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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Cole G BradleyCOO2017-11-07Sell5,00039,935$31.47157.35-8.839,935 (Direct)
Vaughn James JChief Commercial Officer2017-11-02Sell6,99627,620$32.57227.86-11.8827,620 (Direct)
Cole G BradleyCOO2017-10-10Sell5,00039,935$31.93159.65-10.1239,935 (Direct)
Popovits Kimberly JPresident and CEO
(Click for the stocks that their CEOs have bought)
2017-09-14Sell5,000307,567$31155-7.4241,132 (Direct)
12,298 (Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
237,312 (Held by the Popovits 2010 Trust)
Cole G BradleyCOO2017-09-12Sell5,00039,935$31.86159.3-9.9239,935 (Direct)
Popovits Kimberly JPresident and CEO2017-08-14Sell5,000307,567$30.22151.1-5.0379,057 (Direct)
12,298 (Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
199,387 (Held by the Popovits 2010 Trust)
Cole G BradleyCOO2017-08-08Sell5,00039,935$30.57152.85-6.1239,935 (Direct)
Vaughn James JChief Commercial Officer2017-08-08Sell8,00029,785$30.59244.72-6.1829,785 (Direct)
Febbo Phillip G.Chief Medical Officer2017-07-19Sell3,17417,800$33.57106.55-14.5117,800 (Direct)
Cole G BradleyCOO2017-07-11Sell5,00039,935$32.53162.65-11.7739,935 (Direct)
Popovits Kimberly JPresident and CEO2017-07-05Sell5,000307,567$32.59162.95-11.9479,057 (Direct)
12,298 (Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
199,387 (Held by the Popovits 2010 Trust)
Shak StevenChief Scientific Officer2017-06-23Sell5,000331,924$33.27166.35-13.74331,924 (Direct)
Cole G BradleyCOO2017-06-13Sell5,00039,935$31.67158.35-9.3839,935 (Direct)
Popovits Kimberly JPresident and CEO2017-06-05Sell5,000307,567$32.32161.6-11.279,057 (Direct)
199,387 (Held by the Popovits 2010 Trust)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
12,298 (Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits)
Shak StevenChief Scientific Officer2017-05-23Sell5,000331,103$29.4147-2.38331,103 (Direct)
Cohen Fred EDirector2017-05-19Sell8,25071,963$29.54243.71-2.8465,895 (Direct)
6,068 (By the Jane K Cohen Trust)
Cohen Fred EDirector2017-05-18Sell16,50071,963$29.88493.02-3.9565,895 (Direct)
6,068 (By the Jane K Cohen Trust)
Cohen Fred EDirector2017-05-16Sell8,25071,963$30.68253.11-6.4565,895 (Direct)
6,068 (By the Jane K Cohen Trust)
Popovits Kimberly JPresident and CEO2017-05-03Sell5,000306,846$31.77158.85-9.6678,236 (Direct)
12,298 (Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
199,487 (Held by the Popovits 2010 Trust)
Shak StevenChief Scientific Officer2017-04-24Sell5,000331,103$31.46157.3-8.77331,103 (Direct)
Popovits Kimberly JPresident and CEO2017-04-03Sell5,000306,846$31.3156.5-8.3178,236 (Direct)
199,487 (Held by the Popovits 2010 Trust)
12,298 (Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
Shak StevenChief Scientific Officer2017-03-23Sell5,000331,103$31.26156.3-8.19331,103 (Direct)
Leber LauraChief Communication Officer2017-03-20Sell3,07214,627$31.8897.94-9.9714,627 (Direct)
Cole G BradleyCOO2017-03-08Sell5,71039,528$31.55180.15-9.0339,528 (Direct)
Popovits Kimberly JPresident and CEO2017-03-06Sell5,000308,210$31.09155.45-7.6978,236 (Direct)
12,298 (Held by UBS for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
200,851 (Held by the Popovits 2010 Trust)
Shak StevenChief Scientific Officer2017-02-23Sell5,000331,103$29.36146.8-2.25331,103 (Direct)
Febbo Phillip G.Chief Medical Officer2017-02-16Sell2,49520,644$30.0975.07-4.6220,644 (Direct)
Cole G BradleyCOO2017-02-15Sell5,00039,728$29145-1.0339,728 (Direct)
Shak StevenChief Scientific Officer2017-01-23Sell5,000327,207$27.28136.45.21327,207 (Direct)
Cole G BradleyCOO2017-01-10Sell5,00035,882$29.22146.1-1.7835,882 (Direct)
Cole G BradleyCOO2016-12-06Sell5,00035,882$30.61153.05-6.2435,882 (Direct)
Popovits Kimberly JPresident and CEO2016-12-05Sell5,000289,594$30.02150.1-4.459,620 (Direct)
12,298 (Held by UBS for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
200,851 (Held by the Popovits 2010 Trust)
Leber LauraChief Communication Officer2016-11-21Sell7,06814,331$31.73224.27-9.5514,331 (Direct)
Shak StevenChief Scientific Officer2016-11-10Sell5,000327,207$31.71158.55-9.49327,207 (Direct)
Cole G BradleyCOO2016-11-08Sell5,00035,426$29.68148.4-3.335,426 (Direct)
Popovits Kimberly JPresident and CEO2016-11-03Sell5,313289,594$28.88153.44-0.6259,620 (Direct)
200,851 (Held by the Popovits 2010 Trust)
12,298 (Held by UBS for Benefit of Kimberly Popovits)
16,825 (Held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits is trustee.)
