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WAVE Life SciencesFRA:1U5 +4.68%58 Cyclically Adjusted PB Ratio is 2.25 as of Aug. 06, 2026, which is 8% below its 10-year median of 2.45. GuruFocus rates FRA:1U5 with a GF Score™ of 58/100 and a GF Value™ of €3.44 (Significantly Overvalued). The stock has 2 warning signs investors should review. Among 695 Biotechnology companies, WAVE Life Sciences ranks worse than 58.42% on this metric.
The historical rank and industry rank for WAVE Life Sciences's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:1U5'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 1.53 Med: 2.45 Max: 5.61
Current: 2.18
During the past years, WAVE Life Sciences's highest Cyclically Adjusted PB Ratio was 5.61. The lowest was 1.53. And the median was 2.45.
FRA:1U5's Cyclically Adjusted PB Ratio is ranked worse than 58.42% of 695
companies
in the Biotechnology industry
Industry Median: 1.58
vs FRA:1U5: 2.18
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
WAVE Life Sciences's adjusted book value per share data for the three months ended in Jun. 2026 was €2.037. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €2.19 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
WAVE Life Sciences (FRA:1U5) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
WAVE Life Sciences Cyclically Adjusted PB Ratio Related Terms
WAVE Life Sciences Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for WAVE Life Sciences's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
WAVE Life Sciences Cyclically Adjusted PB Ratio Chart
FRA:1U5 vs FBRX, SVRA, SPTX: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, WAVE Life Sciences's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
WAVE Life Sciences Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, WAVE Life Sciences's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where WAVE Life Sciences's Cyclically Adjusted PB Ratio falls into.
WAVE Life Sciences Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
WAVE Life Sciences's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 2.25 mean?
WAVE Life Sciences (FRA:1U5) has a Cyclically Adjusted PB Ratio of 2.25 as of Aug. 06, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on WAVE Life Sciences and its competitors. This is near median its historical median of 2.45. Over the past decade, WAVE Life Sciences' Cyclically Adjusted PB Ratio has ranged from 1.53 to 5.61. According to the industry distribution chart, WAVE Life Sciences ranks #406 out of 695 companies in the Biotechnology industry, placing it in the top 58.4%.
Is WAVE Life Sciences' Cyclically Adjusted PB Ratio too high?
WAVE Life Sciences' current Cyclically Adjusted PB Ratio of 2.25 is near median its 10-year median of 2.45. Over the past 10 years, this metric has ranged from a low of 1.53 to a high of 5.61. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.58. WAVE Life Sciences' value of 2.25 is 42.4% above this industry median. Based on the distribution chart, WAVE Life Sciences ranks #406 out of 695 companies in the Biotechnology industry, which is below the industry midpoint. Overall, WAVE Life Sciences has a GF Score™ of 58/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does WAVE Life Sciences' Cyclically Adjusted PB Ratio compare to FBRX and SVRA?
According to the Biotechnology industry distribution chart, WAVE Life Sciences ranks #406 out of 695 companies for Cyclically Adjusted PB Ratio. This places WAVE Life Sciences in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.58. WAVE Life Sciences' value of 2.25 is 42.4% above this benchmark. Historically, WAVE Life Sciences' own Cyclically Adjusted PB Ratio has ranged from 1.53 to 5.61 over the past decade. While the company's 10-year median is 2.45 vs. the industry median of 1.58, WAVE Life Sciences has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.58, based on 695 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. WAVE Life Sciences's current Cyclically Adjusted PB Ratio of 2.25 is 42.4% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on WAVE Life Sciences and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.58 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. WAVE Life Sciences's current Cyclically Adjusted PB Ratio is 2.25, which is near median its own 10-year median of 2.45. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is WAVE Life Sciences stock overvalued right now?
Based on GuruFocus' analysis, WAVE Life Sciences (FRA:1U5) is currently considered Significantly Overvalued. The stock's GF Value™ is €3.44, compared to a current price of €4.92 — trading 43% above its estimated fair value. The current Cyclically Adjusted PB Ratio is 2.25, which is near median its 10-year median of 2.45 and 42.4% above the Biotechnology industry median of 1.58. WAVE Life Sciences' overall GF Score™ is 58/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For WAVE Life Sciences (FRA:1U5), the current Cyclically Adjusted PB Ratio is 2.25 as of Aug. 06, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is WAVE Life Sciences (FRA:1U5) Overvalued in 2026?
Based on GuruFocus' analysis, WAVE Life Sciences stock appears to be overvalued.
The current stock price of €4.92 is trading 43% above its estimated GF Value™ of €3.44.
GuruFocus considers WAVE Life Sciences to be Significantly Overvalued.
Key valuation signals for FRA:1U5:
Cyclically Adjusted PB Ratio: 2.25 (near median its 10-year median of 2.45)
GF Value™: €3.44 vs. price of €4.92 (43% above fair value)
Industry Position: 42.4% above the Biotechnology median (#406 of 695)
No single metric tells the full story. See the FRA:1U5 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
WAVE Life Sciences Ltd is a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines also known as oligonucleotides, targeting ribonucleic acid (RNA), to transform human health. RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Its toolkit of RNA-targeting modalities includes RNA editing, antisense silencing, and RNA interference, providing capabilities for designing and sustainably delivering candidates that optimally address disease biology. Its programs are for rare and prevalent diseases, including alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.
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