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GuruFocus Financial Strength Rank measures how strong a company’s financial situation is. It is based on these factors

1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.

A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.

Financial Strength : 2/10

vs
industry
vs
history
Cash-to-Debt 0.75
NAS:AMRN's Cash-to-Debt is ranked lower than
83% of the 943 Companies
in the Global Biotechnology industry.

( Industry Median: 54.02 vs. NAS:AMRN: 0.75 )
Ranked among companies with meaningful Cash-to-Debt only.
NAS:AMRN' s Cash-to-Debt Range Over the Past 10 Years
Min: 0.07  Med: N/A Max: No Debt
Current: 0.75
Equity-to-Asset -0.16
NAS:AMRN's Equity-to-Asset is ranked lower than
93% of the 709 Companies
in the Global Biotechnology industry.

( Industry Median: 0.67 vs. NAS:AMRN: -0.16 )
Ranked among companies with meaningful Equity-to-Asset only.
NAS:AMRN' s Equity-to-Asset Range Over the Past 10 Years
Min: -1.11  Med: -0.1 Max: 1
Current: -0.16
-1.11
1
Piotroski F-Score: 5
Altman Z-Score: -7.06
Beneish M-Score: -2.46
WACC vs ROIC
12.21%
-801.78%
WACC
ROIC
GuruFocus Profitability Rank ranks how profitable a company is and how likely the company’s business will stay that way. It is based on these factors:

1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
••3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank•

The maximum rank is 10. A rank of 7 or higher means a higher profitability and may stay that way. A rank of 3 or lower indicates that the company has had trouble to make a profit.

Profitability Rank is not directly related to the Financial Strength Rank. But if a company is consistently profitable, its financial strength will be stronger.

Profitability & Growth : 3/10

vs
industry
vs
history
Operating Margin % -43.88
NAS:AMRN's Operating Margin % is ranked higher than
56% of the 737 Companies
in the Global Biotechnology industry.

( Industry Median: -92.31 vs. NAS:AMRN: -43.88 )
Ranked among companies with meaningful Operating Margin % only.
NAS:AMRN' s Operating Margin % Range Over the Past 10 Years
Min: -691.08  Med: -148.59 Max: -43.88
Current: -43.88
-691.08
-43.88
Net Margin % -55.70
NAS:AMRN's Net Margin % is ranked higher than
53% of the 737 Companies
in the Global Biotechnology industry.

( Industry Median: -79.00 vs. NAS:AMRN: -55.70 )
Ranked among companies with meaningful Net Margin % only.
NAS:AMRN' s Net Margin % Range Over the Past 10 Years
Min: -630.82  Med: -122.45 Max: -55.7
Current: -55.7
-630.82
-55.7
ROA % -46.34
NAS:AMRN's ROA % is ranked lower than
67% of the 950 Companies
in the Global Biotechnology industry.

( Industry Median: -29.87 vs. NAS:AMRN: -46.34 )
Ranked among companies with meaningful ROA % only.
NAS:AMRN' s ROA % Range Over the Past 10 Years
Min: -549.69  Med: -66.17 Max: -26.61
Current: -46.34
-549.69
-26.61
ROC (Joel Greenblatt) % -4398.08
NAS:AMRN's ROC (Joel Greenblatt) % is ranked lower than
79% of the 907 Companies
in the Global Biotechnology industry.

( Industry Median: -394.49 vs. NAS:AMRN: -4398.08 )
Ranked among companies with meaningful ROC (Joel Greenblatt) % only.
NAS:AMRN' s ROC (Joel Greenblatt) % Range Over the Past 10 Years
Min: -231547.22  Med: -8240.48 Max: -1589.48
Current: -4398.08
-231547.22
-1589.48
3-Year Revenue Growth Rate 57.20
NAS:AMRN's 3-Year Revenue Growth Rate is ranked higher than
88% of the 507 Companies
in the Global Biotechnology industry.

( Industry Median: 5.10 vs. NAS:AMRN: 57.20 )
Ranked among companies with meaningful 3-Year Revenue Growth Rate only.
NAS:AMRN' s 3-Year Revenue Growth Rate Range Over the Past 10 Years
Min: 0  Med: -75.7 Max: 57.2
Current: 57.2
0
57.2
3-Year EBITDA Growth Rate -30.60
NAS:AMRN's 3-Year EBITDA Growth Rate is ranked lower than
82% of the 534 Companies
in the Global Biotechnology industry.

( Industry Median: -0.90 vs. NAS:AMRN: -30.60 )
Ranked among companies with meaningful 3-Year EBITDA Growth Rate only.
NAS:AMRN' s 3-Year EBITDA Growth Rate Range Over the Past 10 Years
Min: 0  Med: -31.4 Max: 66.3
Current: -30.6
0
66.3
3-Year EPS without NRI Growth Rate -31.60
NAS:AMRN's 3-Year EPS without NRI Growth Rate is ranked lower than
80% of the 519 Companies
in the Global Biotechnology industry.

( Industry Median: -2.90 vs. NAS:AMRN: -31.60 )
Ranked among companies with meaningful 3-Year EPS without NRI Growth Rate only.
NAS:AMRN' s 3-Year EPS without NRI Growth Rate Range Over the Past 10 Years
Min: -81.1  Med: -16.2 Max: 88.5
Current: -31.6
-81.1
88.5
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» NAS:AMRN's 30-Y Financials

Financials (Next Earnings Date: 2017-08-03 Est.)


Revenue & Net Income
Cash & Debt
Operating Cash Flow & Free Cash Flow
Operating Cash Flow & Net Income

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Guru Trades

Q1 2016

AMRN Guru Trades in Q1 2016

Jim Simons Sold Out
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Q3 2016

AMRN Guru Trades in Q3 2016

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Q4 2016

AMRN Guru Trades in Q4 2016

Jim Simons 386,000 sh (+662.85%)
Paul Tudor Jones 10,998 sh (-63.10%)
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Q1 2017

AMRN Guru Trades in Q1 2017

Steven Cohen 300,000 sh (New)
Jim Simons 1,730,200 sh (+348.24%)
Paul Tudor Jones Sold Out
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Business Description

Industry: Biotechnology » Biotechnology    NAICS: 325412    SIC: 2834
Compare:NAS:ALDR, NYSE:BHVN, NAS:AMRI, NAS:TGTX, NYSE:MYOV, NAS:ZIOP, NAS:FPRX, NAS:ASND, NAS:AKAO, NAS:IMMU, NAS:AIMT, NAS:CLLS, NAS:ESPR, OTCPK:IPHYF, NAS:BYSI, NAS:EPZM, NAS:FWP, NAS:ADRO, NAS:KERX, NAS:OMER » details
Traded in other countries:EH3A.Germany,
Headquarter Location:Ireland
Amarin Corp PLC is a biopharmaceutical company with expertise in lipid science. The Company is engaged in commercialization and development of therapeutics to improve cardiovascular health.