Shak StevenChief Scientific Officer2016-10-11Sell5,000327,207$30.39151.95-5.56327,207 (Direct)
Cole G BradleyCOO2016-10-10Sell8,29035,426$30.59253.59-6.1835,426 (Direct)
Vaughn James JChief Commercial Officer2016-10-06Sell3,00026,079$29.6889.04-3.326,079 (Direct)
Shak StevenChief Scientific Officer2016-09-13Sell5,000327,207$26.83134.156.97327,207 (Direct)
Cole G BradleyCOO2016-09-06Sell4,00035,426$27.41109.644.7135,426 (Direct)
Shak StevenChief Scientific Officer2016-08-23Sell5,000327,207$27.24136.25.36327,207 (Direct)
BAKER FELIXDirector, 10% Owner2016-08-15Buy100,00011,841,478$27.0227026.22
318,623 (See footnote(,))
11,348,958 (See footnote(,,))
173,897 (See footnote(F1,))
Cole G BradleyCOO2016-08-11Sell5,00035,426$28.87144.35-0.5935,426 (Direct)
Vaughn James JChief Commercial Officer2016-08-08Sell3,00029,079$28.7486.22-0.1429,079 (Direct)
Shak StevenChief Scientific Officer2016-07-19Sell5,000327,207$27.42137.14.67327,207 (Direct)
Cole G BradleyCOO2016-07-06Sell5,00035,426$26.64133.27.7335,426 (Direct)
Shak StevenChief Scientific Officer2016-06-21Sell5,000327,207$25.77128.8511.37327,207 (Direct)
Cole G BradleyCOO2016-06-09Sell5,00035,426$26.62133.17.8135,426 (Direct)
Vaughn James JChief Commercial Officer2016-06-06Sell1,99732,079$2855.922.532,079 (Direct)
Cole G BradleyCOO2016-05-16Sell5,00034,970$27.61383.9934,970 (Direct)
Febbo Phillip G.Chief Medical Officer2016-05-10Sell6,32415,013$27.2172.015.5115,013 (Direct)
Vaughn James JChief Commercial Officer2016-05-09Sell2,00031,255$28562.531,255 (Direct)
Shak StevenChief Scientific Officer2016-05-04Sell10,000326,383$25.43254.312.86326,383 (Direct)
Vaughn James JChief Commercial Officer2016-02-09Sell324,076$280.082.524,076 (Direct)
LIVINGSTON RANDALL SDirector2016-01-13Sell1,2506,149$32.1440.18-10.76,149 (Direct)
Cole G BradleyCOO2016-01-12Sell4,00027,428$31.69126.76-9.4427,428 (Direct)
Vaughn James JChief Commercial Officer2016-01-07Sell2,00024,076$33.6367.26-14.6624,076 (Direct)
Cole G BradleyCOO2015-12-08Sell4,00027,428$29.26117.04-1.9127,428 (Direct)
Leber LauraChief Communication Officer2015-12-07Sell4,20012,959$29.33123.19-2.1512,959 (Direct)
Vaughn James JChief Commercial Officer2015-12-07Sell2,00024,076$29.3358.66-2.1524,076 (Direct)
Cole G BradleyCOO2015-11-10Sell4,00030,326$26.03104.1210.2630,326 (Direct)
Cole G BradleyCOO2015-09-09Sell9,66430,326$25.35244.9813.2130,326 (Direct)
Cole G BradleyCOO2015-07-07Sell4,00030,326$27.53110.124.2530,326 (Direct)
Cole G BradleyCOO2015-06-09Sell4,00030,326$26.24104.969.3830,326 (Direct)
Cole G BradleyCOO2015-05-12Sell4,00029,658$27.54110.164.2129,658 (Direct)
Popovits Kimberly JPresident and CEO2015-04-13Sell3,000203,001$31.2893.84-8.25Link
Cole G BradleyCOO2015-04-07Sell4,00029,658$30.44121.76-5.7229,658 (Direct)
Popovits Kimberly JPresident and CEO2015-03-12Sell3,000204,101$31.9195.73-10.06Link
Cole G BradleyCOO2015-03-10Sell4,00029,658$31.84127.36-9.8629,658 (Direct)
Popovits Kimberly JPresident and CEO2015-02-12Sell3,000204,601$29.8689.58-3.88Link
Cole G BradleyCOO2015-02-10Sell4,00021,645$31.37125.48-8.5121,645 (Direct)
LIVINGSTON RANDALL SDirector2015-02-02Sell1,0006,149$31.9331.93-10.126,149 (Direct)
Popovits Kimberly JPresident and CEO2015-01-12Sell3,000204,601$33.46100.38-14.23Link
Popovits Kimberly JPresident and CEO2014-12-11Sell3,000204,601$32.9998.97-13Link
Cole G BradleyCOO2014-12-08Sell4,33621,645$32.52141.01-11.7521,645 (Direct)
Popovits Kimberly JPresident and CEO2014-11-12Sell4,300205,201$34.82149.73-17.58Link
Cole G BradleyCOO2014-11-10Sell4,00022,891$35.35141.4-18.8122,891 (Direct)
LIVINGSTON RANDALL SDirector2014-11-03Sell3,0006,149$36.24108.72-20.816,149 (Direct)
Popovits Kimberly JPresident and CEO2014-10-13Sell3,000205,201$30.7892.34-6.76Link
Cole G BradleyCOO2014-10-08Sell4,00022,891$28.77115.08-0.2422,891 (Direct)
Popovits Kimberly JPresident and CEO2014-09-11Sell3,000205,201$29.8289.46-3.76Link
Cole G BradleyCOO2014-09-08Sell4,70022,891$30.09141.42-4.6222,891 (Direct)
Shak StevenEVP of R&D2014-08-14Sell13,348312,298$27.36365.24.9312,298 (Direct)
Popovits Kimberly JPresident and CEO2014-08-12Sell3,000205,201$26.0778.2110.09Link
Popovits Kimberly JPresident and CEO2014-07-14Sell3,000205,201$26.5979.777.94Link
Cole G BradleyCOO2014-07-08Sell2,30022,891$27.0562.226.122,891 (Direct)
Shak StevenEVP of R&D2014-07-01Sell7,000312,298$271896.3312,298 (Direct)
Shak StevenEVP of R&D2014-06-12Sell7,000312,298$26.73187.117.37312,298 (Direct)
Popovits Kimberly JPresident and CEO2014-06-12Sell3,000271,289$26.178.39.96Link
Schorno Dean LCFO2014-06-10Sell4,00030,673$27.62110.483.9124,524 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2014-06-09Sell2,33722,891$27.2963.785.1722,891 (Direct)
Popovits Kimberly JPresident and CEO2014-05-12Sell3,000270,579$26.5479.628.14Link
Schorno Dean LCFO2014-05-09Sell4,00029,963$25.09100.3614.3923,814 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Shak StevenEVP of R&D2014-04-14Sell7,000311,588$26.25183.759.33311,588 (Direct)
Cole G BradleyCOO2014-04-08Sell3,00022,226$27816.322,226 (Direct)
Shak StevenEVP of R&D2014-03-14Sell7,000311,588$28.36198.521.2311,588 (Direct)
Cole G BradleyCOO2014-03-10Sell3,00022,226$27.7683.283.3922,226 (Direct)
HIBBS KATHY LSVP & General Counsel2014-02-18Sell1,31215,787$27.8836.582.9415,787 (Direct)
Shak StevenEVP of R&D2014-02-14Sell7,000311,588$27.38191.664.82311,588 (Direct)
Cole G BradleyCOO2014-02-10Sell3,00024,789$27816.324,789 (Direct)
Shak StevenEVP of R&D2014-01-15Sell7,000308,283$31.51220.57-8.92308,283 (Direct)
Popovits Kimberly JPresident and CEO2014-01-13Sell2,500261,190$3075-4.33Link
Cole G BradleyCOO2014-01-08Sell3,00018,369$28.1784.511.8818,369 (Direct)
Shak StevenEVP of R&D & CMO2013-12-17Sell14,000308,283$29.57413.98-2.94308,283 (Direct)
Popovits Kimberly JPresident and CEO2013-12-12Sell2,5000$30.6876.7-6.45Link
Schorno Dean LCFO2013-12-09Sell3,00027,706$33.2599.75-13.6821,557 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
LIVINGSTON RANDALL SDirector2013-12-02Sell1,0006,149$34.9234.92-17.816,149 (Direct)
Popovits Kimberly JPresident and CEO2013-11-13Sell5,0000$34.58172.9-17Link
Schorno Dean LCFO2013-11-08Sell3,00027,585$33.36100.08-13.9721,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-11-06Sell2,86818,135$31.3890-8.5418,135 (Direct)
