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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Samuel F. Colin, M.D.N/A500,0000.48%2014-05-01
Mr. Seth H.Z. FischerN/A186,0800.18%2015-08-03
Mr. Svai SanfordN/A128,3590.12%2015-08-03
Neil Gesundheit,M.D.N/A127,6530.12%2005-01-14
Leland F. WilsonN/A119,9250.12%2013-01-25
Mr. Santosh T VargheseChief Medical Officer101,8910.1%2016-04-07
Dr. Ernest Mario,PhDN/A81,125less than 0.1%2013-05-29
Mark B. LoganN/A74,125less than 0.1%2013-01-25
Terry M. NidaN/A65,727less than 0.1%2006-12-01
Mr. John L. SlebirSVP, Business Development & GC59,893less than 0.1%2015-07-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.5-16.97101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43-2.14
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.56.2
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.222.32
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.2160513.22
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.544.21102,220 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.3-40.9541,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.4-40.9563,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.3-40.9549,118 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.7-37.7335,373 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.9-37.7359,893 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.3-50.7256,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.8-50.7272,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.7-50.7231,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.3-50.7265,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.9-54.9330,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-56.09
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.5-54.93
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.3-52.76
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049-54.9344,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.7-54.9346,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-77.433,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.2-84.05
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.3-88.54Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-88.5510,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-89.344,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-90.6781,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.8-93.445,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165-93.3666,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.2-94.0853,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72409-93.975,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.6-93.7253,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-93.695,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-93.740,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-95.494,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.8-95.5737,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510-95.49Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-95.49Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-95.49119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.8-95.492,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-95.497,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-95.127,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-95.11119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-94.9737,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-94.8237,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-94.5737,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-94.5897,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-94.527,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-94.56119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.5-93.2648,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.1-93.251,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.2-93.261,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.6-93.46Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-93.63Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.2-93.56Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-94.52118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-94.037,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-93.38118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.3-93.387,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.3-93.3816,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-93.38Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.2-88.5896,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.6-88.58123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.5-88.34Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-88.0916,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.4-86.1216,800 (Direct)
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.9-85.33Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.4-85.64Link
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.5-85.64Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-85.24Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.5-85.28Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.9-85.04Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-88.73Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-89.46Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.1-85.21Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.5-87.36Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-86.96Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.7-88.63Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-88.05Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-87.8Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-88.68Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.5-78.15Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.5-79.79Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.9-81.81Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.3-81.73Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-80.34
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-80.34
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-80.34Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-80.43
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-80.43
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-80.43Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.8-77.17
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.8-77.17
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-77.17
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.7-77.24
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-77.54
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.4-76.86
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-78.66
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.6-84.78
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-83.98
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.4-83.84
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-78.92
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.7-67.15
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.5-67.15
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-67.15
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-78.92
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.7-77.13
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-77.17
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.1-74.25
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-74.25
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.4-74.15
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.1-67.61
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.3-67.61
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.1-67.61
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.5-75.09
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.7-73.14
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.8-73.4
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-73.7
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-74.15
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-74.1
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-73.45
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-73.19
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5383-75.23
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.2-75.62
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-75.45
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-65.75
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184-66.5
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-59.71Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.6-40.69Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.2-40.69Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.6-54.33Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.9-40.43Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.3-40.43Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.5-40.43Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.4-61.84Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.2-61.84Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.6-61.84Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.9-61.84Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.2-57.59Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-57.59Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.7-57.59Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.9-74.72Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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