Amarin Corp PLC, formerly known as Ethical Holdings plc was incorporated under the laws of England and Wales on March 1, 1989 under the Companies Act 1985. It is a biopharmaceutical company with expertise in lipid science focused on the commercialization and development of therapeutics to improve cardiovascular health. The Company's product Vascepa (icosapent ethyl) capsules is approved by the U.S. Food and Drug Administration for the use as an adjunct to diet to reduce triglyceride levels in adult patients with severe (TG>500mg/dL) hypertriglyceridemia. On January 28, 2013 the Company commenced full commercial launch of Vascepa. The Company refers to its second indication for Vascepa as the ANCHOR indication. The FDA views the proposed ANCHOR indication as ostensibly and impliedly an indication to reduce cardiovascular risk. In addition, in December 2011, the Company announced commencement of patient dosing in cardiovascular outcomes study of Vascepa, titled REDUCE-IT or Reduction of Cardiovascular Events with EPA-Intervention Trial. The REDUCE-IT study is designed to evaluate the efficacy of Vascepa in reducing cardiovascular events in a high risk patient population on statin therapy. On January 28, 2013, the Company commenced full commercial launch of Vascepa in the United States for use in the MARINE indication. The Company now markets Vascepa in the United States through sales force of approximately 150 sales professionals and also employed marketing and medical affairs personnel to support commercialization of Vascepa. As of February 1, 2014, over 16,000 clinicians had written prescriptions for Vascepa. In November 2010, the Company reported top-line data for the MARINE trial. Vascepa was well tolerated in the MARINE trial, with a safety profile comparable to placebo and there were no treatment-related serious adverse events observed. The Company uses third party manufacturers and suppliers to manufacture clinical and commercial quantities of ethyl-EPA, which constitutes the only active pharmaceutical ingredient within Vascepa, to encapsulate, bottle and package Vascepa and to maintain inventory of Vascepa. The Company currently relies on Patheon for the encapsulation of Vascepa. The Companies competitors include GlaxoSmithKline plc and AbbVie, Inc., and Niaspan. The Company is subject to regulation by government authorities, including FDA.

Top Ranked Articles about Amarin Corp PLC

Amarin to Report First Quarter 2017 Results and Host Conference Call on May 3, 2017
Amarin Reaches the Onset of Approximately 80% of the Target Aggregate Number of Primary Major Adverse Cardiovascular Events Within the REDUCE-IT Study

REDUCE-IT Cardiovascular Outcomes Study Remains on Schedule to Reach Onset of Target Final Primary Major Adverse Cardiovascular Event Near the End of 2017

BEDMINSTER, N.J., and DUBLIN, Ireland, March 16, 2017 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN), a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health, announced today the onset of approximately 80% of the target aggregate number of primary cardiovascular events within the REDUCE-IT study. This milestone has triggered preparation for a pre-specified interim efficacy and safety analysis by the study’s independent Data Monitoring Committee (DMC). Amarin currently expects the independent interim analysis to be conducted before the end of the third calendar quarter of this year.
Interim Analysis Expected in Q3 The REDUCE-IT study's event rate continues to track consistently with Amarin’s existing public guidance for the timing of the interim analysis and study completion. A pre-specified interim efficacy and safety analysis is designed to be conducted upon achieving approximately 80% of the target 1,612 aggregate primary major adverse cardiovascular events within the study. REDUCE-IT patients are in the process of completing a study visit over the coming months, after which additional time is required by the contract research organizations to finish collecting and preparing data for transfer to and analysis by the DMC. This data preparation and transfer process is expected to take several months as is typical for large-scale, multi-national studies, and consistent with the process for the first pre-specified interim analysis of the REDUCE-IT study, regardless of the strength of the study results. The DMC's analysis is anticipated to occur before the end of the third calendar quarter of 2017. Amarin will remain blinded to the interim and ongoing results of the REDUCE-IT study until after the study is ready to be stopped either at the interim analysis or at the final analysis. Guidelines for the independent DMC to recommend stopping the study for overwhelming efficacy require that the study achieve statistical significance on the primary endpoint and generate robust findings on certain, pre-specified secondary outcome measures. Given the high thresholds of overwhelming efficacy required prior to a DMC recommending an early stop to a cardiovascular outcomes trial like REDUCE-IT, Amarin continues to expect that the DMC's interim analysis will result in a recommendation to continue the REDUCE-IT study as planned to completion of 100% of the target events. The efficacy requirements detailed to the DMC for early study stoppage after the 80% interim assessment are high and include robustness thresholds for underlying data that go beyond the assessment for statistical significance on the analysis of the primary endpoint after the expected completion of the study at 100% of planned events. First Multinational Outcomes Study to Evaluate Cardiovascular Benefit of High-Dose EPA Therapy as an Add-on to Statin Therapy Heart disease remains the number one cause of death in the United States. REDUCE-IT is the first multinational outcomes study being conducted to evaluate the cardiovascular benefits of treating patients with high cardiovascular risk who, despite having their LCL-cholesterol controlled with statin therapy, have elevated triglyceride levels. The study is designed to examine whether the demonstrated clinical effects and postulated pleiotropic cardioprotective benefits of high-dose EPA-only Vascepa therapy, when added to statin therapy, will offer improved cardiovascular outcomes for patients. The results of this important trial, if successful, could lead to improved medical care for tens of millions of patients.   The design of the REDUCE-IT cardiovascular outcomes study was published in March 2017 in Clinical Cardiology. A copy of this publication is available at: http://onlinelibrary.wiley.com/doi/10.1002/clc.22692/full. Amarin believes that the REDUCE-IT study is designed for success based on extensive review of data from clinical, epidemiologic and genetic studies. Amarin estimates that results of the trial will become available to Amarin and be publicly communicated in mid-2018. This estimated timing reflects our assumptions of the time necessary to collect vital data from all patients in the study, compile the results, and subject the results to scrutiny of the independent review committees and the REDUCE-IT operational team after reaching the onset of the target final aggregate cardiovascular event in this study. The onset of the target final aggregate cardiovascular event in this study is estimated to occur near the end of 2017. The primary endpoint of this global, double-blind study is the time to the first occurrence of a composite of major adverse cardiovascular events (MACE). Results will be compared between the Vascepa and placebo groups. The study is being conducted under a special protocol assessment (SPA) agreement with the FDA. About Amarin Amarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health.  Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to an ongoing outcomes study.  Vascepa® (icosapent ethyl), Amarin's first FDA approved product, is a highly-pure, omega-3 fatty acid product available by prescription.  For more information about Vascepa visit www.vascepa.com.  For more information about Amarin visit www.amarincorp.com. About VASCEPA® (icosapent ethyl) capsules VASCEPA® (icosapent ethyl) capsules are a single-molecule prescription product consisting of the omega-3 acid commonly known as EPA in ethyl-ester form. VASCEPA is not fish oil, but is derived from fish through a stringent and complex FDA-regulated manufacturing process designed to effectively eliminate impurities and isolate and protect the single molecule active ingredient. VASCEPA is known in scientific literature as AMR101. FDA-approved Indication and Usage VASCEPA (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia.The effect of VASCEPA on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined. Important Safety Information for VASCEPA VASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components.Use with caution in patients with known hypersensitivity to fish and/or shellfish.The most common reported adverse reaction (incidence >2% and greater than placebo) was arthralgia (2.3% for VASCEPA, 1.0% for placebo). There was no reported adverse reaction >3% and greater than placebo.Patients receiving treatment with VASCEPA and other drugs affecting coagulation (e.g., anti-platelet agents) should be monitored periodically.In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy.Patients should be advised to swallow VASCEPA capsules whole; not to break open, crush, dissolve, or chew VASCEPA.Adverse events and product complaints may be reported by calling 1‑855‑VASCEPA or the FDA at 1‑800‑FDA‑1088. FULL VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM. VASCEPA has been approved for use by the United States Food and Drug Administration (FDA) as an adjunct to diet to reduce triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. VASCEPA is under various stages of development for potential use in other indications that have not been approved by the FDA. Nothing in this press release should be construed as promoting the use of VASCEPA in any indication that has not been approved by the FDA. Forward-looking statements This press release contains forward-looking statements, including expectations for continued event rates, interim data review, results and related timing and announcements with respect to Amarin's REDUCE-IT cardiovascular outcomes study; expectations related to the interim and final outcomes of the REDUCE-IT study and the anticipated successful completion of the REDUCE-IT study; and statements regarding the potential and therapeutic benefits of Vascepa. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. In particular, as disclosed in filings with the U.S. Securities and Exchange Commission, Amarin's ability to effectively develop and commercialize Vascepa will depend in part on its ability to continue to effectively finance its business, efforts of third parties, its ability to create market demand for Vascepa through education, marketing and sales activities, to achieve increased market acceptance of Vascepa, to receive adequate levels of reimbursement from third-party payers, to develop and maintain a consistent source of commercial supply at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection for Vascepa. Among the factors that could cause actual results to differ materially from those described or projected herein include the following: uncertainties associated generally with research and development, clinical trials and related regulatory approvals; the risk that historical REDUCE-IT event rates may not be predictive of future results and related cost may increase beyond expectations; the risk that regulatory reviews may impact the current design of the REDUCE-IT study or cause a change in strategic direction with respect to continuation of the study; the risk that future legal determinations and interactions with regulatory authorities may impact Vascepa marketing and sales rights and efforts; the risk that Vascepa may not show clinically meaningful effects in REDUCE-IT or support regulatory approvals for cardiovascular risk reduction; and the risk that patents may not be upheld in anticipated patent litigation. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin’s filings with the U.S. Securities and Exchange Commission, including its most recent Annual Report on Form 10-K. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Amarin undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise. Availability of other information about Amarin Investors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://investor.amarincorp.com), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin contact information:

Investor Relations:

Elisabeth Schwartz
Investor Relations and Corporate Communications
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]

Lee M. Stern
Trout Group
In U.S.: 1 (646) 378-2992
[email protected]

Media Inquiries:

Kristie Kuhl
Finn Partners
In U.S.: 1 (212) 583-2791
[email protected]

Read more...
Amarin Announces Publication of REDUCE-IT Cardiovascular Outcomes Study Rationale and Design in Clinical Cardiology
BEDMINSTER, N.J. and DUBLIN, Ireland, March 15, 2017 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) announced the publication today of the rationale and design for the company’s REDUCE-IT Phase 3 cardiovascular outcomes study in Clinical Cardiology, available at: http://onlinelibrary.wiley.com/doi/10.1002/clc.22692/full.
Deepak L. Bhatt, M.D., M.P.H., executive director of the Interventional Cardiovascular Programs at Brigham and Women’s Hospital, professor of medicine, Harvard Medical School in Boston, Mass., is the lead author of the published article titled, “Rationale and Design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl - Intervention Trial.”REDUCE-IT is a landmark global study of approximately 8,000 patients to evaluate whether treatment with prescription pure EPA Vascepa® (icosapent ethyl) at four grams per day reduces cardiovascular events in patients, who despite having their LDL-cholesterol (LDL-C) controlled with statin therapy, have elevated triglyceride levels and demonstrate other risk factors, such as diabetes and previous cardiovascular events.“Controlling LDL-C is critically important but only one aspect of overall good cardiovascular health,” said Dr. Bhatt. “The risk of cardiovascular events remains high due to independent factors that cannot be addressed only by reducing LDL-C. The question of how best to achieve cardiovascular risk reduction beyond the benefits realized from effective management of LDL-C remains unanswered. The REDUCE-IT trial is designed to address whether the demonstrated clinical effects and postulated pleiotropic cardioprotective benefits of icosapent ethyl when added to statin therapy will offer improved cardiovascular outcomes for patients and provide physicians with a new treatment option in the studied high cardiovascular risk population.”The publication notes that, while clinical and epidemiological studies have demonstrated patients with elevated triglycerides remain at high cardiovascular risk despite controlling LDL-C, to date no study has prospectively examined this population. For this population, high dose prescription pure EPA may prove beneficial. EPA has been shown to improve relevant lipid, lipoprotein and inflammatory parameters without raising LDL-C and may have pleiotropic benefits. An open label, blinded endpoint outcomes study in Japan of low doses of prescription pure EPA added to statin therapies has been shown to produce further cardiovascular event reduction with moderately elevated triglycerides, by 19% in the overall population and by 53% in a subgroup of patients similar to those enrolled in the REDUCE-IT study. REDUCE-IT is evaluating whether treatment with high dose EPA reduces ischemic events in statin-treated patients with persistent elevated triglycerides.    â€œDespite significant advances in the diagnosis, management, and understanding of cardiovascular disease, it remains the leading killer in this country,” said Steven B. Ketchum, Ph.D., president of R&D and chief scientific officer of Amarin. “We are confident that REDUCE-IT will provide important answers on whether the addition of prescription pure EPA Vascepa to patients with persistent elevated triglycerides after statin therapy confers a meaningful reduction in the occurrence of major cardiovascular events in this high-risk patient population.”Residual Cardiovascular Risk in Statin-Treated PatientsCardiovascular disease remains the leading cause of death in the United States, with the estimated costs of treating heart attacks, strokes and other cardiovascular diseases exceeding $300 billion annually.  In the United States, more than 35 million patients are treated with statins for the primary and secondary prevention of atherosclerotic cardiovascular events, including myocardial infarctions (heart attacks), and stroke.  Despite the demonstrated clinical benefits of lowering LDL-C with statins, significant residual cardiovascular risk remains for statin-treated patients. Vascepa is being studied in REDUCE-IT as an add-on to statin therapy to further reduce cardiovascular risk, not as a replacement for statin therapy. About REDUCE-IT REDUCE-IT is a global Phase 3, randomized, multicenter, double-blind, placebo-controlled study designed to evaluate whether treatment with Vascepa reduces cardiovascular events in patients who despite stabilized statin therapy have elevated triglyceride levels and other cardiovascular risk factors. The primary endpoint of the study is the time to the first occurrence of the composite endpoint of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or hospitalization for unstable angina. Secondary endpoints include time to event analyses of components of the primary endpoint.  The study is being conducted under a special protocol assessment agreement with the FDA.Additional information on the REDUCE-IT trial and Amarin's other clinical studies of Vascepa can be found at www.clinicaltrials.gov.About Vascepa® (icosapent ethyl) capsulesVascepa® (icosapent ethyl) capsules are a single-molecule prescription product consisting of the omega-3 acid commonly known as EPA in ethyl-ester form. Vascepa is not fish oil, but is derived from fish through a stringent and complex FDA-regulated manufacturing process designed to effectively eliminate impurities and isolate and protect the single molecule active ingredient. Vascepa is known in scientific literature as AMR101.FDA-approved Indication and UsageVascepa (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe ( ≥ 500 mg/dL) hypertriglyceridemia.The effect of Vascepa on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined.Important Safety Information for VascepaVascepa is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to Vascepa or any of its components.Use with caution in patients with known hypersensitivity to fish and/or shellfish.The most common reported adverse reaction (incidence > 2% and greater than placebo) was arthralgia (2.3% for Vascepa, 1.0% for placebo). There was no reported adverse reaction > 3% and greater than placebo.Patients receiving treatment with Vascepa and other drugs affecting coagulation (e.g., anti-platelet agents) should be monitored periodically.In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy.Patients should be advised to swallow Vascepa capsules whole; not to break open, crush, dissolve, or chew Vascepa.Adverse events and product complaints may be reported by calling 1‑855‑VASCEPA or the FDA at 