Shak StevenEVP of R&D & CMO2013-10-15Sell5,000308,283$29.67148.35-3.27308,283 (Direct)
Popovits Kimberly JPresident and CEO2013-10-10Sell2,5000$3075-4.33Link
Cole G BradleyCOO2013-10-09Sell2,50018,135$29.9574.88-4.1718,135 (Direct)
Shak StevenEVP of R&D & CMO2013-09-18Sell5,000313,283$33.73168.65-14.91313,283 (Direct)
Popovits Kimberly JPresident and CEO2013-09-12Sell2,5000$34.3185.78-16.35Link
Cole G BradleyCOO2013-09-09Sell2,50018,135$32.5381.33-11.7718,135 (Direct)
Schorno Dean LCFO2013-09-06Sell4,00027,585$32.9131.6-12.7721,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
LIVINGSTON RANDALL SDirector2013-09-03Sell1,0006,149$31.4931.49-8.866,149 (Direct)
Shak StevenEVP of R&D & CMO2013-08-14Sell5,000318,283$32.98164.9-12.98318,283 (Direct)
Popovits Kimberly JPresident and CEO2013-08-12Sell2,5000$33.0382.58-13.11Link
Schorno Dean LCFO2013-08-09Sell4,00027,585$33.15132.6-13.4221,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Schorno Dean LCFO2013-08-09Sell4,00027,585$33.15132.6-13.4221,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-08-07Sell2,50019,135$33.6684.15-14.7419,135 (Direct)
Shak StevenEVP of R&D & CMO2013-07-23Sell5,000318,283$35.33176.65-18.77318,283 (Direct)
Popovits Kimberly JPresident and CEO2013-07-12Sell5,0000$34.61173.05-17.08Link
Schorno Dean LCFO2013-07-09Sell4,00023,985$33.81135.24-15.1117,836 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Schorno Dean LCFO2013-07-09Sell4,00023,985$33.81135.24-15.1117,836 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-07-08Sell2,50013,135$33.3383.33-13.8913,135 (Direct)
Shak StevenEVP of R&D & CMO2013-06-18Sell5,000323,283$33.52167.6-14.38323,283 (Direct)
Popovits Kimberly JPresident and CEO2013-06-12Sell5,0000$35.68178.4-19.56Link
Schorno Dean LCFO2013-06-10Sell4,00023,985$35.88143.52-20.0117,836 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-06-05Sell2,50013,135$36.4791.18-21.3113,135 (Direct)
BAKER FELIXDirector, 10% Owner2013-06-05Buy381,43213,288,253$36.1613792.58-20.63
1,730,777 (See Footnote)
11,241,654 (See Footnotes(F7,F14,F15))
301,215 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
BAKER FELIXDirector, 10% Owner2013-06-03Buy179,58312,906,821$36.716592.49-21.82
1,690,226 (See Footnote)
10,909,066 (See Footnotes(F7,F14,F15))
292,922 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
LIVINGSTON RANDALL SDirector2013-06-03Sell1,0006,149$36.436.4-21.156,149 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-29Buy121,26612,727,238$36.894473.5-22.2
1,671,081 (See Footnote)
10,752,532 (See Footnotes(F7,F14,F15))
289,018 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
BAKER FELIXDirector, 10% Owner2013-05-24Buy79,41714,257,273$36.932932.87-22.29
1,651,301 (See Footnote)
10,646,920 (See Footnotes(F7,F17,F18))
286,384 (See Footnotes(F9,F17,F18))
1,658,061 (See Footnotes(F5,F17,F18))
14,607 (See Footnote(F9,F17,F18))
HIBBS KATHY LSVP & General Counsel2013-05-22Sell1,0007,087$37.4837.48-23.437,087 (Direct)
Shak StevenEVP of R&D & CMO2013-05-21Sell5,000327,380$37.19185.95-22.83327,380 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-16Buy71,43912,526,555$36.452603.95-21.26
1,649,473 (See Footnote)
10,577,816 (See Footnotes(F7,F14,F15))
284,659 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
LIVINGSTON RANDALL SDirector2013-05-15Sell1,3376,149$35.8347.9-19.96,149 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-14Buy240,42614,093,759$34.348256.23-16.42
1,638,643 (See Footnote)
10,515,769 (See Footnotes(F7,F17,F18))
283,112 (See Footnotes(F9,F17,F18))
1,641,628 (See Footnotes(F5,F17,F18))
14,607 (See Footnote(F9,F17,F18))
HIBBS KATHY LSVP & General Counsel2013-05-13Sell1,2507,087$34.4243.03-16.627,087 (Direct)
Popovits Kimberly JPresident and CEO2013-05-13Sell5,0000$34.7173.5-17.29Link
Schorno Dean LCFO2013-05-09Sell4,00023,241$36.02144.08-20.3217,092 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-05-08Sell2,50012,540$35.9989.98-20.2612,540 (Direct)
Popovits Kimberly JPresident and CEO2013-04-23Sell2,5000$3075-4.33Link
Cole G BradleyCOO2013-04-03Sell2,50012,540$27.7969.483.2712,540 (Direct)
Cole G BradleyCOO2013-03-06Sell2,50012,540$28.5771.430.4612,540 (Direct)
BAKER FELIXDirector, 10% Owner2013-02-21Buy49,08512,211,834$27.781363.583.31
1,614,513 (See Footnote)
10,306,239 (See Footnotes(F7,F14,F15))
277,189 (See Footnotes(F9,F14,F15))
13,893 (See Footnote(F9,F14,F15))
HIBBS KATHY LSVP & General Counsel2013-02-20Sell2,7167,087$28.1376.42.037,087 (Direct)
MYERS WOODROW A JRDirector2013-02-14Sell41,2502,891$28.41171.51.062,891 (Direct)
BAKER FELIXDirector, 10% Owner2013-02-14Buy52,00012,162,749$28.481480.960.77
1,609,152 (See Footnote)
10,263,580 (See Footnotes(F7,F14,F15))
276,124 (See Footnotes(F9,F14,F15))
13,893 (See Footnote(F9,F14,F15))
BAKER FELIXDirector, 10% Owner2013-02-11Buy116,36012,110,749$28.153275.531.95
1,603,265 (See Footnote)
10,218,600 (See Footnotes(F7,F14,F15))
274,991 (See Footnotes(F9,F14,F15))
13,893 (See Footnote(F9,F14,F15))
Cole G BradleyCOO2013-02-06Sell2,50014,085$28.0370.082.3914,085 (Direct)
LIVINGSTON RANDALL SDirector2013-01-28Sell2,0006,149$28.7757.54-0.246,149 (Direct)
Schorno Dean LCFO2013-01-09Sell2,62523,504$2873.52.517,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-01-09Sell2,50014,085$27.8869.72.9414,085 (Direct)
Shak StevenEVP of R&D & CMO2012-12-18Sell5,000333,768$27.74138.73.46333,768 (Direct)
Popovits Kimberly JPresident and CEO2012-12-13Sell5,0000$27.79138.953.27Link
Schorno Dean LCFO2012-12-11Sell3,00023,504$28842.517,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
LIVINGSTON RANDALL SDirector2012-11-26Sell2,0006,149$27.8455.683.096,149 (Direct)
BAKER FELIXDirector, 10% Owner2012-11-21Buy229,30012,263,857$26.836152.126.97288 (Direct)
271,800 (See Footnote)
1,589,551 (See Footnotes(F5,F14,F15))
10,117,174 (See Footnotes(F7,F14,F15))
271,806 (See Footnotes(F9,F14,F15))
13,238 (See Footnote(F9,F14,F15))
Shak StevenEVP of R&D & CMO2012-11-20Sell5,000338,768$26.94134.76.53338,768 (Direct)
COLELLA SAMUEL DDirector2012-11-20Sell30,61636,437$26.89823.266.7336,437 (Direct)
0 (Versant Venture Capital I, L.P.)
0 (Versant Side Fund I, L.P.)
0 (Versant Affiliates Fund I-A, L.P.)
0 (Versant Affiliates Fund I-B, L.P.)
