P/B Range
Min: 0.64   Max: 7.98
Current: 2.6

0.64
7.98
P/S 266.10
FOLD's P/S is ranked lower than
86% of the 785 Companies
in the Global Biotechnology industry.

( Industry Median: 10.38 vs. FOLD: 266.10 )
FOLD' s 10-Year P/S Range
Min: 0.71   Max: 290
Current: 266.1

0.71
290
EV-to-EBIT 12.30
FOLD's EV-to-EBIT is ranked higher than
75% of the 478 Companies
in the Global Biotechnology industry.

( Industry Median: 20.00 vs. FOLD: 12.30 )
FOLD' s 10-Year EV-to-EBIT Range
Min: 0.1   Max: 0.8
Current: 12.3

0.1
0.8

Valuation & Return

vs
industry
vs
history
Price/Net Current Asset Value 185.00
FOLD's Price/Net Current Asset Value is ranked lower than
94% of the 520 Companies
in the Global Biotechnology industry.

( Industry Median: 9.30 vs. FOLD: 185.00 )
FOLD' s 10-Year Price/Net Current Asset Value Range
Min: 1.39   Max: 235
Current: 185

1.39
235
Price/Tangible Book 3.49
FOLD's Price/Tangible Book is ranked higher than
75% of the 727 Companies
in the Global Biotechnology industry.

( Industry Median: 6.00 vs. FOLD: 3.49 )
FOLD' s 10-Year Price/Tangible Book Range
Min: 1.25   Max: 4.43
Current: 3.49

1.25
4.43
Price/Median PS Value 23.13
FOLD's Price/Median PS Value is ranked higher than
95% of the 717 Companies
in the Global Biotechnology industry.

( Industry Median: 1.10 vs. FOLD: 23.13 )
FOLD' s 10-Year Price/Median PS Value Range
Min: 0.18   Max: 29.38
Current: 23.13

0.18
29.38
Forward Rate of Return (Yacktman) -43.78
FOLD's Forward Rate of Return (Yacktman) is ranked higher than
64% of the 669 Companies
in the Global Biotechnology industry.

( Industry Median: -9.87 vs. FOLD: -43.78 )
FOLD' s 10-Year Forward Rate of Return (Yacktman) Range
Min: 86.4   Max: 734.4
Current: -43.78

86.4
734.4

Business Description

Industry: Biotechnology » Biotechnology
Compare:NVO, AMGN, GILD, BIIB, CELG » details
Traded in other countries:AM6.Germany
Amicus Therapeutics, Inc. was incorporated on February 4, 2002 in Delaware. The Company is a Biopharmaceutical Company focused on the discovery, development and commercialization of orally-administered, small molecule drugs known as pharmacological chaperones, a novel, first-in-class approach to treating a broad range of diseases including lysosomal storage disorders and diseases of neurodegeneration. The Company is focused on the development of pharmacological chaperones as monotherapies and in combination with enzyme replacement therapy (ERT), the current standard of treatment for Fabry and other lysosomal storage diseases. In 2012, it is advancing two monotherapy programs for genetic diseases: Migalastat HCl for patients with Fabry disease identified as having alpha-galactosidase A (alpha-Gal A) mutations amenable to chaperone therapy, and AT3375 for Parkinson's disease in Gaucher disease carriers and potentially the broader Parkinson's population. Its pharmacological chaperone-ERT combination programs for 2012 include: Migalastat HCl co-administered with ERT for patients with Fabry disease receiving ERT treatment with any genetic mutation, AT2220 (duvoglustat HCl) co-administered with ERT for Pompe disease, AT3375 and afegostat tartrate co-administered with ERT for Gaucher disease, and Several new, undisclosed pharmacological chaperone programs focused on the combination of chaperones with ERTs for additional lysosomal storage diseases. The Company's novel approach to the treatment of human genetic diseases consists of using pharmacological chaperones that selectively bind to the target protein; increasing the stability of the protein and helping it fold into the correct three-dimensional shape. Its product candidate, migalastat HCl for Fabry disease, is in late Phase 3 development. It is developing and commercializing migalastat HCl with an affiliate of GlaxoSmithKline PLC (GSK) pursuant to a License and Collaboration Agreement entered into in October 2010. Its partnership with GSK allows it to utilize GSK's significant expertise in clinical, regulatory, commercial and manufacturing matters in the development of migalastat HCl. In addition, it is conducting another Phase 2 co-administration study evaluating its pharmacological chaperone AT2220 (duvoglustat HCl) co-administered with ERT in Pompe patients. Unlike migalastat HCl, it owns rights to the development of AT2220. In addition to its patents and trade secrets, The Company owns certain trademarks in the U.S. and/or abroad, including A AMICUS THERAPEUTICS & design and AMICUS THERAPEUTICS. Its competitors include Sanofi Aventis, Shire, Actelion, Ltd. and Protalix Biotherapeutics. The Company's product candidates, including migalastat HCl, and the activities associated with their development and commercialization, including their testing, manufacture, safety, efficacy, recordkeeping, labeling, storage, approval, advertising, promotion, sale and distribution, are subject to

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