30 Year Financial Data of Ionis Pharmaceuticals Inc (NAS:IONS)

IONS- NAS (USA) Also traded in: Germany, Mexico, Switzerland, UK
Ionis Pharmaceuticals Inc

Currently 1/5

Business Predictability Rank: 1-Star (On Watch)
Back Testing Results:
Average gain of all 1-Star stocks: 1.1% per year.
% of Stocks that are in still loss if held for 10yrs: 45%.
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$52.78

1.51(2.95%) Volume: 918,678 4:00PM EST

Avg Vol (1m): 911,717

Warning! GuruFocus has detected 2 Severe Warning Signs with NAS:IONS. Click here to check it out.

Market Cap : 7.43 B	Enterprise Value : 6.38 B	PE Ratio :	PB Ratio : 8.76

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Also traded in: Germany, Mexico, Switzerland, UK

Annual Rates (per share)	10 yrs*	5 yrs*	12 months*
Revenue Growth (%)	23.60	21.60	-33.50
EBITDA Growth (%)	N/A	N/A	-126.80
Operating Income Growth (%)	N/A	N/A	-148.10
EPS without NRI Growth (%)	N/A	N/A	-255.30
Free Cash Flow Growth (%)	N/A	N/A	-101.70
Book Value Growth (%)	13.90	54.80	-42.40

*12-month growth rate is calculated with the quarterly per share revenue (EBITDA, FCF, earnings) of the last 12 months over the per share revenue (EBITDA, FCF, earnings) over the previous 12 months. 5-year and 10-year growth rates are calculated with least-square regression based on the 6-year and 11-year annual numbers. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the growth rate you want.

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* All numbers are in millions except for per share data, ratios, and percentage data * All shares outstanding data and per share data are split adjusted * Empty lines (lines with only 0's) are hidden by default * Preliminary data is from the companies' press releases. 10-Q/K data is not available yet. Preliminary data is not used in the calculation of Ratios,Scores or Rankings * Financial Statement Template: Manufacturing / Mining / Transportation / Utility / Others * Cash Flow from Operations Template: Indirect Method * For latest financial page display change, please click GuruFocus 30-Y Financials Page Item Changes

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Fiscal Period	Trend	Dec06	Dec07	Dec08	Dec09	Dec10	Dec11	Dec12	Dec13	Dec14	Dec15	Dec16	Dec17	Dec18	Dec19	Dec20	TTM	Dec19	Mar20	Jun20	Sep20	Dec20
Per Share Data	Annuals (USD $)View: $ % YOY																	Quarterly

Revenue per Share													4.08	4.47	7.86	5.22	5.22	3.45	0.96	1.04	1.15	2.07
EBITDA per Share													0.29	-0.14	2.88	-0.77	-0.77	1.79	-0.33	-0.21	-0.18	-0.05
EBIT per Share													0.22	-0.23	2.77	-0.90	-0.90	1.76	-0.36	-0.24	-0.21	-0.09
Earnings per Share (Diluted)													0.15	2.07	2.08	-3.23	-3.24	1.28	-0.35	-0.23	-0.22	-2.44
EPS without NRI													0.15	2.07	2.08	-3.23	-3.24	1.28	-0.35	-0.23	-0.22	-2.44
Owner Earnings per Share (TTM)													0.24	5.31	0.78	-1.58	-1.58	0.78	0.09	-0.04	-0.19	-1.58
Free Cash Flow per Share													1.08	4.37	2.17	-0.04	-0.04	1.88	-0.13	-0.40	-0.17	0.65
Operating Cash Flow per Share													1.38	4.50	2.42	0.26	0.26	1.94	-0.05	-0.32	-0.07	0.70
Cash per Share													8.18	15.11	17.81	13.56	13.52	17.81	17.12	16.84	16.66	13.52
Dividends per Share													--	--	--	--	--	--	--	--	--	--
Book Value per Share													2.25	7.60	10.48	6.04	6.03	10.48	9.77	9.87	9.89	6.03
Tangible Book per Share													2.07	7.42	10.30	5.84	5.83	10.30	9.57	9.67	9.69	5.83
Total Debt per Share													4.86	4.69	5.61	6.01	6.00	5.61	5.74	5.80	5.87	6.00
Month End Stock Price													50.30	54.06	60.41	56.54	52.78	60.41	47.28	58.96	47.45	56.54

