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Top Direct Holders

HolderPositionShares% of Shares
Outstanding
Report Date
Dr. Randal W. Scott,PhDN/A1,185,1173.59%2012-07-10
Steven Shak,M.D.Chief Scientific Officer326,3830.99%2016-05-04
Joffre B. Baker,PhDN/A132,8460.4%2012-02-15
Dr. Fred E. Cohen,M.D.,D.Phil.N/A64,5200.2%2016-04-01
Kimberly J. PopovitsN/A58,7960.18%2016-02-15
G. Bradley ColeCOO34,9700.11%2016-05-16
Mr. James J. VaughnChief Commercial Officer31,255less than 0.1%2016-05-09
Mr. Frederic PlaN/A25,618less than 0.1%2016-02-15
Mr. Dean L. SchornoN/A24,524less than 0.1%2014-06-10
Brook H. ByersN/A23,951less than 0.1%2010-12-09

Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
Cole G BradleyCOO2016-05-16Sell5,00034,970$27.6138-3.734,970 (Direct)
Febbo Phillip G.Chief Medical Officer2016-05-10Sell6,32415,013$27.2172-2.2815,013 (Direct)
Vaughn James JChief Commercial Officer2016-05-09Sell2,00031,255$2856-5.0731,255 (Direct)
Shak StevenChief Scientific Officer2016-05-04Sell10,000326,383$25.43254.34.52326,383 (Direct)
Vaughn James JChief Commercial Officer2016-02-09Sell324,076$280.1-5.0724,076 (Direct)
LIVINGSTON RANDALL SDirector2016-01-13Sell1,2506,149$32.1440.2-17.36,149 (Direct)
Cole G BradleyCOO2016-01-12Sell4,00027,428$31.69126.8-16.1227,428 (Direct)
Vaughn James JChief Commercial Officer2016-01-07Sell2,00024,076$33.6367.3-20.9624,076 (Direct)
Cole G BradleyCOO2015-12-08Sell4,00027,428$29.26117-9.1627,428 (Direct)
Leber LauraChief Communication Officer2015-12-07Sell4,20012,959$29.33123.2-9.3812,959 (Direct)
Vaughn James JChief Commercial Officer2015-12-07Sell2,00024,076$29.3358.7-9.3824,076 (Direct)
Cole G BradleyCOO2015-11-10Sell4,00030,326$26.03104.12.1130,326 (Direct)
Cole G BradleyCOO2015-09-09Sell9,66430,326$25.352454.8530,326 (Direct)
Cole G BradleyCOO2015-07-07Sell4,00030,326$27.53110.1-3.4530,326 (Direct)
Cole G BradleyCOO2015-06-09Sell4,00030,326$26.241051.330,326 (Direct)
Cole G BradleyCOO2015-05-12Sell4,00029,658$27.54110.2-3.4929,658 (Direct)
Popovits Kimberly JPresident and CEO
(Click for the stocks that their CEOs have bought)
2015-04-13Sell3,000203,001$31.2893.8-15.03Link
Cole G BradleyCOO2015-04-07Sell4,00029,658$30.44121.8-12.6829,658 (Direct)
Popovits Kimberly JPresident and CEO2015-03-12Sell3,000204,101$31.9195.7-16.7Link
Cole G BradleyCOO2015-03-10Sell4,00029,658$31.84127.4-16.5229,658 (Direct)
Popovits Kimberly JPresident and CEO2015-02-12Sell3,000204,601$29.8689.6-10.98Link
Cole G BradleyCOO2015-02-10Sell4,00021,645$31.37125.5-15.2721,645 (Direct)
LIVINGSTON RANDALL SDirector2015-02-02Sell1,0006,149$31.9331.9-16.766,149 (Direct)
Popovits Kimberly JPresident and CEO2015-01-12Sell3,000204,601$33.46100.4-20.56Link
Popovits Kimberly JPresident and CEO2014-12-11Sell3,000204,601$32.9999-19.43Link
Cole G BradleyCOO2014-12-08Sell4,33621,645$32.52141-18.2721,645 (Direct)
Popovits Kimberly JPresident and CEO2014-11-12Sell4,300205,201$34.82149.7-23.66Link
Cole G BradleyCOO2014-11-10Sell4,00022,891$35.35141.4-24.8122,891 (Direct)
LIVINGSTON RANDALL SDirector2014-11-03Sell3,0006,149$36.24108.7-26.666,149 (Direct)
Popovits Kimberly JPresident and CEO2014-10-13Sell3,000205,201$30.7892.3-13.65Link
Cole G BradleyCOO2014-10-08Sell4,00022,891$28.77115.1-7.6122,891 (Direct)
Popovits Kimberly JPresident and CEO2014-09-11Sell3,000205,201$29.8289.5-10.87Link
Cole G BradleyCOO2014-09-08Sell4,70022,891$30.09141.4-11.6722,891 (Direct)
Shak StevenEVP of R&D2014-08-14Sell13,348312,298$27.36365.2-2.85312,298 (Direct)
Popovits Kimberly JPresident and CEO2014-08-12Sell3,000205,201$26.0778.21.96Link
Popovits Kimberly JPresident and CEO2014-07-14Sell3,000205,201$26.5979.8-0.04Link
Cole G BradleyCOO2014-07-08Sell2,30022,891$27.0562.2-1.7422,891 (Direct)
Shak StevenEVP of R&D2014-07-01Sell7,000312,298$27189-1.56312,298 (Direct)
Shak StevenEVP of R&D2014-06-12Sell7,000312,298$26.73187.1-0.56312,298 (Direct)
Popovits Kimberly JPresident and CEO2014-06-12Sell3,000271,289$26.178.31.84Link
Schorno Dean LCFO2014-06-10Sell4,00030,673$27.62110.5-3.7724,524 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2014-06-09Sell2,33722,891$27.2963.8-2.622,891 (Direct)
Popovits Kimberly JPresident and CEO2014-05-12Sell3,000270,579$26.5479.60.15Link
Schorno Dean LCFO2014-05-09Sell4,00029,963$25.09100.45.9423,814 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Shak StevenEVP of R&D2014-04-14Sell7,000311,588$26.25183.81.26311,588 (Direct)
Cole G BradleyCOO2014-04-08Sell3,00022,226$2781-1.5622,226 (Direct)
Shak StevenEVP of R&D2014-03-14Sell7,000311,588$28.36198.5-6.28311,588 (Direct)
Cole G BradleyCOO2014-03-10Sell3,00022,226$27.7683.3-4.2522,226 (Direct)
HIBBS KATHY LSVP & General Counsel2014-02-18Sell1,31215,787$27.8836.6-4.6615,787 (Direct)
Shak StevenEVP of R&D2014-02-14Sell7,000311,588$27.38191.7-2.92311,588 (Direct)
Cole G BradleyCOO2014-02-10Sell3,00024,789$2781-1.5624,789 (Direct)
Shak StevenEVP of R&D2014-01-15Sell7,000308,283$31.51220.6-15.65308,283 (Direct)
Popovits Kimberly JPresident and CEO2014-01-13Sell2,500261,190$3075-11.4Link
Cole G BradleyCOO2014-01-08Sell3,00018,369$28.1784.5-5.6418,369 (Direct)
Shak StevenEVP of R&D & CMO2013-12-17Sell14,000308,283$29.57414-10.11308,283 (Direct)
Popovits Kimberly JPresident and CEO2013-12-12Sell2,5000$30.6876.7-13.36Link
Schorno Dean LCFO2013-12-09Sell3,00027,706$33.2599.8-20.0621,557 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
LIVINGSTON RANDALL SDirector2013-12-02Sell1,0006,149$34.9234.9-23.886,149 (Direct)
Popovits Kimberly JPresident and CEO2013-11-13Sell5,0000$34.58172.9-23.13Link
Schorno Dean LCFO2013-11-08Sell3,00027,585$33.36100.1-20.3221,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-11-06Sell2,86818,135$31.3890-15.318,135 (Direct)
Shak StevenEVP of R&D & CMO2013-10-15Sell5,000308,283$29.67148.4-10.41308,283 (Direct)
Popovits Kimberly JPresident and CEO2013-10-10Sell2,5000$3075-11.4Link
