4DMT Announces Accelerated 4D-150 Phase 3 Development in Wet AMD and Streamlined Organization to Drive Late-Stage Execution | FDMT Stock News

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Jul 02, 2025
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  • 4D Molecular Therapeutics (FDMT, Financial) accelerates 4D-150 Phase 3 trial timelines for wet AMD.
  • Workforce reduction of 25% to save $15 million annually, maintaining cash position of $458 million.
  • Company cash runway extended into 2028, supporting Phase 3 trials and BLA preparation.

4D Molecular Therapeutics (FDMT), a leading biotechnology company, has announced a significant advancement in the development of its 4D-150 program for treating wet age-related macular degeneration (AMD). The company has successfully accelerated the expected data readout for its 4FRONT-1 Phase 3 trial from the second half of 2027 to the first half, reflecting robust patient enrollment and site activation.

This strategic move suggests strong interest from both investigators and patients, supporting the potential value of 4D-150. The advancement could potentially lead to a faster market introduction by six months if approved.

Moreover, the 4FRONT-2 Phase 3 trial was initiated ahead of schedule in June 2025, aiming to include both treatment-naïve and recently treated patients, which could allow for a broader label upon regulatory approval.

In line with these developments, 4DMT has implemented a 25% workforce reduction primarily affecting early-stage research and development and support functions. This realignment is projected to generate annual cash savings of approximately $15 million, ensuring a more streamlined organizational focus on late-stage clinical execution for 4D-150 and other pipeline priorities.

As of March 31, 2025, the company reported a strong cash position of $458 million, providing a sufficient runway to support ongoing and future clinical trials and regulatory preparations into 2028, thereby solidifying its commitment to advancing its innovative treatments for retinal vascular diseases.

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I/We may personally own shares in some of the companies mentioned above. However, those positions are not material to either the company or to my/our portfolios.