Ratios	AnnualsView: $ % YOY																	Quarterly
Fiscal Period		Dec06	Dec07	Dec08	Dec09	Dec10	Dec11	Dec12	Dec13	Dec14	Dec15	Dec16	Dec17	Dec18	Dec19	Dec20	TTM	Dec19	Mar20	Jun20	Sep20	Dec20

ROE %													9.88	41.66	23.54	-39.01	-35.08	53.24	-13.63	-9.31	-8.97	-122.33
ROE % Adjusted to Book Value													0.44	5.86	4.09	-4.17	-4.00	9.24	-2.82	-1.56	-1.87	-13.04
ROA %													0.03	13.72	9.97	-16.05	-15.16	24.07	-6.10	-4.13	-4.01	-49.63
Return-on-Tangible-Equity													11.11	43.16	24.02	-39.94	-35.84	54.26	-13.88	-9.50	-9.15	-125.50
Return-on-Tangible-Asset													0.03	13.88	10.05	-16.21	-15.30	24.28	-6.15	-4.17	-4.05	-50.14
ROC (Joel Greenblatt) %													26.07	-24.69	276.78	-74.71	-73.31	665.75	-127.82	-78.52	-65.79	-26.78
ROCE %													3.01	-1.81	14.79	-5.25	-4.70	35.80	-7.01	-4.65	-4.09	-2.09
ROIC %													8.03	35.75	48.00	-70.18	-71.36	135.13	-34.45	-30.36	-22.68	-182.79
WACC %													20.16	19.26	10.30	7.61	7.39	10.30	9.25	8.77	8.85	7.61
Effective Interest Rate on Debt %													7.48	7.14	6.80	5.53	5.55	7.31	5.54	5.56	5.56	5.54

Gross Margin %													--	99.70	99.61	98.36	98.36	99.80	98.09	97.93	98.07	98.86
Operating Margin %													6.04	-10.23	32.60	-23.59	-23.59	52.81	-45.83	-35.56	-22.82	-7.80
Net Margin %													0.07	45.65	26.20	-61.88	-61.88	37.36	-36.16	-21.88	-19.33	-117.22
FCF Margin %													26.51	97.60	27.56	-0.71	-0.71	54.47	-13.17	-38.04	-14.57	31.38

Debt-to-Equity													2.16	0.62	0.54	1.00	1.00	0.54	0.59	0.59	0.59	1.00
Equity-to-Asset													0.21	0.39	0.46	0.35	0.35	0.46	0.44	0.45	0.45	0.35
Debt-to-Asset													0.46	0.24	0.24	0.35	0.35	0.24	0.26	0.26	0.27	0.35
Gross-Profit-to-Asset %													46.01	29.96	37.90	25.51	24.09	64.32	16.55	18.48	20.34	41.85

Asset Turnover													0.46	0.30	0.38	0.26	0.24	0.16	0.04	0.05	0.05	0.11
Dividend Payout Ratio													--	--	--	--	--	--	--	--	--	--

Days Sales Outstanding													--	--	--	--	--	--	--	--	--	--
Days Payable													--	5,747.75	1,337.70	525.46	525.46	1,450.16	758.29	224.40	479.67	475.43
Days Inventory													--	1,861.50	1,114.07	613.25	665.56	1,694.80	735.32	705.99	678.52	610.04
Cash Conversion Cycle													--	-3,886.25	-223.63	87.79	140.10	244.64	-22.97	481.59	198.85	134.61

Inventory Turnover													--	0.20	0.33	0.60	0.55	0.05	0.12	0.13	0.13	0.15
COGS-to-Revenue													--	--	--	0.02	0.02	--	0.02	0.02	0.02	0.01
Inventory-to-Revenue													0.02	0.02	0.01	0.03	0.03	0.04	0.15	0.16	0.14	0.08

Income Statement	Annual (USD $) View: $%/share% YOY																	Quarterly
Fiscal Period		Dec06	Dec07	Dec08	Dec09	Dec10	Dec11	Dec12	Dec13	Dec14	Dec15	Dec16	Dec17	Dec18	Dec19	Dec20	TTM	Dec19	Mar20	Jun20	Sep20	Dec20