Cole G BradleyCOO2013-10-09Sell2,50018,135$29.9574.9-11.2518,135 (Direct)
Shak StevenEVP of R&D & CMO2013-09-18Sell5,000313,283$33.73168.7-21.2313,283 (Direct)
Popovits Kimberly JPresident and CEO2013-09-12Sell2,5000$34.3185.8-22.53Link
Cole G BradleyCOO2013-09-09Sell2,50018,135$32.5381.3-18.2918,135 (Direct)
Schorno Dean LCFO2013-09-06Sell4,00027,585$32.9131.6-19.2121,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
LIVINGSTON RANDALL SDirector2013-09-03Sell1,0006,149$31.4931.5-15.596,149 (Direct)
Shak StevenEVP of R&D & CMO2013-08-14Sell5,000318,283$32.98164.9-19.41318,283 (Direct)
Popovits Kimberly JPresident and CEO2013-08-12Sell2,5000$33.0382.6-19.53Link
Schorno Dean LCFO2013-08-09Sell4,00027,585$33.15132.6-19.8221,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Schorno Dean LCFO2013-08-09Sell4,00027,585$33.15132.6-19.8221,436 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-08-07Sell2,50019,135$33.6684.2-21.0319,135 (Direct)
Shak StevenEVP of R&D & CMO2013-07-23Sell5,000318,283$35.33176.7-24.77318,283 (Direct)
Popovits Kimberly JPresident and CEO2013-07-12Sell5,0000$34.61173.1-23.2Link
Schorno Dean LCFO2013-07-09Sell4,00023,985$33.81135.2-21.3817,836 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Schorno Dean LCFO2013-07-09Sell4,00023,985$33.81135.2-21.3817,836 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-07-08Sell2,50013,135$33.3383.3-20.2513,135 (Direct)
Shak StevenEVP of R&D & CMO2013-06-18Sell5,000323,283$33.52167.6-20.7323,283 (Direct)
Popovits Kimberly JPresident and CEO2013-06-12Sell5,0000$35.68178.4-25.5Link
Schorno Dean LCFO2013-06-10Sell4,00023,985$35.88143.5-25.9217,836 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
BAKER FELIXDirector, 10% Owner2013-06-05Buy381,43213,288,253$36.1613792.6-26.49
1,730,777 (See Footnote)
11,241,654 (See Footnotes(F7,F14,F15))
301,215 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
Cole G BradleyCOO2013-06-05Sell2,50013,135$36.4791.2-27.1213,135 (Direct)
BAKER FELIXDirector, 10% Owner2013-06-03Buy179,58312,906,821$36.716592.5-27.59
1,690,226 (See Footnote)
10,909,066 (See Footnotes(F7,F14,F15))
292,922 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
LIVINGSTON RANDALL SDirector2013-06-03Sell1,0006,149$36.436.4-26.986,149 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-29Buy121,26612,727,238$36.894473.5-27.95
1,671,081 (See Footnote)
10,752,532 (See Footnotes(F7,F14,F15))
289,018 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
BAKER FELIXDirector, 10% Owner2013-05-24Buy79,41714,257,273$36.932932.9-28.03
1,651,301 (See Footnote)
10,646,920 (See Footnotes(F7,F17,F18))
286,384 (See Footnotes(F9,F17,F18))
1,658,061 (See Footnotes(F5,F17,F18))
14,607 (See Footnote(F9,F17,F18))
HIBBS KATHY LSVP & General Counsel2013-05-22Sell1,0007,087$37.4837.5-29.087,087 (Direct)
Shak StevenEVP of R&D & CMO2013-05-21Sell5,000327,380$37.19186-28.53327,380 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-16Buy71,43912,526,555$36.452604-27.08
1,649,473 (See Footnote)
10,577,816 (See Footnotes(F7,F14,F15))
284,659 (See Footnotes(F9,F14,F15))
14,607 (See Footnote(F9,F14,F15))
LIVINGSTON RANDALL SDirector2013-05-15Sell1,3376,149$35.8347.9-25.826,149 (Direct)
BAKER FELIXDirector, 10% Owner2013-05-14Buy240,42614,093,759$34.348256.2-22.6
1,638,643 (See Footnote)
10,515,769 (See Footnotes(F7,F17,F18))
283,112 (See Footnotes(F9,F17,F18))
1,641,628 (See Footnotes(F5,F17,F18))
14,607 (See Footnote(F9,F17,F18))
HIBBS KATHY LSVP & General Counsel2013-05-13Sell1,2507,087$34.4243-22.787,087 (Direct)
Popovits Kimberly JPresident and CEO2013-05-13Sell5,0000$34.7173.5-23.4Link
Schorno Dean LCFO2013-05-09Sell4,00023,241$36.02144.1-26.2117,092 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-05-08Sell2,50012,540$35.9990-26.1512,540 (Direct)
Popovits Kimberly JPresident and CEO2013-04-23Sell2,5000$3075-11.4Link
Cole G BradleyCOO2013-04-03Sell2,50012,540$27.7969.5-4.3512,540 (Direct)
Cole G BradleyCOO2013-03-06Sell2,50012,540$28.5771.4-6.9712,540 (Direct)
BAKER FELIXDirector, 10% Owner2013-02-21Buy49,08512,211,834$27.781363.6-4.32
1,614,513 (See Footnote)
10,306,239 (See Footnotes(F7,F14,F15))
277,189 (See Footnotes(F9,F14,F15))
13,893 (See Footnote(F9,F14,F15))
HIBBS KATHY LSVP & General Counsel2013-02-20Sell2,7167,087$28.1376.4-5.517,087 (Direct)
BAKER FELIXDirector, 10% Owner2013-02-14Buy52,00012,162,749$28.481481-6.67
1,609,152 (See Footnote)
10,263,580 (See Footnotes(F7,F14,F15))
276,124 (See Footnotes(F9,F14,F15))
13,893 (See Footnote(F9,F14,F15))
MYERS WOODROW A JRDirector2013-02-14Sell41,2502,891$28.41171.5-6.412,891 (Direct)
BAKER FELIXDirector, 10% Owner2013-02-11Buy116,36012,110,749$28.153275.5-5.58
1,603,265 (See Footnote)
10,218,600 (See Footnotes(F7,F14,F15))
274,991 (See Footnotes(F9,F14,F15))
13,893 (See Footnote(F9,F14,F15))
Cole G BradleyCOO2013-02-06Sell2,50014,085$28.0370.1-5.1714,085 (Direct)
LIVINGSTON RANDALL SDirector2013-01-28Sell2,0006,149$28.7757.5-7.616,149 (Direct)
Schorno Dean LCFO2013-01-09Sell2,62523,504$2873.5-5.0717,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2013-01-09Sell2,50014,085$27.8869.7-4.6614,085 (Direct)
Shak StevenEVP of R&D & CMO2012-12-18Sell5,000333,768$27.74138.7-4.18333,768 (Direct)
Popovits Kimberly JPresident and CEO2012-12-13Sell5,0000$27.79139-4.35Link
Schorno Dean LCFO2012-12-11Sell3,00023,504$2884-5.0717,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
LIVINGSTON RANDALL SDirector2012-11-26Sell2,0006,149$27.8455.7-4.536,149 (Direct)
BAKER FELIXDirector, 10% Owner2012-11-21Buy229,30012,263,857$26.836152.1-0.93288 (Direct)
271,800 (See Footnote)
1,589,551 (See Footnotes(F5,F14,F15))
10,117,174 (See Footnotes(F7,F14,F15))
271,806 (See Footnotes(F9,F14,F15))
13,238 (See Footnote(F9,F14,F15))
COLELLA SAMUEL DDirector2012-11-20Sell30,61636,437$26.89823.3-1.1536,437 (Direct)
0 (Versant Venture Capital I, L.P.)
