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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
SIEGALL CLAY BPresident and CEO
(Click for the stocks that their CEOs have bought)
2017-09-11Sell18,832678,129$53.491007.32-1.89678,129 (Direct)
HIMES VAUGHN BChief Technical Officer2017-09-08Sell10,000164,906$53.22532.2-1.39164,906 (Direct)
Cline Darren SEVP, Commercial2017-09-06Sell5,02477,230$51.94260.951.0477,230 (Direct)
SIMPSON TODD ECFO2017-09-06Sell9,638218,377$52501.180.92218,377 (Direct)
Cline Darren SEVP, Commercial2017-08-31Sell7,56972,206$52.51397.45-0.0672,206 (Direct)
DOBMEIER ERICCOO2017-08-31Sell25,000117,424$52.2413060.46117,424 (Direct)
Cline Darren SEVP, Commercial2017-08-28Sell1,78876,868$47.8985.639.5876,868 (Direct)
DOBMEIER ERICCOO2017-08-28Sell5,343117,424$47.89255.889.58117,424 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2017-08-28Sell8,502133,702$47.89407.169.58133,702 (Direct)
HIMES VAUGHN BChief Technical Officer2017-08-28Sell6,377164,906$47.89305.399.58164,906 (Direct)
SIEGALL CLAY BPresident and CEO2017-08-28Sell25,506678,129$47.891221.489.58678,129 (Direct)
SIMPSON TODD ECFO2017-08-28Sell4,937228,015$47.89236.439.58228,015 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2017-08-24Sell10,000142,204$47.54475.410.39142,204 (Direct)
Cline Darren SEVP, Commercial2017-08-07Sell6,00061,656$49.19295.146.6961,656 (Direct)
SIEGALL CLAY BPresident and CEO2017-08-07Sell10,413636,435$48.91509.37.3636,435 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2017-07-27Sell10,000115,204$54.54545.4-3.78115,204 (Direct)
SIEGALL CLAY BPresident and CEO2017-07-05Sell10,423636,435$51.98541.790.96636,435 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2017-06-22Sell10,000115,204$64.01640.1-18.01115,204 (Direct)
SIEGALL CLAY BPresident and CEO2017-06-05Sell10,423636,435$65.21679.68-19.52636,435 (Direct)
HIMES VAUGHN BChief Technical Officer2017-05-31Sell10,000151,283$62.59625.9-16.15151,283 (Direct)
SIEGALL CLAY BPresident and CEO2017-05-05Sell14,462636,435$61.74892.88-15636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-04-05Sell14,465636,435$62.99911.15-16.69636,435 (Direct)
HIMES VAUGHN BChief Technical Officer2017-03-31Sell10,000151,283$62.75627.5-16.37151,283 (Direct)
SIEGALL CLAY BPresident and CEO2017-03-06Sell14,465636,435$68.04984.2-22.87636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-02-06Sell14,465636,435$61.54890.18-14.72636,435 (Direct)
SIEGALL CLAY BPresident and CEO2017-01-06Sell14,465638,835$57.89837.38-9.35638,835 (Direct)
Cline Darren SEVP, Commercial2016-12-13Sell10,00058,504$63.38633.8-17.258,504 (Direct)
DOBMEIER ERICCOO2016-12-08Sell12,50087,767$65.92824-20.3987,767 (Direct)
HIMES VAUGHN BChief Technical Officer2016-12-07Sell30,000135,379$65.321959.6-19.66135,379 (Direct)
SIEGALL CLAY BPresident and CEO2016-12-06Sell14,465638,835$66.17957.15-20.69638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-09Sell7,751109,837$66.75517.38-21.38109,837 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-08Buy382,50040,992,596$59.3622705.2-11.59107,504 (Direct)
40,885,092 (See footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-11-07Sell14,465638,835$58.43845.19-10.18638,835 (Direct)
LIPPMAN MARC EDirector2016-11-07Sell1,000131,350$57.7557.75-9.13131,350 (Direct)
BAKER FELIXDirector, 10% Owner2016-11-03Buy198,43345,482,921$56.4311197.57-7107,504 (Direct)
4,835,170 (See footnote(,,,))
40,540,247 (See Footnote(,,,))
BAKER FELIXDirector, 10% Owner2016-11-03Buy1,030,62945,194,447$56.1357849.21-6.5107,504 (Direct)
4,725,543 (See footnote(,,,))
40,361,400 (See Footnote(,,,))
DRACHMAN JONATHAN GCMO & EVP, R & D2016-11-01Sell3,418109,837$51.74176.851.43109,837 (Direct)
SIEGALL CLAY BPresident and CEO2016-10-06Sell14,465638,835$54.41787.04-3.55638,835 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-09-22Sell2,249113,255$56.75127.63-7.52113,255 (Direct)
DOBMEIER ERICCOO2016-09-14Sell22,91887,767$54.041238.49-2.8987,767 (Direct)
BAKER FELIXDirector, 10% Owner2016-09-13Buy447,31144,233,991$50.7122683.143.49107,504 (Direct)
4,693,991 (See footnote(,,,))
39,432,496 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-08Sell31,269638,835$50.081565.954.79638,835 (Direct)
0 (by Trust)
BAKER FELIXDirector, 10% Owner2016-09-08Buy414,01643,696,884$48.4320050.798.36107,504 (Direct)
4,559,012 (See footnote(,,,))
39,030,368 (See Footnote(,,,))
SIEGALL CLAY BPresident and CEO2016-09-06Sell11,653644,983$45.4529.0515.59617,038 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-09-06Sell5,39751,576$46.01248.3214.0651,576 (Direct)
DOBMEIER ERICCOO2016-08-23Sell12,58958,767$48604.279.3358,767 (Direct)
Cline Darren SEVP, Commercial2016-08-22Sell1,77440,973$46.5982.6512.6440,973 (Direct)
DOBMEIER ERICCOO2016-08-22Sell5,41167,525$46.59252.112.6467,525 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2016-08-22Sell3,99184,255$46.59185.9412.6484,255 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2016-08-22Sell3,991108,779$46.59185.9412.64108,779 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-22Sell23,381560,679$46.591089.3212.64532,734 (Direct)
27,945 (by Trust)
SIMPSON TODD ECFO2016-08-22Sell3,991191,445$46.59185.9412.64191,445 (Direct)
SIEGALL CLAY BPresident and CEO2016-08-08Sell11,660584,060$47.19550.2411.21556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-27Sell4,042584,060$45.2182.716.11556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-07-06Sell7,618584,060$40.56308.9929.39556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-06-06Sell22,083584,060$43.59962.620.39556,115 (Direct)
