Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Lobe SciencesFRA:LOBE +8.33% Cyclically Adjusted PB Ratio is 0.43 as of Aug. 18, 2026, which is 258% above its 10-year median of 0.12. The stock has 2 warning signs investors should review. Among 693 Biotechnology companies, Lobe Sciences ranks better than 75.32% on this metric.
The historical rank and industry rank for Lobe Sciences's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:LOBE'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.06 Med: 0.12 Max: 0.64
Current: 0.49
During the past years, Lobe Sciences's highest Cyclically Adjusted PB Ratio was 0.64. The lowest was 0.06. And the median was 0.12.
FRA:LOBE's Cyclically Adjusted PB Ratio is ranked better than 75.32% of 693
companies
in the Biotechnology industry
Industry Median: 1.63
vs FRA:LOBE: 0.49
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Lobe Sciences's adjusted book value per share data for the three months ended in May. 2026 was €0.004. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €0.09 for the trailing ten years ended in May. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Lobe Sciences (FRA:LOBE) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Lobe Sciences Cyclically Adjusted PB Ratio Related Terms
Lobe Sciences Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Lobe Sciences's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
FRA:LOBE vs VRTX, REGN, RVMD: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Lobe Sciences's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Lobe Sciences Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Lobe Sciences's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Lobe Sciences's Cyclically Adjusted PB Ratio falls into.
Lobe Sciences Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Lobe Sciences's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 0.43 mean?
Lobe Sciences (FRA:LOBE) has a Cyclically Adjusted PB Ratio of 0.43 as of Aug. 18, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Lobe Sciences and its competitors. This is 258% above median its historical median of 0.12. Over the past decade, Lobe Sciences' Cyclically Adjusted PB Ratio has ranged from 0.06 to 0.64. According to the industry distribution chart, Lobe Sciences ranks #171 out of 693 companies in the Biotechnology industry, placing it in the top 24.7%.
Is Lobe Sciences' Cyclically Adjusted PB Ratio too high?
Lobe Sciences' current Cyclically Adjusted PB Ratio of 0.43 is 258% above median its 10-year median of 0.12. Over the past 10 years, this metric has ranged from a low of 0.06 to a high of 0.64. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.63. Lobe Sciences' value of 0.43 is 73.6% below this industry median. Based on the distribution chart, Lobe Sciences ranks #171 out of 693 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers.
How does Lobe Sciences' Cyclically Adjusted PB Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Lobe Sciences ranks #171 out of 693 companies for Cyclically Adjusted PB Ratio. This places Lobe Sciences in the top 25% of its industry — outperforming the majority of peers. The industry median Cyclically Adjusted PB Ratio is 1.63. Lobe Sciences' value of 0.43 is 73.6% below this benchmark. Historically, Lobe Sciences' own Cyclically Adjusted PB Ratio has ranged from 0.06 to 0.64 over the past decade. While the company's 10-year median is 0.12 vs. the industry median of 1.63, Lobe Sciences has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.63, based on 693 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Lobe Sciences's current Cyclically Adjusted PB Ratio of 0.43 is 73.6% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Lobe Sciences and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.63 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Lobe Sciences's current Cyclically Adjusted PB Ratio is 0.43, which is 258% above median its own 10-year median of 0.12. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lobe Sciences stock overvalued right now?
Lobe Sciences (FRA:LOBE) has a current Cyclically Adjusted PB Ratio of 0.43. The current Cyclically Adjusted PB Ratio is 0.43, which is 258% above median its 10-year median of 0.12 and 73.6% below the Biotechnology industry median of 1.63. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Lobe Sciences (FRA:LOBE), the current Cyclically Adjusted PB Ratio is 0.43 as of Aug. 18, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Lobe Sciences Ltd is a biopharmaceutical company focused on using lipid technology that develop therapies for orphan and rare diseases. It commercializes Altemia MF, a medical food intended to address nutritional deficiencies associated with sickle cell disease. Through its subsidiaries, the company also holds a majority interest in the development of Conjugated Psilocin for potential use in neurological and psychiatric indications. The company operates in one reportable segment, being the biopharmaceutical development of new medicines.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
FRA:LOBE has been successfully added to your 
