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Plus TherapeuticsPSTV -1.93%28 Debt-to-Equity is 0.06 as of Mar. 2026, which is 94% below its 10-year median of 0.98. GuruFocus rates PSTV with a GF Score™ of 28/100. The stock has 2 warning signs investors should review. Among 966 Biotechnology companies, Plus Therapeutics ranks better than 68.32% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Plus Therapeutics's Debt-to-Equity or its related term are showing as below:
PSTV'
s Debt-to-Equity Range Over the Past 10 Years
Min: -3.1 Med: 0.98 Max: 140.49
Current: 0.06
During the past 13 years, the highest Debt-to-Equity Ratio of Plus Therapeutics was 140.49. The lowest was -3.10. And the median was 0.98.
PSTV's Debt-to-Equity is ranked better than 68.32% of 966
companies
in the Biotechnology industry
Industry Median: 0.16
vs PSTV: 0.06
Plus Therapeutics (NAS:PSTV) Debt-to-Equity Explanation
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Plus Therapeutics Debt-to-Equity Related Terms
Plus Therapeutics Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Plus Therapeutics's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PSTV vs KYNB, VTGN, TVGN: Debt-to-Equity Comparison
For the Biotechnology subindustry, Plus Therapeutics's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Plus Therapeutics Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Plus Therapeutics's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Plus Therapeutics's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Plus Therapeutics (PSTV) has a Debt-to-Equity of 0.06 as of Mar. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Plus Therapeutics and its competitors. This is 94% below median its historical median of 0.98. According to the industry distribution chart, Plus Therapeutics ranks #306 out of 966 companies in the Biotechnology industry, placing it in the top 31.7%.
Is Plus Therapeutics' Debt-to-Equity too high?
Plus Therapeutics' current Debt-to-Equity of 0.06 is 94% below median its 10-year median of 0.98. The Biotechnology industry median Debt-to-Equity is 0.16. Plus Therapeutics' value of 0.06 is 62.5% below this industry median. Based on the distribution chart, Plus Therapeutics ranks #306 out of 966 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Plus Therapeutics has a GF Score™ of 28/100, reflecting its overall financial health beyond just this single metric.
How does Plus Therapeutics' Debt-to-Equity compare to KYNB and VTGN?
According to the Biotechnology industry distribution chart, Plus Therapeutics ranks #306 out of 966 companies for Debt-to-Equity. This puts Plus Therapeutics in the upper half of its industry. The industry median Debt-to-Equity is 0.16. Plus Therapeutics' value of 0.06 is 62.5% below this benchmark. While the company's 10-year median is 0.98 vs. the industry median of 0.16, Plus Therapeutics has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 966 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Plus Therapeutics's current Debt-to-Equity of 0.06 is 62.5% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Plus Therapeutics and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Plus Therapeutics's current Debt-to-Equity is 0.06, which is 94% below median its own 10-year median of 0.98. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Plus Therapeutics stock overvalued right now?
Plus Therapeutics (PSTV) has a current Debt-to-Equity of 0.06. The current Debt-to-Equity is 0.06, which is 94% below median its 10-year median of 0.98 and 62.5% below the Biotechnology industry median of 0.16. Plus Therapeutics' overall GF Score™ is 28/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Plus Therapeutics (PSTV), the current Debt-to-Equity is 0.06 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Plus Therapeutics Inc is a clinical-stage pharmaceutical company that focuses on discovering, developing, commercializing and delivering complex treatments for patients with cancer and rare diseases. The company is working on a range of potential products, with its main programs targeting recurrent glioblastoma (GBM) and leptomeningeal metastases (LM). One of its key candidates, rhenium (186Re) obisbemeda, is specifically designed to treat central nervous system (CNS) cancers such as GBM, LM, and pediatric brain cancers (PBC).
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