27,945 (by Trust)
Cline Darren SEVP, Commercial2016-06-02Sell3,36642,747$42.07141.6124.7442,747 (Direct)
SIEGALL CLAY BPresident and CEO2016-05-27Sell48,660584,060$40.411966.3529.87556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-24Sell8,400584,060$40.09336.7630.91556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-05-17Sell7,618584,060$35.16267.8549.26556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-25Sell800584,060$403231.2556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-04-05Sell7,618584,060$36.12275.1645.29556,115 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2016-03-22Sell15,236584,060$35.52541.1847.75556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2016-03-17Buy124,06547,873,417$31.853951.4764.77107,504 (Direct)
4,486,246 (See footnotes(F4,F5,F8,F9))
38,783,387 (See footnotes(F5,F6,F8,F9))
4,496,280 (See Footnotes(F4,F5,F8,F9))
BAKER FELIXDirector, 10% Owner2016-03-16Buy1,349,23747,668,558$32.143310.5163.49107,504 (Direct)
4,484,096 (See footnotes(F4,F5,F14,F15))
38,671,506 (See footnotes(F5,F6,F14,F15))
4,405,452 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-11Buy694,66646,212,264$32.4622548.8661.68107,504 (Direct)
4,351,589 (See footnotes(F4,F5,F14,F15))
37,454,776 (See footnotes(F5,F6,F14,F15))
4,298,395 (See Footnotes(F4,F5,F14,F15))
BAKER FELIXDirector, 10% Owner2016-03-08Buy502,523127,365,973$22.6611387.17131.6107,504 (Direct)
4,255,959 (See footnotes(F4,F17))
36,682,540 (See footnotes(F5,F17))
4,249,772 (See Footnotes(F4,F17))
4,265,959 (See footnotes(F9,F12,F13,F17))
36,692,540 (See footnotes(F10,F12,F14,F17))
4,281,431 (See footnotes(F13,F17))
36,830,268 (See footnotes(F14,F17))
BAKER FELIXDirector, 10% Owner2016-03-02Buy675,92244,876,220$31.7721474.0465.19107,504 (Direct)
4,221,368 (See footnotes(F4,F9))
36,367,808 (See footnotes(F5,F9))
4,179,540 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-26Buy314,50844,148,952$29.559293.7177.6107,504 (Direct)
4,154,719 (See footnotes(F4,F9))
35,758,535 (See footnotes(F5,F9))
4,128,194 (See Footnotes(F4,F9))
BAKER FELIXDirector, 10% Owner2016-02-22Buy1,001,47143,804,485$29.6329673.5977.12107,504 (Direct)
4,122,878 (See footnotes(F4,F7))
35,475,868 (See footnotes(F5,F7))
4,098,235 (See Footnotes(F4,F7))
BAKER FELIXDirector, 10% Owner2016-02-17Buy1,269,14776,210,189$30.4338620.1472.46107,504 (Direct)
3,916,805 (See footnotes(F4,F11))
33,588,605 (See footnotes(F5,F11))
4,023,889 (See Footnotes(F4,F11))
34,573,386 (See Footnotes(F5,F11))
Orwin John ADirector2016-02-12Buy2,00010,700$28.3356.6685.2510,700 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-12-15Sell40,50076,212$39.941617.5731.476,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-12-03Sell3,720584,060$39.99148.7631.23556,115 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-11-20Buy329,35837,435,632$43.9414471.9919.44107,504 (Direct)
3,899,276 (See footnote)
33,428,852 (See Footnote)
SIEGALL CLAY BPresident and CEO2015-11-17Sell87,473584,060$45.43971.2715.59556,115 (Direct)
27,945 (by Trust)
Cline Darren SSVP, Commercial2015-11-11Sell5,76937,713$45.68263.5314.8937,713 (Direct)
BAKER FELIXDirector, 10% Owner2015-11-10Buy934,6244,006,780$42.9540142.122.19107,504 (Direct)
3,899,276 (See footnote)
DOBMEIER ERICCOO2015-11-06Sell17,45280,888$42.5741.7123.4880,888 (Direct)
GRYSKA DAVID WDirector2015-11-05Sell10,00023,950$43.57435.720.4523,950 (Direct)
SIEGALL CLAY BPresident and CEO2015-11-04Sell3,718671,533$43.14160.3921.65643,588 (Direct)
27,945 (by Trust)
SIEGALL CLAY BPresident and CEO2015-10-05Sell3,718639,268$41.3153.5527.07611,323 (Direct)
27,945 (by Trust)
BAKER FELIXDirector, 10% Owner2015-09-15Buy5,159,4844,006,780$42.56219587.6423.31107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-09-03Sell3,718639,268$40.12149.1730.81611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1924.8998,340 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7524.8943,482 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-20Sell31,754639,268$42.021334.324.89611,323 (Direct)
27,945 (by Trust)
DOBMEIER ERICCOO2015-08-20Sell8,54898,340$42.02359.1924.8998,340 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2015-08-20Sell4,46282,724$42.02187.4924.8982,724 (Direct)
Cline Darren SSVP, Commercial2015-08-20Sell2,23143,482$42.0293.7524.8943,482 (Direct)
SIMPSON TODD ECFO2015-08-20Sell5,825179,874$42.02244.7724.89179,874 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-08-20Sell5,99776,212$42.02251.9924.8976,212 (Direct)
SIEGALL CLAY BPresident and CEO2015-08-05Sell3,718657,022$46.91174.4111.87557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-07-06Sell3,718657,022$46.94174.5211.8557,022 (Direct)
100,000 (by Trust)
SIEGALL CLAY BPresident and CEO2015-06-03Sell3,718657,022$45.72169.9914.79557,022 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2015-05-21Buy950,8864,006,780$42.4940403.1523.51107,504 (Direct)
3,899,276 (See footnote)
SIEGALL CLAY BPresident and CEO2015-05-08Sell52,052657,022$40.652115.9129.1557,022 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2015-05-08Sell17,07482,777$40.38689.4529.9782,777 (Direct)
BAKER FELIXDirector, 10% Owner2015-05-07Buy1,032,6643,993,080$35.5636721.5347.58107,504 (Direct)
3,885,576 (See footnote)
Cline Darren SSVP, Commercial2015-03-13Sell7,50033,135$38.65289.8835.7833,135 (Direct)
HIMES VAUGHN BEVP, Proc Svcs & Tech Ops2015-03-12Sell20,00067,209$36.6573343.1967,209 (Direct)
