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GuruFocus Financial Strength Rank measures how strong a company’s financial situation is. It is based on these factors

1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.

A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.

Financial Strength : 5/10

vs
industry
vs
history
Cash to Debt 1.50
ISIS's Cash to Debt is ranked lower than
74% of the 842 Companies
in the Global Biotechnology industry.

( Industry Median: 60.34 vs. ISIS: 1.50 )
Ranked among companies with meaningful Cash to Debt only.
ISIS' s 10-Year Cash to Debt Range
Min: 0.24  Med: 1.41 Max: 4.87
Current: 1.5
0.24
4.87
Equity to Asset 0.29
ISIS's Equity to Asset is ranked lower than
85% of the 594 Companies
in the Global Biotechnology industry.

( Industry Median: 0.69 vs. ISIS: 0.29 )
Ranked among companies with meaningful Equity to Asset only.
ISIS' s 10-Year Equity to Asset Range
Min: -0.85  Med: 0.33 Max: 0.76
Current: 0.29
-0.85
0.76
F-Score: 4
Z-Score: 5.73
M-Score: -1.53
GuruFocus Profitability Rank ranks how profitable a company is and how likely the company’s business will stay that way. It is based on these factors:

1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
••3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank•

The maximum rank is 10. A rank of 7 or higher means a higher profitability and may stay that way. A rank of 3 or lower indicates that the company has had trouble to make a profit.

Profitability Rank is not directly related to the Financial Strength Rank. But if a company is consistently profitable, its financial strength will be stronger.

Profitability & Growth : 4/10

vs
industry
vs
history
Operating margin (%) -11.02
ISIS's Operating margin (%) is ranked higher than
64% of the 657 Companies
in the Global Biotechnology industry.

( Industry Median: -71.01 vs. ISIS: -11.02 )
Ranked among companies with meaningful Operating margin (%) only.
ISIS' s 10-Year Operating margin (%) Range
Min: -438.91  Med: -80.37 Max: -12.18
Current: -11.02
-438.91
-12.18
Net-margin (%) -9.82
ISIS's Net-margin (%) is ranked higher than
63% of the 657 Companies
in the Global Biotechnology industry.

( Industry Median: -69.93 vs. ISIS: -9.82 )
Ranked among companies with meaningful Net-margin (%) only.
ISIS' s 10-Year Net-margin (%) Range
Min: -334.33  Med: -102.40 Max: 127.52
Current: -9.82
-334.33
127.52
ROE (%) -7.54
ISIS's ROE (%) is ranked higher than
67% of the 763 Companies
in the Global Biotechnology industry.

( Industry Median: -30.92 vs. ISIS: -7.54 )
Ranked among companies with meaningful ROE (%) only.
ISIS' s 10-Year ROE (%) Range
Min: -280.13  Med: -40.12 Max: 86.43
Current: -7.54
-280.13
86.43
ROA (%) -2.80
ISIS's ROA (%) is ranked higher than
71% of the 848 Companies
in the Global Biotechnology industry.

( Industry Median: -26.61 vs. ISIS: -2.80 )
Ranked among companies with meaningful ROA (%) only.
ISIS' s 10-Year ROA (%) Range
Min: -59.44  Med: -21.74 Max: 25.19
Current: -2.8
-59.44
25.19
ROC (Joel Greenblatt) (%) -12.06
ISIS's ROC (Joel Greenblatt) (%) is ranked higher than
70% of the 819 Companies
in the Global Biotechnology industry.

( Industry Median: -356.32 vs. ISIS: -12.06 )
Ranked among companies with meaningful ROC (Joel Greenblatt) (%) only.
ISIS' s 10-Year ROC (Joel Greenblatt) (%) Range
Min: -800.86  Med: -124.62 Max: -22.1
Current: -12.06
-800.86
-22.1
Revenue Growth (3Y)(%) 22.50
ISIS's Revenue Growth (3Y)(%) is ranked higher than
79% of the 402 Companies
in the Global Biotechnology industry.