0 (Versant Side Fund I, L.P.)
0 (Versant Affiliates Fund I-A, L.P.)
0 (Versant Affiliates Fund I-B, L.P.)
Shak StevenEVP of R&D & CMO2012-11-20Sell5,000338,768$26.94134.7-1.34338,768 (Direct)
BAKER FELIXDirector, 10% Owner2012-11-14Buy103,16713,526$27.322818.5-2.71288 (Direct)
13,238 (See Footnote)
Popovits Kimberly JPresident and CEO2012-11-14Sell5,0000$27.24136.2-2.42Link
BAKER FELIXDirector, 10% Owner2012-11-13Buy823,77213,526$27.8122909.1-4.42288 (Direct)
13,238 (See Footnote)
Schorno Dean LCFO2012-11-12Sell3,00023,504$2884-5.0717,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2012-11-08Sell2,50014,085$28.6271.6-7.1314,085 (Direct)
Popovits Kimberly JPresident and CEO2012-10-16Sell10,0000$33.08330.8-19.65Link
Shak StevenEVP of R&D & CMO2012-10-16Sell5,000343,768$35.25176.3-24.6343,768 (Direct)
Schorno Dean LCFO2012-10-12Sell3,00023,504$33.79101.4-21.3417,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
HIBBS KATHY LSVP & General Counsel2012-10-11Sell1,25011,367$33.7842.2-21.3111,367 (Direct)
Cole G BradleyCOO2012-10-09Sell2,50014,085$34.887-23.6214,085 (Direct)
Shak StevenEVP of R&D & CMO2012-09-18Sell5,000348,768$33.76168.8-21.27348,768 (Direct)
Popovits Kimberly JPresident and CEO2012-09-13Sell5,0000$31.69158.5-16.12Link
Cole G BradleyCOO2012-09-06Sell2,50014,085$35.0187.5-24.0814,085 (Direct)
MYERS WOODROW A JRDirector2012-08-21Sell16,5002,236$35.2580.8-24.492,236 (Direct)
Shak StevenEVP of R&D & CMO2012-08-20Sell5,000353,768$34.99175-24.04353,768 (Direct)
Popovits Kimberly JPresident and CEO2012-08-13Sell10,0000$34.72347.2-23.44Link
Cole G BradleyCOO2012-08-08Sell2,50014,085$30.4976.2-12.8214,085 (Direct)
LIVINGSTON RANDALL SDirector2012-07-26Sell2,0006,149$35.971.8-25.966,149 (Direct)
Shak StevenChief Medical Officer2012-07-24Sell5,000358,768$34.24171.2-22.37358,768 (Direct)
Popovits Kimberly JPresident and CEO2012-07-13Sell7,1000$34.76246.8-23.53Link
Scott Randal WCEO, InVitae Corporation*2012-07-11Sell30,0000$35.391061.7-24.89Link
Cole G BradleyCOO2012-07-05Sell2,50014,085$35.9589.9-26.0614,085 (Direct)
Shak StevenChief Medical Officer2012-06-25Sell5,000363,768$33.25166.3-20.06363,768 (Direct)
Popovits Kimberly JPresident and CEO2012-06-13Sell5,0000$33.36166.8-20.32Link
Popovits Kimberly JPresident and CEO2012-06-13Sell5,0000$33.36166.8-20.32Link
Scott Randal WCEO, InVitae Corporation*2012-06-12Sell30,0000$33.541006.2-20.75Link
Cole G BradleyCOO2012-06-06Sell2,50013,507$33.9784.9-21.7513,507 (Direct)
Shak StevenChief Medical Officer2012-05-24Sell5,000367,849$33.8169-21.36367,849 (Direct)
BAKER JULIANDirector, 10% Owner2012-05-22Buy167,4061,488,539$32.265400.5-17.61
1,488,539 (See Footnote)
COLELLA SAMUEL DDirector2012-05-18Sell26,294664,113$33.03868.5-19.5326,891 (Direct)
582,174 (Versant Venture Capital I, L.P.)
11,210 (Versant Side Fund I, L.P.)
13,222 (Colella Family Partners, L.P.)
10,414 (Versant Affiliates Fund I-A, L.P.)
20,202 (Versant Affiliates Fund I-B, L.P.)
