Affimed Provides Updated Clinical Data from Phase 1/2 Study of AFM13 Precomplexed with Cord Blood-Derived NK Cells at the ASH 2022 Annual Meeting

Dec 10, 2022

AFM13 in combination with NK cells shows very high overall and complete response rates in 41 heavily pre-treated CD30-positive Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL) patients
Patients had a median of seven prior lines of treatment; of note, all patients failed to demonstrate objective response to immediate prior line of therapy
31 Hodgkin lymphoma patients treated at the recommended phase 2 dose (RP2D) showed an objective response rate (ORR) of 97% and a complete response (CR) rate of 77%
Three of four NHL patients treated at the RP2D achieved an objective response, including one CR
63% of patients treated at the RP2D with at least 6 months follow-up after initial infusion (n=24) remain in complete response for at least 6 months
Treatment continues to be well tolerated; no instances of cytokine release syndrome, immune effector cell-associated neurotoxicity or graft versus host disease observed
Affimed to host investor event and webcast today at 4:00 p.m. CST / 5:00 p.m. EST to discuss the development plan for AFM13

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