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Insider Charts

Insider Transactions

Insider Position Date Buy/Sell Shares Shares Owned Following This (Direct & Indirect) Trade Price ($) Cost ($1000) Price Change
Since Trade (%)
Share Ownership Details
FISHERMAN JASON SDirector2016-12-22Buy10,00050,000$3.9639.64.850,000 (Direct)
Fenton Mary KayCFO
(Click for the stocks that their CFOs have bought)
2016-12-05Buy2,5002,500$4.1110.280.972,500 (Direct)
Truitt JosephChief Commercial Officer2016-12-02Buy3,5003,500$4.0614.212.223,500 (Direct)
MANNING MARTHA EEVP, General Counsel2016-12-02Buy2,5002,500$4.0910.231.472,500 (Direct)
Deshpande MilindCEO
(Click for the stocks that their CEOs have bought)
2016-12-02Buy2,5002,500$4.0610.152.222,500 (Direct)
Barrish Joel CChief Scientific Officer2016-12-02Buy2,5002,500$4.0610.152.222,500 (Direct)
Apelian DavidChief Medical Officer2015-12-30Sell10,0000$10.5105-60.48Link
Fenton Mary KayCFO2015-12-28Sell43,5000$10.08438.48-58.83Link
VITULLO NICOLEDirector2015-11-11Sell550,0002,391,407$10.175593.5-59.1931,431 (Direct)
2,317,797 (By Domain Partners VIII, L.P.)
17,179 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-09-25Sell9,3102,941,407$8.2276.53-49.5131,431 (Direct)
2,863,727 (By Domain Partners VIII, L.P.)
21,249 (By DP VIII Associates, L.P.)
25,000 (By Domain Associates, LLC)
VITULLO NICOLEDirector2015-08-14Sell37,84377,749$7.51284.2-44.7431,431 (Direct)
21,318 (By DP VIII Associates, L.P.)
0 (By One Palmer Square Associates VIII, LLC)
25,000 (By Domain Associates, LLC)
Fenton Mary KayEVP and CFO2015-01-23Sell13,1250$16210-74.06Link
Deshpande MilindPresident and CEO2015-01-21Sell100,0000$151500-72.33Link
RA CAPITAL MANAGEMENT, LLC2014-09-30Sell1,332,0146,700,000$10.213586.54-59.31
6,700,000 (See Footnotes(F5,F6))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-26Sell2,372,9158,032,014$11.1726505.46-62.85
8,032,014 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-23Sell2,595,07110,404,929$11.2929298.35-63.24
10,404,929 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$20356.334694504.18-99.98
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-11Sell1,704,36213,000,000$12.4521219.31-66.67
13,000,000 (See Footnotes(F12,F13))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-09-02Sell835,29314,704,362$11.639714.46-64.32
14,704,362 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-27Sell2,711,35215,539,655$11.3330719.62-63.37
15,539,655 (See Footnotes(F11,F12))
Truitt JosephEVP, Chief Commercial Officer2014-08-25Sell25,0000$10.82270.5-61.65Link
RA CAPITAL MANAGEMENT, LLC10% Owner2014-08-18Sell4,235,00018,251,007$9.5340359.55-56.45
18,251,007 (See Footnotes(F11,F12))
Deshpande MilindPresident and CEO2014-08-18Sell216,6240$102166.24-58.5Link
KISHBAUCH MICHAEL DDirector2014-08-15Sell495,8120$9.44660.63-55.85Link
FRASHIER GARY EDirector2014-08-13Sell5,0005,000$840-48.135,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)(5)2014-06-20Sell880,00022,486,007$8.47392-50.6
22,486,007 (See Footnotes(F4,F5))
FRASHIER GARY EDirector2014-06-16Sell55,0005,000$8440-48.135,000 (Direct)
FRASHIER GARY EDirector2014-06-16Sell55,0000$8440-48.13Link
Truitt JosephEVP, Chief Commercial Officer2014-06-16Sell25,0000$7.82195.5-46.93Link
QVT Associates GP LLC10% Owner2014-06-16Sell1,819,5518,868,753$7.714010.54-46.1
8,868,753 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2014-06-11Sell128,64910,688,304$7.66985.45-45.82
10,688,304 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Truitt JosephEVP, Chief Commercial Officer2014-06-10Sell50,0000$6.02301-31.06Link
KISHBAUCH MICHAEL DDirector2014-06-10Sell371,9370$7.752882.51-46.45Link
QVT Associates GP LLC10% Owner2013-12-30Sell170,23910,816,953$3.34568.624.25
10,816,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-26Sell121,20510,987,192$3.44416.9520.64
10,987,192 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-23Sell289,14111,108,397$3.24936.8228.09