BAKER FELIXDirector, 10% Owner2015-03-10Buy285,0363,993,080$34.669879.3551.41107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-03-04Buy448,8413,993,080$34.8415637.6250.63107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2015-02-25Buy281,1153,993,080$33.929535.4254.72107,504 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2015-01-06Sell16,804659,710$31.8534.3765.03559,710 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-12-16Buy2,883,3783,993,080$31.8691864.4264.72107,504 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-12-10Buy1,247,8963,993,080$33.8242203.8455.17107,504 (Direct)
3,885,576 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-11-12Sell10,00067,209$37.52375.239.8767,209 (Direct)
BAKER FELIXDirector, 10% Owner2014-11-10Buy1,653,925493,205$34.5657159.6551.8576,997 (Direct)
416,208 (See footnote)
SIEGALL CLAY BPresident and CEO2014-09-04Sell5,600659,710$42.54238.2223.37559,710 (Direct)
100,000 (by Trust)
DOBMEIER ERICCOO2014-08-25Sell4,81891,432$43.55209.8220.5191,432 (Direct)
SIMPSON TODD ECFO2014-08-24Sell3,696168,699$43.55160.9620.51168,699 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-24Sell25,507659,710$43.551110.8320.51559,710 (Direct)
100,000 (by Trust)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-08-24Sell3,31067,209$43.55144.1520.5167,209 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-08-24Sell2,77266,481$43.55120.7220.5166,481 (Direct)
BOERNER CHRISTOPHER S.Executive Vice President, Comm2014-08-24Sell1,24872,358$43.5554.3520.5172,358 (Direct)
SIEGALL CLAY BPresident and CEO2014-08-12Sell11,200625,217$40.38452.2629.97525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-13Buy216,5953,962,573$39.928646.4731.4676,997 (Direct)
3,885,576 (See footnote)
SIEGALL CLAY BPresident and CEO2014-06-10Sell11,200625,217$40.14449.5730.74525,217 (Direct)
100,000 (by Trust)
BAKER FELIXDirector, 10% Owner2014-06-09Buy546,2523,962,573$38.1620844.9837.5376,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-06-04Buy281,9633,962,573$34.869829.2350.5576,997 (Direct)
3,885,576 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-16Buy189,611467,941$34.076460.0554.0476,997 (Direct)
390,944 (See footnote)
BAKER FELIXDirector, 10% Owner2014-05-09Buy488,3823,949,073$33.9616585.4554.5376,997 (Direct)
3,872,076 (See footnote)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2014-05-09Sell10,00055,519$3535049.9455,519 (Direct)
SIEGALL CLAY BPresident and CEO2014-04-03Sell5,600955,696$43.34242.721.09955,696 (Direct)
SIEGALL CLAY BPresident and CEO2014-03-05Sell9,318955,696$52.89492.83-0.78955,696 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2014-02-21Sell1,45246,075$54.9879.83-4.5546,075 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-02-20Sell1,24148,670$53.2566.08-1.4548,670 (Direct)
HIMES VAUGHN BEVP, Tech, Ops. & Proc. Sci.2014-02-19Sell5,08844,219$52.01264.630.944,219 (Direct)
SIEGALL CLAY BPresident and CEO2014-02-18Sell100,000955,696$51.9751970.98955,696 (Direct)
DOBMEIER ERICCOO2014-01-21Sell56,01077,833$47.9226849.5277,833 (Direct)
DRACHMAN JONATHAN GCMO & EVP, R & D2014-01-16Sell1,20149,911$45.7554.9514.7149,911 (Direct)
SIEGALL CLAY BPresident and CEO2014-01-02Sell1,8581,043,554$39.2772.9633.641,043,554 (Direct)
BAKER FELIXDirector, 10% Owner2013-12-16Buy407,0783,949,073$39.6616144.7132.3276,997 (Direct)
3,872,076 (See footnote)
BAKER FELIXDirector, 10% Owner2013-12-05Buy1,005,9013,949,073$43.1943444.8621.5176,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-12-02Sell2,0001,024,558$41.2582.527.221,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-11-01Sell2,0001,024,558$38.6377.2635.851,024,558 (Direct)
SIEGALL CLAY BPresident and CEO2013-10-01Sell2,0001,024,558$43.8787.7419.631,024,558 (Direct)
DOBMEIER ERICCOO2013-09-10Sell42,000133,843$46.41948.813.1133,843 (Direct)
DOBMEIER ERICCOO2013-09-05Sell75,000135,843$42.64319823.08135,843 (Direct)
SIEGALL CLAY BPresident and CEO2013-09-03Sell102,000977,211$43.94477.819.54977,211 (Direct)
GRYSKA DAVID WDirector2013-09-03Sell10,00022,000$42.48424.823.5422,000 (Direct)
SIMPSON TODD ECFO2013-08-27Sell37,763155,395$41.451565.2826.61155,395 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-19Sell7,6531,124,558$40.91313.0828.281,124,558 (Direct)
SIMPSON TODD ECFO2013-08-19Sell3,328125,029$40.91136.1528.28125,029 (Direct)
DOBMEIER ERICCOO2013-08-19Sell3,328127,620$40.91136.1528.28127,620 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-08-19Sell1,73646,307$40.9171.0228.2846,307 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-08-19Sell22647,527$40.919.2528.2847,527 (Direct)
SIEGALL CLAY BPresident and CEO2013-08-01Sell2,0001,077,211$40.0380.0631.11,077,211 (Direct)
SIMPSON TODD ECFO2013-07-12Sell92,527113,957$37.453465.1440.13113,957 (Direct)
SIEGALL CLAY BPresident and CEO2013-07-01Sell2,0001,077,211$32.5965.1861.031,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-06-14Sell5,00013,905$32.75163.7560.2413,905 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2013-06-13Sell10,00033,643$32.11321.163.4433,643 (Direct)
SIEGALL CLAY BPresident and CEO2013-06-03Sell2,0001,077,211$33.8867.7654.91,077,211 (Direct)
AKKARAJU SRINIVASDirector2013-05-10Sell17,50010,405$37.17650.4841.1910,405 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-09Buy488,3823,949,073$33.9616585.4554.5376,997 (Direct)
3,872,076 (See footnote)
SIEGALL CLAY BPresident and CEO2013-05-01Sell2,0001,077,211$36.5873.1643.471,077,211 (Direct)