BAKER JULIANDirector, 10% Owner2012-05-16Buy376,0591,488,539$33.8812740.9-21.55
1,488,539 (See Footnote)
Popovits Kimberly JPresident and CEO2012-05-16Sell10,0000$34.23342.3-22.35Link
Schorno Dean LCFO2012-05-15Sell1,00023,504$33.6933.7-21.117,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
BAKER JULIANDirector, 10% Owner2012-05-11Buy114,8881,488,539$29.963442-11.28
1,488,539 (See Footnote)
Scott Randal WCEO, InVitae Corporation*2012-05-11Sell30,0000$30.22906.6-12.05Link
Cole G BradleyCOO2012-05-09Sell2,50013,507$28.8772.2-7.9313,507 (Direct)
BAKER JULIANDirector, 10% Owner2012-05-08Buy195,70113,238$28.455567.7-6.57
13,238 (See Footnote)
LIVINGSTON RANDALL SDirector2012-04-26Sell2,0006,149$28.2156.4-5.786,149 (Direct)
Shak StevenChief Medical Officer2012-04-24Sell5,000372,849$27.93139.7-4.83372,849 (Direct)
Popovits Kimberly JPresident and CEO2012-04-23Sell5,0000$27.79139-4.35Link
Schorno Dean LCFO2012-04-16Sell1,00024,504$27.9828-518,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WCEO, InVitae Corporation*2012-04-11Sell20,0000$28.59571.8-7.03Link
Cole G BradleyCOO2012-04-04Sell2,50013,507$30.2875.7-12.2213,507 (Direct)
Shak StevenChief Medical Officer2012-03-22Sell5,000377,849$30.08150.4-11.64377,849 (Direct)
Popovits Kimberly JPresident and CEO2012-03-22Sell5,0000$30.07150.4-11.61Link
Popovits Kimberly JPresident and CEO2012-03-22Sell5,0000$30.07150.4-11.61Link
Shak StevenChief Medical Officer2012-03-22Sell5,000377,849$30.08150.4-11.64377,849 (Direct)
Schorno Dean LCFO2012-03-15Sell1,00025,504$31.0831.1-14.4819,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WCEO, InVitae Corporation2012-03-13Sell30,0000$31.05931.5-14.4Link
Cole G BradleyCOO2012-03-08Sell2,50013,507$29.9474.9-11.2213,507 (Direct)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-03-08Buy4,5081,484,977$30.11135.7-11.72
1,484,977 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-03-08Buy1,099227,840$30.1133.1-11.72
227,840 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-03-08Buy41,5848,255,421$30.111252.1-11.72
8,255,421 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-03-05Buy261,7618,213,837$29.817803.1-10.84
8,213,837 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-03-05Buy6,923226,741$29.81206.4-10.84
226,741 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-03-05Buy31,3321,480,469$29.81934-10.84
1,480,469 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-29Buy6,476219,818$29.06188.2-8.53
219,818 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-29Buy245,0317,952,076$29.067120.6-8.53
7,952,076 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-29Buy29,7561,449,137$29.06864.7-8.53
1,449,137 (Through Partnership)
Popovits Kimberly JPresident and CEO2012-02-24Sell10,0000$28.5285-6.74Link
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-23Buy114,5187,707,045$28.063213.4-5.27
7,707,045 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-23Buy3,022213,342$28.0684.8-5.27
213,342 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-23Buy13,3321,419,381$28.06374.1-5.27
1,419,381 (Through Partnership)
Shak StevenChief Medical Officer2012-02-23Sell5,000382,849$28.14140.7-5.54382,849 (Direct)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-16Buy33,1851,406,049$29.34973.6-9.41
1,406,049 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-16Buy7,213210,320$29.37211.8-9.5
210,320 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-16Buy272,9097,592,527$29.378015.3-9.5
7,592,527 (Through Partnership)
Schorno Dean LCFO2012-02-15Sell75526,749$28.7621.7-7.5820,600 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Schorno Dean LCFO2012-02-15Sell1,00026,504$28.7628.8-7.5820,355 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Baker Brothers Life Sciences CDirector, 10% Owner2012-02-10Buy417,9157,319,618$26.3611016.20.83
7,319,618 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2012-02-10Buy11,043203,107$26.36291.10.83
203,107 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2012-02-10Buy66,5831,372,864$26.361755.10.83
1,372,864 (Through Partnership)
Scott Randal WExecutive Chairman2012-02-10Sell20,0000$26.18523.61.53Link
Scott Randal WExecutive Chairman2012-02-10Sell20,0000$26.18523.61.53Link
Cole G BradleyCOO2012-02-08Sell2,50014,450$26.4766.20.4214,450 (Direct)
LIVINGSTON RANDALL SDirector2012-01-26Sell2,0006,149$27.5155-3.386,149 (Direct)
Popovits Kimberly JPresident and CEO2012-01-25Sell5,0000$26.42132.10.61Link
Popovits Kimberly JPresident and CEO2012-01-24Sell5,0000$26.62133.1-0.15Link
Shak StevenChief Medical Officer2012-01-24Sell5,000382,778$26.74133.7-0.6382,778 (Direct)
Schorno Dean LCFO2012-01-17Sell1,00024,049$2828-5.0717,900 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Cole G BradleyCOO2012-01-12Sell2,5007,750$27.5468.9-3.497,750 (Direct)
Scott Randal WExecutive Chairman2012-01-11Sell20,0000$27.46549.2-3.2Link
Shak StevenChief Medical Officer2011-12-22Sell5,000387,778$26.03130.22.11387,778 (Direct)
Scott Randal WExecutive Chairman2011-12-13Sell20,0000$27.29545.8-2.6Link
Cole G BradleyCOO2011-12-06Sell2,5007,750$28.5971.5-7.037,750 (Direct)
14159 capital (GP), LLCDirector, 10% Owner2011-12-05Buy3,152192,064$28.1288.6-5.48
192,064 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-12-05Buy45,9771,306,281$27.661271.7-3.9
1,306,281 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-12-05Buy117,7516,901,703$28.123311.2-5.48
6,901,703 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-23Buy5,5311,260,304$25.91143.32.59
1,260,304 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-23Buy5,750188,912$25.94149.22.47
188,912 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-23Buy193,7396,783,952$25.915019.82.59
6,783,952 (Through Partnership)