BAKER FELIXDirector, 10% Owner2012-11-14Buy103,16713,526$27.322818.525.05288 (Direct)
13,238 (See Footnote)
Popovits Kimberly JPresident and CEO2012-11-14Sell5,0000$27.24136.25.36Link
BAKER FELIXDirector, 10% Owner2012-11-13Buy823,77213,526$27.8122909.13.2288 (Direct)
13,238 (See Footnote)
Schorno Dean LCFO2012-11-12Sell3,00023,504$28842.517,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2012-11-08Sell2,50014,085$28.6271.550.2814,085 (Direct)
Popovits Kimberly JPresident and CEO2012-10-16Sell10,0000$33.08330.8-13.24Link
Shak StevenEVP of R&D & CMO2012-10-16Sell5,000343,768$35.25176.25-18.58343,768 (Direct)
Schorno Dean LCFO2012-10-12Sell3,00023,504$33.79101.37-15.0617,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
HIBBS KATHY LSVP & General Counsel2012-10-11Sell1,25011,367$33.7842.23-15.0411,367 (Direct)
Cole G BradleyCOO2012-10-09Sell2,50014,085$34.887-17.5314,085 (Direct)
Shak StevenEVP of R&D & CMO2012-09-18Sell5,000348,768$33.76168.8-14.99348,768 (Direct)
Popovits Kimberly JPresident and CEO2012-09-13Sell5,0000$31.69158.45-9.44Link
Cole G BradleyCOO2012-09-06Sell2,50014,085$35.0187.53-18.0214,085 (Direct)
MYERS WOODROW A JRDirector2012-08-21Sell16,5002,236$35.2580.8-18.472,236 (Direct)
Shak StevenEVP of R&D & CMO2012-08-20Sell5,000353,768$34.99174.95-17.98353,768 (Direct)
Popovits Kimberly JPresident and CEO2012-08-13Sell10,0000$34.72347.2-17.34Link
Cole G BradleyCOO2012-08-08Sell2,50014,085$30.4976.23-5.8714,085 (Direct)
LIVINGSTON RANDALL SDirector2012-07-26Sell2,0006,149$35.971.8-20.066,149 (Direct)
Shak StevenChief Medical Officer2012-07-24Sell5,000358,768$34.24171.2-16.18358,768 (Direct)
Popovits Kimberly JPresident and CEO2012-07-13Sell7,1000$34.76246.8-17.43Link
Scott Randal WCEO, InVitae Corporation*2012-07-11Sell30,0000$35.391061.7-18.9Link
Cole G BradleyCOO2012-07-05Sell2,50014,085$35.9589.88-20.1714,085 (Direct)
Shak StevenChief Medical Officer2012-06-25Sell5,000363,768$33.25166.25-13.68363,768 (Direct)
Popovits Kimberly JPresident and CEO2012-06-13Sell5,0000$33.36166.8-13.97Link
Popovits Kimberly JPresident and CEO2012-06-13Sell5,0000$33.36166.8-13.97Link
Scott Randal WCEO, InVitae Corporation*2012-06-12Sell30,0000$33.541006.2-14.43Link
Cole G BradleyCOO2012-06-06Sell2,50013,507$33.9784.93-15.5113,507 (Direct)
Shak StevenChief Medical Officer2012-05-24Sell5,000367,849$33.8169-15.09367,849 (Direct)
BAKER JULIANDirector, 10% Owner2012-05-22Buy167,4061,488,539$32.265400.52-11.04
1,488,539 (See Footnote)
COLELLA SAMUEL DDirector2012-05-18Sell26,294664,113$33.03868.49-13.1126,891 (Direct)
582,174 (Versant Venture Capital I, L.P.)
11,210 (Versant Side Fund I, L.P.)
13,222 (Colella Family Partners, L.P.)
10,414 (Versant Affiliates Fund I-A, L.P.)
20,202 (Versant Affiliates Fund I-B, L.P.)
BAKER JULIANDirector, 10% Owner2012-05-16Buy376,0591,488,539$33.8812740.88-15.29
1,488,539 (See Footnote)
Popovits Kimberly JPresident and CEO2012-05-16Sell10,0000$34.23342.3-16.16Link
Schorno Dean LCFO2012-05-15Sell1,00023,504$33.6933.69-14.8117,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
BAKER JULIANDirector, 10% Owner2012-05-11Buy114,8881,488,539$29.963442.04-4.21
1,488,539 (See Footnote)
Scott Randal WCEO, InVitae Corporation*2012-05-11Sell30,0000$30.22906.6-5.03Link
Cole G BradleyCOO2012-05-09Sell2,50013,507$28.8772.18-0.5913,507 (Direct)
BAKER JULIANDirector, 10% Owner2012-05-08Buy195,70113,238$28.455567.690.88
13,238 (See Footnote)
LIVINGSTON RANDALL SDirector2012-04-26Sell2,0006,149$28.2156.421.746,149 (Direct)
Shak StevenChief Medical Officer2012-04-24Sell5,000372,849$27.93139.652.76372,849 (Direct)
Popovits Kimberly JPresident and CEO2012-04-23Sell5,0000$27.79138.953.27Link
Schorno Dean LCFO2012-04-16Sell1,00024,504$27.9827.982.5718,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WCEO, InVitae Corporation*2012-04-11Sell20,0000$28.59571.80.38Link
Cole G BradleyCOO2012-04-04Sell2,50013,507$30.2875.7-5.2213,507 (Direct)
Shak StevenChief Medical Officer2012-03-22Sell5,000377,849$30.08150.4-4.59377,849 (Direct)
Popovits Kimberly JPresident and CEO2012-03-22Sell5,0000$30.07150.35-4.56Link
Popovits Kimberly JPresident and CEO2012-03-22Sell5,0000$30.07150.35-4.56Link
Shak StevenChief Medical Officer2012-03-22Sell5,000377,849$30.08150.4-4.59377,849 (Direct)
Schorno Dean LCFO2012-03-15Sell1,00025,504$31.0831.08-7.6619,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WCEO, InVitae Corporation2012-03-13Sell30,0000$31.05931.5-7.57Link
Cole G BradleyCOO2012-03-08Sell2,50013,507$29.9474.85-4.1413,507 (Direct)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-03-08Buy4,5081,484,977$30.11135.74-4.68
1,484,977 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-03-08Buy1,099227,840$30.1133.09-4.68
227,840 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-03-08Buy41,5848,255,421$30.111252.09-4.68
8,255,421 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-03-05Buy261,7618,213,837$29.817803.1-3.72
8,213,837 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-03-05Buy6,923226,741$29.81206.37-3.72
226,741 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-03-05Buy31,3321,480,469$29.81934.01-3.72
1,480,469 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-29Buy6,476219,818$29.06188.19-1.24
219,818 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-29Buy245,0317,952,076$29.067120.6-1.24
7,952,076 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-29Buy29,7561,449,137$29.06864.71-1.24
1,449,137 (Through Partnership)
Popovits Kimberly JPresident and CEO2012-02-24Sell10,0000$28.52850.7Link
Shak StevenChief Medical Officer2012-02-23Sell5,000382,849$28.14140.71.99382,849 (Direct)
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-23Buy114,5187,707,045$28.063213.382.28
7,707,045 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-23Buy3,022213,342$28.0684.82.28
213,342 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-23Buy13,3321,419,381$28.06374.12.28
1,419,381 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-16Buy33,1851,406,049$29.34973.65-2.18
1,406,049 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-16Buy7,213210,320$29.37211.85-2.28
210,320 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-16Buy272,9097,592,527$29.378015.34-2.28
7,592,527 (Through Partnership)
