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GuruFocus Financial Strength Rank measures how strong a company’s financial situation is. It is based on these factors

1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.

A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.

Financial Strength : 4/10

vs
industry
vs
history
Cash to Debt 2.91
ASTM's Cash to Debt is ranked higher than
77% of the 901 Companies
in the Global Biotechnology industry.

( Industry Median: 68.42 vs. ASTM: 2.91 )
ASTM' s 10-Year Cash to Debt Range
Min: 2.91   Max: No Debt
Current: 2.91

Equity to Asset 0.14
ASTM's Equity to Asset is ranked lower than
76% of the 751 Companies
in the Global Biotechnology industry.

( Industry Median: 0.65 vs. ASTM: 0.14 )
ASTM' s 10-Year Equity to Asset Range
Min: -7.22   Max: 0.98
Current: 0.14

-7.22
0.98
F-Score: 2
Z-Score: -21.76
M-Score: -99999999.99
GuruFocus Profitability Rank ranks how profitable a company is and how likely the company’s business will stay that way. It is based on these factors:

1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
••3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank•

The maximum rank is 10. A rank of 7 or higher means a higher profitability and may stay that way. A rank of 3 or lower indicates that the company has had trouble to make a profit.

Profitability Rank is not directly related to the Financial Strength Rank. But if a company is consistently profitable, its financial strength will be stronger.

Profitability & Growth : 2/10

vs
industry
vs
history
Operating margin (%) -110336.84
ASTM's Operating margin (%) is ranked lower than
52% of the 794 Companies
in the Global Biotechnology industry.

( Industry Median: -68.50 vs. ASTM: -110336.84 )
ASTM' s 10-Year Operating margin (%) Range
Min: -161333.33   Max: -656.25
Current: -110336.84

-161333.33
-656.25
Net-margin (%) -82221.05
ASTM's Net-margin (%) is ranked lower than
52% of the 794 Companies
in the Global Biotechnology industry.

( Industry Median: -59.60 vs. ASTM: -82221.05 )
ASTM' s 10-Year Net-margin (%) Range
Min: -140352.38   Max: -618.75
Current: -82221.05

-140352.38
-618.75
ROE (%) -401.18
ASTM's ROE (%) is ranked lower than
51% of the 823 Companies
in the Global Biotechnology industry.

( Industry Median: -21.52 vs. ASTM: -401.18 )
ASTM' s 10-Year ROE (%) Range
Min: -401.18   Max: -35.76
Current: -401.18

-401.18
-35.76
ROA (%) -169.53
ASTM's ROA (%) is ranked lower than
51% of the 897 Companies
in the Global Biotechnology industry.

( Industry Median: -17.51 vs. ASTM: -169.53 )
ASTM' s 10-Year ROA (%) Range
Min: -254.14   Max: -34.84
Current: -169.53

-254.14
-34.84
ROC (Joel Greenblatt) (%) -2836.81
ASTM's ROC (Joel Greenblatt) (%) is ranked higher than
58% of the 876 Companies
in the Global Biotechnology industry.

( Industry Median: -201.33 vs. ASTM: -2836.81 )
ASTM' s 10-Year ROC (Joel Greenblatt) (%) Range
Min: -3340.41   Max: -101.35
Current: -2836.81

-3340.41
-101.35
Revenue Growth (%) -47.70
ASTM's Revenue Growth (%) is ranked higher than
59% of the 638 Companies
in the Global Biotechnology industry.

( Industry Median: -1.80 vs. ASTM: -47.70 )
ASTM' s 10-Year Revenue Growth (%) Range
Min: -75.1   Max: 12.5
Current: -47.7

-75.1
12.5
EBITDA Growth (%) -28.90
ASTM's EBITDA Growth (%) is ranked higher than
60% of the 600 Companies
in the Global Biotechnology industry.

( Industry Median: -9.10 vs. ASTM: -28.90 )
ASTM' s 10-Year EBITDA Growth (%) Range
Min: -47.6   Max: 6.4
Current: -28.9

-47.6
6.4
EPS Growth (%) -28.80
ASTM's EPS Growth (%) is ranked higher than
63% of the 636 Companies
in the Global Biotechnology industry.

( Industry Median: -12.20 vs. ASTM: -28.80 )
ASTM' s 10-Year EPS Growth (%) Range
Min: -49.1   Max: 7.3
Current: -28.8

-49.1
7.3
» ASTM's 10-Y Financials

Financials


Revenue & Net Income
Cash & Debt
Oprt. Cash Flow & Free Cash Flow

» Details

Guru Trades

Q3 2013

ASTM Guru Trades in Q3 2013

Jim Simons 434,187 sh (-81.98%)
» More
Q4 2013

ASTM Guru Trades in Q4 2013

Jim Simons Sold Out
» More
Q1 2014

ASTM Guru Trades in Q1 2014

Jim Simons 64,743 sh (New)
» More
Q2 2014

ASTM Guru Trades in Q2 2014

Jim Simons Sold Out
» More
» Details

Insider Trades

Latest Guru Trades with ASTM

(List those with share number changes of more than 20%, or impact to portfolio more than 0.1%)



No Insider Trades Found!
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Ratios

vs
industry
vs
history
P/S 4.09
ASTM's P/S is ranked lower than
74% of the 961 Companies
in the Global Biotechnology industry.

( Industry Median: 17.18 vs. ASTM: 4.09 )
ASTM' s 10-Year P/S Range
Min: 4.66   Max: 2820
Current: 4.09

4.66
2820
EV-to-EBIT -2.45
ASTM's EV-to-EBIT is ranked lower than
51% of the 961 Companies
in the Global Biotechnology industry.