1‑800‑FDA‑1088.FULL VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM.Vascepa has been approved for use by the United States Food and Drug Administration (FDA) as an adjunct to diet to reduce triglyceride levels in adult patients with severe ( ≥ 500 mg/dL) hypertriglyceridemia. Vascepa is under various stages of development for potential use in other indications that have not been approved by the FDA. Nothing in this press release should be construed as promoting the use of Vascepa in any indication that has not been approved by the FDA.About AmarinAmarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to the ongoing REDUCE-IT cardiovascular outcomes study. Vascepa® (icosapent ethyl), Amarin's first FDA-approved product, is a highly-pure, EPA-only, omega-3 fatty acid product available by prescription. For more information about Vascepa, visit www.vascepa.com. For more information about Amarin, visit www.amarincorp.com.Forward-looking statements This press release contains forward-looking statements such as expectations regarding the ability of REDUCE-IT to provide important answers on whether the addition of Vascepa to statin therapy would confer a meaningful reduction in the occurrence of major cardiovascular events in the patient population studied. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties.  For example, statements related to the potential efficacy and therapeutic benefits of Vascepa have been subject to different interpretations on matters such as the potential clinical importance of lowering triglyceride levels in studied patients. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with complex clinical trials like REDUCE-IT and research and development and clinical trial risk generally; differing views on interpretation of clinical trial results including the results of the cited Japanese study and other relevant studies; and reliance on third parties. Due to these risks and other uncertainties, REDUCE-IT may not generate positive or useful results. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including its most recent Annual Report on Form 10-K. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Amarin undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.Availability of other information about AmarinInvestors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://investor.amarincorp.com), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin Contact Information:

Investor Relations:
Elisabeth Schwartz
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]

Lee M. Stern
Trout Group
In U.S.: 1 (646) 378-2922
[email protected]

Media Inquiries:
Ovidio Torres
Finn Partners
In U.S.: 1 (312) 329 3911
[email protected]

Read more...
Amarin Appoints Michael W. Kalb Chief Financial Officer
BEDMINSTER, NJ and DUBLIN, IRELAND--(Marketwired - June 30, 2016) - Amarin Corporation plc (NASDAQ: AMRN) announced that starting today Michael W. Kalb has joined its senior management team as senior vice president and chief financial officer. A seasoned financial executive, Mr. Kalb brings over 20 years of international financial operations and accounting advisory experience. "We are delighted to welcome Mike to our team and look forward to leveraging his extensive experience and leadership capabilities as we continue to grow our commercial business and work toward the completion of our cardiovascular outcomes study," commented John F. Thero, president and chief executive officer of Amarin. "Mike's broad, global business and pharmaceutical experience will further strengthen our executive, financial and operational capabilities as we continue our commercial growth and work toward expanding our business in the future."Mr. Kalb joins Amarin from Taro Pharmaceutical Industries, Ltd., a publicly-traded, multinational, science-based pharmaceutical company where he served as chief financial officer and chief accounting officer. Prior to joining Taro, Mr. Kalb was a director in the Accounting and Financial Consulting Group of Huron Consulting Group Inc. Mr. Kalb's experience also includes over ten years at Ernst & Young, LLP within its Transaction Advisory Services Group and Audit and Assurance Services Group. He is a certified public accountant. Mr. Kalb added, "I am very happy to become a part of the Amarin team. The company has made great progress recently in increasing awareness of Vascepa® and its clinical profile. I am excited both by Vascepa's revenue growth and its large potential upside and look forward to working with the Amarin team to help build upon the company's success and drive shareholder value."About AmarinAmarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to an ongoing outcomes study. Vascepa® (icosapent ethyl), Amarin's first FDA-approved product, is a highly pure omega-3 fatty acid product available by prescription. For more information about Vascepa, visit www.vascepa.com. For more information about Amarin, visit www.amarincorp.com.Forward-looking statementsThis press release contains forward-looking statements, including statements about Amarin's commercial development and research programs and the anticipated contribution of executives to Amarin's progress. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. In particular, as disclosed in its previous filings with the U.S. Securities and Exchange Commission, Amarin's ability to effectively commercialize Vascepa will depend in part on its ability to continue to effectively finance its development programs, create market demand for Vascepa through education, marketing and sales activities, to develop and maintain a consistent source of commercial supply at a competitive price, to comply with legal and regulatory requirements in connection with the sale and promotion of Vascepa and to maintain patent protection for Vascepa. Among the factors that could cause actual results to differ materially from those described or projected herein include the following: individual contributions to Amarin from the named executives, uncertainties associated generally with research and development, clinical trials and related regulatory approvals; the risk that related cost may increase beyond expectations; the risk that Vascepa may not show clinically meaningful effects in REDUCE-IT or support regulatory approvals for cardiovascular risk reduction; and the risk that Amarin's patent applications and patents may not be sufficient to protect the company from generic competition. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including its most recent Quarterly Report on Form 10-Q. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Amarin undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.Availability of Other Information about AmarinInvestors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://www.amarincorp.com/investor-splash.html), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin Contact Information:

Investor Relations:

Kathryn McNeil
Investor Relations and Corporate Communications
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]

Lee M. Stern
Trout Group
In U.S.: 1 (646) 378-2992
[email protected]

Media Inquiries:

Kristie Kuhl
Finn Partners
In U.S.: 1 (212) 583-2791
[email protected]



Read more...
Vascepa(R) (Icosapent Ethyl) Showed Significant Reductions in Potentially Atherogenic Lipid Parameters in Statin-Treated Patients With Type 2 Diabetes and Persistent High Triglycerides
BEDMINSTER, NJ and DUBLIN, IRELAND--(Marketwired - June 11, 2016) - Amarin Corporation plc (NASDAQ: AMRN) today announced additional data on Vascepa (icosapent ethyl) presented at the annual meeting of the American Diabetes Association (ADA) supporting its efficacy in reducing concentrations of potentially atherogenic lipoproteins (lipoproteins that could promote fat deposits in arteries) in patients with Type 2 diabetes and persistent high triglyceride (TG) levels despite statin therapy.The poster (#1173), titled "Effects of Icosapent Ethyl on Lipoprotein Particle Concentration and Size in Statin-Treated Patients with Persistent High Triglycerides: ANCHOR Patients with Diabetes Mellitus," was presented on June 11, 2016. Lipoproteins such as low density lipoprotein (LDL) and very low density lipoprotein (VLDL) carry cholesterol, fat, and other lipids in the blood and are considered potentially atherogenic at persistently elevated levels. Researchers using nuclear magnetic resonance (NMR) spectroscopy observed that, compared with placebo, Vascepa administered at 4 g/day significantly reduced the median concentrations of VLDL and LDL particles in patients with Type 2 diabetes who, despite statin therapy, have persistent high TG levels (≥200 and <500 mg/dL). The analysis was led by Eliot A. Brinton, MD, FAHA, FNLA; Director of Atherometabolic Research at the Utah Foundation for Biomedical Research, and President of the Utah Lipid Center, both in Salt Lake City. Dr. Brinton will be available at an author question and answer session on Sunday, June 12 from noon to 2:00 PM CDT."The findings presented today suggest multiple lipoprotein-related benefits of pure EPA Vascepa in patients with Type 2 diabetes, which merit further investigation of the potential cardiovascular benefits from icosapent ethyl therapy in cardiovascular outcomes trials," said Dr. Brinton. "In addition to the significant reductions in potentially atherogenic lipoprotein particle concentrations with Vascepa 4 g/day, apolipoprotein B (Apo B), which is carried on VLDL and LDL, was also significantly reduced by 9.3% compared with placebo. Furthermore, ApoB levels were correlated with levels of potentially atherogenic lipoproteins. While further study of Vascepa is needed and ongoing, ApoB and potentially atherogenic lipoprotein levels have been linked in the broader scientific literature to atherosclerosis and heart disease, so these new analyses support the hypothesis that Vascepa could prove beneficial to this historically difficult-to-treat patient population believed to be at increased cardiovascular risk." The clinical implications of lowering triglycerides with Vascepa 4 g/day are being investigated in the REDUCE-IT cardiovascular outcomes study of statin-treated subjects with persistent elevated TG levels.About the Presented ResearchDr. Brinton's analysis was a post-hoc subgroup analysis of patients with Type 2 diabetes enrolled in the ANCHOR trial for whom NMR data were available. ANCHOR investigated Vascepa as a treatment for patients with residual high TG (≥200 and <500mg/dL) despite statin-induced control of LDL-C. ANCHOR enrolled 702 patients, of which the majority (73%) had Type 2 diabetes. The primary endpoint was percent change in TG levels from baseline to 12 weeks compared with placebo in subjects treated with placebo or Vascepa at 2 or 4 g/day. In April 2011, Amarin reported top-line results from the ANCHOR trial, which met its primary and secondary endpoints.The data presented at ADA is an analysis of NMR measurements providing the concentration and size of lipoprotein particles (VLDL, LDL and HDL) in ANCHOR subjects with Type 2 diabetes, and comparing the results of subjects taking 4 g/day Vascepa (n=160) to those taking placebo (n=154). The analysis showed that, compared with placebo, Vascepa significantly reduced the median concentration of: total (−11.3%; P=0.004), large (−48.9%; P<0.0001), and medium (−12.0%; P=0.02) VLDL particles; total (−7.4%; P=0.009) and small (−13.1%; P<0.0001) LDL particles; and total (−7.5%; P<0.0001) and large (−29.7%; P<0.0001) HDL particles. In addition, potentially atherogenic particle concentration (defined as total VLDL IDL LDL) decreased significantly (−7.7%; P=0.003). Both LDL and potentially atherogenic particle concentrations were significantly correlated with plasma Apo B at baseline (R2=0.49; P<0.0001 and R2=0.53; P<0.0001, respectively), which increased numerically for both at 12 weeks (R2=0.56 P<0.0001 and R2=0.64 P<0.0001, respectively).The efficacy and safety of Vascepa 4 g/day in patients with Type 2 diabetes were consistent with the overall ANCHOR results.As with many subgroup analyses, limitations of this analysis include the smaller sample size, the 12-week study duration and the post-hoc nature. Nonetheless, the results are suggestive of complementary beneficial changes in TG levels and lipoprotein parameters with Vascepa compared with placebo. Amarin's clinical development program for Vascepa includes a trial known as REDUCE-IT, the first multinational cardiovascular outcomes study evaluating the benefit of pure EPA therapy, or any triglyceride lowering therapy, as an add-on to statins in patients with high cardiovascular risk who, despite stable statin therapy, have elevated triglyceride levels (≥200 and <500mg/dL). Amarin recently announced that it has achieved its target enrollment of 8,000 patients for the trial and that an interim efficacy analysis by the independent Data Monitoring Committee of the REDUCE-IT trial is expected in September or October 2016.Additional information on ANCHOR, REDUCE-IT and Amarin's other clinical studies of Vascepa can be found at www.clinicaltrials.gov.About VASCEPA® (icosapent ethyl) capsulesVASCEPA® (icosapent ethyl) capsules are a single-molecule prescription product consisting of 1 gram of the omega-3 acid commonly known as EPA in ethyl-ester form. Vascepa is not fish oil, but is derived from fish through a stringent and complex FDA-regulated manufacturing process designed to effectively eliminate impurities and isolate and protect the single molecule active ingredient. Vascepa is known in scientific literature as AMR101.FDA-approved Indication and UsageVASCEPA (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia.The effect of VASCEPA on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined.Important Safety Information for VASCEPAVASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components.Use with caution in patients with known hypersensitivity to fish and/or shellfish.The most common reported adverse reaction (incidence >2% and greater than placebo) was arthralgia (2.3% for Vascepa, 1.0% for placebo). There was no reported adverse reaction >3% and greater than placebo.Patients receiving treatment with VASCEPA and other drugs affecting coagulation (e.g., anti-platelet agents) should be monitored periodically.In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy.Patients should be advised to swallow VASCEPA capsules whole; not to break open, crush, dissolve, or chew VASCEPA.Adverse events and product complaints may be reported by calling 1-855-VASCEPA or the FDA at 1-800-FDA-1088.FULL VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM.Vascepa has been approved for use by the United States Food and Drug Administration (FDA) as an adjunct to diet to reduce triglyceride levels in adult patients with severe (≥ 500 mg/dL) hypertriglyceridemia. Vascepa is under various stages of development for potential use in other indications that have not been approved by the FDA. Nothing in this press release should be construed as promoting the use of Vascepa in any indication that has not been approved by the FDA.About AmarinAmarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to the ongoing REDUCE-IT cardiovascular outcomes study. Vascepa® (icosapent ethyl), Amarin's first FDA-approved product, is a highly-pure, EPA-only, omega-3 fatty acid product available by prescription. For more information about Vascepa, visit www.vascepa.com. For more information about Amarin, visit www.amarincorp.com.Forward-looking statementsThis press release contains forward-looking statements, including statements about the potential efficacy and therapeutic benefits of Vascepa and EPA, including implications about the potential clinical importance of the findings presented. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with retrospective sub-set analyses, research on biomarkers thought to be relevant in the treatment of cardiovascular disease, research and development and clinical trial risk generally, including the risk that study results in small sample sizes in short-term studies may not be predictive of future results in larger, longer-term studies and that studied parameters may not have clinically meaningful effect. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including its most recent Quarterly Report on Form 10-Q. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Amarin undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.Availability of other information about AmarinInvestors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://www.amarincorp.com/investor-splash.html), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin Contact Information:
Investor Relations:
Kathryn McNeil
Investor Relations and Corporate Communications
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]