Schorno Dean LCFO2012-02-15Sell1,00026,504$28.7628.76-0.2120,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Schorno Dean LCFO2012-02-15Sell75526,749$28.7621.71-0.2120,600 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WExecutive Chairman2012-02-10Sell20,0000$26.18523.69.63Link
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-10Buy417,9157,319,618$26.3611016.248.88
7,319,618 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-10Buy11,043203,107$26.36291.098.88
203,107 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-10Buy66,5831,372,864$26.361755.138.88
1,372,864 (Through Partnership)
Scott Randal WExecutive Chairman2012-02-10Sell20,0000$26.18523.69.63Link
Cole G BradleyCOO2012-02-08Sell2,50014,450$26.4766.188.4214,450 (Direct)
LIVINGSTON RANDALL SDirector2012-01-26Sell2,0006,149$27.5155.024.336,149 (Direct)
Popovits Kimberly JPresident and CEO2012-01-25Sell5,0000$26.42132.18.63Link
Popovits Kimberly JPresident and CEO2012-01-24Sell5,0000$26.62133.17.81Link
Shak StevenChief Medical Officer2012-01-24Sell5,000382,778$26.74133.77.33382,778 (Direct)
Schorno Dean LCFO2012-01-17Sell1,00024,049$28282.517,900 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2012-01-12Sell2,5007,750$27.5468.854.217,750 (Direct)
Scott Randal WExecutive Chairman2012-01-11Sell20,0000$27.46549.24.52Link
Shak StevenChief Medical Officer2011-12-22Sell5,000387,778$26.03130.1510.26387,778 (Direct)
Scott Randal WExecutive Chairman2011-12-13Sell20,0000$27.29545.85.17Link
Cole G BradleyCOO2011-12-06Sell2,5007,750$28.5971.480.387,750 (Direct)
14159 capital (GP), LLCDirector, 10% Owner2011-12-05Buy3,152192,064$28.1288.632.06
192,064 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-12-05Buy45,9771,306,281$27.661271.723.76
1,306,281 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-12-05Buy117,7516,901,703$28.123311.162.06
6,901,703 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-23Buy5,5311,260,304$25.91143.3110.77
1,260,304 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-23Buy5,750188,912$25.94149.1610.64
188,912 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-23Buy193,7396,783,952$25.915019.7810.77
6,783,952 (Through Partnership)
Shak StevenChief Medical Officer2011-11-22Sell5,000392,778$26.07130.3510.09392,778 (Direct)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-16Buy64,5976,590,213$27.711789.983.57
6,590,213 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-16Buy2,550183,162$27.7170.663.57
183,162 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-16Buy4581,254,773$27.3512.534.94
1,254,773 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-14Buy10,106180,612$27.23275.195.4
180,612 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-14Buy249,3756,525,616$27.236790.485.4
6,525,616 (Through Partnership)
Scott Randal WExecutive Chairman2011-11-11Sell20,0000$27.24544.85.36Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-09Buy5421,254,315$26.7914.527.13
1,254,315 (Through Partnership)
Cole G BradleyCOO2011-11-08Sell2,5007,750$26.666.57.897,750 (Direct)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-07Buy209,5126,276,241$25.945434.7410.64
6,276,241 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-07Buy8,847170,506$25.94229.4910.64
170,506 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-03Buy1201,253,773$24.482.9417.24
1,253,773 (Through Partnership)
LIVINGSTON RANDALL SDirector2011-10-27Sell2,0006,149$22.0844.1629.986,149 (Direct)
Shak StevenChief Medical Officer2011-10-24Sell5,000392,778$21.76108.831.89392,778 (Direct)
Scott Randal WExecutive Chairman2011-10-11Sell20,0000$22.83456.625.71Link
Cole G BradleyCOO2011-10-06Sell5,0007,750$22.31111.5528.647,750 (Direct)
Scott Randal WExecutive Chairman2011-09-13Sell20,0000$20.81416.237.91Link
Cole G BradleyCOO2011-09-06Sell2,5007,750$22.0855.229.987,750 (Direct)
Shak StevenChief Medical Officer2011-08-24Sell5,000392,778$23.02115.124.67392,778 (Direct)
Scott Randal WExecutive Chairman2011-08-11Sell20,0000$24.44488.817.43Link
Cole G BradleyCOO2011-08-08Sell2,5007,750$25.2663.1513.627,750 (Direct)
Cole G BradleyCOO2011-08-08Sell2,5007,750$25.2663.1513.627,750 (Direct)
LIVINGSTON RANDALL SDirector2011-07-27Sell2,0006,149$26.4552.98.516,149 (Direct)
Shak StevenChief Medical Officer2011-07-25Sell5,000392,778$27.61138.053.95392,778 (Direct)
Scott Randal WExecutive Chairman2011-07-12Sell20,0001,503,444$27.36547.24.91,491,146 (Direct)
12,298 (By Morgan Stanley DW Inc. as Custodian for Randal W. Scott, IRA)
Cole G BradleyCOO2011-07-06Sell5,0007,750$27.74138.73.467,750 (Direct)
Shak StevenChief Medical Officer2011-06-23Sell5,000392,778$27.12135.65.83392,778 (Direct)
Schorno Dean LCFO2011-06-15Sell1,00025,049$25.9125.9110.7718,900 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WExecutive Chairman2011-06-13Sell20,0001,523,444$25.69513.811.721,511,146 (Direct)
12,298 (By Morgan Stanley DW Inc. as Custodian for Randal W. Scott, IRA)
Baker Bros. Capital (GP), LLCDirector, 10% Owner2011-06-09Buy119194,415$26.193.129.58
194,415 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-06-09Buy4,388161,659$26.19114.929.58
161,659 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-06-09Buy203,6526,059,449$26.25335.689.54
6,059,449 (Through Partnership)
Cole G BradleyCOO2011-06-06Sell2,5007,750$26.1865.459.637,750 (Direct)
14159 capital (GP), LLCDirector, 10% Owner2011-06-01Buy4,631157,271$27.34126.614.97
157,271 (Through Partnership)
Baker Bros. Capital (GP), LLCDirector, 10% Owner2011-06-01Buy112194,296$27.353.064.94
194,296 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-06-01Buy181,6935,855,797$27.354969.34.94
5,855,797 (Through Partnership)
Shak StevenChief Medical Officer2011-05-25Sell5,000392,778$25.55127.7512.33392,778 (Direct)
Schorno Dean LCFO2011-05-12Sell1,00026,049$26.4826.488.3819,900 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WExecutive Chairman2011-05-11Sell20,0000$26.66533.27.65Link
Cole G BradleyCOO2011-05-09Sell2,5007,750$25.9364.8310.687,750 (Direct)
LIVINGSTON RANDALL SDirector2011-04-27Sell2,0000$26.0452.0810.22Link
Shak StevenChief Medical Officer2011-04-25Sell5,0000$25.38126.913.08Link
Popovits Kimberly JPresident and CEO2011-04-15Sell8,0000$25.49203.9212.59Link
Schorno Dean LCFO2011-04-14Sell1,0000$25.3225.3213.35Link
Scott Randal WExecutive Chairman2011-04-12Sell20,0000$25.96519.210.55Link
Cole G BradleyCOO2011-04-06Sell5,0000$26.91134.556.65Link
