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Madrigal PharmaceuticalsFRA:YDO1 +1.24%37 Cyclically Adjusted PB Ratio is 23.56 as of Sep. 15, 2026, which is 29% above its 10-year median of 18.27. GuruFocus rates FRA:YDO1 with a GF Score™ of 37/100. The stock has 4 warning signs investors should review. Among 680 Biotechnology companies, Madrigal Pharmaceuticals ranks worse than 95.29% on this metric.
The historical rank and industry rank for Madrigal Pharmaceuticals's Cyclically Adjusted PB Ratio or its related term are showing as below:
FRA:YDO1'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 10.88 Med: 18.27 Max: 29.16
Current: 23.6
During the past years, Madrigal Pharmaceuticals's highest Cyclically Adjusted PB Ratio was 29.16. The lowest was 10.88. And the median was 18.27.
FRA:YDO1's Cyclically Adjusted PB Ratio is ranked worse than 95.29% of 680
companies
in the Biotechnology industry
Industry Median: 1.575
vs FRA:YDO1: 23.60
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Madrigal Pharmaceuticals's adjusted book value per share data for the three months ended in Jun. 2026 was €19.836. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is €19.78 for the trailing ten years ended in Jun. 2026.
Shiller PE for Stocks: The True Measure of Stock Valuation
Madrigal Pharmaceuticals (FRA:YDO1) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Madrigal Pharmaceuticals Cyclically Adjusted PB Ratio Related Terms
Madrigal Pharmaceuticals Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Madrigal Pharmaceuticals's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Madrigal Pharmaceuticals Cyclically Adjusted PB Ratio Chart
FRA:YDO1 vs CORT, BMRN, ARWR: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Madrigal Pharmaceuticals's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Madrigal Pharmaceuticals Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Madrigal Pharmaceuticals's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Madrigal Pharmaceuticals's Cyclically Adjusted PB Ratio falls into.
Madrigal Pharmaceuticals Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 23.56 mean?
Madrigal Pharmaceuticals (FRA:YDO1) has a Cyclically Adjusted PB Ratio of 23.56 as of Sep. 15, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Madrigal Pharmaceuticals and its competitors. This is 29% above median its historical median of 18.27. Over the past decade, Madrigal Pharmaceuticals' Cyclically Adjusted PB Ratio has ranged from 10.88 to 29.16. According to the industry distribution chart, Madrigal Pharmaceuticals ranks #648 out of 680 companies in the Biotechnology industry, placing it in the top 95.3%.
Is Madrigal Pharmaceuticals' Cyclically Adjusted PB Ratio too high?
Madrigal Pharmaceuticals' current Cyclically Adjusted PB Ratio of 23.56 is 29% above median its 10-year median of 18.27. Over the past 10 years, this metric has ranged from a low of 10.88 to a high of 29.16. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.58. Madrigal Pharmaceuticals' value of 23.56 is 1395.9% above this industry median. Based on the distribution chart, Madrigal Pharmaceuticals ranks #648 out of 680 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Madrigal Pharmaceuticals has a GF Score™ of 37/100, reflecting its overall financial health beyond just this single metric.
How does Madrigal Pharmaceuticals' Cyclically Adjusted PB Ratio compare to CORT and BMRN?
According to the Biotechnology industry distribution chart, Madrigal Pharmaceuticals ranks #648 out of 680 companies for Cyclically Adjusted PB Ratio. This places Madrigal Pharmaceuticals in the lower half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.58. Madrigal Pharmaceuticals' value of 23.56 is 1395.9% above this benchmark. Historically, Madrigal Pharmaceuticals' own Cyclically Adjusted PB Ratio has ranged from 10.88 to 29.16 over the past decade. While the company's 10-year median is 18.27 vs. the industry median of 1.58, Madrigal Pharmaceuticals has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.58, based on 680 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Madrigal Pharmaceuticals's current Cyclically Adjusted PB Ratio of 23.56 is 1395.9% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Madrigal Pharmaceuticals and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.58 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Madrigal Pharmaceuticals's current Cyclically Adjusted PB Ratio is 23.56, which is 29% above median its own 10-year median of 18.27. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Madrigal Pharmaceuticals stock overvalued right now?
Madrigal Pharmaceuticals (FRA:YDO1) has a current Cyclically Adjusted PB Ratio of 23.56. The current Cyclically Adjusted PB Ratio is 23.56, which is 29% above median its 10-year median of 18.27 and 1395.9% above the Biotechnology industry median of 1.58. Madrigal Pharmaceuticals' overall GF Score™ is 37/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Madrigal Pharmaceuticals (FRA:YDO1), the current Cyclically Adjusted PB Ratio is 23.56 as of Sep. 15, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Madrigal Pharmaceuticals Inc is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease with high unmet medical need that can lead to cirrhosis, liver failure, liver cancer, need for liver transplantation and premature mortality. Its medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed thyroid hormone receptor beta agonist designed to target key underlying causes of MASH.
37GF Score
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