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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Samuel F. Colin, M.D.N/A500,0000.48%2014-05-01
Mr. Seth H.Z. FischerN/A186,0800.18%2015-08-03
Mr. Svai SanfordN/A128,3590.12%2015-08-03
Neil Gesundheit,M.D.N/A127,6530.12%2005-01-14
Leland F. WilsonN/A119,9250.12%2013-01-25
Mr. Santosh T VargheseChief Medical Officer101,8910.1%2016-04-07
Dr. Ernest Mario,PhDN/A81,125less than 0.1%2013-05-29
Mark B. LoganN/A74,125less than 0.1%2013-01-25
Terry M. NidaN/A65,727less than 0.1%2006-12-01
Mr. John L. SlebirSVP, Business Development & GC59,893less than 0.1%2015-07-01

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Varghese Santosh TChief Medical Officer2016-04-07Sell329101,891$1.650.5-25.45101,891 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2016-04-01Buy2,16013,587,460$1.43-12.14
13,587,460 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-31Buy383,30013,585,300$1.29494.5-4.65
13,585,300 (See Footnote(,,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-28Buy202,00013,202,000$1.12226.29.82
13,202,000 (See Footnote(F1,))
NORTH TIDE CAPITAL, LLC10% Owner2016-03-16Buy500,00013,000,000$1.216051.65
13,000,000 (See Footnotes(F1,F2))
Varghese Santosh TChief Medical Officer2016-01-13Sell1,553102,220$0.951.529.47102,220 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell7,89941,234$2.3218.3-46.9841,234 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,21563,584$2.3221.4-46.9863,584 (Direct)
Day WesleyVP, Clinical Development2015-07-01Sell7,88149,118$2.3218.3-46.9849,118 (Direct)
Varghese Santosh TVP, Medical & Reg Affairs2015-07-01Sell8,51435,373$2.218.7-44.0935,373 (Direct)
Slebir John LSVP, Business Development & GC2015-07-01Sell9,93359,893$2.221.9-44.0959,893 (Direct)
Day WesleyVP, Clinical Development2015-01-29Sell47256,999$2.781.3-55.7656,999 (Direct)
Slebir John LSVP, Business Development & GC2015-01-29Sell63072,799$2.781.8-55.7672,799 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell23831,487$2.780.7-55.7631,487 (Direct)
Sanford Svai SCFO & Chief Accounting Officer
(Click for the stocks that their CFOs have bought)
2015-01-29Sell47265,559$2.781.3-55.7665,559 (Direct)
MARSH GUY PVP, US Operations & GM2015-01-29Sell63330,854$3.041.9-59.5430,854 (Direct)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-08Buy500,00037,039,570$3.121560-60.58
12,382,470 (See Footnotes(F1,F3))
12,500,000 (See Footnotes(F1,F2))
12,157,100 (See Footnote2(F1,F3))
NORTH TIDE CAPITAL, LLC10% Owner2015-01-06Buy476,80012,000,000$3.041449.5-59.54
12,000,000 (See Footnote)
NORTH TIDE CAPITAL, LLC10% Owner2015-01-02Buy523,20011,523,200$2.91517.3-57.59
11,523,200 (See Footnote)
Slebir John LSVP, Business Development & GC2015-01-01Sell2,97344,555$3.049-59.5444,555 (Direct)
Day WesleyVP, Clinical Development2015-01-01Sell2,54946,569$3.047.7-59.5446,569 (Direct)
Fischer Seth H.Z.CEO
(Click for the stocks that their CEOs have bought)
2014-03-11Buy3,0803,080$6.0718.7-79.743,080 (Direct)
DENNER ALEXANDER JDirector2013-11-11Buy566,8442,573,943$8.594869.2-85.68
2,573,943 (See footnotes(F4,F5))
MORRIS TIMOTHY EVP, Finance and CFO2013-09-05Sell10,6540$11.95127.3-89.71Link
