Ceryvyn Therapeutics (ASX:CYV) Cyclically Adjusted PB Ratio: 0.09 (As of Jul. 11, 2026) — 97% Below Median


What is Ceryvyn Therapeutics Cyclically Adjusted PB Ratio?

Ceryvyn Therapeutics ASX:CYV -7.69% Cyclically Adjusted PB Ratio is 0.09 as of Jul. 11, 2026, which is 97% below its 10-year median of 3.04. The stock has 3 warning signs investors should review. Among 699 Biotechnology companies, Ceryvyn Therapeutics ranks better than 89.27% on this metric.

As of today (2026-07-11), Ceryvyn Therapeutics's current share price is A$0.012. Ceryvyn Therapeutics's Cyclically Adjusted Book per Share for the fiscal year that ended in Jun25 was A$0.14. Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio for today is 0.09.

The historical rank and industry rank for Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio or its related term are showing as below:

ASX:CYV' s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.04   Med: 3.04   Max: 11.96
Current: 0.09

During the past 13 years, Ceryvyn Therapeutics's highest Cyclically Adjusted PB Ratio was 11.96. The lowest was 0.04. And the median was 3.04.

ASX:CYV's Cyclically Adjusted PB Ratio is ranked better than
89.27% of 699 companies
in the Biotechnology industry
Industry Median: 1.66 vs ASX:CYV: 0.09

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

Ceryvyn Therapeutics's adjusted book value per share data of for the fiscal year that ended in Jun25 was A$-0.251. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is A$0.14 for the trailing ten years ended in Jun25.

Shiller PE for Stocks: The True Measure of Stock Valuation


Ceryvyn Therapeutics  (ASX:CYV) Cyclically Adjusted PB Ratio Explanation

Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.


Ceryvyn Therapeutics Cyclically Adjusted PB Ratio Related Terms


Ceryvyn Therapeutics Cyclically Adjusted PB Ratio Historical Data

* Premium members only.

The historical data trend for Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ceryvyn Therapeutics Cyclically Adjusted PB Ratio Chart

Ceryvyn Therapeutics Annual Data
Trend Jun16 Jun17 Jun18 Jun19 Jun20 Jun21 Jun22 Jun23 Jun24 Jun25
Cyclically Adjusted PB Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 5.09 4.43 2.42 2.03 4.44

Ceryvyn Therapeutics Semi-Annual Data
Dec15 Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25
Cyclically Adjusted PB Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 2.42 0.00 2.03 0.00 4.44

ASX:CYV vs VRTX, REGN, ALNY: Cyclically Adjusted PB Ratio Comparison

For the Biotechnology subindustry, Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Ceryvyn Therapeutics Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio falls into.



Ceryvyn Therapeutics Cyclically Adjusted PB Ratio Calculation

Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.

Ceryvyn Therapeutics's Cyclically Adjusted PB Ratio for today is calculated as

Cyclically Adjusted PB Ratio=Share Price/ Cyclically Adjusted Book per Share
=0.012/0.14
=0.09

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ceryvyn Therapeutics's Cyclically Adjusted Book per Share for the fiscal year that ended in Jun25 is calculated as:

For example, Ceryvyn Therapeutics's adjusted Book Value per Share data for the fiscal year that ended in Jun25 was:

Adj_Book=Book Value per Share/CPI of Jun25 (Change)*Current CPI (Jun25)
=-0.251/131.5506*131.5506
=-0.251

Current CPI (Jun25) = 131.5506.

Ceryvyn Therapeutics Annual Data

Book Value per Share CPI Adj_Book
201606 0.087 0.000
201706 0.240 0.000
201806 0.161 0.000
201906 0.110 0.000
202006 0.208 0.000
202106 0.438 0.000
202206 0.168 0.000
202306 -0.016 0.000
202406 -0.105 0.000
202506 -0.251 131.551 -0.251

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

What does a Cyclically Adjusted PB Ratio of 0.09 mean?
Ceryvyn Therapeutics (ASX:CYV) has a Cyclically Adjusted PB Ratio of 0.09 as of Jul. 11, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Ceryvyn Therapeutics and its competitors. This is 97% below median its historical median of 3.04. Over the past decade, Ceryvyn Therapeutics' Cyclically Adjusted PB Ratio has ranged from 0.04 to 11.96. According to the industry distribution chart, Ceryvyn Therapeutics ranks #75 out of 699 companies in the Biotechnology industry, placing it in the top 10.7%.
Is Ceryvyn Therapeutics' Cyclically Adjusted PB Ratio too high?
Ceryvyn Therapeutics' current Cyclically Adjusted PB Ratio of 0.09 is 97% below median its 10-year median of 3.04. Over the past 10 years, this metric has ranged from a low of 0.04 to a high of 11.96. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.66. Ceryvyn Therapeutics' value of 0.09 is 94.6% below this industry median. Based on the distribution chart, Ceryvyn Therapeutics ranks #75 out of 699 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers.
How does Ceryvyn Therapeutics' Cyclically Adjusted PB Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Ceryvyn Therapeutics ranks #75 out of 699 companies for Cyclically Adjusted PB Ratio. This places Ceryvyn Therapeutics in the top 11% of its industry — outperforming the majority of peers. The industry median Cyclically Adjusted PB Ratio is 1.66. Ceryvyn Therapeutics' value of 0.09 is 94.6% below this benchmark. Historically, Ceryvyn Therapeutics' own Cyclically Adjusted PB Ratio has ranged from 0.04 to 11.96 over the past decade. While the company's 10-year median is 3.04 vs. the industry median of 1.66, Ceryvyn Therapeutics has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.66, based on 699 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Ceryvyn Therapeutics's current Cyclically Adjusted PB Ratio of 0.09 is 94.6% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Ceryvyn Therapeutics and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.66 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Ceryvyn Therapeutics's current Cyclically Adjusted PB Ratio is 0.09, which is 97% below median its own 10-year median of 3.04. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ceryvyn Therapeutics stock overvalued right now?
Ceryvyn Therapeutics (ASX:CYV) has a current Cyclically Adjusted PB Ratio of 0.09. The current Cyclically Adjusted PB Ratio is 0.09, which is 97% below median its 10-year median of 3.04 and 94.6% below the Biotechnology industry median of 1.66. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Ceryvyn Therapeutics (ASX:CYV), the current Cyclically Adjusted PB Ratio is 0.09 as of Jul. 11, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Ceryvyn Therapeutics Business Description

Address C/ Prime Company Compliance, 505 Little Collins Street, Level 9, Melbourne, VIC, AUS, 3000
Opthea Ltd is engaged in researching and developing novel therapeutic products that target Vascular Endothelial Growth Factors (VEGF) C, D, and R3. The Group operates in one industry and two geographical areas, namely biotechnology and healthcare, with operations in Australia and the United States. The company focuses on developing biological therapeutics for eye diseases and is currently developing a novel biologic therapy, OPT-302, for the treatment of eye conditions. Its products are based on an intellectual property portfolio covering VEGF-C, VEGF-D, and VEGF Receptor-3 targets, aimed at treating diseases associated with blood and lymphatic vessel growth and vascular leakage.