SIEGALL CLAY BPresident and CEO2013-04-01Sell2,0001,077,211$35.5371.0647.711,077,211 (Direct)
BOERNER CHRISTOPHER S.SVP, Commercial2013-03-15Sell8,50033,753$33.61285.6956.1433,753 (Direct)
DOBMEIER ERICCOO2013-03-11Sell60,000112,948$31.161869.668.42112,948 (Direct)
SIMPSON TODD ECFO2013-03-07Sell49,718113,957$30.751528.8370.67113,957 (Direct)
DOBMEIER ERICCOO2013-03-06Sell100,000122,948$29.68296876.82122,948 (Direct)
SIEGALL CLAY BPresident and CEO2013-03-05Sell95,7501,077,211$28.712748.9882.791,077,211 (Direct)
GRYSKA DAVID WDirector2013-02-25Sell10,00018,500$27.17271.793.1518,500 (Direct)
SIEGALL CLAY BPresident and CEO2013-02-01Sell2,0001,170,961$29.6159.2277.241,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-28Sell7,29057,601$30.09219.3674.4157,601 (Direct)
Reynolds Thomas CChief Medical Officer2013-01-15Sell125,07957,601$283502.2187.4357,601 (Direct)
SIEGALL CLAY BPresident and CEO2013-01-04Sell8,2491,170,961$24.13199.05117.491,170,961 (Direct)
DOBMEIER ERICCOO2013-01-04Sell50,983122,846$24.951272.03110.34122,846 (Direct)
DOBMEIER ERICCOO2012-12-17Sell50,000113,829$23.71185121.43113,829 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-10Sell66,58857,601$25.771715.97103.6557,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-05Sell40,00057,601$25.591023.6105.0857,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-12-03Sell8,2501,170,961$25.19207.82108.341,170,961 (Direct)
Reynolds Thomas CChief Medical Officer2012-12-03Sell40,00057,601$25.411016.4106.5357,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-26Sell30,00057,601$25.34760.2107.157,601 (Direct)
Reynolds Thomas CChief Medical Officer2012-11-20Sell20,00057,601$24.95499110.3457,601 (Direct)
DOBMEIER ERICCOO2012-11-13Sell27,327101,411$23.59644.64122.47101,411 (Direct)
SIEGALL CLAY BPresident and CEO2012-11-01Sell8,2501,170,961$25.51210.46105.721,170,961 (Direct)
DOBMEIER ERICCOO2012-10-15Sell25,00069,352$25.01625.25109.8469,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-10-01Sell8,2501,170,961$26.59219.3797.371,170,961 (Direct)
HIMES VAUGHN BEVP, Tech. Ops. & Proc. Sci.2012-09-10Sell10,00033,643$28.79287.982.2933,643 (Direct)
SIMPSON TODD ECFO2012-09-06Sell95,00070,762$28.52707.584.1470,762 (Direct)
Reynolds Thomas CChief Medical Officer2012-09-06Sell48,54057,601$29.751444.0776.457,601 (Direct)
SIEGALL CLAY BPresident and CEO2012-09-04Sell8,2501,170,961$26.54218.9697.741,170,961 (Direct)
SIMPSON TODD ECFO2012-08-27Sell45,00070,762$26.971213.6594.5970,762 (Direct)
SIMPSON TODD ECFO2012-08-16Sell40,00050,762$25.971038.8102.0850,762 (Direct)
DOBMEIER ERICCOO2012-08-13Sell25,00043,352$24.01600.25118.5843,352 (Direct)
SIEGALL CLAY BPresident and CEO2012-08-02Sell8,2501,096,711$26214.5101.851,096,711 (Direct)
SIEGALL CLAY BPresident & CEO2012-07-02Sell8,2501,096,711$25.36209.22106.941,096,711 (Direct)
DOBMEIER ERICCOO2012-06-18Sell25,00068,073$25.36634106.9468,073 (Direct)
SIMPSON TODD ECFO2012-06-14Sell95,00050,762$24.52327.5114.250,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-12Sell10,00017,643$24240118.6717,643 (Direct)
SIMPSON TODD ECFO2012-06-08Sell35,00050,762$22.97803.95128.4750,762 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-06-07Sell13,56617,643$22.5305.24133.2417,643 (Direct)
GRYSKA DAVID WDirector2012-06-05Sell8,00011,500$19.75158165.7211,500 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-05-18Sell65,00017,643$21.541400.1143.6417,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-05-15Sell94931,073$19.7518.74165.7231,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-04-25Sell40,00031,073$19.75790165.7231,073 (Direct)
DOBMEIER ERICCOO2012-04-25Sell25,00068,073$19.95498.75163.0668,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-20Sell38,28117,643$19.51746.86168.9917,643 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-04-17Sell44,21917,643$18.88834.85177.9717,643 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-22Sell40,00031,073$19.78791.2165.3231,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-03-19Sell40,00031,073$19.75790165.7231,073 (Direct)
ROSENBERG MORRISEVP, Process Sciences2012-03-13Sell69,62617,643$18.591294.35182.317,643 (Direct)
DOBMEIER ERICCOO2012-02-28Sell46,00072,073$18.52851.92183.3772,073 (Direct)
DOBMEIER ERICCOO2012-02-28Sell4,00068,073$18.5374.12183.2268,073 (Direct)
Reynolds Thomas CChief Medical Officer2012-01-27Sell40,00030,169$19.75790165.7230,169 (Direct)
SIEGALL CLAY BPresident and CEO2012-01-03Sell15,0001,130,055$16.73250.95213.691,045,055 (Direct)
85,000 (by Trust)
GRYSKA DAVID WDirector2011-12-09Sell10,00015,000$18.09180.9190.1115,000 (Direct)
SIEGALL CLAY BPresident and CEO2011-12-01Sell15,0001,130,055$15.97239.55228.621,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-11-01Sell15,0001,130,055$21.89328.35139.741,045,055 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-10-27Sell20,91859,327$21.95459.15139.0959,327 (Direct)
DOBMEIER ERICCOO2011-10-20Sell20,46159,327$20.58421.0915559,327 (Direct)
SIMPSON TODD ECFO2011-10-07Sell24,35049,242$21.97534.97138.8749,242 (Direct)
SIEGALL CLAY BPresident and CEO2011-10-04Sell15,0001,130,055$20.15302.25160.451,045,055 (Direct)
85,000 (by Trust)
SIEGALL CLAY BPresident and CEO2011-09-21Sell30,0001,130,055$20.12603.6160.831,045,055 (Direct)
85,000 (by Trust)
14159 capital (GP), LLCDirector, 10% Owner2011-09-06Buy1,773323,148$17.0830.28207.26
323,148 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-09-06Buy129,18714,776,080$17.082206.51207.26
