- Bruker Corporation (BRKR, Financial) has launched the new timsUltra AIP system, promising groundbreaking sensitivity for single-cell proteomics and metaproteomics.
- The new system offers up to a 35% increase in peptide identifications and a 20% boost in protein identifications.
- This innovation is expected to revolutionize high-throughput applications in various research fields, including immunopeptidomics and single-cell studies.
Bruker Corporation (BRKR) unveiled its latest advancement in ultra-high sensitivity proteomics with the introduction of the timsUltra AIP mass spectrometer at the 73rd Conference on Mass Spectrometry and Allied Topics (ASMS). The system features the innovative Athena Ion Processor (AIP) technology, enhancing the extreme sensitivity of timsTOF UltraPASEF® methods for low-sample biological and clinical research applications, such as fine-needle aspiration (FNA) biopsies, immunopeptidomics, single-cell proteomics, and metaproteomics.
The timsUltra AIP delivers significant advancements in sensitivity with up to a 20% increase in protein identifications and a 35% gain in peptide identifications. This system offers enhanced sequence coverage for sample-limited applications and facilitates comprehensive ion coverage for de novo peptide sequencing and immunopeptidomics neoantigen discovery.
Leading researchers, including Jennifer Van Eyk from Cedars-Sinai and Nikolai Slavov from Northeastern University, have highlighted the system's potential to provide deeper insights into complex biological challenges, including cardiovascular diseases and the proteomic analysis of single-cell studies.
Additionally, the system's TIMS-enhanced ultra-high sensitivity addresses the challenges posed by metaproteomics, enabling the detection of bacterial peptides in the sub-picogram range. This capability marks a significant advancement in exploring microbial life and understanding the functional diversity of microorganisms.
Preliminary data indicate that when used in conjunction with the new Evosep EnonLC system, the timsUltra AIP can achieve over 5000 protein identifications from a single HeLa cell sample amount, with a throughput of 100 samples per day. This combined high-throughput and sensitivity is expected to be transformative for applications requiring both depth and scale, such as rapid immunopeptidomics neoantigen profiling and single-cell proteomics.