Shak StevenChief Medical Officer2011-03-24Sell5,0000$24.45122.2517.38Link
Popovits Kimberly JPresident and CEO2011-03-15Sell8,0000$24.29194.3218.16Link
Schorno Dean LCFO2011-03-15Sell1,0000$23.7923.7920.64Link
Popovits Kimberly JPresident and CEO2011-03-15Sell8,0000$24.29194.3218.16Link
Scott Randal WExecutive Chairman2011-03-11Sell20,0000$25.62512.412.02Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-03-10Buy70,8560$26.031844.3810.26Link
Cole G BradleyCOO2011-03-08Sell2,5000$25.2363.0813.75Link
14159 capital (GP), LLCDirector, 10% Owner2011-03-08Buy9,6480$25.06241.7814.53Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-03-08Buy349,5660$25.068760.1214.53Link
COLELLA SAMUEL DDirector2011-03-03Sell34,3200$25.45873.4412.77Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-03-02Buy160,3370$25.694119.0611.72Link
14159 capital (GP), LLCDirector, 10% Owner2011-03-02Buy4,4260$25.69113.711.72Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-25Buy158,3550$23.393703.9222.7Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-25Buy4,3700$23.39102.2122.7Link
Shak StevenChief Medical Officer2011-02-24Sell5,0000$23.27116.3523.33Link
Schorno Dean LCFO2011-02-15Sell1,0000$22.5122.5127.5Link
Popovits Kimberly JPresident and CEO2011-02-15Sell8,0000$22.51180.0827.5Link
Scott Randal WExecutive Chairman2011-02-11Sell20,0000$22.244429.28Link
Popovits Kimberly JPresident and CEO2011-01-18Sell8,0000$21.15169.235.7Link
Popovits Kimberly JPresident and CEO2011-01-18Sell8,000309,424$21.15169.235.7Link
Schorno Dean LCFO2011-01-13Sell1,27626,149$21.0626.8736.28Link
Scott Randal WExecutive Chairman2011-01-11Sell20,0001,642,410$21.73434.632.08Link
Cole G BradleyCOO2011-01-06Sell5,0001,000$22.13110.6529.69Link
Popovits Kimberly JPresident and CEO2010-12-16Sell8,000310,624$22.71181.6826.38Link
Scott Randal WExecutive Chairman2010-12-13Sell20,0001,696,410$22.46449.227.78Link
Cole G BradleyCOO & CFO2010-12-13Sell2,5001,000$22.6456.626.77Link
Popovits Kimberly JPresident and CEO2010-11-16Sell8,000310,624$17.514064Link
Cole G BradleyCOO & CFO2010-11-11Sell2,5001,000$18.0445.159.09Link
Scott Randal WExecutive Chairman2010-11-11Sell20,0001,666,410$18.27365.457.09Link
Scott Randal WExecutive Chairman2010-10-12Sell20,0001,686,410$13.95279105.73Link
Popovits Kimberly JPresident and CEO2010-09-15Sell7,734310,624$15.1116.7890.07Link
Scott Randal WExecutive Chairman2010-09-13Sell20,0001,706,410$14.87297.493.01Link
Cole G BradleyCOO & CFO2010-09-13Sell2,5001,000$15.0137.5391.21Link
14159 capital (GP), LLCDirector, 10% Owner2010-09-09Buy145134,196$14.812.1593.79Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-09-09Buy5,2614,934,990$14.8177.9293.79Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-09-02Buy65,4664,929,729$14.46946.6498.48Link
14159 capital (GP), LLCDirector, 10% Owner2010-09-02Buy1,807134,051$14.4626.1398.48Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-30Buy3,415132,244$14.3749.0799.72Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-30Buy123,7114,864,263$14.371777.7399.72Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-23Buy150,4694,740,552$14.522184.8197.66Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-23Buy4,153128,829$14.5260.397.66Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-18Buy530124,676$14.997.9491.46Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-18Buy19,1874,590,083$14.99287.6191.46Link
Popovits Kimberly JPresident and CEO2010-08-17Sell8,000288,116$15.07120.5690.44Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-13Buy2,924124,146$14.8543.4293.27Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-13Buy105,9104,570,896$14.851572.7693.27Link
Cole G BradleyCOO & CFO2010-08-12Sell2,5001,000$1537.591.33Link
Scott Randal WExecutive Chairman2010-08-11Sell20,0001,726,410$14.71294.295.11Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-10Buy164,2424,464,986$14.612399.5896.44Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-10Buy4,533121,222$14.6166.2396.44Link
Baker JoffreChief Scientific Officer2010-08-09Sell4,629163,088$14.7568.2894.58Link
Scott Randal WExecutive Chairman2010-07-13Sell20,0001,746,410$12.81256.2124.04Link
Baker JoffreChief Scientific Officer2010-07-07Sell4,629167,717$13.0560.41119.92Link
Scott Randal WExecutive Chairman2010-06-11Sell20,0001,766,410$14.15283102.83Link
Baker JoffreChief Scientific Officer2010-06-10Sell4,629172,346$14.0565.04104.27Link
Popovits Kimberly JPresident and CEO2010-05-17Sell8,000310,624$15.78126.2481.88Link
Cole G BradleyCOO & CFO2010-05-12Sell2,5001,000$15.8739.6880.84Link
Scott Randal WExecutive Chairman2010-05-11Sell20,0001,776,410$15.61312.283.86Link
Baker JoffreChief Scientific Officer2010-05-10Sell4,629176,975$15.5171.885.04Link
Scott Randal WExecutive Chairman2010-04-13Sell20,0001,796,410$16.87337.470.12Link
Cole G BradleyCOO & CFO2010-04-12Sell5,0001,000$16.984.569.82Link
Baker JoffreChief Scientific Officer2010-04-12Sell4,629181,604$16.8878.1470.02Link
Popovits Kimberly JPresident and CEO2010-03-16Sell20,000288,116$19.4538947.56Link
Scott Randal WExecutive Chairman2010-03-11Sell20,0001,800,646$19.338648.7Link
Cole G BradleyCOO & CFO2010-03-11Sell2,5001,000$19.3948.4848.01Link
COLELLA SAMUEL DDirector2010-03-10Sell106,70085,050$19.452075.3247.56Link
Baker JoffreChief Scientific Officer2010-03-08Sell4,629150,120$19.8391.7944.73Link
14159 capital (GP), LLCDirector, 10% Owner2010-02-19Buy3,645116,689$17.0562.1568.33Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-02-19Buy132,0704,300,744$17.052251.7968.33Link
Scott Randal WExecutive Chairman2010-02-11Sell20,0001,830,646$17.23344.666.57Link
Cole G BradleyCOO & CFO2010-02-11Sell2,5001,000$17.5143.7863.91Link
14159 capital (GP), LLCDirector, 10% Owner2010-02-10Buy9,437113,044$17.01160.5268.72Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-02-10Buy341,8544,168,674$17.015814.9468.72Link
Baker JoffreChief Scientific Officer2010-02-09Sell4,629145,491$17.1479.3467.44Link
Cole G BradleyCOO & CFO2010-01-12Sell5,0001,000$17.2586.2566.38Link
Baker JoffreChief Scientific Officer2010-01-11Sell4,629150,120$17.4780.8764.28Link
Shak StevenChief Medical Officer2009-12-21Sell5,000388,278$20.12100.642.64Link
Popovits Kimberly JPresident and CEO2009-12-15Sell5,000313,506$20.39101.9540.76Link
Cole G BradleyCOO & CFO2009-12-14Sell2,0001,000$20.4240.8440.55Link