14,776,080 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-08-25Buy1,165,43514,646,893$15.3817924.39241.22
14,646,893 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-08-25Buy17,926321,375$15.38275.7241.22
321,375 (Through Partnership)
Reynolds Thomas CChief Medical Officer2011-08-01Sell1,5391,488$17.3726.73202.131,488 (Direct)
SIEGALL CLAY BPresident and CEO2011-07-01Sell15,0001,035,667$20.66309.9154.02950,667 (Direct)
85,000 (by Trust)
BERGER FRANKLIN MDirector2011-06-22Buy7,000163,720$20.04140.28161.88163,720 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-20Sell9,0001,035,667$20.01180.09162.27950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICCOO2011-06-20Sell13,3858,817$20267.7162.48,817 (Direct)
SIEGALL CLAY BPresident and CEO2011-06-09Sell1,0001,035,667$2020162.4950,667 (Direct)
85,000 (by Trust)
DOBMEIER ERICChief Business Officer2011-06-09Sell3,60022,202$2072162.422,202 (Direct)
SIMPSON TODD ECFO2011-06-07Sell10,7509,359$19.96214.57162.939,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-06-07Sell2,5030$19.6749.23166.8Link
ROSENBERG MORRISEVP, Process Sciences2011-05-27Sell17,4970$19.5341.19169.13Link
Reynolds Thomas CChief Medical Officer2011-05-19Sell19,9983,027$18.71374.16180.493,027 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-19Sell20,0000$18.8376179.15Link
SIMPSON TODD ECFO2011-05-18Sell21,2509,359$18.64396.1181.559,359 (Direct)
ROSENBERG MORRISEVP, Process Sciences2011-05-13Sell20,0000$17.8356194.83Link
Reynolds Thomas CChief Medical Officer2011-05-13Sell20,0003,027$17.8356194.833,027 (Direct)
DOBMEIER ERICChief Business Officer2011-05-13Sell42,71525,802$18768.87191.5625,802 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-09Sell50,0001,030,667$17.35867.5202.48945,667 (Direct)
85,000 (by Trust)
SIMPSON TODD ECFO2011-05-09Sell20,0009,359$17.74354.8195.839,359 (Direct)
SIEGALL CLAY BPresident and CEO2011-05-02Sell50,0000$17.43871.5201.09Link
ROSENBERG MORRISEVP, Process Sciences2011-05-02Sell25,0000$17.15428.75206.01Link
SIMPSON TODD ECFO2011-04-29Sell15,0000$16.94254.1209.8Link
Reynolds Thomas CChief Medical Officer2011-04-29Sell11,9150$16.95201.96209.62Link
SIEGALL CLAY BPresident and CEO2011-04-14Sell50,0000$15.27763.5243.68Link
SIEGALL CLAY BPresident and CEO2011-04-07Sell50,0000$16.06803226.77Link
DOBMEIER ERICChief Business Officer2011-04-05Sell40,0000$16640228Link
SIEGALL CLAY BPresident and CEO2011-03-17Sell200,0000$14.092818272.46Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-02Buy48,1970$15.5747.05238.58Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-02Buy1,751,80313,470,692$15.527152.95238.58
13,470,692 (Through Partnership)
ROSENBERG MORRISEVP, Process Sciences2010-12-15Sell25,0000$16.22405.5223.55Link
ROSENBERG MORRISEVP, Process Sciences2010-12-02Sell25,0000$15.81395.25231.94Link
ROSENBERG MORRISEVP, Process Sciences2010-11-04Sell25,0000$14.7367.5257.01Link
Reynolds Thomas CChief Medical Officer2010-10-11Sell25,0005,719$16.95423.75209.62Link
Reynolds Thomas CChief Medical Officer2010-09-27Sell25,0005,719$14.95373.75251.04Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-06-08Buy599,06911,718,889$11.947152.88339.53Link
14159 capital (GP), LLCDirector, 10% Owner2010-06-08Buy16,536255,252$11.94197.44339.53Link
LIPPMAN MARC EDirector2010-06-04Buy20,000103,575$12.49249.8320.18Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-25Buy150238,716$11.951.79339.16Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-25Buy5,41611,119,820$11.9564.72339.16Link
BERGER FRANKLIN MDirector2010-05-13Buy5,000138,720$13.3766.85292.52Link
LIPPMAN MARC EDirector2010-05-10Buy11,07583,575$11.92132.01340.27Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-05-04Buy561,70911,114,404$12.797184.26310.32Link
14159 capital (GP), LLCDirector, 10% Owner2010-05-04Buy15,506238,566$12.79198.32310.32Link
Reynolds Thomas CChief Medical Officer2010-05-03Sell25,0004,508$12.95323.75305.25Link
14159 capital (GP), LLCDirector, 10% Owner2010-04-30Buy51,581223,060$11.06570.49374.5Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-04-30Buy1,868,68610,552,695$11.0620667.67374.5Link
BERGER FRANKLIN MDirector2010-03-30Buy11,500116,720$12.05138.58335.52Link
BERGER FRANKLIN MDirector2010-03-12Buy13,000105,220$11.9154.7341.01Link
AKKARAJU SRINIVASDirector2009-08-18Buy4,90510,405$11.4756.26357.54Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-11Buy273,4044,626,213$10.752939.09388.19Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-11Buy798481,890$10.758.58388.19Link
Reynolds Thomas CChief Medical Officer2009-07-30Sell25,0003,713$12.47311.75320.85Link
DOBMEIER ERICChief Business Officer2009-07-30Sell60,00012,206$12.36741.6324.6Link
ROSENBERG MORRISEVP, Development2009-07-28Sell25,0000$11.81295.25344.37Link
AKKARAJU SRINIVASDirector2009-06-25Buy5,5005,500$9.2150.66469.82
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-05-20Buy378,0534,352,809$9.723674.68439.92
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-20Buy746,5718,684,009$9.727256.67439.92
14159 capital (GP), LLCDirector, 10% Owner2009-05-20Buy14,576171,479$9.72141.68439.92
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-20Buy3,710481,092$9.7236.06439.92
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-20Buy35,253400,898$9.72342.66439.92
DOBMEIER ERICChief Business Officer2008-09-26Sell24,4279,000$11.53281.64355.16
AKKARAJU SRINIVASDirector2008-09-22Sell18,601600,559$12.79237.91310.32
Reynolds Thomas CChief Medical Officer2008-09-22Sell12,3092,626$12.52154.11319.17
