Rallybio Corporation (Nasdaq: RLYB) today announced publication of preclinical study results for two human HPA-1a-specific antibodies in development for the prevention of FNAIT. The results demonstrate that low doses of the two HPA-1a-specific antibodies, the polyclonal candidate RLYB211 and the monoclonal candidate RLYB212, are equally effective at rapidly clearing HPA-1a-positive platelets from circulation and preventing alloimmunization to HPA-1a. As expected, prophylactically blocking HPA-1a alloimmunization prevented the onset of FNAIT. These results also establish the concentration-effect relationship and threshold exposure targets for effective prophylactic treatment with HPA-1a specific antibodies to prevent FNAIT. The findings were published in the journal Blood, the official journal of the American Society of Hematology.
Rallybio Announces Publication of Data Highlighting the Ability of HPA-1a-Specific Antibodies to Prevent Alloimmunization in an Authentic Mouse Model of FNAIT
Dec 15, 2022
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