ASTRUE MICHAEL JDirector2013-09-04Buy10,00010,000$11.96119.6-89.7210,000 (Direct)
BIRO JON CSEE REMARKS2013-06-27Buy2,0004,000$12.8525.7-90.434,000 (Direct)
MARIO ERNESTDirector2013-05-29Buy15,00081,125$14.68220.2-91.6281,125 (Direct)
MARIO ERNESTDirector2012-08-20Buy5,00045,000$20.75103.8-94.0745,000 (Direct)
CASAMENTO CHARLES JDirector2012-08-20Sell8,00066,000$20.63165-94.0466,000 (Direct)
LOGAN MARK BDirector2012-08-14Sell49,81653,000$23.131152.2-94.6853,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-14Sell18,0005,000$22.72409-94.595,000 (Direct)
LOGAN MARK BDirector2012-08-13Sell18,18453,000$21.81396.6-94.3653,000 (Direct)
SHORTLIFFE LINDA M DAIRIKIDirector2012-08-13Sell45,0005,000$21.72977.4-94.345,000 (Direct)
MARIO ERNESTDirector2012-08-10Buy20,00040,000$21.74434.8-94.3440,000 (Direct)
Slebir John LVP, General Counsel2012-07-18Sell10,0004,126$30.36303.6-95.954,126 (Direct)
TAM PETER YPresident2012-07-18Sell25,00037,629$30.95773.8-96.0337,629 (Direct)
Day WesleyVP, Clinical Research2012-07-18Sell16,8000$30.36510-95.95Link
MORRIS TIMOTHY EVP, Finance and CFO2012-07-18Sell25,0000$30.36759-95.95Link
WILSON LELAND FCEO2012-07-18Sell100,000119,112$30.363036-95.95119,112 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-07-18Sell36,1912,074$30.361098.8-95.952,074 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-07-18Sell25,0007,943$30.36759-95.957,943 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-27Sell25,0007,943$28.08702-95.627,943 (Direct)
WILSON LELAND FCEO2012-06-27Sell50,000119,112$281400-95.61119,112 (Direct)
TAM PETER YPresident2012-06-19Sell20,00037,629$27.25545-95.4937,629 (Direct)
TAM PETER YPresident2012-06-18Sell20,00037,629$26.45529-95.3537,629 (Direct)
TAM PETER YPresident2012-06-14Sell60,00037,629$25.251515-95.1337,629 (Direct)
TAM PETER YPresident2012-06-14Sell236,25097,629$25.285972.4-95.1397,629 (Direct)
MILLER MICHAEL PATRICKChief Commercial Officer2012-06-12Sell25,0007,943$25625-95.087,943 (Direct)
WILSON LELAND FCEO2012-06-11Sell50,000119,112$25.181259-95.12119,112 (Direct)
LOGAN MARK BDirector2012-03-16Sell14,00048,000$20.32284.5-93.9548,000 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-03-15Sell6,6051,106$20.31134.1-93.941,106 (Direct)
CASAMENTO CHARLES JDirector2012-03-12Sell37,00061,000$20.14745.2-93.8961,000 (Direct)
Perry LeeVP & Chief Accounting Officer2012-03-09Sell87,6230$20.961836.6-94.13Link
SHORTLIFFE LINDA M DAIRIKIDirector2012-03-08Sell52,0000$21.51118-94.28Link
MORRIS TIMOTHY ESVP, Finance and CFO2012-02-27Sell329,3580$21.267002.2-94.21Link
WILSON LELAND FCEO2012-02-27Sell50,000118,271$251250-95.08118,271 (Direct)
MARSH GUY PVP, Operations and General Mgr2012-02-27Sell47,0787,711$22.931079.5-94.647,711 (Direct)
WILSON LELAND FCEO2012-02-23Sell150,000118,271$20.693103.5-94.06118,271 (Direct)
MARSH GUY PVP, Operations & General Mgr.2012-02-23Sell86,7777,711$20.71796.3-94.067,711 (Direct)
Day WesleyVP, Clinical Development2012-02-23Sell79,95816,800$20.691654.3-94.0616,800 (Direct)
Perry LeeVP & Chief Accounting Officer2012-02-23Sell171,8320$20.693555.2-94.06Link
TAM PETER YPresident2012-01-11Sell27,01496,221$12324.2-89.7596,221 (Direct)