11,108,397 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-19Sell222,61211,397,538$3.09687.8734.3
11,397,538 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-12-17Sell92,80311,620,150$3.11288.6233.44
11,620,150 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
Liotta DennisDirector2013-11-22Buy10,000100,000$2.9829.839.26100,000 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-11-20Buy1,110,00023,366,007$2.552830.562.75
23,366,007 (See Footnotes(F4,F5))
FISHERMAN JASON SDirector2013-11-19Buy15,00040,000$2.6339.4557.7940,000 (Direct)
RA CAPITAL MANAGEMENT, LLCSee Footnotes (1)-(2)2013-11-12Buy1,795,00022,256,007$2.484451.667.34
22,256,007 (See Footnotes(F3,F4))
RA CAPITAL MANAGEMENT, LLC2013-10-31Buy1,186,00720,461,007$2.452905.7269.39
20,461,007 (See Footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-10-14Buy2,369,22919,275,000$2.796610.1548.75
19,275,000 (See Footnotes(F10,F11))
RA CAPITAL MANAGEMENT, LLC2013-10-11Buy2,448,71016,905,771$2.566268.762.11
16,905,771 (See Footnotes(F8,F9))
QVT Associates GP LLC10% Owner2013-09-30Sell2,754,90011,712,953$3.479559.519.6
11,712,953 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
RA CAPITAL MANAGEMENT, LLC2013-09-30Buy2,800,00014,457,061$2.98834439.26
14,457,061 (See footnotes(F6,F7))
RA CAPITAL MANAGEMENT, LLC2013-09-25Sell548,9454,816,562$7.374045.72-43.694,816,562 (Direct)
RA CAPITAL MANAGEMENT, LLC2013-09-12Sell200,0804,848,760$7.191438.58-42.284,848,760 (Direct)
FISHERMAN JASON SDirector2013-08-14Buy5,00025,000$6.8334.15-39.2425,000 (Direct)
Liotta DennisDirector2013-08-12Buy5,00090,000$6.4732.35-35.8690,000 (Direct)
QVT Associates GP LLC10% Owner2013-08-09Buy102,28214,467,853$6.41655.63-35.26
14,467,853 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-11Buy401,01714,365,571$6.462590.57-35.76
14,365,571 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-10Buy390,94413,964,554$6.332474.68-34.44
13,964,554 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-08Buy642,50913,573,610$6.284034.96-33.92
13,573,610 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
QVT Associates GP LLC10% Owner2013-07-03Buy1,963,24812,931,101$6.4312623.68-35.46
12,931,101 (Through QVT Fund IV LP, QVT Fund V LP and Quintessence Fund L.P.)
FRASHIER GARY EDirector2013-07-01Sell5,0005,000$8.1740.85-49.25,000 (Direct)
FISHERMAN JASON SDirector2013-06-21Buy10,00020,000$7.6376.3-45.6120,000 (Direct)
FRASHIER GARY EDirector2013-06-07Sell5,0005,000$8.3741.85-50.425,000 (Direct)
Liotta DennisDirector2013-06-03Buy20,00085,000$7.91158.2-47.5385,000 (Direct)
FISHERMAN JASON SDirector2013-06-03Buy10,00010,000$7.8778.7-47.2710,000 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2013-01-02Sell115,1333,125$8.1932.58-48.773,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-27Sell7,0053,125$1070.05-58.53,125 (Direct)
Shah GautamEVP and Chief Compliance Ofc.2012-09-12Sell11,2503,125$890-48.133,125 (Direct)
WRIGHT DAVID PDirector2012-06-15Sell10,0000$6.4364.3-35.46Link
Liotta DennisDirector2012-06-12Buy20,00065,000$6.19123.8-32.9665,000 (Direct)
FRASHIER GARY EDirector2012-06-11Sell16,2505,000$6.19100.59-32.965,000 (Direct)
Clarus Lifesciences II, L.P.10% Owner2012-05-31Sell1,316,95610,942,471$7.499864-44.59
10,942,471 (By Fund)
Shah GautamSVP and Chief Compliance Ofc.2012-03-19Sell4,7963,125$10.7251.41-61.293,125 (Direct)
Deshpande MilindPresident and CSO2012-03-15Sell5,3120$10.756.84-61.21Link
KISHBAUCH MICHAEL DCEO and President2012-01-13Sell198,3060$12.632504.6-67.14Link
KISHBAUCH MICHAEL DCEO and President2012-01-11Sell99,1090$10.241014.88-59.47Link
Shah GautamSVP and Chief Compliance Ofc.2012-01-10Sell25,7453,125$11.62299.16-64.293,125 (Direct)
Olek Elizabeth ASVP and CMO2012-01-10Sell12,4682,000$10.06125.43-58.752,000 (Direct)
Fenton Mary KaySVP and CFO2012-01-10Sell10,6250$12127.5-65.42Link
Shah GautamSVP and Chief Compliance Ofc.2011-12-20Sell10,4233,125$7.6980.15-46.033,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-12-01Sell2,0783,125$714.55-40.713,125 (Direct)
