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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Samuel F. Colin, M.D.N/A500,0000.48%2014-05-01
Mr. Seth H.Z. FischerN/A186,0800.18%2015-08-03
Mr. Svai SanfordN/A128,3590.12%2015-08-03
Neil Gesundheit,M.D.N/A127,6530.12%2005-01-14
Leland F. WilsonN/A119,9250.12%2013-01-25
Mr. Santosh T VargheseVP, Medical & Reg Affairs88,966less than 0.1%2016-08-02
Dr. Ernest Mario,PhDN/A81,125less than 0.1%2013-05-29
Mark B. LoganN/A74,125less than 0.1%2013-01-25
Terry M. NidaN/A65,727less than 0.1%2006-12-01
Mr. John L. SlebirN/A59,893less than 0.1%2015-07-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2016-08-02Sell12,55988,966$1.0713.448.4188,966 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2016-07-01Sell366101,525$1.210.44-4.13101,525 (Direct)
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.54-29.7101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43.02-17.14
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.46-10.08
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.243.57
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.21605-4.13
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.4822.11102,220 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.33-5041,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.38-5063,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.28-5049,118 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.73-47.2735,373 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.85-47.2759,893 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.31-58.2756,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.75-58.2772,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.66-58.2731,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.31-58.2765,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.92-61.8430,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-62.82
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.47-61.84
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.28-60
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049.04-61.8444,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.75-61.8446,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-80.893,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.19-86.5
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.32-90.29Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-90.310,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-90.974,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-92.181,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.75-94.4145,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165.04-94.3866,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.24-94.9853,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72408.96-94.895,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.59-94.6853,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-94.665,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-94.6640,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-96.184,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.75-96.2537,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510.05-96.18Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-96.18Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-96.18119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.76-96.182,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-96.187,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-95.877,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-95.86119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-95.7437,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-95.6137,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-95.4137,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-95.4197,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-95.367,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-95.39119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.48-94.2948,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.15-94.291,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.18-94.2461,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.58-94.47Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-94.6Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.15-94.54Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-95.36118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-94.947,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-94.39118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.28-94.47,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.33-94.3916,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-94.39Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.17-90.3396,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.63-90.33123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.48-90.13Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-89.9116,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.37-88.2516,800 (Direct)
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.92-87.58Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.36-87.84Link
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.52-87.84Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-87.5Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.48-87.54Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.92-87.34Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-90.46Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-91.08Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.08-87.47Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.51-89.3Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-88.96Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.71-90.37Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-89.88Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-89.67Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-90.41Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.49-81.5Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.53-82.89Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.88-84.59Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.25-84.53Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.36
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.36
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.63-83.36Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.43
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.43
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-83.43Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-80.67
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.79-80.67
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-80.67
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.73-80.73
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-80.98
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.44-80.41
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-81.93
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.55-87.11
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-86.43
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.41-86.32
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-82.15
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.75-72.18
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.54-72.18
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-72.18
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-82.15
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.67-80.63
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-80.67
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.08-78.2
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-78.2
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.41-78.11
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.13-72.58
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.32-72.58
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.14-72.58
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.53-78.91
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.68-77.25
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.75-77.48
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-77.74
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-78.11
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-78.07
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-77.52
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-77.3
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5382.95-79.02
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.15-79.36
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-79.21
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-71
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184.05-71.64
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-65.88Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.62-49.78Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.19-49.78Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.63-61.33Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.92-49.57Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.31-49.57Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.49-49.57Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.36-67.69Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.16-67.69Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.63-67.69Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.95-67.69Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.18-64.09Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-64.09Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.71-64.09Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.86-78.6Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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