TAM PETER YPresident2012-01-10Sell12,386123,235$12148.6-89.75123,235 (Direct)
Perry LeeVP & Chief Accounting Officer2012-01-09Sell39,7000$11.75466.5-89.53Link
Day WesleyVP, Clinical Development2012-01-09Sell30,00016,800$11.5345-89.316,800 (Direct)
Day WesleyVP, Clinical Development2011-11-11Sell23,44216,800$9.87231.4-87.5416,800 (Direct)
LOGAN MARK BDirector2010-12-17Sell38,00048,000$9.34354.9-86.83Link
Day WesleyVP, Clinical Development2010-12-17Sell66,60020,800$9.54635.4-87.11Link
Day WesleyVP, Clinical Development2010-12-17Sell70,60016,800$9.54673.5-87.11Link
TAM PETER YPresident2010-12-16Sell10,000126,775$9.2892.8-86.75Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-12-15Sell8,0000$9.3174.5-86.79Link
WILSON LELAND FCEO2010-12-15Sell62,000115,966$9.16567.9-86.57Link
MORRIS TIMOTHY ESVP, Finance & CFO2010-06-14Sell26,2500$12.16319.2-89.88Link
WILSON LELAND FCEO2010-05-18Sell50,00076,772$13650-90.54Link
SHORTLIFFE LINDA M DAIRIKIDirector2010-03-11Sell8,0000$9.2674.1-86.72Link
MARSH GUY PVP, Operations & General Mgr.2009-09-30Sell2,6303,701$10.8428.5-88.65Link
MARSH GUY PVP, Operations & General Mgr.2009-09-25Sell2,0843,701$10.5121.9-88.3Link
MARSH GUY PVP, Operations & General Mgr.2009-09-11Sell34,5823,701$12.05416.7-89.79Link
MARSH GUY PVP, Operations & General Mgr.2009-09-10Sell70,0003,701$11.46802.2-89.27Link
WILSON LELAND FPresident & CEO2009-09-09Sell200,000103,609$11.232246-89.05Link
Perry LeeVP & Chief Accounting Officer2009-09-09Sell12,0000$12.1145.2-89.83Link
MARSH GUY PVP, Operations & General Mgr.2009-08-31Sell2,6303,701$6.2716.5-80.38Link
MARSH GUY PVP, Operations & General Mgr2009-08-24Sell5213,701$6.783.5-81.86Link
MARSH GUY PVP, Operations & General Mgr.2009-07-31Sell54,8313,701$7.53412.9-83.67Link
MARSH GUY PVP, Operations & General Mgr.2009-07-27Sell3003,701$7.52.3-83.6Link
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-82.35
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-82.35
MARSH GUY PVP, Operations & General Mgr.2009-07-23Sell5213,701$6.973.6-82.35Link
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-82.43
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-82.43
WILSON LELAND FPresident & CEO2009-07-22Sell50,000303,609$7350-82.43Link
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.8-79.5
MARSH GUY PVP, Operations & General Mgr.2009-06-30Sell2,6313,701$615.8-79.5
MARSH GUY PVP, Operations & General Mgr.2009-06-26Sell11,8673,701$671.2-79.5
MARSH GUY PVP, Operations & General Mgr.2009-06-15Sell39,1583,701$6.02235.7-79.57
WILSON LELAND FPresident & CEO2009-06-12Sell50,000353,609$6.1305-79.84
SHORTLIFFE LINDA M DAIRIKIDirector2008-12-15Sell32,0000$5.92189.4-79.22
WILSON LELAND FPresident & CEO, Director2008-12-12Sell30,000402,032$6.42192.6-80.84
PLACE VIRGIL AChief Scientific Officer, Director2008-09-11Sell5,950434,049$953.6-86.33
WILSON LELAND FPresident & CEO, Director2008-09-02Sell50,000280,773$8.55427.5-85.61
MARSH GUY PVP, Operations & General Mgr.2008-08-12Sell188,1383,701$8.481595.4-85.5
WILSON LELAND FPresident & CEO, Director2008-05-23Sell85,585290,617$6.5556.3-81.08
