Q4 2024 Cellectis SA Earnings Call Transcript

Mar 14, 2025 / 12:00PM GMT
Release Date Price: $1.25

Key Points

Positve
  • Cellectis SA (CLLS) announced the start of three new research and development programs in collaboration with AstraZeneca, including allogenic CAR T therapies for hematological malignancies and solid tumors, as well as in vivo gene therapy for genetic disorders.
  • AstraZeneca completed an additional equity investment of $140 million in Cellectis SA (CLLS), increasing its ownership to approximately 44% of the share capital.
  • Cellectis SA (CLLS) secured a EUR40 million credit facility from the European Investment Bank, ensuring a cash runway to fund operations into mid-2027.
  • The FDA granted orphan drug designation to Cellectis SA (CLLS)'s product candidate UCART22 for the treatment of relapsed or refractory acute lymphoblastic leukemia.
  • Cellectis SA (CLLS) showcased promising CAR T strategies utilizing TALEN gene editing technology, with data presented at major conferences and published in scientific journals.
Negative
  • Cellectis SA (CLLS) faces risks and uncertainties that may cause actual results to differ from forecasts, as highlighted in their SEC filings.
  • The company is still in the early stages of clinical trials, with Phase 1 data for UCART22 and UCART20x22 expected only in late 2025.
  • Cellectis SA (CLLS) has ongoing legal matters, such as the arbitration with Sevier, which could impact future operations.
  • The competitive landscape for CAR T therapies is challenging, with recent discontinuations in the field highlighting potential hurdles.
  • Cellectis SA (CLLS) has a significant cash burn, with a net cash burn of $60 million in 2024, despite revenue from partnerships.
Operator

Good day, everyone, and welcome to today's Cellectis this full-year 2024 earnings conference call. At this time, all participants are in a listen-only mode. Later, you will have the opportunity to ask questions during the question-answer session. (Operator Instructions) Please note today's conference is being recorded. I will be standing by if you should need any assistance. It is now my pleasure to turn the conference over to Arthur Stril. Please go ahead.

Arthur Stril
Cellectis SA - Chief Business Officer, Member of the Executive Committee

Good morning, and welcome everyone to Cellectis fourth quarter and full-year 2024 business update and financial results conference call. Joining me on the call today are Doctor Andre Choulika, our Chief Executive Officer; and Doctor Adrian Kilcoyne, our Chief Medical Officer.

Yesterday evening, Cellectis issued a [6K-M] press release reporting our financial statements for the 12-month period ended December 30 2024 and a business update. The reports and press release are available on our website at cellectis.com.

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