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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Samuel F. Colin, M.D.N/A500,0000.48%2014-05-01
Mr. Seth H.Z. FischerN/A186,0800.18%2015-08-03
Mr. Svai SanfordN/A128,3590.12%2015-08-03
Neil Gesundheit,M.D.N/A127,6530.12%2005-01-14
Leland F. WilsonN/A119,9250.12%2013-01-25
Mr. Santosh T VargheseVP, Medical & Reg Affairs88,966less than 0.1%2016-08-02
Dr. Ernest Mario,PhDN/A81,125less than 0.1%2013-05-29
Mark B. LoganN/A74,125less than 0.1%2013-01-25
Terry M. NidaN/A65,727less than 0.1%2006-12-01
Mr. John L. SlebirN/A59,893less than 0.1%2015-07-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2016-08-02Sell12,55988,966$1.0713.44-1.8788,966 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2016-07-01Sell366101,525$1.210.44-13.22101,525 (Direct)
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.54-36.36101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43.02-25
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.46-18.6
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.24-6.25
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.21605-13.22
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.4810.53102,220 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.33-54.7441,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.38-54.7463,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.28-54.7449,118 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.73-52.2735,373 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.85-52.2759,893 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.31-62.2356,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.75-62.2372,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.66-62.2331,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.31-62.2365,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.92-65.4630,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-66.35
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.47-65.46
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.28-63.79
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049.04-65.4644,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.75-65.4646,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-82.73,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.19-87.78
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.32-91.21Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-91.2210,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-91.834,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-92.8581,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.75-94.9445,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165.04-94.9166,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.24-95.4653,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72408.96-95.385,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.59-95.1953,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-95.175,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-95.1740,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-96.544,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.75-96.6137,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510.05-96.54Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-96.54Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-96.54119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.76-96.542,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-96.547,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-96.267,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-96.25119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-96.1537,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-96.0337,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-95.8437,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-95.8597,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-95.87,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-95.83119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.48-94.8348,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.15-94.831,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.18-94.7961,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.58-94.99Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-95.12Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.15-95.06Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-95.8118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-95.427,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-94.93118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.28-94.937,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.33-94.9316,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-94.93Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.17-91.2596,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.63-91.25123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.48-91.06Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-90.8716,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.37-89.3616,800 (Direct)
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.92-88.76Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.36-88.99Link
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.52-88.99Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-88.69Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.48-88.72Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.92-88.54Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-91.37Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-91.92Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.08-88.66Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.51-90.31Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-90.01Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.71-91.29Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-90.84Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-90.65Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-91.32Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.49-83.25Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.53-84.51Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.88-86.06Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.25-86Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-84.94
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-84.94
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-84.94Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-85
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-85
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-85Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-82.5
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-82.5
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-82.5
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.73-82.56
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-82.79
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.44-82.26
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-83.64
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.55-88.33
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-87.72
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.41-87.62
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-83.85
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.75-74.82
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.54-74.82
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-74.82
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-83.85
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.67-82.47
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-82.5
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.08-80.26
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-80.26
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.41-80.19
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.13-75.18
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.32-75.18
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.14-75.18
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.53-80.91
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.68-79.41
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.75-79.61
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-79.85
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-80.19
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-80.15
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-79.65
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-79.45
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5382.95-81.01
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.15-81.32
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-81.18
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-73.75
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184.05-74.33
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-69.12Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.62-54.55Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.19-54.55Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.63-65Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.92-54.35Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.31-54.35Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.49-54.35Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.36-70.75Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.16-70.75Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.63-70.75Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.95-70.75Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.18-67.49Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-67.49Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.71-67.49Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.86-80.63Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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