Plus TherapeuticsPSTV -4.33%26 3-Year ROIIC % is 113.85 as of Dec. 2025, which is 95% above its 10-year median of 58.53. GuruFocus rates PSTV with a GF Score™ of 26/100. The stock has 2 warning signs investors should review. Among 1,324 Biotechnology companies, Plus Therapeutics ranks better than 78.85% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Plus Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was 113.85%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Plus Therapeutics's 3-Year ROIIC % or its related term are showing as below:
PSTV's 3-Year ROIIC % is ranked better than 78.85% of 1324
companies
in the Biotechnology industry
Industry Median: -4.42
vs PSTV: 113.85
Plus Therapeutics (NAS:PSTV) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Plus Therapeutics 3-Year ROIIC % Related Terms
Plus Therapeutics 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Plus Therapeutics's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PSTV vs KYNB, VTGN, TVGN: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Plus Therapeutics's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Plus Therapeutics 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Plus Therapeutics's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Plus Therapeutics's 3-Year ROIIC % falls into.
Plus Therapeutics's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -15.298 (Dec. 2025) - -19.712 (Dec. 2022) )
/
( 7.97 (Dec. 2025) - 4.093 (Dec. 2022) )
=
4.414
/
3.877
=
113.85%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Plus Therapeutics (PSTV) has a 3-Year ROIIC % of 113.85 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Plus Therapeutics and its competitors. This is 95% above median its historical median of 58.53. According to the industry distribution chart, Plus Therapeutics ranks #280 out of 1324 companies in the Biotechnology industry, placing it in the top 21.1%.
Is Plus Therapeutics' 3-Year ROIIC % too high?
Plus Therapeutics' current 3-Year ROIIC % of 113.85 is 95% above median its 10-year median of 58.53. Based on the distribution chart, Plus Therapeutics ranks #280 out of 1324 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Plus Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Plus Therapeutics' 3-Year ROIIC % compare to KYNB and VTGN?
According to the Biotechnology industry distribution chart, Plus Therapeutics ranks #280 out of 1324 companies for 3-Year ROIIC %. This places Plus Therapeutics in the top 21% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Plus Therapeutics and its competitors. Plus Therapeutics's current 3-Year ROIIC % is 113.85, which is 95% above median its own 10-year median of 58.53. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Plus Therapeutics stock overvalued right now?
Plus Therapeutics (PSTV) has a current 3-Year ROIIC % of 113.85. The current 3-Year ROIIC % is 113.85, which is 95% above median its 10-year median of 58.53. Plus Therapeutics' overall GF Score™ is 26/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Plus Therapeutics (PSTV), the current 3-Year ROIIC % is 113.85 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Plus Therapeutics Inc is a clinical-stage pharmaceutical company that focuses on discovering, developing, commercializing and delivering complex treatments for patients with cancer and rare diseases. The company is working on a range of potential products, with its main programs targeting recurrent glioblastoma (GBM) and leptomeningeal metastases (LM). One of its key candidates, rhenium (186Re) obisbemeda, is specifically designed to treat central nervous system (CNS) cancers such as GBM, LM, and pediatric brain cancers (PBC).
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