Revenue													514.2	599.7	1,122.6	729.3	729.3	493.7	133.4	145.5	160.1	290.3
Cost of Goods Sold													--	1.8	4.4	11.9	11.9	1.0	2.5	3.0	3.1	3.3
Gross Profit													514.2	597.9	1,118.2	717.3	717.3	492.7	130.8	142.5	157.0	287.0
Gross Margin %													--	99.70	99.61	98.36	98.36	99.80	98.09	97.93	98.07	98.86

Selling, General, & Admin. Expense													108.5	244.6	286.6	354.3	354.3	83.2	75.0	72.0	68.4	138.8
Research & Development													374.6	414.6	465.7	535.1	535.1	148.7	117.0	122.3	125.1	170.8
Other Operating Expense													-0.0	--	-0.0	-0.0	0.0	0.0	--	--	--	0.0
Total Operating Expense													483.1	659.2	752.3	889.4	889.4	232.0	191.9	194.3	193.5	309.6
Operating Income													31.0	-61.4	365.9	-172.1	-172.1	260.7	-61.1	-51.8	-36.5	-22.6
Operating Margin %													6.04	-10.23	32.60	-23.59	-23.59	52.81	-45.83	-35.56	-22.82	-7.80

Interest Income													--	--	--	--	--	--	--	--	--	--
Interest Expense													-44.8	-44.8	-48.8	-45.0	-45.0	-13.4	-11.0	-11.2	-11.3	-11.5
Net Interest Income													-44.8	-44.8	-48.8	-45.0	-45.0	-13.4	-11.0	-11.2	-11.3	-11.5
Other Income (Expense)													-3.1	30.0	29.6	47.0	47.0	-9.1	10.4	18.7	7.4	10.5
Pre-Tax Income													-16.8	-76.2	346.8	-170.0	-170.0	238.3	-61.7	-44.2	-40.4	-23.6
Tax Provision													6.0	291.1	-43.5	-316.7	-316.7	-34.3	3.3	0.4	-2.6	-317.8
Tax Rate %													35.67	382.30	12.55	-186.28	-186.28	14.40	5.28	0.99	-6.55	-1,343.97
Net Income (Continuing Operations)													-10.8	215.0	303.3	-486.8	-486.8	204.0	-58.5	-43.8	-43.1	-341.4
Net Income (Discontinued Operations)													--	--	--	--	--	--	--	--	--	--
Other Income (Minority Interest)													11.1	58.8	-9.1	35.5	35.5	-19.5	10.3	11.9	12.1	1.2
Net Income													0.3	273.7	294.1	-451.3	-451.3	184.4	-48.2	-31.8	-30.9	-340.3
Net Margin %													0.07	45.65	26.20	-61.88	-61.88	37.36	-36.16	-21.88	-19.33	-117.22

Preferred Dividends													--	--	--	--	--	--	--	--	--	--
EPS (Basic)													0.15	2.09	2.12	-3.23	-3.24	1.31	-0.35	-0.23	-0.22	-2.44
EPS (Diluted)													0.15	2.07	2.08	-3.23	-3.24	1.28	-0.35	-0.23	-0.22	-2.44
Shares Outstanding (Diluted Average)													126.1	134.1	142.9	139.6	140.0	143.0	139.4	139.4	139.7	140.0

EBIT													28.0	-31.4	395.5	-125.0	-125.0	251.6	-50.7	-33.0	-29.1	-12.1
Depreciation, Depletion and Amortization													8.3	12.5	16.0	17.2	17.2	4.1	4.1	4.0	4.5	4.6
EBITDA													36.3	-18.8	411.5	-107.9	-107.9	255.7	-46.6	-29.0	-24.7	-7.6

Balance Sheet	Annuals (USD $)View: $%/share% YOY																	Quarterly
Fiscal Period		Dec06	Dec07	Dec08	Dec09	Dec10	Dec11	Dec12	Dec13	Dec14	Dec15	Dec16	Dec17	Dec18	Dec19	Dec20	Latest Q.	Dec19	Mar20	Jun20	Sep20	Dec20

