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EV-to-FCF is calculated as enterprise value divided by its free cash flow. As of today, Prothena's Enterprise Value is $103.04 Mil.
Prothena's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 was $-81.44 Mil. Therefore, Prothena's EV-to-FCF for today is -1.27.
The historical rank and industry rank for Prothena's EV-to-FCF or its related term are showing as below:
LTS:0Y3M'
s EV-to-FCF Range Over the Past 10 Years
Min: -91.53 Med: -3.18 Max: 64.59
Current: -1.27
During the past 13 years, the highest EV-to-FCF of Prothena was 64.59. The lowest was -91.53. And the median was -3.18.
LTS:0Y3M's EV-to-FCF is ranked worse than 100% of 345
companies
in the Biotechnology industry
Industry Median: 14.39
vs LTS:0Y3M: -1.27
EV-to-FCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-FCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Prothena's share price for today is $8.10.
Prothena's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-2.820.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Free Cash Flow is an important financial metric because it represents the actual amount of cash at a company's disposal. Companies with a low EV-to-FCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Prothena EV-to-FCF Related Terms
Prothena EV-to-FCF Historical Data
* Premium members only.
The historical data trend for Prothena's EV-to-FCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
LTS:0Y3M vs KYTX, QTTB, RZLT: EV-to-FCF Comparison
For the Biotechnology subindustry, Prothena's EV-to-FCF, along with its competitors' market caps and EV-to-FCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Prothena EV-to-FCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Prothena's EV-to-FCF distribution charts can be found below:
* The bar in red indicates where Prothena's EV-to-FCF falls into.
Prothena's current Enterprise Value is $103.04 Mil.
Prothena's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-81.44 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Prothena (LTS:0Y3M) has a EV-to-FCF of -1.27 as of Aug. 01, 2026. EV to FCF ratio is the company's enterprise value divided by free cash flow. View historical data on Prothena and its competitors. According to the industry distribution chart, Prothena ranks #999999 out of 345 companies in the Biotechnology industry.
Is Prothena's EV-to-FCF too high?
Prothena's current EV-to-FCF is -1.27. Based on the distribution chart, Prothena ranks #999999 out of 345 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Prothena has a GF Score™ of 73/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Prothena's EV-to-FCF compare to KYTX and QTTB?
According to the Biotechnology industry distribution chart, Prothena ranks #999999 out of 345 companies for EV-to-FCF. This places Prothena in the lower half of its industry. The industry median EV-to-FCF is 14.39. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-FCF for a Biotechnology company?
The median EV-to-FCF among Biotechnology companies is 14.39, based on 345 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-FCF significantly above this median, while those in the bottom quartile fall well below. However, EV-to-FCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-FCF mean?
A high EV-to-FCF can signal that a stock is expensive relative to its fundamentals. EV to FCF ratio is the company's enterprise value divided by free cash flow. View historical data on Prothena and its competitors. For the Biotechnology industry, the median EV-to-FCF is 14.39 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Prothena's current EV-to-FCF is -1.27. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prothena stock overvalued right now?
Based on GuruFocus' analysis, Prothena (LTS:0Y3M) is currently considered Possible Value Trap. The stock's GF Value™ is $14.48, compared to a current price of $8.10 — trading 44.1% below its estimated fair value. The current EV-to-FCF is -1.27. Prothena's overall GF Score™ is 73/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-FCF calculated?
EV-to-FCF is calculated from a company's financial statements. For Prothena (LTS:0Y3M), the current EV-to-FCF is -1.27 as of Aug. 01, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Prothena (LTS:0Y3M) Overvalued in 2026?
Based on GuruFocus' analysis, Prothena stock appears to be undervalued.
The current stock price of $8.10 is trading 44.1% below its estimated GF Value™ of $14.48.
GuruFocus considers Prothena to be Possible Value Trap.
Key valuation signals for LTS:0Y3M:
EV-to-FCF: -1.27
GF Value™: $14.48 vs. price of $8.10 (44.1% below fair value)
No single metric tells the full story. See the LTS:0Y3M stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Prothena Corp PLC is a late-stage clinical biotechnology company that focuses on protein dysregulation and a pipeline of investigational therapeutics with the potential to change the course of devastating neurodegenerative and rare and peripheral amyloid diseases. Prothena is developing and applying its proprietary CYTOPE technology to target a broad spectrum of intracellular disease pathways in the brain and periphery. The company's pipeline includes both wholly-owned and partnered programs like Prasinezumab, Coramitug (PRX004), BMS-986446 (PRX005), PRX019, TDP-43 CYTOPE, and PRX012-TfR, being developed for the potential treatment of Parkinson's disease, ATTR amyloidosis with cardiomyopathy, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases.
73GF Score
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