Shak StevenChief Medical Officer2011-11-22Sell5,000392,778$26.07130.41.96392,778 (Direct)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-16Buy64,5976,590,213$27.711790-4.08
6,590,213 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-16Buy2,550183,162$27.7170.7-4.08
183,162 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-16Buy4581,254,773$27.3512.5-2.82
1,254,773 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-14Buy10,106180,612$27.23275.2-2.39
180,612 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-14Buy249,3756,525,616$27.236790.5-2.39
6,525,616 (Through Partnership)
Scott Randal WExecutive Chairman2011-11-11Sell20,0000$27.24544.8-2.42Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-09Buy5421,254,315$26.7914.5-0.78
1,254,315 (Through Partnership)
Cole G BradleyCOO2011-11-08Sell2,5007,750$26.666.5-0.087,750 (Direct)
Baker Brothers Life Sciences CDirector, 10% Owner2011-11-07Buy209,5126,276,241$25.945434.72.47
6,276,241 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-11-07Buy8,847170,506$25.94229.52.47
170,506 (Through Partnership)
Baker Biotech Capital (GP), LLDirector, 10% Owner2011-11-03Buy1201,253,773$24.482.98.58
1,253,773 (Through Partnership)
LIVINGSTON RANDALL SDirector2011-10-27Sell2,0006,149$22.0844.220.386,149 (Direct)
Shak StevenChief Medical Officer2011-10-24Sell5,000392,778$21.76108.822.15392,778 (Direct)
Scott Randal WExecutive Chairman2011-10-11Sell20,0000$22.83456.616.43Link
Cole G BradleyCOO2011-10-06Sell5,0007,750$22.31111.619.147,750 (Direct)
Scott Randal WExecutive Chairman2011-09-13Sell20,0000$20.81416.227.73Link
Cole G BradleyCOO2011-09-06Sell2,5007,750$22.0855.220.387,750 (Direct)
Shak StevenChief Medical Officer2011-08-24Sell5,000392,778$23.02115.115.46392,778 (Direct)
Scott Randal WExecutive Chairman2011-08-11Sell20,0000$24.44488.88.76Link
Cole G BradleyCOO2011-08-08Sell2,5007,750$25.2663.25.237,750 (Direct)
Cole G BradleyCOO2011-08-08Sell2,5007,750$25.2663.25.237,750 (Direct)
LIVINGSTON RANDALL SDirector2011-07-27Sell2,0006,149$26.4552.90.496,149 (Direct)
Shak StevenChief Medical Officer2011-07-25Sell5,000392,778$27.61138.1-3.73392,778 (Direct)
Scott Randal WExecutive Chairman2011-07-12Sell20,0001,503,444$27.36547.2-2.851,491,146 (Direct)
12,298 (By Morgan Stanley DW Inc. as Custodian for Randal W. Scott, IRA)
Cole G BradleyCOO2011-07-06Sell5,0007,750$27.74138.7-4.187,750 (Direct)
Shak StevenChief Medical Officer2011-06-23Sell5,000392,778$27.12135.6-1.99392,778 (Direct)
Schorno Dean LCFO2011-06-15Sell1,00025,049$25.9125.92.5918,900 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WExecutive Chairman2011-06-13Sell20,0001,523,444$25.69513.83.461,511,146 (Direct)
12,298 (By Morgan Stanley DW Inc. as Custodian for Randal W. Scott, IRA)
Baker Bros. Capital (GP), LLCDirector, 10% Owner2011-06-09Buy119194,415$26.193.11.49
194,415 (Through Partnership)
14159 capital (GP), LLCDirector, 10% Owner2011-06-09Buy4,388161,659$26.19114.91.49
161,659 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-06-09Buy203,6526,059,449$26.25335.71.45
6,059,449 (Through Partnership)
Cole G BradleyCOO2011-06-06Sell2,5007,750$26.1865.51.537,750 (Direct)
14159 capital (GP), LLCDirector, 10% Owner2011-06-01Buy4,631157,271$27.34126.6-2.78
157,271 (Through Partnership)
Baker Bros. Capital (GP), LLCDirector, 10% Owner2011-06-01Buy112194,296$27.353.1-2.82
194,296 (Through Partnership)
Baker Brothers Life Sciences CDirector, 10% Owner2011-06-01Buy181,6935,855,797$27.354969.3-2.82
5,855,797 (Through Partnership)
Shak StevenChief Medical Officer2011-05-25Sell5,000392,778$25.55127.84.03392,778 (Direct)
Schorno Dean LCFO2011-05-12Sell1,00026,049$26.4826.50.3819,900 (Direct)
6,149 (By Charles Schwab & Co. as Custodian for Dean L. Schorno, IRA)
Scott Randal WExecutive Chairman2011-05-11Sell20,0000$26.66533.2-0.3Link
Cole G BradleyCOO2011-05-09Sell2,5007,750$25.9364.82.517,750 (Direct)
LIVINGSTON RANDALL SDirector2011-04-27Sell2,0000$26.0452.12.07Link
Shak StevenChief Medical Officer2011-04-25Sell5,0000$25.38126.94.73Link
Popovits Kimberly JPresident and CEO2011-04-15Sell8,0000$25.49203.94.28Link
Schorno Dean LCFO2011-04-14Sell1,0000$25.3225.34.98Link
Scott Randal WExecutive Chairman2011-04-12Sell20,0000$25.96519.22.39Link
Cole G BradleyCOO2011-04-06Sell5,0000$26.91134.6-1.23Link
Shak StevenChief Medical Officer2011-03-24Sell5,0000$24.45122.38.71Link
Schorno Dean LCFO2011-03-15Sell1,0000$23.7923.811.73Link
Popovits Kimberly JPresident and CEO2011-03-15Sell8,0000$24.29194.39.43Link
Popovits Kimberly JPresident and CEO2011-03-15Sell8,0000$24.29194.39.43Link
Scott Randal WExecutive Chairman2011-03-11Sell20,0000$25.62512.43.75Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-03-10Buy70,8560$26.031844.42.11Link
14159 capital (GP), LLCDirector, 10% Owner2011-03-08Buy9,6480$25.06241.86.07Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-03-08Buy349,5660$25.068760.16.07Link
Cole G BradleyCOO2011-03-08Sell2,5000$25.2363.15.35Link
COLELLA SAMUEL DDirector2011-03-03Sell34,3200$25.45873.44.44Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-03-02Buy160,3370$25.694119.13.46Link
14159 capital (GP), LLCDirector, 10% Owner2011-03-02Buy4,4260$25.69113.73.46Link
Baker Brothers Life Sciences CDirector, 10% Owner2011-02-25Buy158,3550$23.393703.913.64Link
14159 capital (GP), LLCDirector, 10% Owner2011-02-25Buy4,3700$23.39102.213.64Link
Shak StevenChief Medical Officer2011-02-24Sell5,0000$23.27116.414.22Link
Schorno Dean LCFO2011-02-15Sell1,0000$22.5122.518.08Link
Popovits Kimberly JPresident and CEO2011-02-15Sell8,0000$22.51180.118.08Link
Scott Randal WExecutive Chairman2011-02-11Sell20,0000$22.244419.73Link
Popovits Kimberly JPresident and CEO2011-01-18Sell8,000309,424$21.15169.225.67Link
Popovits Kimberly JPresident and CEO2011-01-18Sell8,0000$21.15169.225.67Link
Schorno Dean LCFO2011-01-13Sell1,27626,149$21.0626.926.21Link