( Industry Median: 9999.00 vs. ASTM: -2.45 )
ASTM' s 10-Year EV-to-EBIT Range
Min: 3.2   Max: 21.6
Current: -2.45

3.2
21.6
Current Ratio 0.83
ASTM's Current Ratio is ranked higher than
54% of the 684 Companies
in the Global Biotechnology industry.

( Industry Median: 3.97 vs. ASTM: 0.83 )
ASTM' s 10-Year Current Ratio Range
Min: 0.3   Max: 45.43
Current: 0.83

0.3
45.43
Quick Ratio 0.71
ASTM's Quick Ratio is ranked higher than
58% of the 684 Companies
in the Global Biotechnology industry.

( Industry Median: 3.80 vs. ASTM: 0.71 )
ASTM' s 10-Year Quick Ratio Range
Min: 0.3   Max: 45.15
Current: 0.71

0.3
45.15

Valuation & Return

vs
industry
vs
history
Earnings Yield (Greenblatt) 82.60
ASTM's Earnings Yield (Greenblatt) is ranked higher than
87% of the 463 Companies
in the Global Biotechnology industry.

( Industry Median: 5.00 vs. ASTM: 82.60 )
ASTM' s 10-Year Earnings Yield (Greenblatt) Range
Min: 4.6   Max: 1521.1
Current: 82.6

4.6
1521.1
Forward Rate of Return (Yacktman) -317.37
ASTM's Forward Rate of Return (Yacktman) is ranked higher than
52% of the 739 Companies
in the Global Biotechnology industry.

( Industry Median: -10.00 vs. ASTM: -317.37 )
ASTM' s 10-Year Forward Rate of Return (Yacktman) Range
Min: 8.9   Max: 12.7
Current: -317.37

8.9
12.7

Business Description

Industry: Biotechnology » Biotechnology
Compare:NVO, AMGN, GILD, BIIB, CELG » details
Traded in other countries:ATQP.Germany
Aastrom Biosciences, Inc., was incorporated in 1989 and is a regenerative medicine company focused on the development of innovative cell therapies to repair or regenerate damaged or diseased tissues. The Company is developing patient-specific, expanded multicellular therapies for use in the treatment of severe, chronic ischemic cardiovascular diseases. Ixmyelocel-T (the generic name for a multicellular therapy) is a disease modifying therapy with multi-functional properties including: tissue remodeling, immuno-modulation and the promotion of angiogenesis. The Company's proprietary cell-manufacturing technology enables the manufacture of multicellular therapies, expanded from an adult patient's own bone marrow, to be delivered directly to damage tissues. Preclinical and clinical data suggest that ixmyelocel-T may be safe and effective in treating patients with severe, chronic ischemic cardiovascular diseases such as critical limb ischemia (CLI), the severe form of peripheral arterial disease (PAD), and dilated cardiomyopathy (DCM), the third leading cause of heart failure. Over 200 patients have been treated in recent clinical trials using ixmyelocel-T, and over 400 patients safely treated since the Company's inception. In November2011, the Company released positive Phase 2b data from its RESTORE-CLI clinical trial and launched a pivotal Phase 3 REVIVE trial in CLI in February2012. During the fourth quarter of 2012, it launched a randomized, placebo-controlled, double-blinded Phase 2b ixCELL-DCM trial for patients with ischemic DCM. Ixmyelocel-T is a patient-specific, expanded multicellular therapy developed using the Company's proprietary, fully-closed, automated processing system. Ixmyelocel-T is a product derived from an adult patient's own bone marrow but it is significantly enhanced compared with the original bone marrow. Its process enhances the patient's bone marrow mononuclear cells by expanding the mesenchymal stromal cells and M2 anti-inflammatory macrophages while retaining many of the hematopoietic cells. These cell types, known to regulate the immune response, are important in the resolution of pathologic inflammation and tissue repair. The manufacture of its patient-specific, expanded multicellular therapies is done under current Good Manufacturing Practices (cGMP) and current Good Tissue Practices (cGTP) guidelines required by the U.S. Food and Drug Administration (FDA). The Company's therapy is produced at its cell manufacturing facility in the United States, located at its headquarters in Ann Arbor, Michigan. Its clinical development programs are focused on addressing areas of high unmet medical needs in severe, chronic ischemic cardiovascular diseases. The Company has exclusive rights to approximately 19 unexpired issued U.S. patents. Eleven of these patents are material patents that protect its cellular therapy. It owns ten of these patents and one has been licensed exclusively from the University of Michigan. T
» More Articles for ASTM

Headlines

Articles On GuruFocus.com
comment on ASTM Jan 10 2013 
Weekly CFO Sells Highlight: P, MTOR, PSSI, ASTM Jan 09 2012 
Weekly CFO Buys Highlight: OCWEN FINANCIAL Corp., Aastrom Biosciences Inc. Mar 13 2011 
Aastrom Biosciences Inc. Reports Operating Results (10-Q/A) Feb 24 2011 
Aastrom Biosciences Inc. Reports Operating Results (10-Q/A) Feb 24 2011 
Aastrom Biosciences Inc. Reports Operating Results (10-Q/A) Feb 24 2011 
Aastrom Biosciences Inc. Reports Operating Results (10-Q/A) Feb 24 2011 
Weekly CFO Buys Highlight: JAZZ, VRTB, ASTM, ARWR, CGX Sep 04 2010 
Aastrom Biosciences Inc. (ASTM) CEO Timothy M Mayleben buys 17,200 Shares Aug 31 2010 
Aastrom Biosciences Inc. (ASTM) CFO Scott Durbin buys 16,463 Shares Aug 27 2010 

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