AKKARAJU SRINIVASDirector2008-09-19Sell37,011603,588$12.74471.52311.93
AKKARAJU SRINIVASDirector2008-09-19Sell87,696603,588$12.741117.25311.93
AKKARAJU SRINIVASDirector2008-09-18Sell20,839617,871$12.71264.86312.9
AKKARAJU SRINIVASDirector2008-09-18Sell49,378617,871$12.71627.59312.9
DOBMEIER ERICChief Business Officer2008-09-16Sell30,00033,427$12.25367.5328.41
ROSENBERG MORRISSr. VP, Development2008-08-04Sell50,0000$11.3565364.42
AKKARAJU SRINIVASDirector2008-07-29Sell95,688625,913$10.851038.21383.69
AKKARAJU SRINIVASDirector2008-07-28Sell21,232685,702$10.36219.96406.56
H&Q Holdings, Inc.10% Owner2008-07-28Sell21,50025,052$10.36222.74406.56
SIEGALL CLAY BPresident and CEO, Director2008-07-25Sell100,000953,168$10.781078386.83
H&Q Holdings, Inc.10% Owner2008-07-25Sell150,00025,186$10.811621.5385.48
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell150,00025,186$10.811621.5385.48
AKKARAJU SRINIVASDirector2008-07-25Sell148,136701,432$10.811601.35385.48
JP MORGAN PARTNERS BHCA LP10% Owner2008-07-25Sell21,50025,052$10.36222.74406.56
AKKARAJU SRINIVASDirector2008-05-16Sell42,059811,175$10.39436.99405.1
AKKARAJU SRINIVASDirector2008-05-15Sell98,758842,334$10.141001.41417.55
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-15Sell100,00026,383$10.141014417.55
H&Q Holdings, Inc.10% Owner2008-05-14Sell122,89327,004$10.11241.22419.6
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-14Sell122,89327,004$10.11241.22419.6
AKKARAJU SRINIVASDirector2008-05-14Sell121,365915,496$10.11225.79419.6
H&Q Holdings, Inc.10% Owner2008-05-13Sell51,53627,768$10.06518.45421.67
JP MORGAN PARTNERS BHCA LP10% Owner2008-05-13Sell51,53627,768$10.06518.45421.67
AKKARAJU SRINIVASDirector2008-05-13Sell50,8961,005,407$10.06512.01421.67
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-18Buy41,6663,974,756$7.9329.16564.3
14159 capital (GP), LLCDirector, 10% Owner2008-03-18Buy3,918156,903$7.930.95564.3
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-18Buy123,4937,937,438$7.9975.59564.3
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-17Buy189477,241$7.81.47572.82
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-03-14Buy65,0043,933,090$8.04522.63552.74
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91550.31
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-03-14Buy819365,645$8.046.58552.74
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-03-14Buy361477,052$8.072.91550.31
Baker Brothers Life Sciences CDirector, 10% Owner2008-03-14Buy173,4077,813,945$8.041394.19552.74
14159 capital (GP), LLCDirector, 10% Owner2008-03-14Buy5,503152,985$8.0444.24552.74
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-02-11Buy1,158364,826$9.0310.46481.17
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-02-11Buy177476,588$9.031.6481.17
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-02-11Buy34,6533,868,086$9.01312.22482.46
Baker Brothers Life Sciences CDirector, 10% Owner2008-02-11Buy153,5387,640,538$9.011383.38482.46
14159 capital (GP), LLCDirector, 10% Owner2008-02-11Buy4,883147,482$9.0144482.46
Baker Bros. Capital (GP), LLCDirector, 10% Owner2008-01-23Buy5,006476,173$945.05483.11
Baker / Tisch Capital (GP), LLDirector, 10% Owner2008-01-23Buy43,170363,668$8.99388.1483.76
Baker Brothers Life Sciences CDirector, 10% Owner2008-01-23Buy2,094,2787,487,000$8.9918827.56483.76
14159 capital (GP), LLCDirector, 10% Owner2008-01-23Buy67,001142,599$8.99602.34483.76
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-01-22Buy578,9163,833,433$8.995204.45483.76
BERGER FRANKLIN MDirector2008-01-22Buy52872,220$9.124.82475.44
JP MORGAN PARTNERS BHCA LP10% Owner2007-12-10Sell21,22428,088$12.63268.06315.52
AKKARAJU SRINIVASDirector2007-12-10Sell20,9601,043,112$12.63264.72315.52
SIMPSON TODD ECFO2007-09-26Sell32,2500$11.91384.1340.64
ROSENBERG MORRISSr. VP, Development2007-09-26Sell15,0000$11.93178.95339.9
DOBMEIER ERICChief Business Officer2007-09-20Sell1,9003,798$11.922.61341.01
DOBMEIER ERICChief Business Officer2007-09-20Sell19,1003,798$11.8225.38344.75
DOBMEIER ERICChief Business Officer2007-09-20Sell16,5003,798$11.65192.23350.47
DOBMEIER ERICChief Business Officer2007-09-20Sell18,1003,798$11.61210.14352.02
DOBMEIER ERICChief Business Officer2007-09-19Sell44,4003,798$11.54512.38354.77
LIPPMAN MARC EDirector2007-09-17Buy2,00010,000$10.6221.24394.16
SIEGALL CLAY BPresident and CEO2007-08-22Sell74,0001,053,168$11.09820.66373.22
SIEGALL CLAY BPresident and CEO2007-08-21Sell65,7001,127,168$10.99722.04377.53
SIEGALL CLAY BPresident and CEO2007-08-21Sell110,3001,079,168$11.141228.74371.1
TrailSmith Pamela AChief Scientific Officer2007-05-17Sell59,8916,940$10.23612.68413
ROSENBERG MORRISSr. VP, Development2007-05-17Sell25,0000$10.32258408.53
ROSENBERG MORRISSr. VP, Development2007-04-27Sell25,0000$9.54238.5450.1
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.761313.39499.09
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.768758.09499.09
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.76171.35499.09
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7614014.18499.09
Baker / Tisch Capital (GP), LLDirector2007-02-14Sell102,9353,998$8.76901.71499.09
14159 capital (GP), LLCDirector2007-02-14Sell19,56175,598$8.72170.57501.83
Baker Biotech Capital (GP), LLDirector2007-02-14Sell999,7821,153,217$8.728718.1501.83
Baker Bros. Capital (GP), LLCDirector2007-02-14Sell149,9304,957$8.721307.39501.83
Baker Brothers Life Sciences CDirector2007-02-14Sell1,599,7923,474,819$8.7213950.19501.83