( Industry Median: 0.30 vs. ISIS: 22.50 )
Ranked among companies with meaningful Revenue Growth (3Y)(%) only.
ISIS' s 10-Year Revenue Growth (3Y)(%) Range
Min: -39.4  Med: -2.30 Max: 83.7
Current: 22.5
-39.4
83.7
EBITDA Growth (3Y)(%) -30.30
ISIS's EBITDA Growth (3Y)(%) is ranked lower than
81% of the 427 Companies
in the Global Biotechnology industry.

( Industry Median: -3.90 vs. ISIS: -30.30 )
Ranked among companies with meaningful EBITDA Growth (3Y)(%) only.
ISIS' s 10-Year EBITDA Growth (3Y)(%) Range
Min: -49.6  Med: -4.50 Max: 61.3
Current: -30.3
-49.6
61.3
EPS Growth (3Y)(%) -27.00
ISIS's EPS Growth (3Y)(%) is ranked lower than
75% of the 413 Companies
in the Global Biotechnology industry.

( Industry Median: -7.40 vs. ISIS: -27.00 )
Ranked among companies with meaningful EPS Growth (3Y)(%) only.
ISIS' s 10-Year EPS Growth (3Y)(%) Range
Min: -71.2  Med: 2.00 Max: 117.8
Current: -27
-71.2
117.8
» ISIS's 10-Y Financials

Financials


Revenue & Net Income
Cash & Debt
Oprt. Cash Flow & Free Cash Flow

» Details

Guru Trades

Q2 2014

ISIS Guru Trades in Q2 2014

Murray Stahl 17,000 sh (unchged)
Jim Simons Sold Out
Ron Baron Sold Out
George Soros Sold Out
» More
Q3 2014

ISIS Guru Trades in Q3 2014

Murray Stahl 17,000 sh (unchged)
» More
Q4 2014

ISIS Guru Trades in Q4 2014

Paul Tudor Jones 6,473 sh (New)
Joel Greenblatt 8,745 sh (New)
Murray Stahl 17,000 sh (unchged)
» More
Q1 2015

ISIS Guru Trades in Q1 2015

Murray Stahl 17,000 sh (unchged)
Paul Tudor Jones 6,390 sh (-1.28%)
Joel Greenblatt 7,892 sh (-9.75%)
» More
» Details

Insider Trades

Latest Guru Trades with ISIS

(List those with share number changes of more than 20%, or impact to portfolio more than 0.1%)

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» Interactive Charts

Peter Lynch Chart ( What is Peter Lynch Charts )

Ratios

vs
industry
vs
history
P/B 23.95
ISIS's P/B is ranked lower than
94% of the 743 Companies
in the Global Biotechnology industry.

( Industry Median: 4.68 vs. ISIS: 23.95 )
Ranked among companies with meaningful P/B only.
ISIS' s 10-Year P/B Range
Min: 3  Med: 9.77 Max: 1710
Current: 23.95
3
1710
P/S 26.31
ISIS's P/S is ranked lower than
70% of the 591 Companies
in the Global Biotechnology industry.

( Industry Median: 11.51 vs. ISIS: 26.31 )
Ranked among companies with meaningful P/S only.
ISIS' s 10-Year P/S Range
Min: 4.33  Med: 12.73 Max: 84.47
Current: 26.31
4.33
84.47
Current Ratio 8.33
ISIS's Current Ratio is ranked higher than
68% of the 814 Companies
in the Global Biotechnology industry.

( Industry Median: 4.38 vs. ISIS: 8.33 )
Ranked among companies with meaningful Current Ratio only.
ISIS' s 10-Year Current Ratio Range
Min: 2.49  Med: 4.73 Max: 9.89
Current: 8.33
2.49
9.89
Quick Ratio 8.26
ISIS's Quick Ratio is ranked higher than
69% of the 814 Companies
in the Global Biotechnology industry.