Scott Randal WExecutive Chairman2009-12-11Sell12,0001,880,646$20.24242.8841.8Link
Baker JoffreChief Scientific Officer2009-12-08Sell4,629154,749$20.2693.7841.66Link
Popovits Kimberly JPresident and CEO2009-11-17Sell20,000318,506$19.21384.249.4Link
Cole G BradleyCOO & CFO2009-11-12Sell6653,000$20.0413.3343.21Link
Scott Randal WExecutive Chairman2009-11-11Sell12,0001,892,646$19.99239.8843.57Link
Baker JoffreChief Scientific Officer2009-11-10Sell4,629159,378$2092.5843.5Link
Shak StevenChief Medical Officer2009-10-20Sell5,000393,278$20.65103.2538.98Link
Popovits Kimberly JPresident and CEO2009-10-15Sell5,000338,506$20.42102.140.55Link
Scott Randal WExecutive Chairman2009-10-13Sell12,0001,904,646$20.66247.9238.92Link
Baker JoffreChief Scientific Officer2009-10-07Sell4,629164,007$21.179835.57Link
Shak StevenChief Medical Officer2009-09-22Sell5,000398,278$21.13105.6535.83Link
Popovits Kimberly JPresident and CEO2009-09-15Sell5,000343,506$20.73103.6538.45Link
Scott Randal WExecutive Chairman2009-09-11Sell12,0001,916,646$20.67248.0438.85Link
Baker JoffreChief Scientific Officer2009-09-04Sell4,629168,636$20.1293.1442.64Link
Shak StevenChief Medical Officer2009-08-25Sell5,000403,278$20.77103.8538.18Link
14159 capital (GP), LLCDirector, 10% Owner2009-08-17Buy1,839103,607$19.9836.7443.64Link
Baker Brothers Life Sciences CDirector, 10% Owner2009-08-17Buy66,6303,826,820$19.981331.2743.64Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-17Buy34194,184$19.980.6843.64Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-17Buy11,6571,253,653$19.98232.9143.64Link
Popovits Kimberly JPresident and CEO2009-08-17Sell5,000348,506$19.5397.6546.95Link
Cole G BradleyCOO & CFO2009-08-13Sell5,0003,000$2010043.5Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-12Buy15,8771,241,996$19.49309.4447.26Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-12Buy45194,150$19.50.8847.18Link
Baker Brothers Life Sciences CDirector, 10% Owner2009-08-12Buy90,7543,760,190$19.491768.847.26Link
14159 capital (GP), LLCDirector, 10% Owner2009-08-12Buy2,508101,768$19.4948.8847.26Link
Scott Randal WExecutive Chairman2009-08-11Sell12,0001,928,646$19.42233.0447.79Link
Baker JoffreChief Scientific Officer2009-08-10Sell4,629173,265$19.4890.1747.33Link
Baker JoffreChief Scientific Officer2009-07-08Sell4,629177,894$16.0174.1179.26
Baker JoffreChief Scientific Officer2009-07-08Sell4,629177,894$16.0174.1179.26
Scott Randal WExecutive Chairman2009-06-11Sell6,0001,940,646$18.27109.6257.09
Baker JoffreChief Scientific Officer2009-06-08Sell4,629182,523$17.6981.8962.24
Shak StevenChief Medical Officer2009-05-26Sell5,000408,278$199551.05
14159 capital (GP), LLCDirector, 10% Owner2009-05-21Buy1,10899,260$17.9719.9159.71
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-21Buy90194,161$17.971.6259.71
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-21Buy39,7783,669,436$17.97714.8159.71
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-21Buy25194,105$17.970.4559.71
Popovits Kimberly JPresident and CEO2009-05-15Sell5,000353,506$20.12100.642.64
Scott Randal WExecutive Chairman2009-05-12Sell12,0001,946,646$19.46233.5247.48
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-11Buy88194,080$19.551.7246.8
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-11Buy312194,071$19.556.146.8
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-11Buy137,4663,629,658$19.552687.4646.8
14159 capital (GP), LLCDirector, 10% Owner2009-05-11Buy3,82798,152$19.5574.8246.8
Baker JoffreChief Scientific Officer2009-05-08Sell4,629187,152$19.7291.2845.54
Scott Randal WExecutive Chairman2009-04-14Sell12,0001,958,646$25.47305.6412.68
Baker JoffreChief Scientific Officer2009-04-01Sell4,629191,781$25.27116.9713.57
Scott Randal WExecutive Chairman2009-03-11Sell12,0001,970,646$19.4232.847.94
Baker JoffreChief Scientific Officer2009-03-03Sell4,629196,410$19.1388.5550.03
Cole G BradleyCOO & CFO2009-02-17Sell5,0003,000$21.52107.633.36
Baker JoffreChief Scientific Officer2009-02-12Sell4,629201,039$20.695.3639.32
Baker JoffreChief Scientific Officer2009-02-12Sell4,62922,226$20.695.3639.32
Scott Randal WExecutive Chairman, Director2009-02-11Sell12,0001,982,646$20.85250.237.65
Baker JoffreChief Scientific Officer2009-01-12Sell4,62926,855$19.4189.8547.86
Shak StevenChief Medical Officer2008-12-22Sell100413,278$20.172.0242.29
Baker JoffreChief Scientific Officer2008-12-10Sell4,629205,668$19.2589.1149.09
Baker JoffreChief Scientific Officer2008-12-10Sell4,62931,484$19.2589.1149.09
Scott Randal WCEO, Director2008-12-09Sell12,0001,955,298$18.4220.855.98
Baker JoffreChief Scientific Officer2008-11-12Sell4,629210,297$19.8791.9844.44
Baker JoffreChief Scientific Officer2008-11-12Sell4,62936,113$19.8791.9844.44
Scott Randal WCEO, Director2008-11-11Sell12,0001,967,298$20.05240.643.14
Cole G BradleyEVP & CFO2008-11-10Sell10,0004,000$20.17201.742.29
Scott Randal WCEO, Director2008-10-14Sell12,0001,979,298$20.36244.3240.96
Baker JoffreChief Scientific Officer2008-10-01Sell9,25840,742$22.51208.427.5
Shak StevenChief Medical Officer2008-09-24Sell5,000413,378$22.67113.3526.6
Scott Randal WCEO, Director2008-09-16Sell12,0001,991,298$21.79261.4831.71
Shak StevenChief Medical Officer2008-08-26Sell5,000418,378$22.93114.6525.16
Baker JoffreChief Scientific Officer2008-08-26Sell4,629214,926$22.69105.0326.49
Cole G BradleyEVP & CFO2008-08-18Sell9,2984,000$23.67220.0821.25
Popovits Kimberly JPresident and COO2008-08-15Sell25,000358,506$24.2460618.4
Scott Randal WCEO, Director2008-08-12Sell12,0002,003,298$23.76285.1220.79
Scott Randal WCEO, Director2008-07-15Sell12,0002,015,298$2125236.67
Baker JoffreChief Scientific Officer2008-07-01Sell4,629219,555$19.2689.1549.01
Shak StevenChief Medical Officer2008-06-24Sell100423,378$20243.5
Scott Randal WCEO, Director2008-06-10Sell12,0002,027,298$19.92239.0444.08
Baker Brothers Life Sciences CDirector, 10% Owner2008-06-09Buy320,9833,492,192$19.916390.7744.15
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-06-09Buy76,0151,226,119$19.911513.4644.15
14159 capital (GP), LLCDirector, 10% Owner2008-06-09Buy10,29994,325$19.91205.0544.15
Baker JoffreChief Scientific Officer2008-06-02Sell4,629228,813$17.9983.2859.53
Scott Randal WCEO, Director2008-05-13Sell12,0002,039,298$18.7522553.07
Baker JoffreChief Scientific Officer2008-05-08Sell4,629233,442$19.2789.248.94
