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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Samuel F. Colin, M.D.N/A500,0000.48%2014-05-01
Mr. Seth H.Z. FischerCEO186,0800.18%2015-08-03
Mr. John L. SlebirSVP, Business Development & GC139,5840.13%2015-08-03
Mr. Svai SanfordCFO & Chief Accounting Officer128,3590.12%2015-08-03
Neil Gesundheit,M.D.N/A127,6530.12%2005-01-14
Leland F. WilsonCEO119,9250.12%2013-01-25
Mr. Santosh T VargheseVP, Medical & Reg Affairs109,6340.11%2015-08-03
Dr. Ernest Mario,PhDDirector81,125less than 0.1%2013-05-29
Mark B. LoganDirector74,125less than 0.1%2013-01-25
Terry M. NidaVP, Worldwide Marketing/65,727less than 0.1%2006-12-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.3-60.3441,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.4-60.3463,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.3-60.3449,118 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.3-66.9156,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.8-66.9172,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.7-66.9131,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.3-66.9165,559 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-70.51
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.5-69.74
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.3-68.28
11,523,200 (See Footnote)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-84.843,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.2-89.29
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.3-92.3Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-92.3110,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-92.844,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-93.7381,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.8-95.5745,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165-95.5466,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.2-96.0253,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72409-95.955,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.6-95.7853,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-95.765,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-95.7740,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-96.974,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.8-97.0337,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510-96.97Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-96.97Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-96.97119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.8-96.972,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-96.977,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-96.727,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-96.71119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-96.6237,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-96.5237,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-96.3637,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-96.3697,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-96.327,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-96.35119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.5-95.4748,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.1-95.471,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.2-95.4361,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.6-95.61Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-95.72Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.2-95.67Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-96.32118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-95.997,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-95.55118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.3-95.567,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.3-95.5516,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-95.55Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.2-92.3396,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.6-92.33123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.5-92.17Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-9216,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.4-90.6816,800 (Direct)
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.9-90.15Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.4-90.36Link
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.5-90.36Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-90.09Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.5-90.12Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.9-89.96Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-92.43Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-92.92Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.1-90.06Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.5-91.51Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-91.25Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.7-92.37Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-91.97Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-91.81Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-92.4Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.5-85.33Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.5-86.43Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.9-87.78Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.3-87.73Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-86.8
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-86.8
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-86.8Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-86.86
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-86.86
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-86.86Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.8-84.67
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.8-84.67
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-84.67
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.7-84.72
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-84.92
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.4-84.46
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-85.67
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.6-89.78
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-89.24
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.4-89.15
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-85.85
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.7-77.94
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.5-77.94
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-77.94
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-85.85
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.7-84.64
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-84.67
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.1-82.71
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-82.71
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.4-82.64
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.1-78.25
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.3-78.25
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.1-78.25
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.5-83.27
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.7-81.96
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.8-82.14
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-82.34
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-82.64
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-82.61
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-82.17
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-82
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5383-83.36
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.2-83.63
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-83.51
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-77
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184-77.51
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-72.94Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.6-60.17Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.2-60.17Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.6-69.33Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.9-60Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.3-60Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.5-60Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.4-74.37Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.2-74.37Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.6-74.37Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.9-74.37Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.2-71.52Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-71.52Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.7-71.52Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.9-83.03Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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