AKKARAJU SRINIVASDirector2007-02-09Sell2,015,0000$8.5717268.55512.37
DOBMEIER ERICSr. VP, Corporate Development2007-02-09Sell50,0001,798$8.94447487.02
14159 capital (GP), LLCDirector, 10% Owner2006-08-14Buy85095,159$4.053.441195.8Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-14Buy37,0704,149,611$4.05150.131195.8Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-14Buy12,0801,535,999$4.0548.921195.8Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-11Buy110,2194,112,541$4.03444.181202.23Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-11Buy35,9171,523,919$4.03144.751202.23Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-11Buy2,52994,309$4.0310.191202.23Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-09Buy4,65291,239$4.0518.841195.8Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-09Buy202,7613,978,746$4.05821.181195.8Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-09Buy66,0731,480,319$4.05267.61195.8Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-07Buy1,49286,587$4.036.011202.23Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-07Buy65,0203,775,985$4.03262.031202.23Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-08-02Buy23,5763,734,541$3.787.231318.38Link
14159 capital (GP), LLCDirector, 10% Owner2006-08-02Buy54185,636$3.721318.38Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-08-02Buy7,6831,400,741$3.728.431318.38Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-29Buy8,43585,095$4.0333.991202.23Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-29Buy392,8333,710,965$4.031583.121202.23Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-29Buy129,9821,393,058$4.03523.831202.23Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-26Buy50,5351,263,076$4.02203.151205.47Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-26Buy152,9413,318,132$4.02614.821205.47Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-26Buy3,29776,660$4.0213.251205.47Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-21Buy115,7053,165,191$4.02465.131205.47Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-21Buy2,49473,363$4.0210.031205.47Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-21Buy38,2321,212,541$4.02153.691205.47Link
14159 capital (GP), LLCDirector, 10% Owner2006-06-13Buy33,07870,869$4132.311212Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-06-13Buy507,0211,174,309$42028.081212Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-06-13Buy1,534,4433,049,486$46137.771212Link
Baker Brothers Life Sciences CDirector, 10% Owner2006-05-24Buy832,1351,515,043$5.254368.71899.62Link
14159 capital (GP), LLCDirector, 10% Owner2006-05-24Buy18,23037,791$5.2595.71899.62Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2006-05-24Buy278,650667,288$5.251462.91899.62Link
SIEGALL CLAY BPresident and CEO2005-09-13Sell73,0001,086,500$5.97435.81779.06Link
SIEGALL CLAY BPresident and CEO2005-09-09Sell24,0001,159,500$5.99143.76776.13Link
SIEGALL CLAY BPresident and CEO2005-08-02Sell103,0001,183,500$5.96613.88780.54Link
CARROLL TIMCFO2005-05-05Sell86,50062,861$5432.5949.6Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-05-04Buy67826,933$4.793.25995.62Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-05-04Buy94849,807$4.794.54995.62Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-05-04Buy1,22245,090$4.795.85995.62Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-05-04Buy6,305234,861$4.7930.2995.62Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-05-04Buy6,627353,150$4.7931.74995.62Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-05-04Buy7,241388,638$4.7934.68995.62Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-05-04Buy1,44876,887$4.796.94995.62Link
14159 capital (GP), LLCDirector, 10% Owner2005-05-04Buy53119,561$4.792.54995.62Link
14159 capital (GP), LLCDirector, 10% Owner2005-04-29Buy6,39319,030$425.571212Link
Baker / Tisch Capital (GP), LLDirector, 10% Owner2005-04-29Buy8,41026,255$433.641212Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2005-04-29Buy89,394381,397$4357.581212Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-04-29Buy14,73443,868$458.941212Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2005-04-29Buy17,76675,439$471.061212Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-04-29Buy11,54248,859$446.171212Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-04-29Buy76,759228,556$4307.041212Link
Baker Biotech Capital II (GP),Director, 10% Owner2005-04-29Buy81,750346,523$43271212Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy12,040292,003$4.9659.72958.06Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-30Buy10,816264,773$4.9653.65958.06Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy1,13417,845$4.965.62958.06Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-30Buy2,34457,673$4.9611.63958.06Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-30Buy1,50637,317$4.967.47958.06Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-30Buy9,617151,797$4.9647.7958.06Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-30Buy1,84329,134$4.969.14958.06Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-30Buy80012,637$4.963.97958.06Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy96816,711$4.884.72975.41Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy2,00155,329$4.889.76975.41Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-29Buy1,28535,811$4.886.27975.41Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-29Buy9,229253,957$4.8845.04975.41Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-29Buy10,273279,963$4.8850.13975.41Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-29Buy8,205142,180$4.8840.04975.41Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-29Buy1,57327,291$4.887.68975.41Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-29Buy68211,837$4.883.33975.41Link
