ARCA:XBI

State Street SPDR S&P Biotech ETF

$ 152 -4.22 ( -2.7%) 04:00 PM EST
PE Ratio:
17.47
PB Ratio:
4.67
Volume:
9.80M
Dividend Yield %:
0.38
Last Holding update 2026-02-27 148 Stocks (23 new)
Value $7.83 Bil Turnover 25 %
Top Holdings: FOLD(1.49%) PRAX(1.39%) TVTX(1.37%) BMRN(1.37%) HALO(1.33%)
Registrant: State Street(R) SPDR(R) S&P(R) Biotech ETF
Year: 2026
To
10Y: -%
Above Low: +NaN%
Below High: NaN%
Performance Chart Fundamental Charts Technical Indicators Gurus Trades Top Holdings Sector Breakdowns Holding History Back to Top

GuruFocus Rankings

Financial Strength
6 /10
Profitability Rank
3 /10
GF Value Rank
4 /10
Growth Rank
7 /10
Momentum Rank
6 /10

State Street SPDR S&P Biotech ETF Geographic Breakdown

State Street SPDR S&P Biotech ETF Performance

Dividend
Log
Bar
To

Annualized Return %  

Symbol
1 Week
1 Month
3 Months
6 Months
YTD
1 Year
3 Years
5 Years
10 Years

Total Annual Return %  

Symbol
2026
2025
2024
2023
2022
2021
2020
2019
2018
2017

State Street SPDR S&P Biotech ETF Key Statistics

Name Value
Day's Open ($) 155.02
Day's Range ($) 150.93 - 155.65
Day's Volume 9,802,109
52-Week Range ($) 84.39 - 165.71
Beta 1.1055
3-Year Sharpe Ratio 0.8
3-Year Sortino Ratio 1.46
Volatility 18.39
14-Day RSI 59.71
14-Day ATR ($) 4.185574
20-Day SMA ($) 153.828

Fundamental Data

Name Value
Market Cap (Mil $) 10,343.6
Shares Outstanding (Mil) 68.05
PE Ratio 17.47
PE Ratio (10y Range) 14.4 - 37.15
PE Ratio (10y Median) 18.3
PB Ratio 4.67
PB Ratio (10y Range) 2.75 - 6.16
PB Ratio (10y Median) 4.34

Dividend Data

Name Value
Dividends per Share (TTM) ($) 0.579
Dividend Yield % 0.38
Dividend Yield % (10y Range) 0.01 - 0.52
Dividend Yield % (10y Median) 0.23
Next Dividend Payment Date
Dividend Frequency Quarterly

XBI State Street SPDR S&P Biotech ETF Fundamental Charts

Historical TTM Price-to-Earnings for XBI State Street SPDR S&P Biotech ETF

Historical TTM Price-to-Earnings without NRI for XBI State Street SPDR S&P Biotech ETF

Historical Price-to-Book Ratio for XBI State Street SPDR S&P Biotech ETF

Historical Dividend Yields for XBI State Street SPDR S&P Biotech ETF

State Street SPDR S&P Biotech ETF Technical Indicators

Moving Average

Momentum

Gurus Latest Trades with ARCA:XBI

No Available Data

ARCA:XBI is held by these investors

No Available Data
State Street(R) SPDR(R) S&P(R)... Top Holdings of 2025-12-31 View Full List
Ticker
Company
Shares
Value ($1000)
Shares Change %
Weighting %
Trade Impact %
% of Shares outstanding
3M Change %
YTD Change %
Market Cap $Mil
Industry
FOLD
Amicus Therapeutics Inc
8,213,589
116,961.5
+67.90%
1.490
+0.60%
2.620
+1.54%
+1.76%
4,549.9
Biotechnology
PRAX
Praxis Precision Medicines Inc
370,413
109,175.5
-23.24%
1.390
-0.10%
1.340
-3.80%
+4.57%
8,592.2
Biotechnology
TVTX
Travere Therapeutics Inc
2,818,736
107,703.9
+141.72%
1.370
+0.80%
3.150
+39.81%
+44.67%
5,139.7
Biotechnology
BMRN
BioMarin Pharmaceutical Inc
1,804,534
107,243.5
-5.37%
1.370
-0.10%
0.940
+10.91%
+0.96%
11,597.1
Biotechnology
HALO
Halozyme Therapeutics Inc
1,546,804
104,099.9
+12.81%
1.330
+0.15%
1.310
+16.36%
+15.22%
9,197.3
Biotechnology
ROIV
Roivant Sciences Ltd
4,787,868
103,896.7
-20.84%
1.330
-0.33%
0.670
+16.24%
+56.36%
24,404.8
Biotechnology
EXEL
Exelixis Inc
2,359,522
103,417.9
-14.41%
1.320
-0.29%
0.910
+25.46%
+27.04%
13,995.5
Biotechnology
REGN
Regeneron Pharmaceuticals Inc
133,448
103,004.5
-28.64%
1.310
-0.53%
0.130
-8.85%
-11.80%
71,179.4
Biotechnology
PCVX
Vaxcyte Inc
2,228,160
102,807.3
+15.48%
1.310
+0.18%
1.550
-9.90%
+21.46%
8,092.0
Biotechnology
MDGL
Madrigal Pharmaceuticals Inc
175,411
102,148.8
-27.41%
1.300
-0.53%
0.770
+3.96%
-6.32%
12,577.6
Biotechnology

