Spyre Therapeutics Inc logo

Spyre Therapeutics Inc

NEW
NAS:SYRE (USA)  
$ 94.12 -8.05 (-7.88%) 07:08 PM EST
At Loss
P/B:
14.41
Market Cap:
$ 8.17B
Enterprise V:
$ 7.59B
Volume:
1.32M
Avg Vol (2M):
1.48M
Trade In:
Volume:
1.32M
At Loss
Avg Vol (2M):
1.48M

Business Description

Spyre Therapeutics Inc logo
Spyre Therapeutics Inc
NAICS : 325412 SIC : 2834
ISIN : US00773J2024

Total Employee Number:

112
Description
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
Name Current Vs Industry Vs History
Cash-To-Debt
No Debt
Equity-to-Asset
0.88
Interest Coverage
No Debt
Piotroski F-Score
3/9
0
1
2
3
4
5
6
7
8
9
WACC vs ROIC
WACC
ROIC
Name Current Vs Industry Vs History
5-Day RSI
73.52
9-Day RSI
68.91
14-Day RSI
66.48
3-1 Month Momentum %
19.67
6-1 Month Momentum %
150.93
12-1 Month Momentum %
414.88

Liquidity Ratio

Name Current Vs Industry Vs History
Current Ratio
8.97
Quick Ratio
8.97
Cash Ratio
8.71

Dividend & Buy Back

Name Current Vs Industry Vs History
3-Year Average Share Buyback Ratio
-210.4
Shareholder Yield %
-0.11

Profitability Rank

Name Current Vs Industry Vs History
ROE %
-32.28
ROA %
-28.44
ROIC %
-573.22
3-Year ROIIC %
-843.51
ROCE %
-42.98
Moat Score
4
Tariff Resilience Score
6

Financials (Next Earnings Date:2026-08-05 Est.)

SYRE's 30-Y Financials
Income Statement Breakdown FY
Not Enough Data
Balance Sheet Breakdown
Not Enough Data
Cashflow Statement Breakdown
Not Enough Data

Operating Revenue by Business Segment

Operating Revenue by Geographic Region

Historical Operating Revenue by Business Segment

Historical Operating Revenue by Geographic Region

5-Step DuPont Analysis as of
Not Enough Data

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Peter Lynch Chart

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Performance

Dividend
Log
Bar
To

Annualized Return %  

Symbol
1 Week
1 Month
3 Months
6 Months
YTD
1 Year
3 Years
5 Years
10 Years

Total Annual Return %  

Symbol
2026
2025
2024
2023
2022
2021
2020
2019
2018
2017

Spyre Therapeutics Inc Executives

Details

GF Valueâ„¢

Valuation Chart

Year:

Analyst Estimate

Key Statistics

Name Value
Revenue (TTM) (Mil $)
EPS (TTM) ($) -2.229
Beta 2.0394
3-Year Sharpe Ratio 1.25
3-Year Sortino Ratio 2.96
Volatility % 62.13
14-Day RSI 66.48
14-Day ATR ($) 5.930525
20-Day SMA ($) 92.179
12-1 Month Momentum % 414.88
52-Week Range ($) 14.505 - 105.09
Shares Outstanding (Mil) 86.84

Piotroski F-Score Details

Year:
Component Result
Piotroski F-Score 3
Positive ROA
Positive CFROA
Higher ROA yoy
CFROA > ROA
Lower Leverage yoy
Higher Current Ratio yoy
Less Shares Outstanding yoy
Higher Gross Margin yoy
Higher Asset Turnover yoy

Spyre Therapeutics Inc Filings

Filing Date Document Date Form
No Filing Data

Spyre Therapeutics Inc Stock Events

Financials Calendars
Event Date Price ($)
Third quarter earnings results for 2026 2026-11-04 In 111 days
Second quarter earnings results for 2026 2026-08-05 In 20 days
Guidance call for 2026 2026-06-08 10:00 73.65 (-5.30%)
Guidance call for 2026 2026-06-03 12:15 69.16 (-1.19%)
General meeting for 2026 2026-05-27 12:00 73.65 (-1.63%)
First quarter earnings results for 2026 2026-05-05 69.13 (+1.27%)
Spyre Therapeutics SPY001 Part A Induction Topline Results 2026-04-13 08:00 51.29 (-0.21%)
Leerink Global Healthcare Conference 2026-03-09 08:40 40.15 (+0.40%)
TD Cowen 46th Annual Health Care Conference 2026-03-03 15:10 42.49 (+2.96%)
Annual report for 2025 2026-02-19 36.60 (+1.53%)
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Spyre Therapeutics Inc Frequently Asked Questions

What is Spyre Therapeutics Inc(SYRE)'s stock price today?
The current price of SYRE is $94.12. The 52 week high of SYRE is $105.09 and 52 week low is $14.51.
When is next earnings date of Spyre Therapeutics Inc(SYRE)?
The next earnings date of Spyre Therapeutics Inc(SYRE) is 2026-08-05 Est..
Does Spyre Therapeutics Inc(SYRE) pay dividends? If so, how much?
Spyre Therapeutics Inc(SYRE) does not pay dividend.

Guru Commentaries on NAS:SYRE

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Headlines

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  • 1
Jun 24, 2026
Spyre falls after $2M insider sale
Seeking Alpha • 9:39am
  • 1