Cash And Cash Equivalents													129.6	278.8	683.3	397.7	397.7	683.3	486.2	530.2	633.1	397.7
Marketable Securities													893.1	1,805.3	1,816.3	1,494.7	1,494.7	1,816.3	1,897.9	1,818.4	1,696.1	1,494.7
Cash, Cash Equivalents, Marketable Securities													1,022.7	2,084.1	2,499.5	1,892.4	1,892.4	2,499.5	2,384.1	2,348.6	2,329.2	1,892.4
Accounts Receivable													--	--	--	--	--	--	--	--	--	--
Notes Receivable													--	--	--	--	--	--	--	--	--	--
Loans Receivable													--	--	--	--	--	--	--	--	--	--
Other Current Receivables													63.0	12.8	63.0	76.2	76.2	63.0	28.6	27.8	39.0	76.2
Total Receivables													63.0	12.8	63.0	76.2	76.2	63.0	28.6	27.8	39.0	76.2
Inventories, Raw Materials & Components													--	--	15.9	16.7	16.7	15.9	19.6	19.5	17.9	16.7
Inventories, Work In Process													--	--	2.0	2.3	2.3	2.0	2.6	3.5	3.3	2.3
Inventories, Inventories Adjustments													--	--	--	--	--	--	--	--	--	--
Inventories, Finished Goods													--	--	0.3	3.0	3.0	0.3	0.6	0.7	1.0	3.0
Inventories, Other													10.0	8.6	--	0.0	0.0	--	--	--	--	0.0
Total Inventories													10.0	8.6	18.2	22.0	22.0	18.2	22.9	23.7	22.2	22.0
Other Current Assets													73.1	102.5	139.8	140.2	140.2	139.8	122.5	131.0	146.6	140.2
Total Current Assets													1,168.7	2,207.9	2,720.6	2,130.7	2,130.7	2,720.6	2,558.0	2,531.2	2,537.0	2,130.7

Investments And Advances													--	--	--	--	--	--	--	--	--	--
Land And Improvements													17.3	17.3	25.9	31.5	31.5	25.9	--	--	--	31.5
Buildings And Improvements													92.8	97.5	119.8	137.9	137.9	119.8	--	--	--	137.9
Machinery, Furniture, Equipment													72.7	59.8	68.3	81.9	81.9	68.3	--	--	--	81.9
Construction In Progress													--	--	--	--	--	--	--	--	--	--
Other Gross PPE													26.7	19.0	13.6	17.3	17.3	13.6	164.0	172.6	181.5	17.3
Gross Property, Plant and Equipment													209.6	193.6	227.7	268.5	268.5	227.7	164.0	172.6	181.5	268.5
Accumulated Depreciation													-87.7	-61.5	-74.0	-87.4	-87.4	-74.0	--	--	--	-87.4
Property, Plant and Equipment													121.9	132.2	153.7	181.1	181.1	153.7	164.0	172.6	181.5	181.1
Intangible Assets													22.0	24.0	25.7	27.9	27.9	25.7	26.8	27.7	28.3	27.9
Goodwill													--	--	--	--	--	--	--	--	--	--
Other Long Term Assets													10.1	303.7	333.2	50.0	50.0	333.2	342.2	347.4	348.9	50.0
Total Long-Term Assets													154.0	459.9	512.5	259.0	259.0	512.5	532.9	547.8	558.7	259.0
Total Assets													1,322.8	2,667.8	3,233.1	2,389.8	2,389.8	3,233.1	3,090.9	3,079.0	3,095.7	2,389.8

Accounts Payable													24.9	28.7	16.1	17.2	17.2	16.1	21.2	7.4	16.2	17.2
Total Tax Payable													--	0.9	32.5	1.3	1.3	32.5	32.9	27.9	8.9	1.3
Other Current Payables													--	--	--	-0.0	-0.0	--	--	--	-0.0	-0.0
Current Accrued Expense													66.6	47.5	66.8	90.2	90.2	66.8	62.5	67.8	80.8	90.2
Accounts Payable & Accrued Expense													91.5	77.0	115.4	108.7	108.7	115.4	116.6	103.2	105.9	108.7
Short-Term Debt													1.6	13.7	2.0	300.5	300.5	2.0	4.2	5.0	5.8	300.5
Short-Term Capital Lease Obligation													--	--	--	--	--	--	--	--	--	--
Short-Term Debt & Capital Lease Obligation													1.6	13.7	2.0	300.5	300.5	2.0	4.2	5.0	5.8	300.5
Current Deferred Revenue													125.3	160.3	118.3	108.4	108.4	118.3	120.8	100.4	104.4	108.4
Current Deferred Taxes Liabilities													--	--	--	--	--	--	--	--	--	--
DeferredTaxAndRevenue													125.3	160.3	118.3	108.4	108.4	118.3	120.8	100.4	104.4	108.4
Other Current Liabilities													25.2	29.3	37.4	65.7	65.7	37.4	16.4	22.8	28.4	65.7
Total Current Liabilities													243.6	280.3	273.0	583.3	583.3	273.0	258.0	231.3	244.6	583.3