Scott Randal WExecutive Chairman2011-01-11Sell20,0001,642,410$21.73434.622.32Link
Cole G BradleyCOO2011-01-06Sell5,0001,000$22.13110.720.11Link
Popovits Kimberly JPresident and CEO2010-12-16Sell8,000310,624$22.71181.717.04Link
Scott Randal WExecutive Chairman2010-12-13Sell20,0001,696,410$22.46449.218.34Link
Cole G BradleyCOO & CFO2010-12-13Sell2,5001,000$22.6456.617.4Link
Popovits Kimberly JPresident and CEO2010-11-16Sell8,000310,624$17.514051.89Link
Cole G BradleyCOO & CFO2010-11-11Sell2,5001,000$18.0445.147.34Link
Scott Randal WExecutive Chairman2010-11-11Sell20,0001,666,410$18.27365.445.48Link
Scott Randal WExecutive Chairman2010-10-12Sell20,0001,686,410$13.9527990.54Link
Popovits Kimberly JPresident and CEO2010-09-15Sell7,734310,624$15.1116.876.03Link
Scott Randal WExecutive Chairman2010-09-13Sell20,0001,706,410$14.87297.478.75Link
Cole G BradleyCOO & CFO2010-09-13Sell2,5001,000$15.0137.577.08Link
14159 capital (GP), LLCDirector, 10% Owner2010-09-09Buy145134,196$14.812.179.47Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-09-09Buy5,2614,934,990$14.8177.979.47Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-09-02Buy65,4664,929,729$14.46946.683.82Link
14159 capital (GP), LLCDirector, 10% Owner2010-09-02Buy1,807134,051$14.4626.183.82Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-30Buy3,415132,244$14.3749.184.97Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-30Buy123,7114,864,263$14.371777.784.97Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-23Buy150,4694,740,552$14.522184.883.06Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-23Buy4,153128,829$14.5260.383.06Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-18Buy530124,676$14.997.977.32Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-18Buy19,1874,590,083$14.99287.677.32Link
Popovits Kimberly JPresident and CEO2010-08-17Sell8,000288,116$15.07120.676.38Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-13Buy2,924124,146$14.8543.478.99Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-13Buy105,9104,570,896$14.851572.878.99Link
Cole G BradleyCOO & CFO2010-08-12Sell2,5001,000$1537.577.2Link
Scott Randal WExecutive Chairman2010-08-11Sell20,0001,726,410$14.71294.280.69Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-08-10Buy164,2424,464,986$14.612399.681.93Link
14159 capital (GP), LLCDirector, 10% Owner2010-08-10Buy4,533121,222$14.6166.281.93Link
Baker JoffreChief Scientific Officer2010-08-09Sell4,629163,088$14.7568.380.2Link
Scott Randal WExecutive Chairman2010-07-13Sell20,0001,746,410$12.81256.2107.49Link
Baker JoffreChief Scientific Officer2010-07-07Sell4,629167,717$13.0560.4103.68Link
Scott Randal WExecutive Chairman2010-06-11Sell20,0001,766,410$14.1528387.84Link
Baker JoffreChief Scientific Officer2010-06-10Sell4,629172,346$14.056589.18Link
Popovits Kimberly JPresident and CEO2010-05-17Sell8,000310,624$15.78126.268.44Link
Cole G BradleyCOO & CFO2010-05-12Sell2,5001,000$15.8739.767.49Link
Scott Randal WExecutive Chairman2010-05-11Sell20,0001,776,410$15.61312.270.28Link
Baker JoffreChief Scientific Officer2010-05-10Sell4,629176,975$15.5171.871.37Link
Scott Randal WExecutive Chairman2010-04-13Sell20,0001,796,410$16.87337.457.56Link
Cole G BradleyCOO & CFO2010-04-12Sell5,0001,000$16.984.557.28Link
Baker JoffreChief Scientific Officer2010-04-12Sell4,629181,604$16.8878.157.46Link
Popovits Kimberly JPresident and CEO2010-03-16Sell20,000288,116$19.4538936.66Link
Scott Randal WExecutive Chairman2010-03-11Sell20,0001,800,646$19.338637.72Link
Cole G BradleyCOO & CFO2010-03-11Sell2,5001,000$19.3948.537.08Link
COLELLA SAMUEL DDirector2010-03-10Sell106,70085,050$19.452075.336.66Link
Baker JoffreChief Scientific Officer2010-03-08Sell4,629150,120$19.8391.834.04Link
14159 capital (GP), LLCDirector, 10% Owner2010-02-19Buy3,645116,689$17.0562.155.89Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-02-19Buy132,0704,300,744$17.052251.855.89Link
Scott Randal WExecutive Chairman2010-02-11Sell20,0001,830,646$17.23344.654.27Link
Cole G BradleyCOO & CFO2010-02-11Sell2,5001,000$17.5143.851.8Link
14159 capital (GP), LLCDirector, 10% Owner2010-02-10Buy9,437113,044$17.01160.556.26Link
Baker Brothers Life Sciences CDirector, 10% Owner2010-02-10Buy341,8544,168,674$17.015814.956.26Link
Baker JoffreChief Scientific Officer2010-02-09Sell4,629145,491$17.1479.355.08Link
Cole G BradleyCOO & CFO2010-01-12Sell5,0001,000$17.2586.354.09Link
Baker JoffreChief Scientific Officer2010-01-11Sell4,629150,120$17.4780.952.15Link
Shak StevenChief Medical Officer2009-12-21Sell5,000388,278$20.12100.632.11Link
Popovits Kimberly JPresident and CEO2009-12-15Sell5,000313,506$20.3910230.36Link
Cole G BradleyCOO & CFO2009-12-14Sell2,0001,000$20.4240.830.17Link
Scott Randal WExecutive Chairman2009-12-11Sell12,0001,880,646$20.24242.931.32Link
Baker JoffreChief Scientific Officer2009-12-08Sell4,629154,749$20.2693.831.19Link
Popovits Kimberly JPresident and CEO2009-11-17Sell20,000318,506$19.21384.238.37Link
Cole G BradleyCOO & CFO2009-11-12Sell6653,000$20.0413.332.63Link
Scott Randal WExecutive Chairman2009-11-11Sell12,0001,892,646$19.99239.932.97Link
Baker JoffreChief Scientific Officer2009-11-10Sell4,629159,378$2092.632.9Link
Shak StevenChief Medical Officer2009-10-20Sell5,000393,278$20.65103.328.72Link
Popovits Kimberly JPresident and CEO2009-10-15Sell5,000338,506$20.42102.130.17Link
Scott Randal WExecutive Chairman2009-10-13Sell12,0001,904,646$20.66247.928.65Link
Baker JoffreChief Scientific Officer2009-10-07Sell4,629164,007$21.179825.56Link
Shak StevenChief Medical Officer2009-09-22Sell5,000398,278$21.13105.725.79Link
Popovits Kimberly JPresident and CEO2009-09-15Sell5,000343,506$20.73103.728.22Link
Scott Randal WExecutive Chairman2009-09-11Sell12,0001,916,646$20.6724828.59Link
Baker JoffreChief Scientific Officer2009-09-04Sell4,629168,636$20.1293.132.11Link