Scott Randal WCEO, Director2008-04-15Sell12,0002,051,298$17.22206.6466.67
Scott Randal WCEO, Director2008-03-11Sell12,0002,063,298$18.84226.0852.34
Baker JoffreChief Scientific Officer2008-03-05Sell4,629242,700$20.4894.840.14
Shak StevenChief Medical Officer2008-02-26Sell5,000423,478$20.23101.1541.87
Cole G BradleyEVP & CFO2008-02-19Sell9,0008,298$22.58203.2227.1
Scott Randal WCEO, Director2008-02-12Sell12,0002,075,298$23.01276.1224.73
Baker JoffreChief Scientific Officer2008-02-11Sell4,629247,329$22.94106.1925.11
Scott Randal WCEO, Director2008-01-15Sell12,0002,087,298$25.54306.4812.37
Baker JoffreChief Scientific Officer2008-01-02Sell4,629251,958$22.66104.8926.65
Baker JoffreChief Scientific Officer2007-12-03Sell4,6290$23.1106.9324.24
Popovits Kimberly JPresident and COO2007-11-27Sell6,655383,506$22146.4130.45
Scott Randal WCEO, Director2007-11-09Sell12,0002,111,299$23.07276.8424.4
Baker JoffreChief Scientific Officer2007-11-08Sell4,629265,845$23.21107.4423.65
Scott Randal WCEO2007-10-09Sell12,0002,123,299$20.16241.9242.36
Baker JoffreChief Scientific Officer2007-10-01Sell4,629270,474$19.8491.8444.66
Scott Randal WCEO, Director2007-09-11Sell12,0002,135,299$19.7236.445.69
Scott Randal WCEO2007-09-11Sell12,0002,135,299$19.69236.2845.76
Baker JoffreChief Scientific Officer2007-09-10Sell4,629275,103$19.5790.5946.65
Goldberg Michael DDirector2007-08-23Buy5,3505,350$18.76100.3752.99
Scott Randal WCEO2007-08-15Sell12,0002,147,299$19.91238.9244.15
Baker JoffreChief Scientific Officer2007-08-08Sell4,629279,732$19.4489.9947.63
Scott Randal WCEO2007-07-18Sell12,0002,159,299$21.18254.1635.51
Baker JoffreChief Scientific Officer2007-07-02Sell4,629284,361$19.018850.97
Scott Randal WCEO2007-06-19Sell12,0002,171,299$19.16229.9249.79
Baker JoffreChief Scientific Officer2007-06-01Sell4,629288,990$17.5681.2963.44
Baker Bros. Capital (GP), LLCDirector2007-05-30Buy545193,992$16.328.8975.86
Baker Biotech Capital (GP), LLDirector2007-05-30Buy81,1811,150,104$16.321324.8775.86
Baker Brothers Life Sciences CDirector2007-05-30Buy214,0993,171,209$16.323494.175.86
14159 capital (GP), LLCDirector2007-05-30Buy6,80784,026$16.32111.0975.86
14159 capital (GP), LLCDirector2007-05-24Buy16,26177,219$16.59269.7773
Baker Brothers Life Sciences CDirector2007-05-24Buy511,5532,957,110$16.598486.6673
Baker Biotech Capital (GP), LLDirector2007-05-24Buy193,9661,068,923$16.593217.973
Baker Bros. Capital (GP), LLCDirector2007-05-24Buy1,303193,447$16.5921.6273
14159 capital (GP), LLCDirector2007-05-21Buy22,49160,958$15.5348.6185.16
14159 capital (GP), LLCDirector2007-05-21Buy160,958$15.50.0285.16
Baker Brothers Life Sciences CDirector2007-05-21Buy707,4582,445,557$15.510965.685.16
Baker Biotech Capital (GP), LLDirector2007-05-21Buy268,248874,957$15.54157.8485.16
Baker Bros. Capital (GP), LLCDirector2007-05-21Buy1,803192,144$15.527.9585.16
Baker Bros. Capital (GP), LLCDirector2007-05-21Buy1,803192,144$15.527.9585.16
Scott Randal WCEO2007-05-08Sell12,0002,183,299$16.62199.4472.68
Baker JoffreChief Scientific Officer2007-05-08Sell4,629293,619$16.3175.575.97
Scott Randal WCEO2007-04-10Sell12,0002,195,299$17.27207.2466.18
Baker JoffreChief Scientific Officer2007-04-02Sell4,629298,248$17.1679.4367.25
Baker / Tisch Capital (GP), LLDirector2007-03-09Buy3,181193,759$18.2858.1557
Baker Bros. Capital (GP), LLCDirector2007-03-09Buy376190,341$18.286.8757
Baker Biotech Capital (GP), LLDirector2007-03-09Buy62,325606,709$18.281139.357
Baker Brothers Life Sciences CDirector2007-03-09Buy168,5601,738,099$18.283081.2857
14159 capital (GP), LLCDirector2007-03-09Buy5,37538,467$18.2898.2657
Scott Randal WCEO2007-03-06Sell12,0002,207,299$18.35220.256.4
Baker Bros. Capital (GP), LLCDirector2007-03-02Buy119189,965$18.092.1558.65
14159 capital (GP), LLCDirector2007-03-02Buy1,70733,092$18.0930.8858.65
Baker / Tisch Capital (GP), LLDirector2007-03-02Buy1,072190,578$18.119.458.56
Baker Biotech Capital (GP), LLDirector2007-03-02Buy19,795544,384$18.09358.0958.65
Baker Brothers Life Sciences CDirector2007-03-02Buy53,5331,569,539$18.09968.4158.65
Baker JoffreChief Scientific Officer2007-03-01Sell4,629302,877$18.1884.1657.87
MYERS WOODROW A JRDirector2007-02-21Buy2,00012,000$19.6339.2646.2
Baker Brothers Life Sciences CDirector2007-02-16Buy25,4121,516,006$18.54471.1454.8
Baker Biotech Capital (GP), LLDirector2007-02-16Buy9,396524,589$18.54174.254.8
Baker / Tisch Capital (GP), LLDirector2007-02-16Buy525189,506$18.549.7354.8
14159 capital (GP), LLCDirector2007-02-16Buy81131,385$18.5415.0454.8
Baker Bros. Capital (GP), LLCDirector2007-02-16Buy56189,846$18.541.0454.8
Baker Bros. Capital (GP), LLCDirector2007-02-14Buy579189,790$18.2510.5757.26
Baker / Tisch Capital (GP), LLDirector2007-02-14Buy5,346188,981$18.2597.5657.26
Baker Biotech Capital (GP), LLDirector2007-02-14Buy95,783515,193$18.251748.0457.26
14159 capital (GP), LLCDirector2007-02-14Buy8,25630,574$18.25150.6757.26
Baker Brothers Life Sciences CDirector2007-02-14Buy259,0441,490,594$18.254727.5557.26
Scott Randal WCEO2007-02-13Sell12,0002,219,299$18.12217.4458.39
Baker JoffreChief Scientific Officer2007-02-08Sell4,629307,506$18.9787.8151.29
Baker / Tisch Capital (GP), LLDirector2006-12-06Buy642183,635$21.5813.8532.99
Baker Brothers Life Sciences CDirector2006-12-06Buy34,1731,231,550$21.58737.4532.99
14159 capital (GP), LLCDirector2006-12-06Buy1,12022,318$21.5824.1732.99
Baker Biotech Capital (GP), LLDirector2006-12-06Buy12,237419,410$21.58264.0732.99
MYERS WOODROW A JRDirector2006-12-05Buy10,00010,000$21.97219.730.63
Baker / Tisch Capital (GP), LLDirector2006-12-05Buy9,096182,993$20.6187.3839.32
Baker Biotech Capital (GP), LLDirector2006-12-05Buy173,441407,173$20.63572.8839.32
14159 capital (GP), LLCDirector2006-12-05Buy15,88021,198$20.6327.1339.32
Baker Brothers Life Sciences CDirector2006-12-05Buy484,3331,197,377$20.69977.2639.32
14159 capital (GP), LLCDirector2006-09-08Buy5,3185,318$14.0574.72104.27Link
Baker Biotech Capital (GP), LLDirector2006-09-08Buy75,246233,732$14.051057.21104.27Link
Baker Brothers Life Sciences CDirector2006-09-08Buy237,236713,044$14.053333.17104.27Link
Baker Biotech Capital III (GP)10% Owner2005-10-04Buy136,316252,529$121635.79139.17Link
Baker Biotech Capital II (GP),10% Owner2005-10-04Buy38,684181,478$12464.21139.17Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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