Oncternal Therapeutics Presents Updated Interim Data for Zilovertamab in Combination with Ibrutinib at ASH 2022

Dec 10, 2022

Updated MCL and CLL data from the ongoing Phase 1/2 study of zilovertamab and ibrutinib are encouraging and continue to improve over prior reporting
The ORR of 89% and CR rate of 43% for patients with MCL treated with zilovertamab plus ibrutinib compare favorably to the historical ORR of 66% and CR rate of 20% for ibrutinib monotherapy
Median PFS and OS have not been reached after a median follow up of 19.5 months for patients with MCL treated with zilovertamab plus ibrutinib, which compares favorably to the historical median PFS and OS of 12.8 months and 25 months, respectively, for ibrutinib monotherapy
Landmark PFS was 100% at 42 months for patients with CLL expressing p53 mutation/del(17p) treated with zilovertamab plus ibrutinib

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