Shak StevenChief Medical Officer2009-08-25Sell5,000403,278$20.77103.927.97Link
14159 capital (GP), LLCDirector, 10% Owner2009-08-17Buy1,839103,607$19.9836.733.03Link
Baker Brothers Life Sciences CDirector, 10% Owner2009-08-17Buy66,6303,826,820$19.981331.333.03Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-17Buy34194,184$19.980.733.03Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-17Buy11,6571,253,653$19.98232.933.03Link
Popovits Kimberly JPresident and CEO2009-08-17Sell5,000348,506$19.5397.736.1Link
Cole G BradleyCOO & CFO2009-08-13Sell5,0003,000$2010032.9Link
Baker Biotech Capital (GP), LLDirector, 10% Owner2009-08-12Buy15,8771,241,996$19.49309.436.38Link
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-08-12Buy45194,150$19.50.936.31Link
Baker Brothers Life Sciences CDirector, 10% Owner2009-08-12Buy90,7543,760,190$19.491768.836.38Link
14159 capital (GP), LLCDirector, 10% Owner2009-08-12Buy2,508101,768$19.4948.936.38Link
Scott Randal WExecutive Chairman2009-08-11Sell12,0001,928,646$19.4223336.87Link
Baker JoffreChief Scientific Officer2009-08-10Sell4,629173,265$19.4890.236.45Link
Baker JoffreChief Scientific Officer2009-07-08Sell4,629177,894$16.0174.166.02
Baker JoffreChief Scientific Officer2009-07-08Sell4,629177,894$16.0174.166.02
Scott Randal WExecutive Chairman2009-06-11Sell6,0001,940,646$18.27109.645.48
Baker JoffreChief Scientific Officer2009-06-08Sell4,629182,523$17.6981.950.25
Shak StevenChief Medical Officer2009-05-26Sell5,000408,278$199539.89
14159 capital (GP), LLCDirector, 10% Owner2009-05-21Buy1,10899,260$17.9719.947.91
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-21Buy90194,161$17.971.647.91
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-21Buy39,7783,669,436$17.97714.847.91
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-21Buy25194,105$17.970.447.91
Popovits Kimberly JPresident and CEO2009-05-15Sell5,000353,506$20.12100.632.11
Scott Randal WExecutive Chairman2009-05-12Sell12,0001,946,646$19.46233.536.59
Baker Bros. Capital (GP), LLCDirector, 10% Owner2009-05-11Buy88194,080$19.551.735.96
Baker / Tisch Capital (GP), LLDirector, 10% Owner2009-05-11Buy312194,071$19.556.135.96
Baker Brothers Life Sciences CDirector, 10% Owner2009-05-11Buy137,4663,629,658$19.552687.535.96
14159 capital (GP), LLCDirector, 10% Owner2009-05-11Buy3,82798,152$19.5574.835.96
Baker JoffreChief Scientific Officer2009-05-08Sell4,629187,152$19.7291.334.79
Scott Randal WExecutive Chairman2009-04-14Sell12,0001,958,646$25.47305.64.36
Baker JoffreChief Scientific Officer2009-04-01Sell4,629191,781$25.271175.18
Scott Randal WExecutive Chairman2009-03-11Sell12,0001,970,646$19.4232.837.01
Baker JoffreChief Scientific Officer2009-03-03Sell4,629196,410$19.1388.638.94
Cole G BradleyCOO & CFO2009-02-17Sell5,0003,000$21.52107.623.51
Baker JoffreChief Scientific Officer2009-02-12Sell4,62922,226$20.695.429.03
Baker JoffreChief Scientific Officer2009-02-12Sell4,629201,039$20.695.429.03
Scott Randal WExecutive Chairman, Director2009-02-11Sell12,0001,982,646$20.85250.227.48
Baker JoffreChief Scientific Officer2009-01-12Sell4,62926,855$19.4189.836.94
Shak StevenChief Medical Officer2008-12-22Sell100413,278$20.17231.78
Baker JoffreChief Scientific Officer2008-12-10Sell4,62931,484$19.2589.138.08
Baker JoffreChief Scientific Officer2008-12-10Sell4,629205,668$19.2589.138.08
Scott Randal WCEO, Director2008-12-09Sell12,0001,955,298$18.4220.844.46
Baker JoffreChief Scientific Officer2008-11-12Sell4,62936,113$19.879233.77
Baker JoffreChief Scientific Officer2008-11-12Sell4,629210,297$19.879233.77
Scott Randal WCEO, Director2008-11-11Sell12,0001,967,298$20.05240.632.57
Cole G BradleyEVP & CFO2008-11-10Sell10,0004,000$20.17201.731.78
Scott Randal WCEO, Director2008-10-14Sell12,0001,979,298$20.36244.330.55
Baker JoffreChief Scientific Officer2008-10-01Sell9,25840,742$22.51208.418.08
Shak StevenChief Medical Officer2008-09-24Sell5,000413,378$22.67113.417.25
Scott Randal WCEO, Director2008-09-16Sell12,0001,991,298$21.79261.521.98
Shak StevenChief Medical Officer2008-08-26Sell5,000418,378$22.93114.715.92
Baker JoffreChief Scientific Officer2008-08-26Sell4,629214,926$22.6910517.14
Cole G BradleyEVP & CFO2008-08-18Sell9,2984,000$23.67220.112.29
Popovits Kimberly JPresident and COO2008-08-15Sell25,000358,506$24.246069.65
Scott Randal WCEO, Director2008-08-12Sell12,0002,003,298$23.76285.111.87
Scott Randal WCEO, Director2008-07-15Sell12,0002,015,298$2125226.57
Baker JoffreChief Scientific Officer2008-07-01Sell4,629219,555$19.2689.238.01
Shak StevenChief Medical Officer2008-06-24Sell100423,378$20232.9
Scott Randal WCEO, Director2008-06-10Sell12,0002,027,298$19.9223933.43
Baker Brothers Life Sciences CDirector, 10% Owner2008-06-09Buy320,9833,492,192$19.916390.833.5
Baker Biotech Capital (GP), LLDirector, 10% Owner2008-06-09Buy76,0151,226,119$19.911513.533.5
14159 capital (GP), LLCDirector, 10% Owner2008-06-09Buy10,29994,325$19.91205.133.5
Baker JoffreChief Scientific Officer2008-06-02Sell4,629228,813$17.9983.347.75
Scott Randal WCEO, Director2008-05-13Sell12,0002,039,298$18.7522541.76
Baker JoffreChief Scientific Officer2008-05-08Sell4,629233,442$19.2789.237.93
Scott Randal WCEO, Director2008-04-15Sell12,0002,051,298$17.22206.654.36
Scott Randal WCEO, Director2008-03-11Sell12,0002,063,298$18.84226.141.08
Baker JoffreChief Scientific Officer2008-03-05Sell4,629242,700$20.4894.829.79
Shak StevenChief Medical Officer2008-02-26Sell5,000423,478$20.23101.231.39
Cole G BradleyEVP & CFO2008-02-19Sell9,0008,298$22.58203.217.71
Scott Randal WCEO, Director2008-02-12Sell12,0002,075,298$23.01276.115.51
Baker JoffreChief Scientific Officer2008-02-11Sell4,629247,329$22.94106.215.87
Scott Randal WCEO, Director2008-01-15Sell12,0002,087,298$25.54306.54.07
Baker JoffreChief Scientific Officer2008-01-02Sell4,629251,958$22.66104.917.3