Lee M. Stern
Trout Group
In U.S.: 1 (646) 378-2922
[email protected]

Media Inquiries:
Ovidio Torres
Finn Partners
In U.S.: 1 (312) 329 3911
[email protected]



Read more...
Vascepa(R) (Icosapent Ethyl) Data to Be Presented at American Diabetes Association's 76th Scientific Sessions
BEDMINSTER, NJ AND DUBLIN, IRELAND--(Marketwired - June 06, 2016) -  Amarin Corporation plc (NASDAQ: AMRN) today announced that new data related to Vascepa® (icosapent ethyl) will be presented at the upcoming American Diabetes Association (ADA) 76th Scientific Sessions in New Orleans (June 10-14) and published as an abstract in the Diabetes® Abstract Book. The poster presentation is a post-hoc analysis of Type 2 diabetes patients from Amarin's ANCHOR trial who, despite statin therapy, have persistent high triglyceride levels. The 12-week ANCHOR trial studied the effects of Vascepa in adult patients at high risk for cardiovascular disease with persistent high triglyceride levels (≥200 mg/dL and <500 mg/dL) after stable statin therapy.Presentation information is as follows:
Poster Presentation #173-P, Category 12-E Clinical Therapeutics/New Technology-Oral Agents: Effects ofIcosapent Ethyl on Lipoprotein Particle Concentration and Size in Statin-Treated Patients with Persistent High Triglycerides: ANCHOR Patients with Diabetes Mellitus -- (Authors: Eliot A. Brinton, MD, FAHA, FNLA, Christie M. Ballantyne, MD, Harold E. Bays, MD, et al.)
The poster will be on display from Saturday, June 11 starting at 10 a.m. CDT to Monday, June 13 at 2 p.m. CDT, with the author presentation scheduled for Sunday, June 12, between 12:00 - 2:00 p.m. CDT. Additional data that was accepted by the ADA Scientific Sessions Planning Committee and will be published in the Diabetes® Abstract Book is titled: "Eicosapentaenoic Acid, but not other TG-lowering Agents, Reversed Hyperglycemia-Induced Rat Endothelial Cell Dysfunction and Enhanced the Benefits of Atorvastatin Active Metabolite Ex Vivo" (Authors: R. Preston Mason, PhD, Robert F. Jacob, PhD, Hazem Dawoud, MS, Haidar Alhumaid, MS, et al.). This was an ex vivo experiment looking at the effects of eicosapentaenoic acid ± atorvastatin active metabolite (ATM) relative to niacin or fenofibrate in glomerular endothelial cells from rats exposed to high glucose. About VASCEPA®
(icosapent ethyl) capsules
VASCEPA® (icosapent ethyl) capsules are a single-molecule prescription product consisting of 1 gram of the omega-3 acid commonly known as EPA in ethyl-ester form. Vascepa is not fish oil, but is derived from fish through a stringent and complex FDA-regulated manufacturing process designed to effectively eliminate impurities and isolate and protect the single molecule active ingredient. Vascepa is known in scientific literature as AMR101. FDA-approved Indication and Usage

VASCEPA (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. The effect of VASCEPA on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined. Important Safety Information for VASCEPA

VASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components. Use with caution in patients with known hypersensitivity to fish and/or shellfish. The most common reported adverse reaction (incidence >2% and greater than placebo) was arthralgia (2.3% for Vascepa, 1.0% for placebo). There was no reported adverse reaction >3% and greater than placebo. Patients receiving treatment with VASCEPA and other drugs affecting coagulation (e.g., anti-platelet agents) should be monitored periodically. In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy. Patients should be advised to swallow VASCEPA capsules whole; not to break open, crush, dissolve, or chew VASCEPA. Adverse events and product complaints may be reported by calling

1-855-VASCEPA or the FDA at 1-800-FDA-1088. FULL VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM.Vascepa has been approved for use by the United States Food and Drug Administration (FDA) as an adjunct to diet to reduce triglyceride levels in adult patients with severe (≥ 500 mg/dL) hypertriglyceridemia. Vascepa is under various stages of development for potential use in other indications that have not been approved by the FDA. Nothing in this press release should be construed as promoting the use of Vascepa in any indication that has not been approved by the FDA. About Amarin
Amarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to the ongoing REDUCE-IT cardiovascular outcomes study. Vascepa® (icosapent ethyl), Amarin's first FDA-approved product, is a highly-pure, EPA-only, omega-3 fatty acid product available by prescription. For more information about Vascepa, visit www.vascepa.com. For more information about Amarin, visit www.amarincorp.com. Forward-looking statements
This press release contains forward-looking statements, including statements about the potential efficacy and therapeutic benefits of Vascepa and EPA, including implications about the potential clinical importance of the findings presented. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with research on biomarkers thought to be relevant in the treatment of cardiovascular disease, research and development and clinical trial risk generally, including the risk that study results may not be predictive of future results and that studied parameters may not have clinically meaningful effect. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including its most recent Quarterly Report on Form 10-Q. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Amarin undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise. Availability of other information about Amarin
Investors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://www.amarincorp.com/investor-splash.html), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin Contact Information: 

Investor Relations: 
Kathryn McNeil 
Investor Relations and Corporate Communications
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]

Lee M. Stern
Trout Group 
In U.S.: 1 (646) 378-2922
[email protected]

Media Inquiries:
Ovidio Torres
Finn Partners
In U.S.: 1 (312) 329 3911
[email protected]



Read more...
Amarin to Present at the Jefferies 2016 Global Healthcare Conference
BEDMINSTER, NJ and DUBLIN, IRELAND--(Marketwired - June 01, 2016) - Amarin Corporation plc (NASDAQ: AMRN), a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health, announced today that John F. Thero, Amarin's president and chief executive officer, is scheduled to present a general company update at the Jefferies 2016 Global Healthcare Conference in New York City on Tuesday, June 7, 2016, at 8:00 a.m. ET. A live audio webcast of the presentation will be available at: http://wsw.com/webcast/jeff97/amrn
About Amarin
Amarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to an ongoing outcomes study. Vascepa® (icosapent ethyl), Amarin's first FDA-approved product, is a highly-pure, EPA-only, omega-3 fatty acid product available by prescription. For more information about Vascepa, visit www.vascepa.com. For more information about Amarin, visit www.amarincorp.com. Availability of Other Information about Amarin
Investors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://www.amarincorp.com/investor-splash.html), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin contact information




Investor Relations: 
Kathryn McNeil 
Investor Relations and Corporate Communications
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]

Lee M. Stern
Trout Group 
In U.S.: 1 (646) 378-2922
[email protected]

Media Inquiries:
Ovidio Torres
Finn Partners
In U.S.: 1 (312) 329 3911
[email protected]



Read more...
Amarin Announces FDA New Chemical Entity Market Exclusivity Determination for Vascepa(R) (icosapent ethyl) Capsules
BEDMINSTER, NJ and DUBLIN, IRELAND--(Marketwired - May 31, 2016) - Amarin Corporation plc (NASDAQ: AMRN) announced today that the U.S. Food and Drug Administration (FDA) has determined that Vascepa® (icosapent ethyl) capsules are eligible for five-year, new chemical entity (NCE), marketing exclusivity pursuant to the Hatch-Waxman Amendments to the Federal Food, Drug, and Cosmetic Act. This determination provides Vascepa with the benefits of NCE exclusivity afforded by statute. NCE exclusivity for Vascepa runs from its date of FDA approval on July 26, 2012 and extends until July 26, 2017. The statutory 30-month stay triggered by patent litigation following generic application submissions permitted on July 26, 2016 would expire on January 26, 2020, seven-and-a-half years from FDA approval."Amarin's goal is to protect the commercial potential of Vascepa to 2030," stated John F. Thero, president and chief executive officer of Amarin. "NCE regulatory exclusivity complements multiple patents covering Vascepa with expiration dates in 2030."  About VASCEPA

®

 (icosapent ethyl) capsules
VASCEPA® (icosapent ethyl) capsules are a single-molecule prescription product consisting of 1 gram of the omega-3 acid commonly known as EPA in ethyl-ester form. Vascepa is not fish oil, but is derived from fish through a stringent and complex FDA-regulated manufacturing process designed to effectively eliminate impurities and isolate and protect the single molecule active ingredient. Vascepa is known in scientific literature as AMR101. FDA-approved Indication and Usage

VASCEPA (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe ( ≥ 500 mg/dL) hypertriglyceridemia. The effect of VASCEPA on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined. Important Safety Information for VASCEPA

VASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components. Use with caution in patients with known hypersensitivity to fish and/or shellfish. The most common reported adverse reaction (incidence > 2% and greater than placebo) was arthralgia (2.3% for Vascepa, 1.0% for placebo). There was no reported adverse reaction > 3% and greater than placebo. Patients receiving treatment with VASCEPA and other drugs affecting coagulation (e.g., anti-platelet agents) should be monitored periodically. In patients with hepatic impairment, monitor ALT and AST levels periodically during therapy. Patients should be advised to swallow VASCEPA capsules whole; not to break open, crush, dissolve, or chew VASCEPA. Adverse events and product complaints may be reported by calling