Long-Term Debt													605.9	633.0	785.5	539.1	539.1	785.5	794.6	804.2	814.8	539.1
Long-Term Capital Lease Obligation													--	--	--	--	--	--	--	--	--	--
Long-Term Debt & Capital Lease Obligation													605.9	633.0	785.5	539.1	539.1	785.5	794.6	804.2	814.8	539.1
Debt-to-Equity													2.16	0.62	0.54	1.00	1.00	0.54	0.59	0.59	0.59	1.00
PensionAndRetirementBenefit													--	--	--	--	--	--	--	--	--	--
NonCurrent Deferred Liabilities													108.0	567.4	490.1	424.0	424.0	490.1	467.8	448.6	429.9	424.0
Other Long-Term Liabilities													0.0	-0.0	-0.0	-0.0	-0.0	-0.0	-0.0	-0.0	0.0	-0.0
Total Long-Term Liabilities													713.9	1,200.3	1,275.6	963.2	963.2	1,275.6	1,262.5	1,252.8	1,244.7	963.2
Total Liabilities													957.5	1,480.6	1,548.6	1,546.4	1,546.4	1,548.6	1,520.5	1,484.2	1,489.3	1,546.4

Common Stock													0.1	0.1	0.1	0.1	0.1	0.1	0.1	0.1	0.1	0.1
Preferred Stock													--	--	--	--	--	--	--	--	--	--
Retained Earnings													-1,241.0	-967.3	-707.5	-1,249.4	-1,249.4	-707.5	-846.3	-878.2	-909.1	-1,249.4
Accumulated other comprehensive income (loss)													-31.8	-32.0	-25.3	-21.1	-21.1	-25.3	-27.2	-16.4	-19.6	-21.1
Additional Paid-In Capital													1,553.7	2,047.3	2,203.8	2,113.6	2,113.6	2,203.8	2,233.6	2,271.6	2,311.7	2,113.6
Treasury Stock													--	--	--	--	--	--	--	--	--	--
Other Stockholders Equity													0.0	0.0	0.0	-0.0	-0.0	0.0	--	-0.0	-0.0	-0.0
Total Stockholders Equity													281.0	1,048.1	1,471.1	843.3	843.3	1,471.1	1,360.2	1,377.2	1,383.1	843.3
Minority Interest													84.3	139.1	213.5	--	--	213.5	210.2	217.6	223.2	--
Total Equity													365.3	1,187.2	1,684.5	843.3	843.3	1,684.5	1,570.4	1,594.8	1,606.4	843.3
Equity-to-Asset													0.21	0.39	0.46	0.35	0.35	0.46	0.44	0.45	0.45	0.35

Cashflow Statement	Annuals (USD $)View: $%/share% YOY																	Quarterly
Fiscal Period		Dec06	Dec07	Dec08	Dec09	Dec10	Dec11	Dec12	Dec13	Dec14	Dec15	Dec16	Dec17	Dec18	Dec19	Dec20	TTM	Dec19	Mar20	Jun20	Sep20	Dec20