( Industry Median: 4.23 vs. ISIS: 8.26 )
Ranked among companies with meaningful Quick Ratio only.
ISIS' s 10-Year Quick Ratio Range
Min: 2.49  Med: 4.68 Max: 9.89
Current: 8.26
2.49
9.89
Days Sales Outstanding 39.55
ISIS's Days Sales Outstanding is ranked higher than
71% of the 557 Companies
in the Global Biotechnology industry.

( Industry Median: 61.10 vs. ISIS: 39.55 )
Ranked among companies with meaningful Days Sales Outstanding only.
ISIS' s 10-Year Days Sales Outstanding Range
Min: 1.87  Med: 32.71 Max: 86.04
Current: 39.55
1.87
86.04

Valuation & Return

vs
industry
vs
history
Price/Net Cash 425.85
ISIS's Price/Net Cash is ranked lower than
99% of the 448 Companies
in the Global Biotechnology industry.

( Industry Median: 8.45 vs. ISIS: 425.85 )
Ranked among companies with meaningful Price/Net Cash only.
ISIS' s 10-Year Price/Net Cash Range
Min: 4.75  Med: 22.89 Max: 489.77
Current: 425.85
4.75
489.77
Price/Net Current Asset Value 42.58
ISIS's Price/Net Current Asset Value is ranked lower than
92% of the 533 Companies
in the Global Biotechnology industry.

( Industry Median: 7.60 vs. ISIS: 42.58 )
Ranked among companies with meaningful Price/Net Current Asset Value only.
ISIS' s 10-Year Price/Net Current Asset Value Range
Min: 4.49  Med: 15.34 Max: 705.5
Current: 42.58
4.49
705.5
Price/Tangible Book 25.87
ISIS's Price/Tangible Book is ranked lower than
92% of the 683 Companies
in the Global Biotechnology industry.

( Industry Median: 5.78 vs. ISIS: 25.87 )
Ranked among companies with meaningful Price/Tangible Book only.
ISIS' s 10-Year Price/Tangible Book Range
Min: 2.82  Med: 8.94 Max: 216.67
Current: 25.87
2.82
216.67
Price/Median PS Value 2.06
ISIS's Price/Median PS Value is ranked lower than
76% of the 539 Companies
in the Global Biotechnology industry.

( Industry Median: 1.17 vs. ISIS: 2.06 )
Ranked among companies with meaningful Price/Median PS Value only.
ISIS' s 10-Year Price/Median PS Value Range
Min: 0.2  Med: 0.94 Max: 5.07
Current: 2.06
0.2
5.07
Earnings Yield (Greenblatt) (%) -0.20
ISIS's Earnings Yield (Greenblatt) (%) is ranked higher than
73% of the 816 Companies
in the Global Biotechnology industry.

( Industry Median: -5.50 vs. ISIS: -0.20 )
Ranked among companies with meaningful Earnings Yield (Greenblatt) (%) only.
ISIS' s 10-Year Earnings Yield (Greenblatt) (%) Range
Min: -0.2  Med: 0.20 Max: 0.3
Current: -0.2
-0.2
0.3