1-855-VASCEPA or the FDA at 1-800-FDA-1088. FULL VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM. About Amarin
Amarin Corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. Amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. Amarin's clinical program includes a commitment to the ongoing REDUCE-IT cardiovascular outcomes study. Vascepa® (icosapent ethyl), Amarin's first FDA-approved product, is a highly-pure, EPA-only, omega-3 fatty acid product available by prescription. For more information about Vascepa, visit www.vascepa.com. For more information about Amarin, visit www.amarincorp.com. Forward-looking statements  This press release contains forward-looking statements, including statements about whether NCE exclusivity and Amarin patents would adequately protect Vascepa against competition and Amarin's plan to protect the commercial potential of Vascepa. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. Among the factors that could cause actual results to differ materially from those described herein include the following: events that could interfere with the continued validity or enforceability of a patent; Amarin's ability generally to maintain adequate patent protection and successfully enforce patent claims against third parties; withstanding any challenge to FDA's NCE determination; commercializing Vascepa without violating the intellectual property rights of others; and uncertainties associated generally with research and development, clinical trials and related regulatory approvals and exclusivity grants. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including its most recent Quarterly Report on Form 10-Q. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Amarin undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise. Availability of other information about Amarin
Investors and others should note that we communicate with our investors and the public using our company website (www.amarincorp.com), our investor relations website (http://www.amarincorp.com/investor-splash.html), including but not limited to investor presentations and investor FAQs, Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that we post on these channels and websites could be deemed to be material information. As a result, we encourage investors, the media, and others interested in Amarin to review the information that we post on these channels, including our investor relations website, on a regular basis. This list of channels may be updated from time to time on our investor relations website and may include social media channels. The contents of our website or these channels, or any other website that may be accessed from our website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.
Amarin contact information:



Investor Relations:


Kathryn McNeil 
Investor Relations and Corporate Communications
Amarin Corporation plc
In U.S.: 1 (908) 719-1315
[email protected]


Lee M. Stern
Trout Group 
In U.S.: 1 (646) 378-2922
[email protected]

Media Inquiries:


Kristie Kuhl
Finn Partners
In U.S.: 1 (212) 583-2791
[email protected]



Read more...

Ratios

vs
industry
vs
history
PS Ratio 4.90
AMRN's PS Ratio is ranked higher than
71% of the 685 Companies
in the Global Biotechnology industry.

( Industry Median: 12.47 vs. AMRN: 4.90 )
Ranked among companies with meaningful PS Ratio only.
AMRN' s PS Ratio Range Over the Past 10 Years
Min: 2.82  Med: 42.2 Max: 600
Current: 4.9
2.82
600
Current Ratio 1.99
AMRN's Current Ratio is ranked lower than
76% of the 921 Companies
in the Global Biotechnology industry.

( Industry Median: 4.05 vs. AMRN: 1.99 )
Ranked among companies with meaningful Current Ratio only.
AMRN' s Current Ratio Range Over the Past 10 Years
Min: 0.27  Med: 3.68 Max: 35.14
Current: 1.99
0.27
35.14
Quick Ratio 1.68
AMRN's Quick Ratio is ranked lower than
74% of the 920 Companies
in the Global Biotechnology industry.

( Industry Median: 3.77 vs. AMRN: 1.68 )
Ranked among companies with meaningful Quick Ratio only.
AMRN' s Quick Ratio Range Over the Past 10 Years
Min: 0.22  Med: 3.66 Max: 35.14
Current: 1.68
0.22
35.14
Days Inventory 216.57
AMRN's Days Inventory is ranked lower than
74% of the 436 Companies
in the Global Biotechnology industry.

( Industry Median: 126.28 vs. AMRN: 216.57 )
Ranked among companies with meaningful Days Inventory only.
AMRN' s Days Inventory Range Over the Past 10 Years
Min: 209.74  Med: 262.76 Max: 650.68
Current: 216.57
209.74
650.68
Days Sales Outstanding 77.23
AMRN's Days Sales Outstanding is ranked higher than
54% of the 596 Companies
in the Global Biotechnology industry.

( Industry Median: 61.11 vs. AMRN: 77.23 )
Ranked among companies with meaningful Days Sales Outstanding only.
AMRN' s Days Sales Outstanding Range Over the Past 10 Years
Min: 50.49  Med: 54.45 Max: 77.23
Current: 77.23
50.49
77.23
Days Payable 154.71
AMRN's Days Payable is ranked higher than
53% of the 409 Companies
in the Global Biotechnology industry.

( Industry Median: 58.37 vs. AMRN: 154.71 )
Ranked among companies with meaningful Days Payable only.
AMRN' s Days Payable Range Over the Past 10 Years
Min: 64.39  Med: 146.87 Max: 195.34
Current: 154.71
64.39
195.34

Buy Back

vs
industry
vs
history
3-Year Average Share Buyback Ratio -16.00
AMRN's 3-Year Average Share Buyback Ratio is ranked lower than
63% of the 571 Companies
in the Global Biotechnology industry.

( Industry Median: -11.10 vs. AMRN: -16.00 )
Ranked among companies with meaningful 3-Year Average Share Buyback Ratio only.
AMRN' s 3-Year Average Share Buyback Ratio Range Over the Past 10 Years
Min: -271.2  Med: -38.1 Max: 21.2
Current: -16
-271.2
21.2

Valuation & Return

vs
industry
vs
history
Price-to-Median-PS-Value 0.12
AMRN's Price-to-Median-PS-Value is ranked higher than
97% of the 584 Companies
in the Global Biotechnology industry.

( Industry Median: 0.98 vs. AMRN: 0.12 )
Ranked among companies with meaningful Price-to-Median-PS-Value only.
AMRN' s Price-to-Median-PS-Value Range Over the Past 10 Years
Min: 0.01  Med: 0.09 Max: 11.76
Current: 0.12
0.01
11.76
Earnings Yield (Greenblatt) % -5.96
AMRN's Earnings Yield (Greenblatt) % is ranked higher than
50% of the 1272 Companies
in the Global Biotechnology industry.

( Industry Median: -6.37 vs. AMRN: -5.96 )
Ranked among companies with meaningful Earnings Yield (Greenblatt) % only.
AMRN' s Earnings Yield (Greenblatt) % Range Over the Past 10 Years
Min: -5.96  Med: 501.9 Max: 7646.9
Current: -5.96
-5.96
7646.9

More Statistics

Revenue (TTM) (Mil) $139.2
EPS (TTM) $ -0.33
Beta1.92
Short Percentage of Float0.00%
52-Week Range $1.80 - 3.65
Shares Outstanding (Mil)270.70

Analyst Estimate

Dec17 Dec18 Dec19
Revenue (Mil $) 165 385 531
EPS ($) -0.18 0.24 0.56
EPS without NRI ($) -0.18 0.24 0.56
EPS Growth Rate
(Future 3Y To 5Y Estimate)
N/A
Dividends per Share ($)
» More Articles for NAS:AMRN

Headlines

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Vascepa(R) (icosapent ethyl) and Eicosapentaenoic Acid (EPA) Data to Be Presented at National Lipid May 11 2016 

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