State Street(R) SPDR(R) S&P(R) Biotech ETF's Historical Top Holdings Breakdowns

State Street(R) SPDR(R) S&P(R) Biotech ETF's Top Stock Picks View Full List
Ticker
Company
Date
Action
Impact %
Price Range
Price
Price Change from Avrg%
Comment
Current Shares
Share Change
AKRO Unlock Delisted
Akero Therapeutics Inc
2025-12-31
Sold Out
Sold Out
-1.45%
●
46 ($53.31) 54.69
$54.65
2.51%
Sold Out
0
-1,741,151
MTSR Unlock Delisted
Metsera Inc
2025-12-31
Sold Out
Sold Out
-1.23%
●
51.7 ($59.45) 83.18
$70.50
18.59%
Sold Out
0
-1,336,340
CELC
Celcuity Inc
2025-12-31
Add
Add
+1.08%
●
46.07 ($82.79) 105.87
$88.29
6.64%
Add 819.88%
951,649
848,195
EXAS Unlock Delisted
Exact Sciences Corp
2025-12-31
Reduce
Reduce
-0.90%
●
56.19 ($80.68) 101.93
$104.91
30.03%
Reduce -49.57%
957,047
-940,563
RVMD
Revolution Medicines Inc
2025-12-31
Reduce
Reduce
-0.88%
●
45.7 ($65.88) 81.19
$179.30
172.16%
Reduce -46.41%
1,244,382
-1,077,627
MLYS
Mineralys Therapeutics Inc
2025-12-31
Add
Add
+0.80%
●
35.5 ($40.11) 47.33
$27.08
-32.49%
Add 423.65%
2,130,912
1,723,975
MIRM
Mirum Pharmaceuticals Inc
2025-12-31
Add
Add
+0.80%
●
64.1 ($71.76) 81.07
$117.42
63.63%
Add 183.94%
1,215,159
787,203
TVTX
Travere Therapeutics Inc
2025-12-31
Add
Add
+0.80%
●
24.22 ($32.64) 40.28
$55.27
69.33%
Add 141.72%
2,818,736
1,652,626
RNAM Unlock Delisted
Avidity Biosciences Inc
2025-12-31
Reduce
Reduce
-0.67%
●
44.18 ($64.94) 72.34
$71.34
9.86%
Reduce -39.37%
1,358,205
-881,776
ETNB Unlock Delisted
89bio Inc
2025-12-31
Sold Out
Sold Out
-0.63%
●
14.76 ($14.82) 14.87
$14.84
0.13%
Sold Out
0
-2,452,321

State Street(R) SPDR(R) S&P(R) Biotech ETF Total Holding History ($B)

To

State Street(R) SPDR(R) S&P(R) Biotech ETF's Asset Allocation

To

State Street(R) SPDR(R) S&P(R) Biotech ETF Past Portfolios

Portfolio Date Number of Stocks New Stocks Total Value ($Mil) Q/Q Turnover

Top Ranked Articles

  • 1

State Street(R) SPDR(R) S&P(R) Biotech ETF's Hypothetical Growth since 2025-12-31

State Street(R) SPDR(R) S&P(R) Biotech ETF's Yearly Returns

This information is only displayed for Gurus who publicly disclose audited performance records; most hedge funds and private investment firms do not publish such data or only provide limited historical performance information.

Year Portfolio % % Excess Gain %

State Street(R) SPDR(R) S&P(R) Biotech ETF's Holdings Heat Map

Size field:

State Street(R) SPDR(R) S&P(R) Biotech ETF's Holdings Bubble Chart

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