Net Income From Continuing Operations													-10.8	215.0	303.3	-486.8	-486.8	204.0	-58.5	-43.8	-43.1	-341.4
Depreciation, Depletion and Amortization													8.3	12.5	16.0	17.2	17.2	4.1	4.1	4.0	4.5	4.6
Change In Receivables													45.1	47.6	-47.7	-13.2	-13.2	-14.0	34.4	0.8	-11.1	-37.2
Change In Inventory													-2.5	1.4	-5.4	-1.3	-1.3	1.2	-2.2	-0.8	1.6	0.2
Change In Prepaid Assets													--	--	--	--	--	--	--	--	--	--
Change In Payables And Accrued Expense													30.8	-18.4	31.7	-1.6	-1.6	50.5	0.4	-15.4	-19.7	33.0
Change In Other Working Capital													-36.3	468.8	-147.4	-57.5	-57.5	-26.1	-33.6	-41.2	-0.6	17.9
Change In Working Capital													37.0	499.4	-168.8	-73.6	-73.6	11.6	-1.0	-56.6	-29.9	13.9
Deferred Tax													--	-290.5	-7.1	313.3	313.3	-11.2	-3.4	0.9	-1.0	316.7
Stock Based Compensation													86.0	131.3	146.6	230.1	230.1	35.0	40.8	48.4	45.8	95.0
Asset Impairment Charge													--	--	--	--	--	--	--	--	--	--
Cash from Discontinued Operating Activities													--	--	--	--	--	--	--	--	--	--
Cash Flow from Others													53.6	35.2	55.7	35.7	35.7	34.3	10.4	2.8	13.3	9.2
Cash Flow from Operations													174.1	602.9	345.6	35.9	35.9	277.8	-7.6	-44.1	-10.4	98.0

Purchase Of Property, Plant, Equipment													-34.8	-13.6	-30.9	-35.1	-35.1	-7.8	-9.1	-9.1	-11.8	-5.1
Sale Of Property, Plant, Equipment													--	--	--	--	--	--	--	--	--	--
Purchase Of Business													--	--	--	--	--	--	--	--	--	--
Sale Of Business													2.5	--	--	--	--	--	--	--	--	--
Purchase Of Investment													-880.3	-1,794.7	-1,956.7	-1,570.4	-1,570.4	-339.0	-544.4	-431.9	-400.3	-193.8
Sale Of Investment													557.4	882.8	1,951.7	1,885.9	1,885.9	486.1	459.4	522.8	515.3	388.5
Net Intangibles Purchase And Sale													-3.1	-4.0	-5.4	-5.9	-5.9	-1.2	-0.9	-2.1	-1.2	-1.7
Cash From Discontinued Investing Activities													--	--	--	--	--	--	--	--	--	--
Cash From Other Investing Activities													-0.0	-0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0	-0.0	-0.0
Cash Flow from Investing													-358.3	-929.6	-41.3	274.5	274.5	138.2	-95.0	79.7	101.9	187.8

Issuance of Stock													255.1	475.9	119.7	52.0	52.0	7.5	7.7	8.8	13.0	22.6
Repurchase of Stock													--	--	-34.4	-90.5	-90.5	--	-90.6	0.0	--	--
Net Issuance of Preferred Stock													--	--	--	--	--	--	--	--	--	--
Issuance of Debt													59.8	--	99.1	--	--	99.1	--	--	--	--
Payments of Debt													-83.7	--	-121.2	--	--	-108.7	--	--	--	--
Net Issuance of Debt													-24.0	--	-22.1	--	--	-9.6	--	--	--	--
Cash Flow for Dividends													--	--	--	--	--	--	--	--	--	--
Other Financing													-2.0	--	36.9	-558.1	-558.1	21.3	-11.6	-0.4	-2.1	-544.1
Cash Flow from Financing													229.1	475.9	100.0	-596.6	-596.6	19.2	-94.5	8.4	10.9	-521.5

Effect of Exchange Rate Changes													--	-0.0	0.1	0.6	--	--	--	--	--	--
Net Change in Cash													44.9	149.2	404.5	-285.6	-286.0	435.3	-197.1	44.0	102.5	-235.4
Capital Expenditure													-37.9	-17.7	-36.3	-41.0	-41.0	-8.9	-10.0	-11.2	-13.0	-6.9
Free Cash Flow													136.3	585.3	309.3	-5.2	-5.2	268.9	-17.6	-55.4	-23.3	91.1

Valuation Ratios	AnnualsView: $ % YOY																	Quarterly
Fiscal Period		Dec06	Dec07	Dec08	Dec09	Dec10	Dec11	Dec12	Dec13	Dec14	Dec15	Dec16	Dec17	Dec18	Dec19	Dec20	Current	Dec19	Mar20	Jun20	Sep20	Dec20


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