SL

Siren, L.L.C.

13F
Siren, L.L.C.
Last update 2025-05-23 116 Stocks (24 new)
Value $1.77 Bil Turnover 18 %
Countries:
Top Holdings: SRRK(16.78%)ONC(7.66%)KYMR(5.00%)BPMC(3.63%)CRNX(3.19%)
Summary Stock Picks Current Portfolio
Siren, L.L.C. Top Holdings of 2025-03-31 View Full List
Ticker
Company
Shares
Value ($1000)
Shares Change %
Weighting %
Trade Impact %
% of Shares outstanding
3M Change %
YTD Change %
Market Cap $Mil
Industry
SRRK
Scholar Rock Holding Corp
9,250,005
297,387.7
0%
16.780
0%
9.740
+37.94%
-4.86%
3,904.2
Biotechnology
ONC
BeiGene Ltd
498,689
135,728.2
-23.72%
7.660
-1.26%
0.420
+27.36%
+58.05%
32,718.1
Biotechnology
KYMR
Kymera Therapeutics Inc
3,240,313
88,687.4
+9.11%
5.000
+0.42%
4.980
+66.20%
+12.20%
3,166.9
Biotechnology
BPMC
Blueprint Medicines Corp
726,167
64,273.0
New Holding
3.630
+3.63%
1.120
+52.86%
+48.43%
8,360.8
Biotechnology
CRNX
Crinetics Pharmaceuticals Inc
1,688,611
56,636.0
+4.91%
3.190
+0.15%
1.800
+2.65%
-39.47%
2,899.4
Biotechnology
APLS
Apellis Pharmaceuticals Inc
2,578,396
56,389.5
-8.45%
3.180
-0.34%
2.050
+6.93%
-39.58%
2,423.2
Biotechnology
IRON
Disc Medicine Inc
1,071,865
53,207.4
New Holding
3.000
+3.00%
3.100
+41.18%
-6.34%
2,056.6
Biotechnology
SLNO
Soleno Therapeutics Inc
727,337
51,968.2
+106.74%
2.930
+1.51%
1.440
+26.17%
+93.48%
4,587.4
Biotechnology
ASND
Ascendis Pharma AS
287,366
44,788.9
-3.35%
2.530
-0.06%
0.480
+4.26%
+22.05%
10,163.5
Biotechnology
MRUS
Merus NV
1,043,467
43,919.5
+33.03%
2.480
+0.62%
1.510
+44.27%
+48.32%
4,645.1
Biotechnology

Siren, L.L.C.'s Historical Top Holdings Breakdowns

Siren, L.L.C.'s Top Stock Picks View Full List
Ticker
Company
Date
Action
Impact %
Price Range
Price
Price Change from Avrg%
Comment
Current Shares
Share Change
BPMC
Blueprint Medicines Corp
2025-03-31
New Buy
New Buy
+3.63%
●
86.69 ($97.55) 115.63
$129.46
32.71%
New holding
726,167
726,167
ARGX
argenx SE
2025-03-31
Sold Out
Sold Out
-3.13%
●
571 ($631.12) 671.75
$566.14
-10.30%
Sold Out
0
-115,045
IRON
Disc Medicine Inc
2025-03-31
New Buy
New Buy
+3.00%
●
49.64 ($55.6) 63.82
$59.38
6.80%
New holding
1,071,865
1,071,865
SWTX Unlock Delisted
SpringWorks Therapeutics Inc
2025-03-31
Sold Out
Sold Out
-2.20%
●
32.5 ($46.03) 59.93
$46.99
2.09%
Sold Out
0
-1,377,701
MDGL
Madrigal Pharmaceuticals Inc
2025-03-31
Sold Out
Sold Out
-1.72%
●
272.79 ($328.59) 355.88
$330.94
0.72%
Sold Out
0
-125,942
SLNO
Soleno Therapeutics Inc
2025-03-31
Add
Add
+1.51%
●
42.54 ($48.69) 71.99
$86.97
78.62%
Add 106.74%
727,337
375,519
ONC
BeiGene Ltd
2025-03-31
Reduce
Reduce
-1.26%
●
175.1 ($233.79) 278.38
$291.93
24.87%
Reduce -23.72%
498,689
-155,032
EWTX
Edgewise Therapeutics Inc
2025-03-31
Add
Add
+1.20%
●
22 ($26.23) 30.03
$13.39
-48.95%
Add 131.02%
1,696,444
962,101
CYTK
Cytokinetics Inc
2025-03-31
Sold Out
Sold Out
-0.84%
●
40.19 ($45.96) 51.12
$36.96
-19.58%
Sold Out
0
-402,323
RYTM
Rhythm Pharmaceuticals Inc
2025-03-31
New Buy
New Buy
+0.83%
●
48.56 ($55.48) 61.02
$88.63
59.75%
New holding
277,533
277,533

Siren, L.L.C. Total Holding History ($B)

To

Siren, L.L.C.'s Asset Allocation

To

Siren, L.L.C. Past Portfolios

Portfolio Date Number of Stocks New Stocks Total Value ($Mil) Q/Q Turnover

Top Ranked Articles

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Siren, L.L.C.'s Hypothetical Growth since 2025-03-31

Siren, L.L.C.'s Yearly Returns

Year Portfolio % % Excess Gain %

Siren, L.L.C.'s Holdings Heat Map

Size field:

Siren, L.L.C.'s Holdings Bubble Chart

Siren, L.L.C. News

  • 1

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