Baker JoffreChief Scientific Officer2007-12-03Sell4,6290$23.1106.915.06
Popovits Kimberly JPresident and COO2007-11-27Sell6,655383,506$22146.420.82
Scott Randal WCEO, Director2007-11-09Sell12,0002,111,299$23.07276.815.21
Baker JoffreChief Scientific Officer2007-11-08Sell4,629265,845$23.21107.414.52
Scott Randal WCEO2007-10-09Sell12,0002,123,299$20.16241.931.85
Baker JoffreChief Scientific Officer2007-10-01Sell4,629270,474$19.8491.833.97
Scott Randal WCEO2007-09-11Sell12,0002,135,299$19.69236.334.99
Scott Randal WCEO, Director2007-09-11Sell12,0002,135,299$19.7236.434.92
Baker JoffreChief Scientific Officer2007-09-10Sell4,629275,103$19.5790.635.82
Goldberg Michael DDirector2007-08-23Buy5,3505,350$18.76100.441.68
Scott Randal WCEO2007-08-15Sell12,0002,147,299$19.91238.933.5
Baker JoffreChief Scientific Officer2007-08-08Sell4,629279,732$19.449036.73
Scott Randal WCEO2007-07-18Sell12,0002,159,299$21.18254.225.5
Baker JoffreChief Scientific Officer2007-07-02Sell4,629284,361$19.018839.82
Scott Randal WCEO2007-06-19Sell12,0002,171,299$19.16229.938.73
Baker JoffreChief Scientific Officer2007-06-01Sell4,629288,990$17.5681.351.37
Baker Bros. Capital (GP), LLCDirector2007-05-30Buy545193,992$16.328.962.87
Baker Biotech Capital (GP), LLDirector2007-05-30Buy81,1811,150,104$16.321324.962.87
Baker Brothers Life Sciences CDirector2007-05-30Buy214,0993,171,209$16.323494.162.87
14159 capital (GP), LLCDirector2007-05-30Buy6,80784,026$16.32111.162.87
14159 capital (GP), LLCDirector2007-05-24Buy16,26177,219$16.59269.860.22
Baker Brothers Life Sciences CDirector2007-05-24Buy511,5532,957,110$16.598486.760.22
Baker Biotech Capital (GP), LLDirector2007-05-24Buy193,9661,068,923$16.593217.960.22
Baker Bros. Capital (GP), LLCDirector2007-05-24Buy1,303193,447$16.5921.660.22
Baker Bros. Capital (GP), LLCDirector2007-05-21Buy1,803192,144$15.527.971.48
14159 capital (GP), LLCDirector2007-05-21Buy22,49160,958$15.5348.671.48
14159 capital (GP), LLCDirector2007-05-21Buy160,958$15.5071.48
Baker Brothers Life Sciences CDirector2007-05-21Buy707,4582,445,557$15.510965.671.48
Baker Biotech Capital (GP), LLDirector2007-05-21Buy268,248874,957$15.54157.871.48
Baker Bros. Capital (GP), LLCDirector2007-05-21Buy1,803192,144$15.527.971.48
Scott Randal WCEO2007-05-08Sell12,0002,183,299$16.62199.459.93
Baker JoffreChief Scientific Officer2007-05-08Sell4,629293,619$16.3175.562.97
Scott Randal WCEO2007-04-10Sell12,0002,195,299$17.27207.253.91
Baker JoffreChief Scientific Officer2007-04-02Sell4,629298,248$17.1679.454.9
Baker / Tisch Capital (GP), LLDirector2007-03-09Buy3,181193,759$18.2858.145.4
Baker Bros. Capital (GP), LLCDirector2007-03-09Buy376190,341$18.286.945.4
Baker Biotech Capital (GP), LLDirector2007-03-09Buy62,325606,709$18.281139.345.4
Baker Brothers Life Sciences CDirector2007-03-09Buy168,5601,738,099$18.283081.345.4
14159 capital (GP), LLCDirector2007-03-09Buy5,37538,467$18.2898.345.4
Scott Randal WCEO2007-03-06Sell12,0002,207,299$18.35220.244.85
Baker Bros. Capital (GP), LLCDirector2007-03-02Buy119189,965$18.092.246.93
14159 capital (GP), LLCDirector2007-03-02Buy1,70733,092$18.0930.946.93
Baker / Tisch Capital (GP), LLDirector2007-03-02Buy1,072190,578$18.119.446.85
Baker Biotech Capital (GP), LLDirector2007-03-02Buy19,795544,384$18.09358.146.93
Baker Brothers Life Sciences CDirector2007-03-02Buy53,5331,569,539$18.09968.446.93
Baker JoffreChief Scientific Officer2007-03-01Sell4,629302,877$18.1884.246.2
MYERS WOODROW A JRDirector2007-02-21Buy2,00012,000$19.6339.335.4
Baker Brothers Life Sciences CDirector2007-02-16Buy25,4121,516,006$18.54471.143.37
Baker Biotech Capital (GP), LLDirector2007-02-16Buy9,396524,589$18.54174.243.37
Baker / Tisch Capital (GP), LLDirector2007-02-16Buy525189,506$18.549.743.37
14159 capital (GP), LLCDirector2007-02-16Buy81131,385$18.541543.37
Baker Bros. Capital (GP), LLCDirector2007-02-16Buy56189,846$18.54143.37
Baker Bros. Capital (GP), LLCDirector2007-02-14Buy579189,790$18.2510.645.64
Baker / Tisch Capital (GP), LLDirector2007-02-14Buy5,346188,981$18.2597.645.64
Baker Biotech Capital (GP), LLDirector2007-02-14Buy95,783515,193$18.25174845.64
14159 capital (GP), LLCDirector2007-02-14Buy8,25630,574$18.25150.745.64
Baker Brothers Life Sciences CDirector2007-02-14Buy259,0441,490,594$18.254727.645.64
Scott Randal WCEO2007-02-13Sell12,0002,219,299$18.12217.446.69
Baker JoffreChief Scientific Officer2007-02-08Sell4,629307,506$18.9787.840.12
Baker / Tisch Capital (GP), LLDirector2006-12-06Buy642183,635$21.5813.923.17
Baker Brothers Life Sciences CDirector2006-12-06Buy34,1731,231,550$21.58737.523.17
14159 capital (GP), LLCDirector2006-12-06Buy1,12022,318$21.5824.223.17
Baker Biotech Capital (GP), LLDirector2006-12-06Buy12,237419,410$21.58264.123.17
MYERS WOODROW A JRDirector2006-12-05Buy10,00010,000$21.97219.720.98
Baker / Tisch Capital (GP), LLDirector2006-12-05Buy9,096182,993$20.6187.429.03
Baker Biotech Capital (GP), LLDirector2006-12-05Buy173,441407,173$20.63572.929.03
14159 capital (GP), LLCDirector2006-12-05Buy15,88021,198$20.6327.129.03
Baker Brothers Life Sciences CDirector2006-12-05Buy484,3331,197,377$20.69977.329.03
14159 capital (GP), LLCDirector2006-09-08Buy5,3185,318$14.0574.789.18Link
Baker Biotech Capital (GP), LLDirector2006-09-08Buy75,246233,732$14.051057.289.18Link
Baker Brothers Life Sciences CDirector2006-09-08Buy237,236713,044$14.053333.289.18Link
Baker Biotech Capital III (GP)10% Owner2005-10-04Buy136,316252,529$121635.8121.5Link
Baker Biotech Capital II (GP),10% Owner2005-10-04Buy38,684181,478$12464.2121.5Link

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column) and "Shares Owned Following This (Direct & Indirect)" transactions (sixth column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported.

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