BAKER TISCH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy15,74315,743$4.9978.56951.7Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2005-03-23Buy150,679244,728$4.99751.89951.7Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy167,773269,690$4.99837.19951.7Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2005-03-23Buy32,67053,328$4.99163.02951.7Link
Baker Biotech Capital II (Z) (Director, 10% Owner2005-03-23Buy20,98434,526$4.99104.71951.7Link
Baker Biotech Capital III (GP)Director, 10% Owner2005-03-23Buy63,376133,975$4.96314.34958.06Link
14159 Capital (GP, LLCDirector, 10% Owner2005-03-23Buy5,25111,155$4.9626.04958.06Link
Baker Biotech Capital III (Z) Director, 10% Owner2005-03-23Buy12,16625,718$4.9660.34958.06Link
POWELL MICHAELDirector2004-12-16Sell56,500685,892$7395.5649.71Link
POWELL MICHAELDirector2004-12-07Sell22,450742,392$7.03157.82646.51Link
POWELL MICHAELDirector2004-12-06Sell135,000764,842$7.06953.1643.34Link
POWELL MICHAELDirector2004-12-01Sell32,500899,842$6.94225.55656.2Link
POWELL MICHAELDirector2004-11-16Sell54,000932,342$6.9372.6660.58Link
POWELL MICHAELDirector2004-11-15Sell146,000986,342$6.77988.42675.18Link
POWELL MICHAELDirector2004-09-29Sell50,0001,131,354$6.67333.5686.81Link
POWELL MICHAELDirector2004-09-24Sell10,0001,181,354$6.9269.2658.38Link
POWELL MICHAELDirector2004-09-23Sell94,4881,191,354$6.83645.35668.37Link
POWELL MICHAELDirector2004-09-17Sell55,5001,285,842$6.71372.41682.12Link
POWELL MICHAELDirector2004-09-02Sell26,0001,341,342$6.61171.86693.95Link
POWELL MICHAELDirector2004-08-27Sell35,0001,367,342$6.81238.35670.63Link
POWELL MICHAELDirector2004-08-24Sell121,0001,402,342$6.81824.01670.63Link
POWELL MICHAELDirector2004-08-19Sell44,0001,523,342$6.75297677.48Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy32,72392,120$5.55181.61845.59Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-12Buy45,745188,823$5.49251.14855.92Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-12Buy17,65029,619$5.495.31871.85Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-06Buy21,88962,682$5.53121.05849.01Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy4,21311,969$5.5323.3849.01Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-06Buy20,73459,397$5.53114.66849.01Link
BAKER BIOTECH CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy38,66338,663$5.72221.15817.48Link
BAKER BIOTECH CAPITAL II GP LLDirector, 10% Owner2004-08-04Buy40,79340,793$5.72233.34817.48Link
BAKER BROS CAPITAL GP LLCDirector, 10% Owner2004-08-04Buy7,7567,756$5.7244.36817.48Link
POWELL MICHAELDirector2004-06-29Sell28,5001,567,342$7.03200.36646.51Link
CARROLL TIMCFO2004-06-28Sell60,000152,361$7.04422.4645.45Link
POWELL MICHAELDirector2004-06-25Sell121,5001,595,842$7.08860.22641.24Link
POWELL MICHAELDirector2004-06-22Sell80,0001,717,342$7.12569.6637.08Link
CARROLL TIMCFO2004-05-10Sell8,600212,361$8.2270.69538.44Link
DOBMEIER ERICV. P., Corporate Affairs2004-05-05Sell15,000300$8.59128.85510.94Link
POWELL MICHAELDirector2004-03-09Sell65,0001,797,342$10.42677.3403.65Link
POWELL MICHAELDirector2003-12-30Sell7,0001,862,342$8.962.3489.66Link
POWELL MICHAELDirector2003-12-23Sell87,2501,869,342$7.22629.95626.87Link
POWELL MICHAELDirector2003-12-09Sell56,0001,956,592$7.02393.12647.58Link
CARROLL TIMCFO2003-12-05Sell80,000220,961$6.63530.4691.55Link
POWELL MICHAELDirector2003-12-04Sell11,7032,012,592$6.5676.77700Link
POWELL MICHAELDirector2003-12-02Sell153,0002,024,295$6.33968.49729.07Link
SIEGALL CLAY BPresident and CEO2003-12-02Sell50,0001,291,500$6.47323.5711.13Link
FELL H PERRYChairman2003-12-02Sell50,0001,294,000$6.47323.5711.13Link
SIEGALL CLAY BPresident and CEO2003-11-26Sell4,5001,341,500$6.4428.98714.91Link
FELL H PERRYChairman2003-11-26Sell4,5001,344,000$6.4428.98714.91Link
POWELL MICHAELDirector2003-11-26Sell108,5002,177,295$6.27680.3737Link
SIEGALL CLAY BPresident and CEO2003-11-24Sell56,5001,346,000$6.52368.38704.91Link
FELL H PERRYChairman2003-11-24Sell56,5001,348,500$6.52368.38704.91Link
HELLSTROM KARL ERIKDirector2003-11-19Sell66,500700,000$6.69444.89684.45Link
POWELL MICHAELDirector2003-11-18Sell414,4782,285,795$62486.87774.67Link
HELLSTROM KARL ERIKDirector2003-11-18Sell133,500766,500$6.48865.08709.88Link
SIEGALL CLAY BPresident and CEO2003-09-15Sell10,0001,402,500$5.959789.49Link
FELL H PERRYChairman2003-09-15Sell10,0001,405,000$5.959789.49Link
SIEGALL CLAY BPresident and CEO2003-09-11Sell47,5001,412,500$6.05287.38767.44Link
FELL H PERRYChairman2003-09-11Sell47,5001,415,000$6.05287.38767.44Link
SIEGALL CLAY BPresident and CEO2003-09-08Sell31,5001,460,000$6.18194.67749.19Link
FELL H PERRYChairman2003-09-08Sell31,5001,462,500$6.18194.67749.19Link
SENTER PETERVice President, Chemistry2003-08-21Sell19,60068,148$5.27103.29895.83Link
SING AMYSr. Director Medical Affairs2003-08-18Sell20,00052,107$5.09101.8931.04Link
LIPPMAN MARC EDirector2003-08-14Buy15,00052,500$4.8873.2975.41Link
SING AMYSr. Director Medical Affairs2003-08-04Sell5,00072,107$4.723.51016.6Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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