Q4 2025 Protalix Biotherapeutics Inc Earnings Call Transcript

Mar 18, 2026 / 12:00 PM GMT

Release Date Price: €1.92 (-19.33%)

Transcript 10-K8-K

Key Points

Positve

The European Commission approved a new dosing regimen for EFrio, enhancing treatment options for Fabry disease patients in the EU.
Protalix BioTherapeutics Inc (PLX) received a EUR25 million milestone payment following the EU approval, boosting their financial position.
Projected cash balance of approximately $50 million by early April 2026, providing strong financial flexibility.
Expected revenue growth of over 50% in 2026, driven by increased patient numbers and milestone payments.
Advancement of PRX 115 in the pipeline, with phase 2 trials underway, indicating strong momentum in R&D.

Negative

Net loss of $6.6 million recorded for 2025, compared to a net income of $2.9 million in 2024, reflecting increased R&D investments.
R&D expenses increased by 51% year over year, indicating higher costs associated with advancing the clinical pipeline.
Cost of goods sold increased to $27 million, driven by higher sales volume and manufacturing issues at Pfizer.
Revenue from licensed and R&D services remains minimal, indicating limited diversification in revenue streams.
Uncertainty around the timing of US approval for the new dosing regimen, which could impact future sales growth.

Refinitiv StreetEvents Event Transcript
E D I T E D V E R S I O N

PLX.A - Protalix Biotherapeutics Inc
Q4 2025 Protalix Biotherapeutics Inc Earnings Call
Mar 18, 2026 / 12:00PM GMT

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Presentation
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Unidentified_1 [1]
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Good morning, ladies and gentlemen, and welcome to Protalix Biotherapeutics Full Year 2025 financial results and business update conference call. As a reminder, this call is being recorded. I will now turn the conference over to Mike Moyer, managing director of Life Site Advisors and investor relations representative for Protalix.

Thank you. You may begin.

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Unidentified_2 [2]
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Thank you, operator, and welcome to the Protalix Biotherapeutics full year 2025 financial results and business update conference call. With me today are Door

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