Business Description

Industry: Biotechnology » Biotechnology
Compare:NVO, AMGN, GILD, BIIB, CELG » details
Traded in other countries:ISIS.Switzerland, 0R0N.UK, ISI.Germany,
Isis Pharmaceuticals Inc was incorporated in California in 1989, and in January 1991 the Company changed its state of incorporation to Delaware. The Company is engaged in antisense drug discovery and development, exploiting a novel drug discovery platform it created to generate a pipeline of first-in-class drugs. Antisense technology provides a direct route from genomics to drugs. The Company business segments are Drug Discovery and Development operations. Its flagship product, KYNAMRO (mipomersen sodium) injection, is on the market in the United States for patients with homozygous familial hypercholesterolemia, or HoFH. Patients with HoFH are at high cardiovascular risk and cannot reduce their low-density lipoprotein cholesterol, or LDL-C, sufficiently with currently available lipid-lowering therapies. The Company has a pipeline of 31 drugs in development. Company's ISIS-TTR and ISIS-SMN drugs are in late stage development. Its partners include Biogen Idec, AstraZeneca and Roche. The Company's drugs compete with existing therapies for market share. It also competes with specialized pharmaceutical firms and large pharmaceutical companies acting either independently or together with biopharmaceutical companies. The Company is subject to regulation under the Occupational Safety and Health Act, the Toxic Substances Control Act, the Resource Conservation and Recovery Act and other present and potential future federal, state and local regulations.
» More Articles for ISIS

Headlines

Articles On GuruFocus.com
buffet May 31 2015 
buffet May 31 2015 
Bayer Enters Into Collaboration With Isis For Enhancing Its Drug Portfolio May 07 2015 
Analysts Provide Update for Biogen, PTC Therapeutics, GW Pharma, and Isis Pharma Apr 22 2015 
Value vs. Growth: Is Jim Cramer Right about ISIS Pharmaceuticals? Dec 13 2014 
Weekly CEO Sells Highlight: Keynote Systems Inc., Isis Pharmaceuticals, Coleman Cable Inc. Jul 01 2013 
Isis Pharmaceuticals Inc. (ISIS) Director, COO B Lynne Parshall sells 17,200 Shares Dec 29 2010 
Isis Pharmaceuticals Inc. (ISIS) Chairman, President, CEO Stanley T Crooke sells 32,000 Shares Dec 29 2010 
Isis Pharmaceuticals Inc. Reports Operating Results (10-Q) Nov 05 2010 
Isis Pharmaceuticals Inc. Reports Operating Results (10-Q) May 07 2010 

More From Other Websites
Isis Pharmaceuticals' Lipid Disorder Drug Gets Orphan Status - Analyst Blog Jul 07 2015
Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII... Jul 06 2015
7:01 am ISIS Pharma's Akcea Therapeutics receives Orphan Drug Designation from the FDA for... Jul 06 2015
Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII... Jul 06 2015
ISIS PHARMACEUTICALS INC Files SEC form 8-K, Amendments to Articles of Inc. or Bylaws; Change in... Jul 02 2015
Webcast Alert: Corporate Presentation at the 2015 Isis Pharmaceuticals Annual Stockholder Meeting Jun 30 2015
Webcast Alert: Corporate Presentation at the 2015 Isis Pharmaceuticals Annual Stockholder Meeting Jun 30 2015
ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index Jun 29 2015
ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index Jun 29 2015
Even More Data From Isis Pharmaceuticals Jun 25 2015
Isis Pharmaceuticals Up on Spinal Muscular Atrophy Data - Analyst Blog Jun 23 2015
ISIS Pharma Still Undervalued, Needham Says Jun 23 2015
Isis Pharmaceuticals Reports Data from ISIS-SMN Rx in Children with Spinal Muscular Atrophy Jun 22 2015
Isis Pharmaceuticals Reports Data from ISIS-SMN Rx in Children with Spinal Muscular Atrophy Jun 22 2015
ISIS PHARMACEUTICALS INC Files SEC form 8-K, Entry into a Material Definitive Agreement, Creation of... Jun 19 2015
Isis Pharmaceuticals' 3 Most Important Numbers Jun 16 2015
Isis Pharmaceuticals to Present a General Corporate Update at its 2015 Annual Meeting of... Jun 16 2015
Isis Pharmaceuticals to Present a General Corporate Update at its 2015 Annual Meeting of... Jun 16 2015
Isis Pharmaceuticals Up on Positive Data on ISIS-SMNRx - Analyst Blog Jun 12 2015
Edited Transcript of ISIS conference call or presentation 11-Jun-15 12:30pm GMT Jun 12 2015

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