Liotta DennisDirector2011-11-21Buy5,00045,000$5.9629.8-30.3745,000 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-09-16Sell2,7193,125$5.916.04-29.663,125 (Direct)
WRIGHT DAVID PDirector2011-09-09Sell12,5000$675-30.83Link
Liotta DennisDirector2011-08-22Buy10,00040,000$5.3953.9-23.0140,000 (Direct)
FISHERMAN JASON SDirector2011-07-21Sell1250$7.961-47.86
0 (See footnote)
FISHERMAN JASON SDirector2011-07-20Sell183125$7.481.37-44.52
125 (See footnote)
FISHERMAN JASON SDirector2011-07-15Sell457308$7.733.53-46.31
308 (See footnote)
FISHERMAN JASON SDirector2011-07-12Sell350765$7.892.76-47.4
765 (see footnote)
Shah GautamSVP and Chief Compliance Ofc.2011-06-28Sell19,6253,125$8157-48.133,125 (Direct)
Deshpande MilindPresident and CSO2011-06-28Sell49,6880$8.1402.47-48.77Link
KISHBAUCH MICHAEL DCEO and President2011-06-28Sell72,7090$7.58551.13-45.25Link
KISHBAUCH MICHAEL DCEO and President2011-06-24Sell17,5000$7.51131.43-44.74Link
Deshpande MilindPresident and CSO2011-06-23Sell15,6250$7.51117.34-44.74Link
Shah GautamSVP and Chief Compliance Ofc.2011-06-22Sell2,0783,125$714.55-40.713,125 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-06-16Sell2,7193,125$6.4417.51-35.563,125 (Direct)
Deshpande MilindPres R&D and CSO2011-05-27Sell47,80015,625$7.01335.08-40.815,625 (Direct)
Shah GautamSVP and Chief Compliance Ofc.2011-04-15Sell11,0000$6.672.6-37.12Link
Fenton Mary KaySVP and CFO2011-04-06Sell4,2500$7.531.88-44.67Link
Fenton Mary KaySVP and CFO2011-03-30Sell4,0000$7.530-44.67Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-28Sell2,0780$714.55-40.71Link
Shah GautamSVP and Chief Compliance Ofc.2011-03-16Sell7,7260$646.36-30.83Link
Quaker BioVentures II LP10% Owner2011-03-07Sell200,8220$5.991202.92-30.72Link
Quaker BioVentures II LP10% Owner2011-03-03Sell223,8000$5.91320.42-29.66Link
Quaker BioVentures II LP10% Owner2011-02-17Sell156,7870$5.08796.48-18.31Link
Shah GautamSVP and Chief Compliance Ofc.2011-01-18Sell14,3126,250$4.8669.56-14.61Link
Fenton Mary KaySVP and CFO2011-01-13Sell8,75012,625$543.75-17Link
Clarus Lifesciences II, L.P.10% Owner2010-08-20Buy4,875,5029,262,079$2.491214066.67Link
Clarus Lifesciences II, L.P.10% Owner2010-01-11Sell233,9904,386,577$3.77882.1410.08Link
Clarus Lifesciences II, L.P.10% Owner2010-01-07Sell53,0004,620,567$3.5185.518.57Link
INVESTOR AB10% Owner2009-12-31Sell95,2001,483,810$3.21305.5929.28Link
INVESTOR AB10% Owner2009-12-29Sell251,5081,523,010$3.16794.7731.33Link
Clarus Lifesciences II, L.P.10% Owner2009-12-24Sell3,6004,673,567$3.5312.7117.56Link
Clarus Lifesciences II, L.P.10% Owner2009-12-23Sell284,0004,677,167$3.691047.9612.47Link
Clarus Lifesciences II, L.P.10% Owner2009-12-18Sell207,1764,961,167$3.53731.3317.56Link
Moorin Jay10% Owner2009-12-17Sell563,4522,663,854$3.491966.4518.91Link
INVESTOR AB10% Owner2009-12-17Sell976,9901,626,572$3.333253.3824.62Link
INVESTOR AB10% Owner2008-12-18Buy467,5002,028,862$0.95444.13336.84
INVESTOR AB10% Owner2008-12-09Buy127,5001,836,362$1127.5315
INVESTOR AB10% Owner2008-12-04Buy200,0002,548,360$1200315
INVESTOR AB10% Owner2008-11-26Buy24,7002,348,360$124.7315
Clarus Lifesciences II, L.P.10% Owner2008-09-08Buy4,6545,307,420$2.2510.4784.44
Olek Elizabeth AVice President and CMO2008-08-28Buy2,0002,000$2.424.8471.49
Shah GautamSVP and Chief Compliance Ofc.2007-04-26Sell3,1253,125$5.7918.09-28.32

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as Conversion of derivative security or Exercise of Options are not included. Insiders are only limited to Officers and/or Directors of the company.

"Shares" change (fifth column), "Shares Owned Following This (Direct & Indirect)" transactions (sixth column), and "Trade Price ($)" (seventh column) are split adjusted. The "Share Ownership Details" (last column) displayed data is as of reported (also split adjusted).

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