Day WesleyVP, Clinical Research2008-05-14Buy3,29716,843$4.1713.7-70.5
TAM PETER YSenior VP, Product &2008-05-14Buy3,72772,994$4.1715.5-70.5
WILSON LELAND FPresident & CEO, Director2008-05-14Buy1,295376,202$4.175.4-70.5
WILSON LELAND FPresident and CEO, Director2008-04-07Sell14,415374,907$6.593.7-81.08
WILSON LELAND FPresident & CEO, Director2008-01-16Sell65,721394,601$5.99393.7-79.47
WILSON LELAND FPresident & CEO, Director2008-01-14Sell7,500460,322$645-79.5
WILSON LELAND FPresident & CEO, Director2007-11-28Sell94,375420,134$5.32502.1-76.88
WILSON LELAND FPresident and CEO, Director2007-11-28Sell95,375414,855$5.32507.4-76.88
WILSON LELAND FPresident and CEO, Director2007-11-28Sell44,228466,002$5.3234.4-76.79
Day WesleyVP, Clinical Research2007-11-14Buy3,10413,546$4.2313.1-70.92
TAM PETER YSenior VP, Product &2007-11-14Buy1,49569,267$4.236.3-70.92
WILSON LELAND FPresident & CEO, Director2007-11-14Buy1,216462,197$4.235.1-70.92
WILSON LELAND FPresident & CEO, Director2007-10-22Sell4,279456,702$5.523.5-77.64
PLACE VIRGIL AChief Scientific Officer2007-09-07Sell7,781422,514$5.139.7-75.88
PLACE VIRGIL AChief Scientific Officer2007-09-06Sell25,000430,295$5.15128.8-76.12
PLACE VIRGIL AChief Scientific Officer2007-09-05Sell10,000440,295$5.2152.1-76.39
PLACE VIRGIL AChief Scientific Officer2007-09-04Sell20,000450,295$5.3106-76.79
PLACE VIRGIL AChairman & CSO2007-08-30Sell10,000470,295$5.2952.9-76.75
PLACE VIRGIL AChairman & CSO2007-08-29Sell15,000480,295$5.1677.4-76.16
PLACE VIRGIL AChairman & CSO2007-08-27Sell20,000510,295$5.11102.2-75.93
WILSON LELAND FPresident & CEO2007-08-09Sell15,000460,981$5.5383-77.76
WILSON LELAND FPresident & CEO2007-08-01Sell7,500475,981$5.6242.2-78.11
WILSON LELAND FPresident & CEO2007-04-30Sell200,000481,820$5.581116-77.96
NIDA TERRYVP, Worldwide Marketing/2006-12-01Sell30,00065,727$4120-69.25
WILSON LELAND FDirector2006-11-30Sell44,999681,820$4.09184-69.93
Day WesleyVP, Clinical Research2006-03-02Buy4,0004,000$3.413.6-63.82Link
TAM PETER YSenior VP, Product &2005-10-31Buy3,30055,803$2.317.6-46.75Link
DIETRICH JOHN WVice President, R & D2005-10-31Buy1,38016,374$2.313.2-46.75Link
NIDA TERRYVP, Worldwide Marketing/2005-10-31Sell46,87555,981$3140.6-59Link
DIETRICH JOHN WVice President, R & D2005-04-29Buy1,27014,994$2.32.9-46.52Link
NIDA TERRYVP, Worldwide Marketing/2005-04-29Buy2,74252,787$2.36.3-46.52Link
TAM PETER YSenior VP, Commerical &2005-04-29Buy5,43152,503$2.312.5-46.52Link
TAM PETER YSenior VP, Commerical &2004-10-29Buy2,88747,072$3.5910.4-65.74Link
NIDA TERRYVP, Worldwide Marketing/2004-10-29Buy1,71550,045$3.596.2-65.74Link
NICKEL JAMES RVice President, Clinical2004-10-29Buy2,9624,962$3.5910.6-65.74Link
DIETRICH JOHN WVice President, R & D2004-10-29Buy1,10013,724$3.593.9-65.74Link
TAM PETER YVP, Business Planning2004-04-30Buy2,84344,185$3.239.2-61.92Link
STRAUSS LARRY JVice President, Finance & CFO2004-04-30Buy774774$3.232.5-61.92Link
DIETRICH JOHN WVice President, R & D2004-04-30Buy1,45812,624$3.234.7-61.92Link
DIETRICH JOHN WVice President, R & D2004-02-23Sell1,45011,166$5.427.9-77.31Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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