Orbimed Advisors Llc Buys Adagio Therapeutics Inc, Zimmer Biomet Holdings Inc, Biogen Inc, Sells Prelude Therapeutics Inc, Aurinia Pharmaceuticals Inc, Ascendis Pharma A/S

• New Purchases: ADGI, ZBH, HCA, ERAS, SGEN, CTKB, VECT, CYBN, CMMB, CMMB, CLDX, THC, HUMA, RXST, DICE, EVH, AADI, BMRN, REGN, FTRP, SURF, NTLA, OWLT, PRCT, SGHT, RGEN, CABA, SNDX, PHAS, APTX,
• Added Positions: BIIB, IKNA, ABBV, GLPG, SIBN, MRTX, XBI, IMGN, LUNG, ALPN, CRSP, TBPH, NRIX, SYBX, IMRA, CVRX, ACRS, GRPH, KZR, JNCE, QURE, PCVX, OCX, CBIO, PHGE, CTMX, INZY, MRSN, KDNY,
• Reduced Positions: PRLD, NTRA, ANTM, AFIB, BSX, ABCL, DCPH, VRTX, NVAX, DXCM, HZNP, APTO, XENE, KALA, PGNY, VTGN, BLU, LABP, NBIX, CRVS, RPTX, ASLN, MGTA, NAUT, FLDM,
• Sold Out: AUPH, ASND, TRIL, ARCT, ALXN, ALEC, RLAY, ARPO, OTIC, STRO, DYN, GLUE, VERV, SBBP, OGN, PPBT,

For the details of ORBIMED ADVISORS LLC's stock buys and sells, go to https://www.gurufocus.com/guru/orbimed+advisors+llc/current-portfolio/portfolio

1. SpringWorks Therapeutics Inc (SWTX) - 6,028,307 shares, 4.21% of the total portfolio. Shares reduced by 0.26%
2. Prelude Therapeutics Inc (PRLD) - 10,039,691 shares, 3.45% of the total portfolio.
3. Horizon Therapeutics PLC (HZNP) - 2,610,355 shares, 3.15% of the total portfolio. Shares reduced by 10.67%
4. Merck & Co Inc (MRK) - 3,732,400 shares, 3.08% of the total portfolio.
5. Bristol-Myers Squibb Co (BMY) - 4,515,400 shares, 2.94% of the total portfolio.

Orbimed Advisors Llc initiated holding in Adagio Therapeutics Inc. The purchase prices were between $20.88 and $56.08, with an estimated average price of $37.24. The stock is now traded at around $20.200000. The impact to a portfolio due to this purchase was 2.5%. The holding were 5,383,500 shares as of 2021-09-30.

Orbimed Advisors Llc initiated holding in Zimmer Biomet Holdings Inc. The purchase prices were between $140.44 and $163.52, with an estimated average price of $151.62. The stock is now traded at around $131.760000. The impact to a portfolio due to this purchase was 1.06%. The holding were 660,800 shares as of 2021-09-30.

Orbimed Advisors Llc initiated holding in HCA Healthcare Inc. The purchase prices were between $211.83 and $261.64, with an estimated average price of $244.16. The stock is now traded at around $241.720000. The impact to a portfolio due to this purchase was 0.52%. The holding were 193,800 shares as of 2021-09-30.

Orbimed Advisors Llc initiated holding in Erasca Inc. The purchase prices were between $17.43 and $24.34, with an estimated average price of $20.69. The stock is now traded at around $19.550000. The impact to a portfolio due to this purchase was 0.51%. The holding were 2,167,341 shares as of 2021-09-30.

Orbimed Advisors Llc initiated holding in Seagen Inc. The purchase prices were between $142.45 and $169.82, with an estimated average price of $155.61. The stock is now traded at around $182.410000. The impact to a portfolio due to this purchase was 0.5%. The holding were 268,000 shares as of 2021-09-30.

Orbimed Advisors Llc initiated holding in Cytek Biosciences Inc. The purchase prices were between $17.52 and $27.93, with an estimated average price of $23.54. The stock is now traded at around $22.950000. The impact to a portfolio due to this purchase was 0.45%. The holding were 1,923,139 shares as of 2021-09-30.

Orbimed Advisors Llc added to a holding in Biogen Inc by 247.48%. The purchase prices were between $282.99 and $369.05, with an estimated average price of $328.16. The stock is now traded at around $261.550000. The impact to a portfolio due to this purchase was 0.52%. The holding were 234,200 shares as of 2021-09-30.

Orbimed Advisors Llc added to a holding in Ikena Oncology Inc by 111.85%. The purchase prices were between $9.82 and $15.23, with an estimated average price of $12.16. The stock is now traded at around $16.700000. The impact to a portfolio due to this purchase was 0.45%. The holding were 6,215,466 shares as of 2021-09-30.

Orbimed Advisors Llc added to a holding in AbbVie Inc by 21.68%. The purchase prices were between $106.4 and $120.78, with an estimated average price of $114.24. The stock is now traded at around $116.420000. The impact to a portfolio due to this purchase was 0.3%. The holding were 1,420,600 shares as of 2021-09-30.

Orbimed Advisors Llc added to a holding in Galapagos NV by 213.31%. The purchase prices were between $52.17 and $70.2, with an estimated average price of $59.52. The stock is now traded at around $52.300000. The impact to a portfolio due to this purchase was 0.29%. The holding were 723,457 shares as of 2021-09-30.

Orbimed Advisors Llc added to a holding in SI-BONE Inc by 72.22%. The purchase prices were between $19.65 and $31.89, with an estimated average price of $25.38. The stock is now traded at around $22.040000. The impact to a portfolio due to this purchase was 0.22%. The holding were 2,248,000 shares as of 2021-09-30.

Orbimed Advisors Llc added to a holding in Pulmonx Corp by 248.00%. The purchase prices were between $35.98 and $44.48, with an estimated average price of $39.46. The stock is now traded at around $38.010000. The impact to a portfolio due to this purchase was 0.12%. The holding were 435,000 shares as of 2021-09-30.

Orbimed Advisors Llc sold out a holding in Aurinia Pharmaceuticals Inc. The sale prices were between $10.93 and $23.55, with an estimated average price of $15.85.

Orbimed Advisors Llc sold out a holding in Ascendis Pharma A/S. The sale prices were between $112.67 and $176.92, with an estimated average price of $137.27.

Orbimed Advisors Llc sold out a holding in Trillium Therapeutics Inc. The sale prices were between $5.86 and $17.8, with an estimated average price of $11.74.

Orbimed Advisors Llc sold out a holding in Arcturus Therapeutics Holdings Inc. The sale prices were between $27.88 and $58.25, with an estimated average price of $44.8.

Orbimed Advisors Llc sold out a holding in . The sale prices were between $179.45 and $186.61, with an estimated average price of $183.84.

Orbimed Advisors Llc sold out a holding in Alector Inc. The sale prices were between $21.65 and $39.49, with an estimated average price of $28.1.